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11. 发明申请

WO2014043149A1 MEASURING INFORMATION ACQUISITION USING FREE RECALL 审中-公开
标题翻译：使用免费回收测量信息获取
公开(公告)号：WO2014043149A1
公开(公告)日：2014-03-20
申请号：PCT/US2013/059109
申请日：2013-09-11
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
发明人： WOODS, Russell, L. , SAUNDERS, Daniel, R. , BEX, Peter
IPC分类号： G06F19/00 , A61B5/16
CPC分类号： A61B5/0048 , A61B3/02 , A61B5/1104 , A61B5/123 , A61B5/162 , A61B5/168 , A61B5/4011 , A61B5/4803 , A61B5/7475 , A61B5/749 , G06F19/00 , G09B7/00 , G16H50/20
摘要： Assessing acquisition of information related to a stimulus can be accomplished by providing a stimulus, recording a free recall response in natural language of the stimulus by a subject, and determining automatically a similarity. The similarity is between the recorded free recall response and a database comprising one or more control responses associated with the stimulus. A higher similarity indicates greater information acquisition by the subject. Related apparatus, systems, techniques, and articles are also described.
摘要翻译：对刺激信息的获取的评估可以通过提供刺激，记录受试者的刺激的自然语言的自由回忆响应并自动确定相似性来实现。记录的自由召回响应与包含与刺激相关联的一个或多个控制响应的数据库之间的相似性是相似的。较高的相似性表示受试者获得更多的信息。还描述了相关装置，系统，技术和制品。

12. 发明申请

WO2013170091A1 RAPID MEASUREMENT OF VISUAL SENSITIVITY 审中-公开
标题翻译：快速测量视觉灵敏度
公开(公告)号：WO2013170091A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040434
申请日：2013-05-09
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC. , THE OHIO STATE UNIVERSITY
发明人： BEX, Peter , DORR, Michael , LESMES, Luis , LU, Zhong-lin
IPC分类号： A61B3/028
CPC分类号： A61B3/022 , A61B3/0025 , A61B3/032 , A61B3/06
摘要： Data is received characterizing a result of a first visual sensitivity test assessing capacity to detect spatial form across one or more different target sizes, and different contrasts. Using the received data, one or more first parameters defining a first estimated visual sensitivity for a first range of contrasts and a second range of spatial frequencies is determined. One or more second parameters defining a second estimated visual sensitivity for a third range of contrasts and a fourth range of spatial frequencies is determined using the one or more first parameters and a statistical inference by at least presenting a first visual stimulus, receiving a response, and determining a second visual stimulus based at least on the response and at least a rule. The one or more second parameters is provided. Related apparatus, systems, techniques and articles are also described.
摘要翻译：接收数据，其表征第一视觉敏感性测试的结果，评估能力以检测跨越一个或多个不同目标大小的空间形式的能力，以及不同的对比度。使用所接收的数据，确定对于第一对比度范围和空间频率的第二范围定义第一估计视觉灵敏度的一个或多个第一参数。使用一个或多个第一参数和统计推断来确定对于第三范围的对比度和第四范围的空间频率定义第二估计视觉灵敏度的一个或多个第二参数，至少呈现第一视觉刺激，接收响应，以及至少基于所述响应和至少一个规则来确定第二视觉刺激。提供一个或多个第二参数。还描述了相关设备，系统，技术和物品。

13. 发明申请

WO2013112448A1 GENERATION OF PHOTORECEPTORS FROM HUMAN RETINAL PROGENITOR CELLS USING POLYCAPROLACTONE SUBSTRATES 审中-公开
标题翻译：使用聚碳酸酯基材从人类前体细胞中产生光催化剂
公开(公告)号：WO2013112448A1
公开(公告)日：2013-08-01
申请号：PCT/US2013/022494
申请日：2013-01-22
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE
发明人： REGATIERI, Caio , BARANOV, Petr, Y. , YOUNG, Michael, J.
IPC分类号： A61F2/00 , A01N63/00 , C12N5/00
CPC分类号： A61K47/30 , A61F2/14 , A61F2/16 , A61K9/0051 , A61K35/30 , A61K47/34 , G01N33/5044 , G01N33/5058 , G01N33/5073
摘要： The present invention relates to biocompatible compositions for transplantation into a sub-retinal space of the human eye. The compositions include a biodegradable polyester film, preferably a polycaprolactone (PCL) film, and a layer of human retinal progenitor cells. The compositions of the invention can be used as scaffolds for the treatment a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.
摘要翻译：本发明涉及用于移植到人眼的亚视网膜空间中的生物相容性组合物。组合物包括可生物降解的聚酯膜，优选聚己内酯（PCL）膜和人视网膜祖细胞层。本发明的组合物可用作治疗许多眼部疾病的支架，包括色素性视网膜炎和年龄相关性黄斑变性。

14. 发明申请

WO2012037414A1 SYSTEMS AND METHODS FOR MULTILAYER IMAGING AND RETINAL INJURY ANALYSIS 审中-公开
标题翻译：多层成像和损伤分析的系统与方法
公开(公告)号：WO2012037414A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051848
申请日：2011-09-15
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , SCHEPENS EYE RESEARCH INSTITUTE , MANGOUBI, Rami , DESAI, Mukund , LASHKARI, Kameran , FAZELAT, Ahad
发明人： MANGOUBI, Rami , DESAI, Mukund , LASHKARI, Kameran , FAZELAT, Ahad
IPC分类号： A61B3/12 , G06T7/00
CPC分类号： A61B3/12 , G06T7/0012 , G06T7/13 , G06T7/174 , G06T2207/10048 , G06T2207/10141 , G06T2207/30041
摘要： Systems and methods are provided for imaging an eye and identifying retinal or subretinal features that may be indicative of pathologies such as macular degeneration and traumatic brain injury. An infrared or near-infrared image of an eye is interdependently smoothed and segmented and attributes of the image are determined. The attributes are indicative of retinal or subretinal features.
摘要翻译：提供了系统和方法用于对眼睛进行成像，并且识别可以指示诸如黄斑变性和创伤性脑损伤的病理学的视网膜或视网膜下特征。眼睛的红外或近红外图像被相互平滑和分割，并确定图像的属性。这些属性表示视网膜或视网膜下特征。

15. 发明申请

WO2012009171A2 COMPOSITIONS AND METHODS OF TREATMENT OF CORNEAL ENDOTHELIUM DISORDERS 审中-公开
标题翻译：治疗角膜内膜异物的组合物和方法
公开(公告)号：WO2012009171A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/042664
申请日：2011-06-30
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC. , JURKUNAS, Ula, V.
发明人： JURKUNAS, Ula, V.
IPC分类号： A61K31/122 , A61K31/12 , A61K31/015 , A61P27/02 , A61P27/00
CPC分类号： A61K38/07 , A61K9/0048 , A61K31/00 , A61K31/26 , A61K31/385 , A61K45/06 , A61K2300/00
摘要： This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
摘要翻译：本申请公开了用一种或多种Nrf2激活剂和/或线粒体靶向抗氧化剂治疗福克斯内皮角膜营养不良（FECD）的药物组合物（例如，口服，肠胃外或局部眼用制剂）。组合物可以局部施用于眼睛并且有效治疗FECD。本发明还提供了在需要这种治疗的受试者中通过局部施用本发明的一种或多种Nrf2激活剂和/或线粒体治疗FECD的方法。

16. 发明申请

WO2010081091A2 THERAPEUTIC COMPOSITIONS FOR TREATMENT OF CORNEAL DISORDERS 审中-公开
标题翻译：治疗角膜疾病的治疗组合物
公开(公告)号：WO2010081091A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020646
申请日：2010-01-11
申请人： SCHEPENS EYE RESEARCH INSTITUTE , DANA, Reza , DASTJERDI, Mohammed , CHAUHAN, Sunil
发明人： DANA, Reza , DASTJERDI, Mohammed , CHAUHAN, Sunil
IPC分类号： A61K38/17 , C12N15/113 , A61P27/02
CPC分类号： A61K38/1709 , A61K9/0048 , A61K38/1793 , A61K38/2006 , C12N15/1136 , C12N2310/14 , A61K2300/00
摘要： The invention provides methods and compositions for minimizing, preventing, or treating damage to corneal nerves by administering to a subject with such damage or at risk of exposure to such damage a composition which blocks an activity of an IL-I cytokine and/or an IL-17 cytokine.
摘要翻译：本发明提供了通过向受试者施用具有这种损伤或有暴露于这种损伤的风险的方式来减少，预防或治疗对角膜神经的损伤的方法和组合物，该组合物阻断IL-1细胞因子和/或IL的活性 -17细胞因子。

17. 发明申请

WO2007092628A2 METHODS AND COMPOSITIONS FOR MODULATING CONJUNCTIVAL GOBLET CELLS 审中-公开
标题翻译：调节连接蛋白细胞的方法和组合物
公开(公告)号：WO2007092628A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003609
申请日：2007-02-09
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC. , DARTT, Darlene, A.
发明人： DARTT, Darlene, A.
CPC分类号： A61K38/1858 , A61K9/0048 , A61K38/1732 , A61K38/1825
摘要： The present invention relates to conjunctival goblet cell proliferation and secretions. The present invention also relates to compositions that can modulate conjunctival goblet cell proliferation and secretions. The present invention also relates to galectins, PDGF, bFGF, and the regulation of goblet cells.
摘要翻译：本发明涉及结膜杯状细胞增殖和分泌。本发明还涉及可调节结膜杯状细胞增殖和分泌的组合物。本发明还涉及半乳凝素，PDGF，bFGF和杯状细胞的调节。

18. 发明申请

WO2006007510A1 COMPOSITIONS AND METHODS FOR TREATING EYE DISORDERS AND CONDITIONS 审中-公开
标题翻译：用于治疗眼病和病症的组合物和方法
公开(公告)号：WO2006007510A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/023113
申请日：2005-06-30
申请人： SCHEPENS EYE RESEARCH , JOHNSON & JOHNSON VISION CARE, INC. , DANA, Reza , SCHAUMBERG, Debra , MOLOCK, Frank , COPPER, Lenora , MAHADEVAN, Shiv , LORENZ, Kathy, Osborn , RASHID, Saadia
发明人： DANA, Reza , SCHAUMBERG, Debra , MOLOCK, Frank , COPPER, Lenora , MAHADEVAN, Shiv , LORENZ, Kathy, Osborn , RASHID, Saadia
IPC分类号： A61K31/19
CPC分类号： A61K9/0048 , A61K9/107 , A61K31/202 , A61K2300/00
摘要： The present invention relates to compositions comprising omega-6 and/or omega-3 fatty acids and uses thereof. The present invention also relates to methods of treatment using such compositions.
摘要翻译：本发明涉及包含ω-6和/或ω-3脂肪酸的组合物及其用途。本发明还涉及使用这种组合物的治疗方法。

19. 发明申请

WO2003039332A3 DEVICE FOR DIGITAL RETINAL IMAGING 审中-公开
公开(公告)号：WO2003039332A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/032787
申请日：2002-10-16
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC. , ELSNER, Ann, E.
发明人： ELSNER, Ann, E.
IPC分类号： A61B3/14
摘要： A portable, lightweight digital imaging device uses a slit scanning arrangement (30) to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area (32) illuminated at a time, thereby reducing the amount of unwanted light scatter and providing a higher contrast image. A detection arrangement (38) receives the light remitted from the retinal plane and produces an image. The device is operable under battery power and ambient light conditions, such as outdoor or room lighting. The device is noncontact and does not require that the pupil of the eye be dilated with drops. The device can be used by personnel who do not have specialized training in the eye, such as emergency personnel, pediatricians, or general practitioners. Images can be viewed in the device or transmitted to a remote location via (44). The device can also be used to provide images of the anterior segment of the eye or other small structures.

20. 发明申请

WO2003039332A2 DEVICE FOR DIGITAL RETINAL IMAGING 审中-公开
标题翻译：用于数字化成像的设备
公开(公告)号：WO2003039332A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/032787
申请日：2002-10-16
申请人： THE SCHEPENS EYE RESEARCH INSTITUTE, INC. , ELSNER, Ann, E.
发明人： ELSNER, Ann, E.
IPC分类号： A61B
CPC分类号： A61B3/156
摘要： A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area illuminated at a time, thereby reducing the amount of unwanted light scatter and providing a higher contrast image. A detection arrangement receives the light remitted from the retinal plane and produces an image. The device is operable under battery power and ambient light conditions, such as outdoor or room lighting. The device is noncontact and does not require that the pupil of the eye be dilated with drops. The device can be used by personnel who do not have specialized training in the eye, such as emergency personnel, pediatricians, or general practitioners. Images can be viewed in the device or transmitted to a remote location. The device can also be used to provide images of the anterior segment of the eye or other small structures.
摘要翻译：便携式，轻便的数字成像装置使用狭缝扫描装置来获得眼睛的图像，特别是视网膜。扫描装置减少了一次照射的目标区域的量，从而减少不需要的光散射的量并提供较高的对比度图像。检测装置接收从视网膜平面排出的光并产生图像。该设备可在电池电源和环境光条件下操作，如户外或室内照明。该装置是非接触式的，不需要眼睛的瞳孔用液滴扩张。该装置可以由没有眼睛专门训练的人员使用，如急救人员，儿科医生或全科医生。可以在设备中查看图像或传输到远程位置。该装置还可用于提供眼睛前段或其他小结构的图像。

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