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11. 发明申请

WO2011008738A1 SWAGED BRAIDED CATHETER AND METHOD OF FABRICATION 审中-公开
标题翻译：开关式制动导管及其制造方法
公开(公告)号：WO2011008738A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041798
申请日：2010-07-13
申请人： COOK INCORPORATED , SCHAEFFER, Darin, G.
发明人： SCHAEFFER, Darin, G.
IPC分类号： A61M25/00
CPC分类号： A61M25/005 , A61M25/0012 , A61M2025/0004 , A61M2025/0059
摘要： A swaged braided catheter (30) for use in various medical procedures is provided. The swaged braided catheter includes a tubular braid (32) formed from a plurality of braided wire members (38). A plurality of intersections (40) is formed by the braided wire members. The intersections are compressed defining a plurality of flattened regions along the tubular braid. The intersections have a first thickness (dl) before being compressed and a reduced second thickness (t2) after being compressed. The flattened regions with the reduced second thickness provide the swaged braided catheter with a reduced cross-sectional profile, and reduced catheter recoil.
摘要翻译：提供了用于各种医疗程序的模锻编织导管（30）。编织导管包括由多个编织线构件（38）形成的管状编织物（32）。多个交叉点（40）由编织线构件形成。交叉点被压缩，沿着管状编织层限定多个平坦化区域。交叉点在被压缩之前具有第一厚度（d1），并且在压缩之后具有减小的第二厚度（t2）。具有减小的第二厚度的扁平区域提供具有减小的横截面轮廓的模锻编织导管，并减少导管后坐力。

12. 发明申请

WO2007146021A3 STENT WITH A CRUSH-RESISTANT ZONE 审中-公开
标题翻译：具有耐冲击区域的STENT
公开(公告)号：WO2007146021A3
公开(公告)日：2008-02-07
申请号：PCT/US2007013361
申请日：2007-06-06
申请人： COOK INC , COOK WILLIAM A AUSTRALIA , SCHAEFFER DARIN G , BOATMAN SCOTT E , DITTMAN JAY A , HARTLEY DAVID ERNEST
发明人： SCHAEFFER DARIN G , BOATMAN SCOTT E , DITTMAN JAY A , HARTLEY DAVID ERNEST
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/821 , A61F2002/91525 , A61F2002/91558 , A61F2002/91566 , A61F2220/0016 , A61F2220/0025 , A61F2220/0075 , A61F2250/0018 , A61F2250/0029 , A61F2250/0039 , A61F2250/0073
摘要： An endoluminal prosthesis system for a branched body lumen comprises a branch vessel prosthesis (11 ). The branch vessel prosthesis (11 ) is deployable within a branch vessel body lumen and comprises a stent (48) having a generally tubular body portion (33), a flareable proximal end portion (36), and a coupling portion (38) disposed intermediate the body portion and the flareable portion. The coupling portion is preferably more crush-resistant than the body portion.
摘要翻译：用于分支体腔的腔内假体系统包括分支血管假体（11）。分支血管假体（11）可部署在分支血管体腔内，并且包括具有大致管状体部分（33），可扩张近端部分（36）和中间设置的联接部分（38）的支架（48）主体部分和可扩张部分。联接部分优选地比主体部分更耐压。

13. 发明申请

WO2007106441A2 TAXANE COATINGS FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于可植入医疗器械的TAXANE涂层
公开(公告)号：WO2007106441A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006223
申请日：2007-03-12
申请人： COOK INCORPORATED , MED INSTITUTE, INC. , SCHAEFFER, Darin, G. , MOORE, William, F. , RUANE, Patrick, H. , REYES, Priscilla, T.
发明人： SCHAEFFER, Darin, G. , MOORE, William, F. , RUANE, Patrick, H. , REYES, Priscilla, T.
IPC分类号： A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61L27/54 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61K31/337 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量紫杉烷治疗剂在涂层中。其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

14. 发明申请

WO2006122243A3 CATHETER STIFFENING MEMBER 审中-公开
公开(公告)号：WO2006122243A3
公开(公告)日：2006-11-16
申请号：PCT/US2006/018242
申请日：2006-05-10
申请人： COOK INCORPORATED , LENTZ, D., Christian , SCHAEFFER, Darin, G. , ROBERTS, Kimberly, D.
发明人： LENTZ, D., Christian , SCHAEFFER, Darin, G. , ROBERTS, Kimberly, D.
IPC分类号： A61M25/00
摘要： A stiffening member for providing controllably variable stiffness to a catheter. A hollow elongated tubular member is sized to be received in a lumen of the catheter. At least a length of the tubular member is configured, such as by forming a spiral cut therethrough, in a manner such that the distal portion of the tubular member has a greater flexibility than the proximal portion.

15. 发明申请

WO2004096100A1 ARTIFICIAL VALVE PROSTHESIS WITH IMPROVED FLOW DYNAMICS 审中-公开
标题翻译：人工阀门改进流动动力学
公开(公告)号：WO2004096100A1
公开(公告)日：2004-11-11
申请号：PCT/US2004/012430
申请日：2004-04-21
申请人： COOK INCORPORATED , CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , HOFFA, Andrew, K. , SCHAEFFER, Darin, G.
发明人： CASE, Brian, C. , FLAGLE, Jacob, A. , GARRISON, Michael, L. , HOFFA, Andrew, K. , SCHAEFFER, Darin, G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure (11) that configured to enlarge the area adjacent to the valve structure (12) such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus (34) adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
摘要翻译：一种具有支撑结构（11）的可膨胀静脉瓣，所述支撑结构（11）构造成扩大邻近所述瓣膜结构（12）的区域，使得逆行流的流动模式被改变为有利于在阀门区域，以防止静脉系统中的体液停滞，可导致血栓形成。可以通过在两个支撑框架部分之间的血管壁的无支撑部分中形成邻近阀结构的人造窦（34）来产生扩大的口袋区域，或者支撑框架可以包括形成人造窦的扩张直径的中间或近端部分邻近阀门结构。在另一组实施例中，相对的小叶和支撑框架和/或血管壁之间的附接通路包括近端部分，其将小叶彼此延伸接触，并且远端部分相对于相邻壁形成大角度，在传单的底部创造了一个大口袋。在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸以产生延伸的小叶接触区域，然后沿着远侧连接支柱周向地和远端地从前者角度定位以限定传单的底部边缘。

16. 发明申请

WO2018200453A1 TISSUE FIXATION SYSTEMS 审中-公开
公开(公告)号：WO2018200453A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029044
申请日：2018-04-24
申请人： MELSHEIMER, Jeffry , SCHAEFFER, Darin , TANNER, Shaun , ISCH, Andrew , BAUMGARTNER, Rebecca , XANH, Nolan , GHAMSARI, Ali
发明人： MELSHEIMER, Jeffry , SCHAEFFER, Darin , TANNER, Shaun , ISCH, Andrew , BAUMGARTNER, Rebecca , XANH, Nolan , GHAMSARI, Ali
IPC分类号： A61B17/04 , A61B17/24
CPC分类号： A61F2/20 , A61B17/04 , A61B17/24 , A61F2220/0008 , A61F2220/0041 , A61F2250/0036 , A61F2250/0037
摘要： Tissue fixation systems and tissue manipulators are described herein. In addition, methods of using a tissue fixation system and a tissue manipulator, methods of manufacturing a tissue manipulator, and kits that include a tissue fixation system and a tissue manipulator are described herein. An example embodiment of a tissue fixation system includes a mounting plate, a mounting jaw releasably attached to the mounting plate, a mounting clamp releasably attached to the mounting plate, and a plurality of fasteners.

17. 发明申请

WO2016022454A1 MEDICAL DEVICES HAVING A RELEASABLE TUBULAR MEMBER AND METHODS OF USING THE SAME 审中-公开
标题翻译：具有可释放管状部件的医疗装置及其使用方法
公开(公告)号：WO2016022454A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043375
申请日：2015-08-03
申请人： SCHAEFFER, Darin , HARDERT, Kathryn , HAINES, Joshua
发明人： SCHAEFFER, Darin , HARDERT, Kathryn , HAINES, Joshua
IPC分类号： A61B17/34
CPC分类号： A61B17/34 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B17/3423 , A61B2017/00477 , A61B2017/345 , A61B2017/3492
摘要： Medical devices that have a releasable intermediate member and tubular member are described. Methods of using medical devices that have a releasable intermediate member and tubular member are also described. An example medical device comprises an elongate member, an intermediate member, and a tubular member. Each of the intermediate member and tubular member is releasably disposed on the elongate member.
摘要翻译：描述了具有可释放中间构件和管状构件的医疗装置。还描述了使用具有可释放中间构件和管状构件的医疗装置的方法。示例性医疗装置包括细长构件，中间构件和管状构件。中间构件和管状构件中的每一个可释放地设置在细长构件上。

18. 发明申请

WO2015020953A1 MEDICAL DEVICES HAVING A RELEASABLE TUBULAR MEMBER AND METHODS OF USING THE SAME 审中-公开
标题翻译：具有可释放管状部件的医疗装置及其使用方法
公开(公告)号：WO2015020953A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049589
申请日：2014-08-04
申请人： SCHAEFFER, Darin
发明人： SCHAEFFER, Darin
IPC分类号： A61B17/34
CPC分类号： A61B17/0218 , A61B17/34 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B2017/00477 , A61B2017/345 , A61B2017/3488 , A61B2017/3492
摘要： Medical devices that have a releasable intermediate member and tubular member are described. Methods of using medical devices that have a releasable intermediate member and tubular member are also described. An example of a medical device comprises an elongate member, an intermediate member, and a tubular member. Each of the intermediate member and tubular member is releasably disposed on the elongate member.
摘要翻译：描述了具有可释放中间构件和管状构件的医疗装置。还描述了使用具有可释放中间构件和管状构件的医疗装置的方法。医疗装置的实例包括细长构件，中间构件和管状构件。中间构件和管状构件中的每一个可释放地设置在细长构件上。

19. 发明申请

WO2010024849A1 PROSTHESIS WITH MOVEABLE FENESTRATION 审中-公开
标题翻译：具有可移动的优化
公开(公告)号：WO2010024849A1
公开(公告)日：2010-03-04
申请号：PCT/US2009/004570
申请日：2009-08-10
申请人： COOK INCORPORATED , SCHAEFFER, Darin, G. , KUPPURATHANAM, Shyam, SV
发明人： SCHAEFFER, Darin, G. , KUPPURATHANAM, Shyam, SV
IPC分类号： A61F2/06
CPC分类号： D03D3/02 , A61F2/07 , A61F2/89 , A61F2002/061 , A61F2002/075 , A61F2250/0015 , A61F2250/0017 , A61F2250/0018 , D10B2509/06
摘要： A prosthesis with a moveable fenestration includes a tubular graft body having a proximal end, a distal end, at least one fenestration disposed in a sidewall of the tubular body between the proximal end and the distal end, a first biocompatible graft material, and a second biocompatible graft material adjacent the perimeter of the at least one fenestration, wherein the second biocompatible material is of greater flexibility than the first biocompatible material such that movement of the fenestration relative to the surface plane of the tubular graft body is permitted.
摘要翻译：具有可移动开窗的假体包括管状移植体，其具有近端，远端，设置在近端和远端之间的管状体的侧壁中的至少一个开窗，第一生物相容性移植物材料和第二生物相容性移植物材料与所述至少一个开窗的周边相邻的生物相容性移植材料，其中所述第二生物相容性材料比所述第一生物相容性材料具有更大的柔性，从而允许所述开窗相对于所述管状移植物体的表面平面的移动。

20. 发明申请

WO2006122243A2 CATHETER STIFFENING MEMBER 审中-公开
标题翻译：导管加强件
公开(公告)号：WO2006122243A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018242
申请日：2006-05-10
申请人： COOK INC , LENTZ D CHRISTIAN , SCHAEFFER DARIN G , ROBERTS KIMBERLY D
发明人： LENTZ D CHRISTIAN , SCHAEFFER DARIN G , ROBERTS KIMBERLY D
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/10 , A61M2025/0063
摘要： A stiffening member for providing controllably variable stiffness to a catheter. A hollow elongated tubular member is sized to be received in a lumen of the catheter. At least a length of the tubular member is configured, such as by forming a spiral cut therethrough, in a manner such that the distal portion of the tubular member has a greater flexibility than the proximal portion.
摘要翻译：一种用于向导管提供可控制的可变刚度的加强构件。中空细长管状构件的尺寸被设计成容纳在导管的内腔中。管状构件的至少一段长度被构造成例如通过形成螺旋切口贯穿其中，使得管状构件的远端部分具有比近侧部分更大的柔性。

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