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11. 发明申请

WO2005060361A2 PHARMACEUTICAL FORMULATIONS FOR ITRACONAZOLE 审中-公开
标题翻译： ITRACONAZOLE的药物制剂
公开(公告)号：WO2005060361A2
公开(公告)日：2005-07-07
申请号：PCT/KR2004003422
申请日：2004-12-23
申请人： SAMYANG CORP , YOON HYE-JEONG , SEO MIN HYO , KIM JEONG-KYUNG
发明人： YOON HYE-JEONG , SEO MIN HYO , KIM JEONG-KYUNG
IPC分类号： A61K31/496 , A61K9/10 , A61K31/4196 , A61K47/34 , C08G63/08
CPC分类号： A61K31/496 , A61K9/0019 , A61K9/0024 , A61K9/1075 , A61K9/5153
摘要： The present invention relates to a pharmaceutical composition containing as an active ingredient, itraconazole. More particularly, the present invention relates to the pharmaceutical composition comprising itraconazole, a polylactic acid derivative, and an amphiphilic block copolymer. The polylactic acid derivative may be combined with a metal ion at the carboxylic acid terminal, and the amphiphilic block copolymer forms micelles or nano-particles in an aqueous medium.
摘要翻译：本发明涉及含有伊曲康唑作为活性成分的药物组合物。更具体地说，本发明涉及包含伊曲康唑，聚乳酸衍生物和两亲嵌段共聚物的药物组合物。聚乳酸衍生物可以在羧酸末端与金属离子结合，并且两亲嵌段共聚物在水性介质中形成胶束或纳米颗粒。

12. 发明申请

WO2011139044A3 CONTROLLED-RELEASE PHARMACEUTICAL COMPOSITION INCLUDING TAMSULOSIN OR THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND ORAL PREPARATION INCLUDING SAME 审中-公开
标题翻译：控制释放的药物组合物，包括TAMSULOSIN或其药学上可接受的盐，以及包括其中的口服制剂
公开(公告)号：WO2011139044A3
公开(公告)日：2012-03-01
申请号：PCT/KR2011003098
申请日：2011-04-27
申请人： SAMYANG CORP , CHUNG HO-JIN , PARK SANG-YEOB , PAI CHAUL-MIN
发明人： CHUNG HO-JIN , PARK SANG-YEOB , PAI CHAUL-MIN
IPC分类号： A61K9/52 , A61K9/54 , A61K31/18 , A61K47/38
CPC分类号： A61K31/18 , A61K9/5073 , A61K9/5078 , A61K9/5084
摘要： The present invention relates to a controlled-release pharmaceutical composition including tamsulosin or the pharmaceutically acceptable salts thereof as an active ingredient, and to an oral preparation including same, and more particularly, to a pharmaceutical composition comprising a core that includes tamsulosin or the pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and a plurality of microspheres including an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the controlled-release polymer coating layer has a first and second group of microspheres, the average thicknesses of which are different; and to an oral preparation including same. The controlled-release pharmaceutical composition according to the present invention may increase the therapeutic effects for patients when orally administered, as the degree of release of the active ingredient according to pH changes in the digestive tract and the control of the release pattern of the active ingredient in the small intestine are facilitated, the effective plasma concentration of the active ingredient may be maintained for a certain period of time, and the bitter taste may be suppressed for a certain period of time even though the composition is exposed to the oral cavity.
摘要翻译：本发明涉及包含坦索罗辛或其药学上可接受的盐作为活性成分的控释药物组合物及其包含其的口服制剂，更具体地说涉及包含核心的药物组合物，所述核心包括坦索罗辛或药学上可接受的其盐，形成在芯上的控释聚合物涂层和多个微球，其包含形成在控释聚合物涂层上的肠溶聚合物外层，其中控释聚合物涂层具有第一和第二组的微球，其平均厚度不同; 以及包含其的口服制剂。根据本发明的控释药物组合物可以增加口服给药时对于患者的治疗效果，作为活性成分根据消化道pH变化释放的程度和活性成分的释放模式的控制在小肠方便的情况下，活性成分的有效血浆浓度可以保持一定时间，即使组合物暴露于口腔也可以将苦味抑制一定时间。

13. 发明申请

WO2011081415A3 SIRNA FOR INHIBITING C-MET EXPRESSION AND AN ANTI-CANCER COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：用于抑制C-MET表达的SIRNA和包含其的抗癌组合物
公开(公告)号：WO2011081415A3
公开(公告)日：2011-12-01
申请号：PCT/KR2010009440
申请日：2010-12-28
申请人： SAMYANG CORP , KIM SUN-OK , KIM SANG-HEE , CHO EUN-AH , IN CHANG-HOON
发明人： KIM SUN-OK , KIM SANG-HEE , CHO EUN-AH , IN CHANG-HOON
IPC分类号： C12N15/11 , A61K31/7105 , A61P35/00 , C12N15/63
CPC分类号： A61K31/7105 , A61K31/713 , C12N15/1135 , C12N2310/14
摘要： The present invention provides a small interfering ribonucleic acid (siRNA) which is complementarily bonded to a base sequence of c-Met transcript (mRNA transcript) to suppress c-Met expression in a cell as well as optionally to not induce immunological reactions, and applications of the siRNA for cancer prevention and/or treatment. The siRNA, which is bonded complementarily to the mRNA involved in the encryption of the c-Met, suppresses c-Met expression which is overexpressed in nearly all cancer cells in common due to the RNA interference (RNAi) phenomenon and inhibits the proliferation and metastasis of the cancer cells, thereby making the siRNA very useful as an anticancer agent.
摘要翻译：本发明提供了与c-Met转录物（mRNA转录物）的碱基序列互补结合以抑制细胞中c-Met表达以及任选地不诱导免疫反应的小干扰性核糖核酸（siRNA）和应用的用于癌症预防和/或治疗的siRNA。与参与c-Met加密的mRNA互补键合的siRNA抑制由于RNA干扰（RNAi）现象而在几乎所有癌细胞中过表达的c-Met表达，并抑制增殖和转移的癌细胞，从而使siRNA非常有用作抗癌剂。

14. 发明申请

WO2011049404A3 POLYESTER RESIN AND TONER COMPRISING SAME 审中-公开
标题翻译：聚酯树脂和包含它的棉花
公开(公告)号：WO2011049404A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010007283
申请日：2010-10-22
申请人： SAMYANG CORP , JOUNG UI GAB , ROH HYUNG JIN , CHANG YUN JU , CHO SUNG HWAN , LIM BYUNG HO
发明人： JOUNG UI GAB , ROH HYUNG JIN , CHANG YUN JU , CHO SUNG HWAN , LIM BYUNG HO
IPC分类号： C08G63/12 , C08G63/133 , G03G9/087
CPC分类号： C08G63/12 , G03G9/08755 , G03G9/08795 , G03G9/08797
摘要： The present invention relates to a polyester resin produced by adding an anti-hydrolysis agent to reactants comprising acids selected from alkylester of aromatic dibasic acid or a mixture of alkylester of aromatic dibasic ester and alkylester of aliphatic dibasic ester, aromatic diols, and aliphatic diols; and a toner produced using the same as a binder.
摘要翻译：本发明涉及通过向包含选自芳族二元酸的烷基酯或芳族二元酯的烷基酯与脂族二元酯的烷基酯，芳族二醇和脂族二醇的混合物的反应物的反应物中加入抗水解剂而制备的聚酯树脂; 和使用其作为粘合剂制造的调色剂。

15. 发明申请

WO2010137888A3 MICROSPHERES WITH IMPROVED BIOAVAILABILITY CONTAINING POORLY WATER-SOLUBLE DRUGS, AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：具有改善的包含不良水溶性药物的生物利用度的微球及其制备方法
公开(公告)号：WO2010137888A3
公开(公告)日：2011-04-21
申请号：PCT/KR2010003366
申请日：2010-05-27
申请人： SAMYANG CORP , KIM KYUNG-HEE , LEE HYUN-KI , HWANG JUN-SEOK , HWANG SU-JONG , PAI CHAUL-MIN
发明人： KIM KYUNG-HEE , LEE HYUN-KI , HWANG JUN-SEOK , HWANG SU-JONG , PAI CHAUL-MIN
IPC分类号： A61K9/16 , A61K31/522 , A61K47/34 , A61K47/38
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1652 , A61K31/522
摘要： Provided are microspheres with improved bioavailability containing poorly water-soluble drugs, oral preparations comprising same, and a method for preparing same. The microspheres containing poorly water-soluble drugs are solid dispersions in which poorly water-soluble drugs are dispersed into non-crystalline forms in a water-soluble macromolecular carrier by a spray drying method, and have the advantages of improving the bioavailability of poorly water-soluble drugs.
摘要翻译：提供具有改善的生物利用度的微球，其含有水溶性差的药物，包含其的口服制剂及其制备方法。含有水溶性差的药物的微球体是通过喷雾干燥法在水溶性高分子载体中将难溶于水的药物分散成非结晶形式的固体分散体，具有提高不良水溶性药物的生物利用度的优点，可溶性药物。

16. 发明申请

WO2011034323A2 TRANSDERMAL DELIVERY SYSTEM, METHOD FOR MANUFACTURING THE SAME, AND TRANSDERMAL DELIVERY METHOD USING THE SYSTEM 审中-公开
标题翻译：透皮递送系统，用于制造该透皮递送系统的方法以及使用该系统的透皮递送方法
公开(公告)号：WO2011034323A2
公开(公告)日：2011-03-24
申请号：PCT/KR2010006251
申请日：2010-09-14
申请人： SAMYANG CORP , LEE HEONHAN
发明人： LEE HEONHAN
IPC分类号： A61K9/70 , A61K47/30 , A61P17/00
CPC分类号： A61F13/02 , A61F13/0246 , A61F13/0253 , A61F13/0259 , A61F2013/00646 , A61K9/7061 , A61K9/7092
摘要： Disclosed is a transdermal delivery systemof multiple adhesive layers having a drug-free adhesive layer as an intermediate layer to control drug delivery rate. The transdermal delivery system enhances transdermal delivery rate in the early stage after application on skin and provides sustained control of the drug delivery rate in the intermediate and later stages. Thus, the drug delivery rate effective for treatment can be controlled in a sustained manner.
摘要翻译：公开了一种具有无药粘合剂层作为中间层以控制药物递送速率的多个粘合剂层的透皮递送系统。透皮递送系统在皮肤施用后的早期增加透皮递送速率并且在中间和后期阶段提供对药物递送速率的持续控制。因此，可以以持续的方式控制对治疗有效的药物递送速率。

17. 发明申请

WO2009091150A2 HIGHLY PURE AMPHIPHILIC COPOLYMER COMPRISING HYDROPHOBIC BLOCK FROM ALPHA-HYDROXY ACID AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：包含来自ALPHA-羟基酸的疏水性嵌段的高纯度共聚物及其制备方法
公开(公告)号：WO2009091150A2
公开(公告)日：2009-07-23
申请号：PCT/KR2008007854
申请日：2008-12-31
申请人： SAMYANG CORP , KIM BONG OH , SHIM MYUNG SEOB , SEO MIN-HYO
发明人： KIM BONG OH , SHIM MYUNG SEOB , SEO MIN-HYO
IPC分类号： C08G63/91
CPC分类号： C08G63/90 , C08G63/664 , C08G2261/126
摘要： Disclosed are a highly pure amphiphilic block copolymer including a hydrophobic polymer block of a po Iy ( a -hydroxy acid), and a method for preparing the same. The method for preparing a highly pure amphiphilic block copolymer including a hydrophobic polymer block of a po Iy ( a -hydroxy acid) includes removing a -hydroxy acid, lactone monomers thereof, oligomers thereof and an organometal catalyst in polymerizing the amphiphilic block copolymer.
摘要翻译：公开了一种高纯度的两亲性嵌段共聚物及其制备方法，所述两亲嵌段共聚物包括疏水聚合物嵌段的聚（α-羟基酸）。制备包含聚（α-羟基酸）的疏水性聚合物嵌段的高纯度两亲性嵌段共聚物的方法包括在聚合两亲性嵌段共聚物时除去其羟基酸，其内酯单体，其低聚物和有机金属催化剂。

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