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11. 发明申请

WO2022124957A1 DEVICE FOR INSERTION OF MICROFILAMENTS IN SOFT TISSUE 审中-公开
公开(公告)号：WO2022124957A1
公开(公告)日：2022-06-16
申请号：PCT/SE2021/000012
申请日：2021-12-10
申请人： NEURONANO AB [SE]/[SE]
发明人： SHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/29 , A61B5/293 , A61N1/36
摘要： The present invention relates to an implantable microfilament guiding structure comprising spatially arranged channels intended for the accommodation and movement of microfilaments such as electrically conductive microelectrodes. The microfilament guiding structure comprises materials which disintegrates and/or dissolves when subjected to mammalian tissue fluids. The channels of the microfilament guiding structure are spatially arranged such that the distances between at least some of said channels gradually increase in distal direction. The microfilament guiding structure comprising microfilaments forms part of a proto electrode also referred to as prior microfilament assembly. The invention also encompasses methods for manufacturing the microfilament guiding structure and proto microelectrode assemblies and further a method for implantation of microfilaments in soft tissue.

12. 发明申请

WO2021096403A1 MEDICAL PROTO MICROELECTRODE, METHOD FOR ITS MANUFACTURE, AND USE THEREOF 审中-公开
公开(公告)号：WO2021096403A1
公开(公告)日：2021-05-20
申请号：PCT/SE2020/000028
申请日：2020-11-13
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , AGORELIUS, Johan
IPC分类号： A61N1/05 , A61N1/36
摘要： Proto-microelectrode capable of forming a microelectrode upon implantation into soft tissue, comprising or consisting of an oblong electrode body; an optional first coat of electrically non-conducting material on the electrode body; a second coat of water insoluble flexible polymer material enclosing, at a distance, the electrode body and the first coat, the second coat comprising one or more through openings; a first layer of ice disposed between the electrode body and the second coat. Also disclosed is a proto-microelectrode bundle and array, a method of manufacture of the proto-microelectrode and its use.

13. 发明申请

WO2018222101A1 METHOD OF MICROELECTRODE IDENTIFICATION 审中-公开
公开(公告)号：WO2018222101A1
公开(公告)日：2018-12-06
申请号：PCT/SE2018/000014
申请日：2018-05-29
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61B6/12
摘要： A method of identifying upon insertion into soft tissue a microelectrode of a set of three or more microelectrodes each comprising an electrically conductive body comprises providing the microelectrode with a unique metallic pattern of three or more sections separated from each other and disposed in an axial direction on the body and/or on one or more insulating layers on the body; inserting the microelectrode into the tissue simultaneously or consecutively with the other microelectrodes of the set; detecting the pattern by computer tomography (CT) or X- ray. Also disclosed are microelectrodes provided with unique patterns and sets of such microelectrodes and their use.

14. 发明申请

WO2017209673A1 METHOD AND SYSTEM FOR IMPROVING STIMULATION OF EXCITABLE TISSUE 审中-公开
标题翻译：提高刺激兴奋组织的方法和系统
公开(公告)号：WO2017209673A1
公开(公告)日：2017-12-07
申请号：PCT/SE2016/051227
申请日：2016-12-07
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , BJARTMARZ, Hjalmar
IPC分类号： A61N1/36 , A61N1/05
摘要： A method for optimization of a stimulation specificity of implanted electrodes in excitable tissue of a patient; wherein it comprises the step of electrical stimulation of excitable tissue between one or more combinations of electrode pairs in a cluster of electrodes, or electrical stimulation between one or more combinations of electrode pairs in two or more clusters of electrodes, wherein the two electrodes of said electrode pairs do not belong to the same cluster, wherein the electrical stimulation between different combinations of electrode pairs in a cluster of electrodes, or the electrical stimulation between different combinations of electrode pairs in two or more clusters of electrodes, creates a directed electrical field; wherein the effect of the directed electrical field is assessed after each stimulation step by registering information provided from the patient in view of a therapeutic effect, or by assigning each electrode pair a value related to said information provided by the patient; and choosing, based on the direction of the directed electrical field created, the electrode pair or pairs which give(s) rise to the most favorable assigned value.
摘要翻译：一种用于优化患者的可兴奋组织中的植入电极的刺激特异性的方法; 其中它包括以下步骤：电刺激电极群中的电极对中的一个或多个组合之间的可兴奋组织，或者在两个或更多个电极群中的电极对的一个或多个组合之间的电刺激，其中所述两个电极其中电极群组中的电极对的不同组合之间的电刺激或两个或更多个电极群组中的电极对的不同组合之间的电刺激产生定向电场; 其中在每个刺激步骤之后通过记录从患者提供的考虑治疗效果的信息，或者通过将每个电极对分配与由患者提供的所述信息相关的值，来评估定向电场的效果; 并基于所产生的定向电场的方向来选择使得（一个或多个）电极对升至最有利的指定值的电极对。

15. 发明申请

WO2017010930A1 METHOD AND SYSTEM FOR IMPROVING STIMULATION OF EXCITABLE TISSUE 审中-公开
标题翻译：改善可激活组织刺激的方法和系统
公开(公告)号：WO2017010930A1
公开(公告)日：2017-01-19
申请号：PCT/SE2016/050698
申请日：2016-07-07
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , BJARTMARZ, Hjalmar
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/0484 , A61B2562/0209 , A61B2562/046 , A61N1/05 , A61N1/0534 , A61N1/36185 , A61N1/378
摘要： A method for optimization of the stimulation pattern of a set of implanted electrodes in excitable tissue of a patient is disclosed, wherein it comprises the steps of: (a) choosing a first group of a certain number of from said set of implanted electrodes, (b) stimulating the excitable tissue electrically by said first group of electrodes, (c) registering information provided by the patient, (d) assigning each electrode of said first group of electrodes a value related to said information, wherein these steps are repeated for one or more further groups of said certain number of electrodes chosen from said set of implanted electrodes, wherein each electrode may be included in one or several groups, wherein the total assigned value for each electrode is calculated, and wherein electrodes having a total assigned value exceeding a predetermined value or a predetermined number of the electrodes having the highest total assigned value are chosen to be included in said stimulation pattern, as well as a method for treatment or alleviation of a disease or condition by use of a set of electrodes whose stimulation pattern has been optimized with said method, and a system for optimization of the stimulation pattern.
摘要翻译：公开了一种用于优化患者可兴奋组织中一组植入电极的刺激模式的方法，其中包括以下步骤：（a）从所述植入电极组中选择一定数量的第一组， b）通过所述第一组电极刺激所述可兴奋组织，（c）登记患者提供的信息，（d）将所述第一组电极的每个电极分配给与所述信息相关的值，其中对于一个电极重复这些步骤或更多的一组所述一定数量的电极，其选自所述一组植入电极，其中每个电极可以包括在一个或多个组中，其中计算每个电极的总指定值，并且其中总分配值超过的电极选择具有最高总分配值的预定值或预定数量的电极被包括在所述刺激模式中以及通过使用其刺激模式已经利用所述方法优化的一组电极来治疗或减轻疾病或病症的方法，以及用于优化刺激模式的系统。

16. 发明申请

WO2016032384A1 METHOD OF IMPLANTATION OF A MEDICAL DEVICE INTO NEURAL TISSUE 审中-公开
标题翻译：将医疗器械植入神经组织的方法
公开(公告)号：WO2016032384A1
公开(公告)日：2016-03-03
申请号：PCT/SE2015/000050
申请日：2015-08-28
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36 , A61N1/372
CPC分类号： A61B5/6847 , A61B5/4064 , A61B5/407 , A61B5/6846 , A61B17/3468 , A61B90/13 , A61B2017/00849 , A61B2560/063 , A61B2562/028 , A61L31/022 , A61L31/048 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2420/08
摘要： A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.
摘要翻译：提供填充有水凝胶的神经组织中的通道的方法，其用于植入微电极或其他缺乏足够的物理稳定性的医疗装置，用于通过插入进行直接植入，包括提供包括由干凝胶形成剂覆盖的长圆形刚性销的装置; 将目标定位在组织中; 将所需组织插入点和所述靶标定义为直插入路径; 将销的端部首先与插入路径对准; 将销插入组织到靠近或在目标处的位置; 允许足够的时间通过在销周围形成的凝胶，取出销。还公开了相应的通道; 通过通道将微电极或微探针植入神经组织的方法; 相应的活细胞植入方法; 用于形成通道的相应装置。

17. 发明申请

WO2020141997A1 PROBE FOR IMPLANTATION INTO NERVOUS TISSUE COMPRISING A MICROELECTRODE OR A SET OF MICROELECTRODES 审中-公开
公开(公告)号：WO2020141997A1
公开(公告)日：2020-07-09
申请号：PCT/SE2020/000001
申请日：2020-01-03
申请人： NEURONANO AB , SCHOUENBORG, Jens
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36
摘要： A microelectrode probe for implantation into soft tissue comprises an envelope of flexible polymer material divided by a wall into a distal and a proximal compartment filled with matrices of biocompatible material dissolvable or degradable in aqueous body fluid and comprising a centrally disposed electrically conducting core penetrating the wall and attached to it. The core is insulated at its proximal portion from which it extends to a holder for attachment to a tissue different from said soft tissue. The envelope and the core extending distally from the holder are embedded in an additional matrix of similar kind. Also disclosed is method for its manufacture, an array comprising two or more microelectrode probes and a microelectrode probe for incorporation into the array as well as method for the manufacture of the array.

18. 发明申请

WO2017146626A1 METHOD OF PROVIDING AN IMPLANTATION SITE IN SOFT TISSUE 审中-公开
标题翻译：在软组织中提供植入部位的方法
公开(公告)号：WO2017146626A1
公开(公告)日：2017-08-31
申请号：PCT/SE2017/000013
申请日：2017-02-23
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36 , A61N1/372
CPC分类号： A61B5/04 , A61N1/0551
摘要： A method of providing a channel filled with aqueous gel in soft tissue comprises injecting a biocompatible aqueous gel into the tissue. Also disclosed is a corresponding device, the combination of the device and a guide for its insertion into tissue, and a system comprising the combination and a reservoir filled with aqueous gel comprising means for exerting pressure on the gel.
摘要翻译：在软组织中提供充满含水凝胶的通道的方法包括将生物相容性含水凝胶注射到组织中。还公开了相应的装置，装置和用于插入组织中的导向装置的组合，以及包括该组合的系统和填充有含水凝胶的贮存器，该贮存器包括用于对凝胶施加压力的装置。

19. 发明申请

WO2017095288A1 HAEMORRHAGE AVOIDING MICROELECTRODE 审中-公开
公开(公告)号：WO2017095288A1
公开(公告)日：2017-06-08
申请号：PCT/SE2016/000072
申请日：2016-11-21
申请人： NEURONANO AB
发明人： SCHOUENBORG, Jens , MOHAMMED, Mohsin
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529
摘要： A microelectrode comprises an oblong electrically conducting electrode body covered by distal and proximal sections of a layer of insulating material except for an annular contact section disposed between them, a blunt distal bulge at the distal end of a radial extension substantially greater than that of the proximal section of non-conducting material. For implantation into soft tissue the microelectrode is provided with a support of a material dissolvable in body fluid. Also disclosed is a set of microelectrodes sharing such support, a method of manufacture of the microelectrode and the set, and uses of the microelectrode and the set.

20. 发明申请

WO2015094076A1 MEDICAL DEVICE COMPRISING AN ELECTRODE AND A LIGHT SOURCE 审中-公开
标题翻译：包含电极和光源的医疗装置
公开(公告)号：WO2015094076A1
公开(公告)日：2015-06-25
申请号：PCT/SE2014/000152
申请日：2014-12-18
申请人： NEURONANO AB
发明人： SCHOUENEBORG, Jens
IPC分类号： A61N1/05 , A61N5/06 , A61B5/04 , A61N1/14
CPC分类号： A61B5/686 , A61B5/0086 , A61B2017/00057 , A61B2560/063 , A61B2562/028 , A61N1/0529 , A61N1/37205 , A61N1/37211 , A61N5/0601 , A61N5/0622 , A61N2005/0612 , A61N2005/063 , A61N2005/0651 , A61N2005/067
摘要： A device for insertion into soft tissue comprises a micro electrode, a micro light source; a stiffening element comprising a material dissolvable or degradable in aqueous body fluid or a material swellable in such fluid to form a transparent gel; a coat of a flexible non-conducting polymer material on the stiffening element; a base disposed at the rear end of the device. The flexible coat has a distal opening allowing light emitted from the light source to leave the device upon said collapse or dissolution or swelling. Also disclosed is a therapeutic or diagnostic device formed in the tissue from the insertable device, uses thereof, and a method of disposing the insertable device in soft tissue.
摘要翻译：用于插入软组织的装置包括微电极，微光源; 一种加强元件，其包含在体液中可溶解或可降解的材料或在这种流体中可溶胀以形成透明凝胶的材料; 在加强元件上的柔性非导电聚合物材料的涂层; 设置在设备后端的基座。柔性涂层具有远端开口，允许从光源发射的光在所述塌陷或溶解或膨胀时离开装置。还公开了在可插入装置的组织中形成的治疗或诊断装置，其用途以及将可插入装置设置在软组织中的方法。

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