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11. 发明申请

WO2008082640A1 POWDER FEED SYSTEM 审中-公开
标题翻译：粉末进料系统
公开(公告)号：WO2008082640A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/026465
申请日：2007-12-28
申请人： MANNKIND CORPORATION , WHITE, Michael, A.
发明人： WHITE, Michael, A.
IPC分类号： B65B1/36 , B65B37/12
CPC分类号： B65B1/366 , B65B37/12
摘要： A powder feed system (10) includes a housing that defines a feed chamber (62) to hold powder, the feed chamber having a powder inlet (60) and a powder outlet (64), at least one feed wheel (40) in the feed chamber, the feed wheel rotating about a feed wheel axis, at least one agitator (42) in the feed chamber positioned to move the powder from the feed wheel to the powder outlet of the feed chamber, the agitator rotating about an agitator axis, and a drive mechanism to rotate the feed wheel about the feed wheel axis and to rotate the agitator about the agitator axis.
摘要翻译：粉末进料系统（10）包括限定用于保持粉末的进料室（62）的壳体，所述进料室具有粉末入口（60）和粉末出口（64），所述进料室中的至少一个进料轮进料室，馈送轮围绕供给轮轴线旋转;至少一个供料室中的搅拌器（42），定位成将粉末从进料轮移动到进料室的粉末出口，搅拌器围绕搅拌器轴线旋转，以及驱动机构，用于围绕进给轮轴线旋转进给轮并使搅拌器围绕搅拌器轴线旋转。

12. 发明申请

WO2007098500A2 A METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT 审中-公开
标题翻译：一种改善包含二酮类化合物和活性剂的微量营养物质的方法
公开(公告)号：WO2007098500A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/062626
申请日：2007-02-22
申请人： MANNKIND CORPORATION , WILSON, Bryan R. , GRANT, Marshall
发明人： WILSON, Bryan R. , GRANT, Marshall
CPC分类号： A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1694 , A61K38/28
摘要： Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
摘要翻译：提供了用于干燥颗粒的方法。具体地，提供了具有改进的空气动力学性能的喷雾干燥的二酮哌嗪 - 胰岛素颗粒制剂，其中与冻干的二酮哌嗪 - 胰岛素制剂相比，活性剂更稳定和有效地递送。干粉具有用作肺部输送的药物制剂的效用。

13. 发明申请

WO2007016600A2 METHOD OF PRESERVING THE FUNCTION OF INSULIN-PRODUCING CELLS 审中-公开
标题翻译：保存胰岛素产生细胞功能的方法
公开(公告)号：WO2007016600A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/030014
申请日：2006-08-01
申请人： MANNKIND CORPORATION , BOSS, Anders, Hasager , CHEATHAM, Wayman, Wendell , DIAMOND, David, C.
发明人： BOSS, Anders, Hasager , CHEATHAM, Wayman, Wendell , DIAMOND, David, C.
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K38/28
摘要： Methods and compositions for preserving the function of insulin-producing cells and to furthering the lifespan of insulin-producing cells in non-insulin dependent patients with insulin-related disorders are provided.
摘要翻译：提供了用于保存产生胰岛素的细胞的功能和在具有胰岛素相关疾病的非胰岛素依赖性患者中促进产生胰岛素的细胞的寿命的方法和组合物。

14. 发明申请

WO2006138567A2 METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA 审中-公开
标题翻译：针对癌细胞和肿瘤细胞表达的主要和亚细胞抗原决定多种免疫应答的方法和组合
公开(公告)号：WO2006138567A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023498
申请日：2006-06-16
申请人： MANNKIND CORPORATION , QIU, Zhiyong , BOT, Adrian
发明人： QIU, Zhiyong , BOT, Adrian
IPC分类号： C07K14/435 , A61K39/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/4748 , C07K14/705
摘要： The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
摘要翻译：本发明提供了一种通过向有需要的受试者提供包含编码包含CTL表位PSMA288-297和PRAME425-433或交叉反应性类似物的多肽的核酸构建体的免疫原性组合来治疗癌症的方法。在本发明的实施方案中，提供了用于诱导，携带和/或扩增针对癌抗原的MHC I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。

15. 发明申请

WO2006098793A3 HSLIM MODULATES IMMUNE RESPONSES 审中-公开
公开(公告)号：WO2006098793A3
公开(公告)日：2006-09-21
申请号：PCT/US2006/000188
申请日：2006-01-06
申请人： MANNKIND CORPORATION , FARIS, Mary , LEE, Sandra, Aeyoung , QIU, Zhiyong , BRANDT, David, W.
发明人： FARIS, Mary , LEE, Sandra, Aeyoung , QIU, Zhiyong , BRANDT, David, W.
IPC分类号： C07K14/00 , C07K16/00 , C12N15/00 , C12N15/85 , C12N15/86
摘要： Human SLIM polypeptides for use in modulating STAT-dependent gene transcription.

16. 发明申请

WO2022108939A1 INHALED IMATINIB FOR PULMONARY HYPERTENSION FIELD 审中-公开
公开(公告)号：WO2022108939A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/059553
申请日：2021-11-16
申请人： UNITED THERAPEUTICS CORPORATION , MANNKIND CORPORATION
发明人： SILVERSTEIN, Adam Marc , POISSON, Patrick , KESHAVA, Ajay , FREEMAN, John J., JR. , MILLS, James
IPC分类号： A61K9/00 , A61K9/14 , A61K47/22 , A61K31/506 , A61P11/00
摘要： Methods of treatment of pulmonary hypertension comprising dry powder inhalation administration of imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are provided. Dry powder inhalable compositions comprising imatinib, a pharmaceutically acceptable salt, or a derivative thereof, are also provided as well as methods of making the same.

17. 发明申请

WO2021222740A1 CLOFAZIMINE COMPOSITION AND METHOD FOR THE TREATMENT OR PROPHYLAXIS OF VIRAL INFECTIONS 审中-公开
公开(公告)号：WO2021222740A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/030155
申请日：2021-04-30
申请人： MANNKIND CORPORATION
发明人： HOFMANN, Thomas , UFER, Stefan , FREEMAN, John, J., Jr.
IPC分类号： A61K9/00 , A61K31/498 , A61K9/16 , A61P31/12 , A61P31/14
摘要： Disclosed herein are methods of treatment and/or prophylaxis of viral infections. In particular, the method is for the administration by inhalation of a pharmaceutically effective dose of clofazimine, which is provided in the form of a solution, suspension, or as a dry powder, in formulations suitable for inhalation.

18. 发明申请

WO2019210083A1 METHOD AND COMPOSITION FOR TREATING OBESITY 审中-公开
公开(公告)号：WO2019210083A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/029166
申请日：2019-04-25
申请人： MANNKIND CORPORATION
发明人： CASTAGNA, Michael , KENDALL, David , KRAFT, Kelly , SMUTNEY, Chad, C. , GRANT, Marshall
IPC分类号： A61K31/495 , A61K38/26 , A61K47/48
摘要： A method for treating obesity associated to Prader Willi Syndrome and/or binge eating is disclosed. The method utilizes a rapid drug delivery system which delivers small molecules and peptides to the lungs by oral inhalation.

19. 发明申请

WO2015148905A1 USE OF ULTRARAPID ACTING INSULIN 审中-公开
标题翻译：超声波治疗胰岛素的使用
公开(公告)号：WO2015148905A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022956
申请日：2015-03-27
申请人： MANNKIND CORPORATION
发明人： BOSS, Anders, Hasager , PETRUCCI, Richard
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/007 , A61K9/0075 , A61K31/155 , A61K2300/00
摘要： Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
摘要翻译：本文公开了一种通过超快速作用的胰岛素和甘精胰岛素的组合治疗高血糖的改进方法，其包括餐前施用超级胰岛素，以及在醒来6小时内施用第一剂甘精胰岛素。

20. 发明申请

WO2014066856A9 INHALABLE INFLUENZA VACCINE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2014066856A9
公开(公告)日：2014-05-01
申请号：PCT/US2013/066969
申请日：2013-10-25
申请人： MANNKIND CORPORATION , TECHNOVAX, INC.
发明人： SMUTNEY, Chad, C. , LEONE-BAY, Andrea , GALARZA, Jose, M. , MUNOZ, Hector , MARTIN, George, R. , GRANT, Marshall, L.
IPC分类号： A61K39/12 , A61K39/145 , A61K9/00 , A61P31/16
摘要： Dry powder inhalable compositions and methods for using and making the compositions are disclosed for vaccinating a subject against disease. In particular, the compositions are inhalable dry powders useful for preventing and/or treating diseases caused by microorganisms, for example, microorganisms such as viral or bacterial pathogens, including, the influenza virus. In particular, the method comprises the administration of an inhalable composition comprising virus-like particles and/or specific protein/s or antigenic peptides, peptide fragments and/or derivatives thereof using a dry powder drug delivery system.

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