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11. 发明申请

WO2008130082A1 TGFP-CAP PEPTIDE AND ITS USES 审中-公开
标题翻译： TGFP-CAP肽及其用途
公开(公告)号：WO2008130082A1
公开(公告)日：2008-10-30
申请号：PCT/KR2007/004405
申请日：2007-09-12
申请人： CAREGEN CO., LTD , CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun-Young , KIM, Jin Seuk , SONG, Sang Su , CHO, Kyoung Mi
IPC分类号： C07K19/00
CPC分类号： C07K14/495 , A61K8/64 , A61K38/00 , A61K38/1841 , A61Q19/02 , C07K7/08
摘要： The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有衍生自TGF-β1（转化生长因子-β1）的氨基酸序列和细胞粘附序列的GFP-CAP肽，其中衍生自TGF-β1的氨基酸序列由 SEQ ID NO：1，TGFP-CAP肽由下式I表示：Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-细胞粘附序列（I）。本发明的TGFP-CAP肽表现出优异的抗血管生成活性。此外，本发明的TGFP-CAP肽有效地防止皮肤中的黑色素生成，从而具有皮肤美白效果。本发明的肽显示比天然存在的TGF-β1更高的稳定性和对皮肤的渗透性。本发明肽的这种合理的活性和安全性有利地适用于药物，准药物和化妆品。

12. 发明申请

WO2007102686A1 PEPTIDES HAVING ACTIVITIES OF INSULIN LIKE GROWTH FACTOR-1 AND THEIR USES 审中-公开
标题翻译：胰岛素样生长因子-1及其用途的活性肽
公开(公告)号：WO2007102686A1
公开(公告)日：2007-09-13
申请号：PCT/KR2007/001086
申请日：2007-03-06
申请人： CAREGEN CO., LTD , CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Eun Mi
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-I) and derived from IGF-I, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-I mimicking peptides of this invention have identical functions or actions to natural- occurring IGF-I and much better stability and skin permeation than natural-occurring IGF-I. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-I activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有胰岛素样生长因子-1（IGF-I）的活性并衍生自IGF-1的肽，用于改善皮肤病症或治疗包含该肽的牙周病的组合物。与天然存在的IGF-I相比，本发明的IGF-I模拟肽与天然存在的IGF-I具有相同的功能或作用，并且具有更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要IGF-1活性的疾病或病症方面表现出优异的功效。此外，本发明的肽可以有利地应用于药物组合物，准药物和化妆品。

13. 发明申请

WO2007049905A1 PEPTIDES FOR PROMOTING HAIR GROWTH AND IMPROVING WRINKLE AND COSMETIC COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：用于促进头发生长和改善皱纹的化合物和包含其的化妆品组合物
公开(公告)号：WO2007049905A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/004352
申请日：2006-10-24
申请人： CAREGEN CO., LTD. , CHUNG, Yong Ji , KIM, Young Deug , KIM, Chung Ryul
发明人： CHUNG, Yong Ji , KIM, Young Deug , KIM, Chung Ryul
IPC分类号： C07K7/06
CPC分类号： C07K14/57581
摘要： The present invention relates to a peptide comprising a specific amino acid sequence possessing human thymosin β-4 (Tβ4) activities and its uses. The peptide of this invention has identical or similar functions or actions to human Tβ4 and its biological activity is almost identical to natural-occurring Tβ4. In addition, the peptide of this invention exhibits much higher stability and skin permeation than natural-occurring Tβ4. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in thymosin β-4-effective disorders or conditions. In addition, the peptide of this invention can be advantageously applied to drugs, cosmetics, toothpaste and compositions for mouth cleaning and caring, most preferably, cosmetics. Specifically, the peptide of this invention is advantageously applied to cosmetics for promoting hair growth.
摘要翻译：本发明涉及包含具有人胸腺素β-4（Tβ4）活性的特定氨基酸序列的肽及其用途。本发明的肽对人类Tβ4具有相同或相似的功能或作用，其生物活性几乎与天然发生的Tβ4相同。此外，与天然存在的Tβ4相比，本发明的肽具有更高的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在改善胸腺素β-4有效障碍或病症方面表现出优异的效果。此外，本发明的肽可以有利地应用于药物，化妆品，牙膏和用于口腔清洁和护理的组合物，最优选化妆品。具体地说，本发明的肽有利地用于促进头发生长的化妆品中。

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