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11. 发明申请

WO2016079089A1 METHOD AND APPARATUS FOR NEMATODE WORM DELIVERY 审中-公开
标题翻译： NEMATODE WORM交付的方法和装置
公开(公告)号：WO2016079089A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/076765
申请日：2015-11-17
申请人： UNIVERSITÉ D'AIX-MARSEILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
发明人： BELOUGNE, Jérôme
IPC分类号： A01K67/033 , G01N15/14 , G01N15/00 , G01N1/38
CPC分类号： A01K67/033 , G01N1/38 , G01N15/1459 , G01N2015/0019 , G01N2015/149
摘要： A method of delivering a population of worms to a sorting device (2), comprising. - injecting worms with a liquid carrier into a first inlet (60) of a first chamber (6), - collecting the worms with the liquid carrier at a first outlet (69) of the first chamber (6), the worms moving within the first chamber (6) between the first inlet (60) and the outlet (69) under at least the effect of the flow of the liquid carrier and gravity, - introducing the worms and the liquid carrier collected at the first outlet (69) of the first chamber (6) into a second inlet (70) of a second chamber (7), collecting the worms and the liquid carrier at a second outlet (79) of the second chamber (7), the worms moving within the second chamber (7) under the effects of the flow of liquid carrier and against gravity, for delivery of the worms to the sorting device (2).
摘要翻译：一种将一群蠕虫传送到分拣装置（2）的方法，包括。 - 将具有液体载体的蠕虫注射到第一室（6）的第一入口（60）中， - 在所述第一室（6）的第一出口（69）处收集具有所述液体载体的所述蠕虫，所述蠕虫在所述第一室至少在液体载体和重力的作用下，在第一入口（60）和出口（69）之间的第一腔室（6）， - 引入收集在第一出口（69）处的蠕虫和液体载体所述第一室（6）进入第二室（7）的第二入口（70），在所述第二室（7）的第二出口（79）收集所述蠕虫和所述液体载体，所述蠕虫在所述第二室（7）在液体载体的流动和重力的影响下，用于将蠕虫递送到分拣装置（2）。

12. 发明申请

WO2021231609A1 DECODING MOVEMENT INTENTION USING ULTRASOUND NEUROIMAGING 审中-公开
公开(公告)号：WO2021231609A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032041
申请日：2021-05-12
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , TANTER, Mickael , DEMENE, Charlie
发明人： NORMAN, Sumner L , MARESCA, David , CHRISTOPOULOS, Vasileios , SHAPIRO, Mikhail , ANDERSEN, Richard A
IPC分类号： A61B8/08 , A61B8/00 , A61B8/06 , A61F2/70 , A61F2002/704 , A61F4/00 , A61N1/08 , G06N20/00 , G16H30/40
摘要： Methods and systems are provided for decoding movement intentions using functional ultrasound (fUS) imaging of the brain. In one example, decoding movement intentions include determining a memory phase of a cognitive state of the brain, the memory phase between a gaze fixation phase and movement execution phase, and determining one or more movement intentions including one or more of intended effector (e.g., hand, eye) and intended direction (e.g., right, left) according to a machine learning algorithm trained to classify one or more movement intentions simultaneously.

13. 发明申请

WO2021105761A1 COMPOSITIONS AND THEIR USES FOR TREATING CANCERS 审中-公开
公开(公告)号：WO2021105761A1
公开(公告)日：2021-06-03
申请号：PCT/IB2020/000777
申请日：2020-09-10
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE BORDEAUX , DJAVAHERI-MERGNY, Mojgan , BEAUVARLET, Jennifer , MERGNY, Jean-Louis
发明人： DJAVAHERI-MERGNY, Mojgan , BEAUVARLET, Jennifer , MERGNY, Jean-Louis
IPC分类号： A61K31/4439 , A61K31/4706 , A61K31/4725 , A61K31/5383 , A61P35/00 , A61P35/02 , A61K45/06
摘要： The present invention relates to the field of oncology, and in particular to chemoresistant or potentially chemoresistant cancer diseases. The invention relates to a combination comprising at least one anticancer G-quadruplex ligand (G4 ligand), such as triarylpyridine 20A or quarfloxin, and at least one lysosomotropic agent, such as chloroquine or Lys05. Such combinations promote a significant induction of lysosomal membrane permeabilization (LMP) as compared to a single drug treatment and trigger massive cancer cell death. The observed synergistic effect has advantageous application in the prevention and/or treatment of chemoresistant cancer.

14. 发明申请

WO2020239801A1 CAR-T CELLS TARGETING IL-1RAP AND THEIR USE IN ACUTE MYELOID LEUKEMIA (AML) 审中-公开
公开(公告)号：WO2020239801A1
公开(公告)日：2020-12-03
申请号：PCT/EP2020/064636
申请日：2020-05-27
申请人： ÉTABLISSEMENT FRANÇAIS DU SANG , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE BESANÇON , UNIVERSITÉ DE FRANCHE-COMTÉ
发明人： DESCHAMPS, Marina , FERRAND, Christophe , LAROSA, Fabrice , WARDA, Walid
IPC分类号： A61P35/02 , C07K14/715 , C07K16/28 , C07K16/24 , A61K39/00
摘要： The present invention is relative to a cell comprising a nucleic acid molecule encoding a chimeric antigen receptor (CAR) for use in the treatment of acute myeloid leukemia (AML), wherein the CAR comprises an antibody or antibody fragment which includes an anti-IL-1RAP binding domain, a transmembrane domain, and an intracellular signaling domain comprising at least a stimulatory domain

15. 发明申请

WO2019077028A4 BORDETELLA STRAINS EXPRESSING SEROTYPE 3 FIMBRIAE 审中-公开
公开(公告)号：WO2019077028A4
公开(公告)日：2019-04-25
申请号：PCT/EP2018/078522
申请日：2018-10-18
申请人： INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
发明人： DEBRIE, Anne-Sophie , RAZE, Dominique , LOCHT, Camille
IPC分类号： A61K39/10 , A61K39/00
摘要： A Fim3-producing BPZE1 derivative with sufficiently stable fim3 expression to provide improved protection in mice against Fim3-only producing clinical B. pertussis isolates was developed. The fim3 expression in BPZE1f3 did not alter the protective efficacy against Fim2+ strains, nor against strains that produce neither Fim2 nor Fim3.

16. 发明申请

WO2017191015A1 A METHOD OF OPERATING AN AFM 审中-公开
标题翻译：一种操作AFM的方法
公开(公告)号：WO2017191015A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/059959
申请日：2017-04-26
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , UNIVERSITÉ D'AIX-MARSEILLE
发明人： SCHEURING, Simon , MIYAGI, Atsushi
IPC分类号： G01Q10/06 , G01Q60/34
CPC分类号： G01Q10/065 , G01Q60/34
摘要： A method of operating an atomic force microscope, comprising a probe, the probe being moved forth and back during respective trace and retrace times of a scan line, the method comprising: a) during trace time, oscillating the probe, b) generating a z feedback signal to keep an amplitude of oscillation of the probe constant at a setpoint value, the z feedback signal being generated by a first feedback loop, c) during retrace time, placing the probe in a drift compensation state by changing the setpoint value to a different value so that the z feedback signal being generated by the first feedback loop causes the probe to move away from the sample and oscillate free, d) detecting an amplitude of free oscillation of the probe and adjusting with a second feedback loop its excitation signal to maintain the amplitude of free oscillation of the probe close to a set value.
摘要翻译：一种操作原子力显微镜的方法，所述原子力显微镜包括探针，所述探针在扫描线的相应追踪和回扫期间前后移动，所述方法包括：a）在迹线时间期间，振荡探针，b）产生z反馈信号以保持探针的振荡幅度恒定在设定点值，z反馈信号由第一反馈回路产生，c）在回扫时间期间，将探针置于漂移补偿状态通过将设定值改变为不同的值，使得由第一反馈回路产生的z反馈信号使得探头从样品移开并自由摆动，d）检测探头的自由振动的振幅并且用第二个反馈回路激励信号，以保持探头自由振荡的振幅接近设定值。

17. 发明申请

WO2017182421A1 HORMONES STEROIDIENNES POUR LE TRAITEMENT ET LA PREVENTION DES TORSADES DE POINTES 审中-公开
标题翻译：用于治疗和预防穴位疾病的甾体激素
公开(公告)号：WO2017182421A1
公开(公告)日：2017-10-26
申请号：PCT/EP2017/059097
申请日：2017-04-18
申请人： ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6)
发明人： SALEM, Joe-Elie , FUNCK-BRENTANO, Christian , BACHELOT, Anne , WAINTRAUB, Xavier
IPC分类号： A61K31/568 , A61K31/5685 , A61K31/56 , A61P9/00 , A61K31/57 , A61K31/565 , A61K31/567
摘要： La présente invention se rapporte à un nouveau procédé de prévention et traitement des torsades de pointes par administration d'un progestatif à effet androgénique.
摘要翻译：
本发明涉及一个新的过程; 用于通过服用孕激素来预防和治疗尖端扭转型室性心动过速雄激素作用。

18. 发明申请

WO2016009044A1 PEPTIDES INCLUDING A BINDING DOMAIN OF THE VIRAL PHOSPHOPROTEIN (P) SUBUNIT TO THE VIRAL RNA FREE NUCLEOPROTEIN (N0) 审中-公开
标题翻译：包括病毒磷酸蛋白酶（P）的结合域的肽包含在病毒RNA中的免疫核糖核酸（N0）
公开(公告)号：WO2016009044A1
公开(公告)日：2016-01-21
申请号：PCT/EP2015/066419
申请日：2015-07-17
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITÉ CLAUDE BERNARD - LYON 1 , ECOLE NORMALE SUPÉRIEURE DE LYON (ENS DE LYON) , UNIVERSITÉ JOSEPH FOURIER - GRENOBLE I
发明人： VOLCHKOV, Viktor , JAMIN, Marc , LAWRENCE, Philip , YABUKARSKI, Filip
IPC分类号： C07K14/005 , A61K39/155
CPC分类号： C07K14/005 , A61K38/00 , C12N2760/18222 , C12N2760/18233 , C12N2760/18433
摘要： The invention related to isolated peptides including a binding domain of the viral phosphoprotein (P) subunit to the viral RNA free nucleoprotein (N 0 ) which has the property to inhibit the replication of viruses from the subfamily Paramyxovirinae (like Henipavirus, Rubulavirus or Morbillivirus). These isolated peptides may be used for the prevention or the treatment of Paramyxovirinae infection.
摘要翻译：本发明涉及分离的肽，包括病毒磷蛋白（P）亚基与病毒RNA游离核蛋白（N0）的结合结构域，其具有抑制亚型副粘病毒亚科（如肝炎病毒，Rubulavirus或Morbillivirus）病毒复制的性质。这些分离的肽可以用于预防或治疗副粘病毒感染。

19. 发明申请

WO2016005327A1 COMBINATION OF ANTIRETROVIRAL AGENTS FOR USE IN THE PREVENTION OR TREATMENT OF CHRONIC INFLAMMATORY DISEASES 审中-公开
标题翻译：抗逆转录病毒药物在预防或治疗慢性炎症疾病中的联合应用
公开(公告)号：WO2016005327A1
公开(公告)日：2016-01-14
申请号：PCT/EP2015/065361
申请日：2015-07-06
申请人： UNIVERSITÉ DE MONTPELLIER , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
发明人： MOLES, Jean-Pierre , GUILHOU, Jean-Jacques , DUJOLS, Pierre , NAGOT, Nicolas , VANDE PERRE, Philippe
IPC分类号： A61K31/505 , A61K31/513 , A61K31/52 , A61K31/536 , A61K31/675 , A61P17/06
CPC分类号： A61K45/06 , A61K31/427 , A61K31/505 , A61K31/513 , A61K31/536 , A61K31/675 , A61K2300/00
摘要： The present invention relates to the use of a composition comprising tenofovir in association with an antiviral compound for the treatment or the prevention of pathologies linked to an auto-inflammation.
摘要翻译：本发明涉及包含替诺福韦与抗病毒化合物联合的组合物在治疗或预防与自身炎症相关的病理学中的应用。

20. 发明申请

WO2015140224A1 MITOCHONDRIAL NON-CODING RNAs FOR PREDICTING DISEASE PROGRESSION IN HEART FAILURE AND MYOCARDIAL INFARCTION PATIENTS 审中-公开
标题翻译：用于预防心力衰竭和心肌梗死患者疾病进展的麻醉非编码RNA
公开(公告)号：WO2015140224A1
公开(公告)日：2015-09-24
申请号：PCT/EP2015/055713
申请日：2015-03-18
申请人： MEDIZINISCHE HOCHSCHULE HANNOVER , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM) , INSTITUT PASTEUR DE LILLE (IPL) , UNIVERSITÉ DE LILLE 2 (LILLE 2) - UNIVERSITY OF LAW AND HEALTH , CENTRE HOSPITALIER UNIVERSITAIRE LILLE (CHU)
发明人： THUM, Thomas , KUMARSWAMY, Regalla , PINET, Florence , DE GROOTE, Pascal , BAUTERS, Christophe
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a method for predicting mortality of a test patient with chronic heart failure comprising based on detecting the expression level of one or more long non-coding RNAs (IncRNAs) selected from SEQ ID NOs 1 to 8. The present invention also relates to a method for predicting cardiac remodeling after myocardial infarction in a test patient based on detecting the expression level of one or more IncRNAs selected from SEQ ID NOs 1 to 8.
摘要翻译：本发明涉及一种用于预测具有慢性心力衰竭的测试患者的死亡率的方法，包括基于检测选自SEQ ID NO.1至8的一种或多种长非编码RNA（IncRNA）的表达水平。本发明还涉及一种基于检测选自SEQ ID NO 1至8的一种或多种IncRNA的表达水平，在测试患者中预测心肌梗死后心脏重构的方法。

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