专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO1991000743A1 METHOD FOR DETERMINING ONCOGENIC POTENTIAL OF A CHEMICAL COMPOUND 审中-公开
标题翻译：用于测定化学化合物的燃烧潜力的方法
公开(公告)号：WO1991000743A1
公开(公告)日：1991-01-24
申请号：PCT/US1990003686
申请日：1990-07-03
申请人： GENPHARM INTERNATIONAL, INC.
发明人： GENPHARM INTERNATIONAL, INC. , BERNS, Anton, J., M.
IPC分类号： A61K49/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , C07K14/82 , C12N15/8509
摘要： Methods are provided for determining the oncogenic potential of chemical compounds which utilizes a transgenic mouse predisposed to T-cell lymphomas. The transgenic mouse expresses a pim-1 oncogene and as a consequence is predisposed to the spontaneous onset of T-cell lymphomas. The oncogenic potential of a chemical compound is determined by administering a known dose of the chemical compound of interest to a pim-1 transgenic mouse. Thereafter, the transgenic mouse is monitored to detect the onset of a T-cell lymphoma. The time of onset of the T-cell lymphoma and the dosage of the chemical compound are compared to either the onset of spontaneous T-cell lymphomas in the pim-1 transgenic mouse or to the onset of a T-cell lymphoma in a pim-1 transgenic mouse which has been exposed to a known quantity of a carcinogenic agent. This provides an indication of the oncogenic potential of the chemical compound.
摘要翻译：提供了用于确定利用倾向于T细胞淋巴瘤的转基因小鼠的化合物的致癌潜力的方法。转基因小鼠表达pim-1致癌基因，因此倾向于T细胞淋巴瘤的自发性发作。通过将已知剂量的目的化合物给予pim-1转基因小鼠来确定化合物的致癌潜力。此后，监测转基因小鼠以检测T细胞淋巴瘤的发作。将T细胞淋巴瘤的发病时间和化学化合物的剂量与pim-1转基因小鼠中的自发性T细胞淋巴瘤的发病或Pim-1转基因小鼠中的T细胞淋巴瘤的发作进行比较， 1转基因小鼠已经暴露于已知量的致癌剂。这提供了化合物的致癌潜力的指示。

IPRDB

热门服务

关于我们

友情链接

联系方式