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11. 发明申请

WO2009067550A1 METHODS OF DETECTING AND TREATMENT OF CANCERS USING SCUTTELARIA BARBATA EXTRACT 审中-公开
标题翻译：检测和治疗癌症的方法使用SCUTTELARIA BARBATA提取物
公开(公告)号：WO2009067550A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084082
申请日：2008-11-19
申请人： BIONOVO, INC. , COHEN, Isaac
发明人： COHEN, Isaac
IPC分类号： A61K36/534
CPC分类号： C12Q1/6895 , C12Q1/6886 , C12Q2600/106
摘要： An extract of Scutellaria Barbata D. Don is effective in the arrest of cancer cell growth. The extract of Scutellaria Barbata D. Don may be used as a therapeutic treatment for patients who have been identified as having cancer. In some situations, a patient is identified as having a type of cancer by detecting the presence of a biomarker for that cancer in the patient's system and by further determining the level of that biomarker in the patient's system. If the level of the biomarker is above a predetermined threshold level for that biomarker, the patient may be diagnosed with cancer. Subsquently, treatment using an extract of Scutellaria Barbata D. Don may begin. Biomarkers of interest in the detection of the presence of metastitic breast cancer include 8-oxoguanine and lactate dehydrogenase.
摘要翻译：黄芩提取物有效阻止癌细胞生长。黄芩提取物可用作被鉴定为患有癌症的患者的治疗方法。在某些情况下，通过检测患者系统中癌症的生物标志物的存在以及通过进一步确定患者系统中该生物标志物的水平，将患者鉴定为具有一种类型的癌症。如果生物标志物的水平高于该生物标志物的预定阈值水平，则患者可能被诊断患有癌症。不幸的是，使用黄芩提取物的治疗方法可能开始。感兴趣的检测转移性乳腺癌的生物标志物包括8-氧代鸟嘌呤和乳酸脱氢酶。

12. 发明申请

WO2009002802A2 LIQUIRITIGENIN AND DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR BETA AGONISTS 审中-公开
标题翻译：作为选择性雌激素受体激动剂的LIQUIRITIGININ和衍生物
公开(公告)号：WO2009002802A2
公开(公告)日：2008-12-31
申请号：PCT/US2008/067495
申请日：2008-06-19
申请人： BIONOVO, INC. , COHEN, Isaac
发明人： COHEN, Isaac
IPC分类号： A61K31/352 , A61P13/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , A61P9/00
CPC分类号： A61K31/352
摘要： The disclosure provides compositions comprising liquiritigenin, or derivatives, or prodrugs, useful as estrogen receptor beta selective agonists. The disclosure also provides methods of treating menopausal symptoms, and estrogen-dependent disorders, with said compositions.
摘要翻译：本公开提供了包含用作雌激素受体β选择性激动剂的甘草素或衍生物或前药的组合物。本公开还提供了用所述组合物治疗绝经症状和雌激素依赖性疾病的方法。

13. 发明申请

WO2008070207A2 A MULTIPLE TARGET TRACKING SYSTEM INCORPORATING MERGE, SPLIT AND REACQUISITION HYPOTHESES 审中-公开
标题翻译：包含合并，分裂和重复假设的多目标跟踪系统
公开(公告)号：WO2008070207A2
公开(公告)日：2008-06-12
申请号：PCT/US2007070925
申请日：2007-06-12
申请人： HONEYWELL INT INC , MA YUNQIAN , YU QIAN , COHEN ISAAC
发明人： MA YUNQIAN , YU QIAN , COHEN ISAAC
IPC分类号： G01S13/72 , G06T7/20
CPC分类号： G06K9/32 , G06K9/00771 , G06T7/277 , G06T2207/30241
摘要： A tracking system having a video detector for associating observations of blobs and objects and deriving objects' or blobs' paths. Hypotheses may be computed by the system for merging, splitting and reacquisition of the observations. There may be objects tracked among the observations, and best paths selected as trajectories of corresponding objects. The observations may be placed in a sliding window containing a series of observations inferred from a collection of frames for improving the accuracy of the tracking (or data association). The processed observations and data may be represented graphically.
摘要翻译：具有视频检测器的跟踪系统，用于将斑点和对象的观察结果关联起来并导出对象或斑点的路径。系统可以计算合并，分裂和重新获取观测值的假设。在观察中可以追踪对象，并且选择最佳路径作为相应对象的轨迹。观察可以放置在滑动窗口中，滑动窗口包含从一组帧中推断出的一系列观测结果，以提高跟踪（或数据关联）的准确性。处理后的观测数据可以用图形表示。

14. 发明申请

WO2008063946A2 METHOD AND SYSTEM FOR AUTOMATICALLY ESTIMATING THE SPATIAL POSITIONS OF CAMERAS IN A CAMERA NETWORK 审中-公开
标题翻译：用于自动估计摄像机网络中的摄像机的空间位置的方法和系统
公开(公告)号：WO2008063946A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084408
申请日：2007-11-12
申请人： HONEYWELL INTERNATIONAL INC. , HUSETH, Steve D. , KOLAVENNU, Soumitri N. , BEDROS, Saad J. , COHEN, Isaac
发明人： HUSETH, Steve D. , KOLAVENNU, Soumitri N. , BEDROS, Saad J. , COHEN, Isaac
IPC分类号： H04N5/247
CPC分类号： H04N5/247 , G01S5/02
摘要： A method for automatically estimating the spatial positions between cameras in a camera network utilizes unique identifying signals, such as RFID signals, transmitting between nearby cameras to estimate the relative distances or positions between cameras from received signal strength (RSS), time of arrival (TOA), or time difference of arrival (TDOA) measurements to thereby determine the neighboring relationship among the cameras. A discover-locate process can be used to discover, from the estimated relative distances, unknown cameras in the vicinity of at least three cameras at known locations. Absolute locations of the discovered unknown cameras can then be calculated using a geometric calculation. The discover-locate process can be cascaded throughout the network to discover and locate all unknown cameras automatically using previously discovered and located cameras. Such methods can be implemented in systems having cameras with transceivers integrated therein and a controller operably linked to the cameras.
摘要翻译：用于自动估计照相机网络中的照相机之间的空间位置的方法利用独特的识别信号（诸如RFID信号）在附近的照相机之间传输以根据接收的信号强度估计照相机之间的相对距离或位置（ RSS），到达时间（TOA）或到达时间差（TDOA）测量，从而确定摄像机之间的邻近关系。发现 - 定位过程可以用来从估计的相对距离中发现在已知位置处的至少三台相机附近的未知相机。然后可以使用几何计算来计算发现的未知相机的绝对位置。发现 - 定位过程可以级联在整个网络中，使用先前发现和定位的相机自动发现和定位所有未知相机。这种方法可以在具有集成在其中的收发器的照相机的系统和可操作地连接到照相机的控制器中实现。

15. 发明申请

WO2006107745A2 COMPOSITION FOR TREATMENT OF MENOPAUSE 审中-公开
标题翻译：用于治疗男性的组合物
公开(公告)号：WO2006107745A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/011862
申请日：2006-03-30
申请人： BIONOVO, INC. , COHEN, Isaac
发明人： COHEN, Isaac
IPC分类号： A61K36/906 , A61K36/539 , A61K36/48 , A61K36/8965
CPC分类号： A61K36/488 , A61K36/076 , A61K36/21 , A61K36/284 , A61K36/296 , A61K36/40 , A61K36/48 , A61K36/481 , A61K36/484 , A61K36/489 , A61K36/539 , A61K36/62 , A61K36/638 , A61K36/65 , A61K36/708 , A61K36/725 , A61K36/884 , A61K36/8964 , A61K36/8965 , A61K36/899 , Y10S514/899 , A61K2300/00
摘要： A novel herbal extract, MFl0l, is effective in the treatment of symptoms of menopause.
摘要翻译：一种新颖的草药提取物MF101可有效治疗更年期症状。

16. 发明申请

WO2006065608A2 ESTROGENIC EXTRACTS OF MORUS ALBA AND USES THEREOF 审中-公开
标题翻译：异黄酮提取物及其用途
公开(公告)号：WO2006065608A2
公开(公告)日：2006-06-22
申请号：PCT/US2005044362
申请日：2005-12-09
申请人： BIONOVO INC , COHEN ISAAC
发明人： COHEN ISAAC
IPC分类号： A61K36/605
CPC分类号： A61K36/605
摘要： Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ERa+ and ERß+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
摘要翻译： Moraceae家族的各种提取物具有雌激素特性。例如，Mora alba L.物种的水性和乙醇提取物在ERa +和ERβ+细胞中具有雌激素特性。这些雌激素作用包括雌激素反应元件（ERE）刺激以及肿瘤坏死因子（TNF）镇压。提供了治疗更年期症状，乳房和/或子宫癌以及骨质疏松症的方法。

17. 发明申请

WO2002080951A1 HERBAL EXTRACTS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的草药提取物
公开(公告)号：WO2002080951A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/009937
申请日：2002-03-29
申请人： SYNERGISTIX BIOTECH, INC. , COHEN, Isaac
发明人： COHEN, Isaac
IPC分类号： A61K35/78
CPC分类号： A61K36/00 , A61K2300/00
摘要： The present invention is related to herbal extracts and their use as inhibitors of cancer cells lines in vitro and for the treatment of solid tumor cancer in humans.
摘要翻译：本发明涉及草药提取物及其作为体外癌细胞系抑制剂和用于治疗人体中的实体瘤的用途。

18. 发明申请

WO2011085298A3 COMPOSITIONS COMPRISING PIGMENT PARTICLES ENTRAPPED IN COLLAPSED POLYMERIC MICROSPHERES, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：包含在塌陷聚合物微球中引入的颜料颗粒的组合物以及制备该组合物的方法
公开(公告)号：WO2011085298A3
公开(公告)日：2011-11-10
申请号：PCT/US2011020655
申请日：2011-01-10
申请人： ELC MAN LLC , COHEN ISAAC D , CUMMINS PHILLIP , SOJKA MILAN FRANZ , CULHANE RACHEL J , FTHENAKIS CHRISTINA G , OKO JENNIFER L , DREHER JOHN DUDLEY , NAJDEK LINDA J
发明人： COHEN ISAAC D , CUMMINS PHILLIP , SOJKA MILAN FRANZ , CULHANE RACHEL J , FTHENAKIS CHRISTINA G , OKO JENNIFER L , DREHER JOHN DUDLEY , NAJDEK LINDA J
IPC分类号： A61K47/30 , A61K9/16 , A61K47/48 , C08K7/16 , C08K9/10
CPC分类号： A61Q17/04 , A61K8/025 , A61K8/0275 , A61K2800/412 , A61K2800/43 , A61K2800/63 , A61Q1/02 , C08K3/22 , C08K9/10
摘要： Topical compositions containing pigment particles entrapped in microspheres are provided. Each of the microspheres contains a collapsed polymeric shell that has entrapped therein one or more pigment particles. The microsphere-entrapped pigment particles are characterized by enhanced color intensity, improved stability, and better dispersibility, which can readily be used either alone or in combination with other skin active ingredients to form better colored cosmetics.
摘要翻译：提供含有包埋在微球体中的颜料颗粒的局部用组合物。每个微球含有坍缩的聚合物壳，其中包埋有一种或多种颜料颗粒。包埋微球的颜料颗粒的特征在于增强的颜色强度，改进的稳定性和更好的分散性，其可以容易地单独使用或与其他皮肤活性成分组合使用以形成更好的着色化妆品。

19. 发明申请

WO2011090821A2 COMPOSITE PARTICLES, COMPOSITIONS AND METHODS 审中-公开
标题翻译：复合颗粒，组合物和方法
公开(公告)号：WO2011090821A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/020248
申请日：2011-01-05
申请人： ELC MANAGEMENT LLC , COHEN, Isaac David , CUMMINS, Phillip , SOJKA, Milan Franz , CULHANE, David Walter , FTHENAKIS, Christina G. , OKO, Jennifer L. , DREHER, John Dudley , MIKHAYLOVA, Yelena
发明人： COHEN, Isaac David , CUMMINS, Phillip , SOJKA, Milan Franz , CULHANE, David Walter , FTHENAKIS, Christina G. , OKO, Jennifer L. , DREHER, John Dudley , MIKHAYLOVA, Yelena
IPC分类号： A61K8/29 , A61K8/27 , A61K8/19 , A61K8/37 , A61K8/30 , A61Q1/10 , A61Q1/04 , A61Q7/00
CPC分类号： A61K8/0283 , A61K8/0241 , A61K8/18 , A61K8/19 , A61K8/29 , A61K8/8147 , A61K8/8152 , A61K2800/262 , A61K2800/31 , A61K2800/412 , A61K2800/43 , A61K2800/651 , A61K2800/654 , A61K2800/805 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , D06P5/04
摘要： Composite particulates, topical composition containing composite particulates, methods for improving the appearance of skin depth, dimensionality or undertones; a method for improving the ashy, chalky or mask-like appearance of color cosmetic compositions on the skin; and a method for reducing the number of shades in a color cosmetic shade range by formulating the cosmetic with composite particulates.
摘要翻译：复合颗粒，含有复合颗粒的局部组合物，改善皮肤深度外观，维度或底色的方法; 用于改善皮肤上着色化妆品组合物的灰白色，白垩或掩模样外观的方法; 以及通过用复合颗粒配制化妆品来减少彩色化妆品遮光范围中的色调数量的方法。

20. 发明申请

WO2011085298A2 COMPOSITIONS COMPRISING PIGMENT PARTICLES ENTRAPPED IN COLLAPSED POLYMERIC MICROSPHERES, AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：包含聚合聚合物微囊中的颜料颗粒的组合物及其制备方法
公开(公告)号：WO2011085298A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020655
申请日：2011-01-10
申请人： ELC MANAGEMENT LLC , COHEN, Isaac, D. , CUMMINS, Phillip , SOJKA, Milan Franz , CULHANE, Rachel J. , FTHENAKIS, Christina G. , OKO, Jennifer L. , DREHER, John Dudley , NAJDEK, Linda J.
发明人： COHEN, Isaac, D. , CUMMINS, Phillip , SOJKA, Milan Franz , CULHANE, Rachel J. , FTHENAKIS, Christina G. , OKO, Jennifer L. , DREHER, John Dudley , NAJDEK, Linda J.
IPC分类号： A61K47/30 , A61K47/48 , A61K9/16 , C08K9/10 , C08K7/16
CPC分类号： A61Q17/04 , A61K8/025 , A61K8/0275 , A61K2800/412 , A61K2800/43 , A61K2800/63 , A61Q1/02 , C08K3/22 , C08K9/10
摘要： Topical compositions containing pigment particles entrapped in microspheres are provided. Each of the microspheres contains a collapsed polymeric shell that has entrapped therein one or more pigment particles. The microsphere-entrapped pigment particles are characterized by enhanced color intensity, improved stability, and better dispersibility, which can readily be used either alone or in combination with other skin active ingredients to form better colored cosmetics.
摘要翻译：提供了包含夹在微球中的颜料颗粒的局部组合物。每个微球体都含有一个塌陷的聚合物壳，其中包含一个或多个颜料颗粒。微球捕获的颜料颗粒的特征在于增强的颜色强度，改进的稳定性和更好的分散性，其可以单独使用或与其它皮肤活性成分组合使用以形成更好的有色化妆品。

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