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11. 发明申请

WO2003033654A2 DIRECT TARGETING BINDING PROTEINS 审中-公开
标题翻译：直接定向结合蛋白
公开(公告)号：WO2003033654A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/032718
申请日：2002-10-15
申请人： ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David, M.
发明人： ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David, M.
IPC分类号： C12N
CPC分类号： C07K16/3007 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/626
摘要： The present invention relates to multivalent, monospecific binding proteins. These binding proteins comprise two or more binding sites, where each binding site specifically binds to the same type of target cell, and preferably with the same antigen on such a target cell. The present invention further relates to compositions of monospecific diabodies, triabodies, and tetrabodies, and to recombinant vectors useful for the expression of these functional binding proteins in a microbial host. Also provided are methods of using invention compositions in the treatment and/or diagnosis of tumors.
摘要翻译：本发明涉及多价单特异性结合蛋白。这些结合蛋白包含两个或更多个结合位点，其中每个结合位点特异性结合相同类型的靶细胞，并且优选在这样的靶细胞上具有相同的抗原。本发明还涉及单特异性双抗体，三抗体和四体抗体的组合物，以及用于在微生物宿主中表达这些功能性结合蛋白质的重组载体。还提供了使用本发明组合物治疗和/或诊断肿瘤的方法。

12. 发明申请

WO03033653B1 AFFINITY ENHANCEMENT AGENTS 审中-公开
标题翻译：亲属加强代理
公开(公告)号：WO03033653B1
公开(公告)日：2004-02-12
申请号：PCT/US0232717
申请日：2002-10-15
申请人： IMMUNOMEDICS INC , CHANG CHIEN-HSING KEN , ROSSI EDMUND , IBC PHARMACEUTICALS
发明人： CHANG CHIEN-HSING KEN , ROSSI EDMUND
IPC分类号： C12N15/09 , A61K38/00 , A61K38/02 , A61K38/22 , A61K39/395 , A61K45/00 , A61K45/06 , A61K47/42 , A61K47/48 , A61P9/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , C07K2/00 , C07K16/18 , C07K16/30 , C07K16/32 , C07K16/44 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , C07K16/00 , C12N15/00 , C12N15/85 , C12N15/86
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/3007 , C07K16/44 , C07K2317/24 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： This invention relates to a kit containing a multivalent, multi-specific binding protein and a carrier molecule. The binding protein has two or more binding sites where at least one binding site binds with a hapten moiety and at least one site binds with a target antigen. The carrier molecule contains a linking molecule that bears a diagnostic agent and/or a therapeutic agent and two or more haptens. The present invention further relates to bispecific diabodies that bind with hapten moieties and target antigens and to recombinant vectors useful for the expression of these functional diabodies in a microbial host.
摘要翻译：本发明涉及含有多价多特异性结合蛋白和载体分子的试剂盒。结合蛋白具有两个或多个结合位点，其中至少一个结合位点与半抗原部分结合，并且至少一个位点与靶抗原结合。载体分子含有连接分子，其具有诊断剂和/或治疗剂和两种或更多种半抗原。本发明还涉及与半抗原部分和靶抗原结合的双特异性双抗体以及用于在微生物宿主中表达这些功能性双抗体的重组载体。

13. 发明申请

WO2003057829A3 METHODS OF GENERATING MULTISPECIFIC, MULTIVALENT AGENTS FROM VH AND VL DOMAINS 审中-公开
公开(公告)号：WO2003057829A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/038985
申请日：2002-12-26
申请人： IMMUNOMEDICS, INC. , IBC PHARMACEUTICALS , ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David
发明人： ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David
IPC分类号： C12N15/85
摘要： This invention relates to multi-specific, multivalent binding proteins and methods of generating these agents from V H and V L domains. The binding protein has three or more binding sites where at least one binding site binds with a hapten moiety and at least two sites bind with target antigens. The present invention further relates to bispecific, trivalent heterodimers that have at least one binding site with affinity towards molecules containing a histamine-succinyl-glycyl (HSG) moiety and at least two binding sites with affinity towards carcinoembryonic antigen (CEA), and to trispecific, trivalent heterodimers that have at least one binding site with affinity towards molecules containing a HSG moiety, at least one binding sites with affinity towards CEA, and at least one binding site having affinity towards a metal-chelate complex indium-DTPA. Moreover, this invention relates to recombinant vectors useful for the expression of these functional heterodimers in a suitable host.

14. 发明申请

WO2003057829A2 METHODS OF GENERATING MULTISPECIFIC, MULTIVALENT AGENTS FROM VH AND VL DOMAINS 审中-公开
标题翻译：从VH和VL域产生多重多功能药物的方法
公开(公告)号：WO2003057829A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/038985
申请日：2002-12-26
申请人： ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David
发明人： ROSSI, Edmund , CHANG, Chien-Hsing, Ken , GOLDENBERG, David
IPC分类号： C12N
CPC分类号： C07K16/3007 , C07K16/18 , C07K16/44 , C07K2317/31 , C07K2319/00
摘要： This invention relates to multi-specific, multivalent binding proteins and methods of generating these agents from V H and V L domains. The binding protein has three or more binding sites where at least one binding site binds with a hapten moiety and at least two sites bind with target antigens. The present invention further relates to bispecific, trivalent heterodimers that have at least one binding site with affinity towards molecules containing a histamine-succinyl-glycyl (HSG) moiety and at least two binding sites with affinity towards carcinoembryonic antigen (CEA), and to trispecific, trivalent heterodimers that have at least one binding site with affinity towards molecules containing a HSG moiety, at least one binding sites with affinity towards CEA, and at least one binding site having affinity towards a metal-chelate complex indium-DTPA. Moreover, this invention relates to recombinant vectors useful for the expression of these functional heterodimers in a suitable host.
摘要翻译：本发明涉及多特异性，多价结合蛋白以及从V H和V S结构域产生这些试剂的方法。结合蛋白具有三个或更多个结合位点，其中至少一个结合位点与半抗原部分结合，并且至少两个位点与靶抗原结合。本发明还涉及具有至少一个对包含组胺 - 琥珀酰 - 甘氨酰（HSG）部分和至少两个对癌胚抗原（CEA）具有亲和力的结合位点具有亲和力的结合位点的双特异性三价异源二聚体，并且具有三特异性具有至少一个对含有HSG部分的分子具有亲和力的结合位点，对CEA具有亲和性的至少一个结合位点的至少一个结合位点以及至少一个对金属 - 螯合物复合物铟-DTPA具有亲和性的结合位点的三价异源二聚体。此外，本发明涉及可用于在合适宿主中表达这些功能异二聚体的重组载体。

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