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11. 发明申请

WO2007060618A2 MACROLIDES DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗坏血酸衍生物作为抗菌剂
公开(公告)号：WO2007060618A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054373
申请日：2006-11-21
申请人： RANBAXY LABORATORIES LIMITED , CHAKRABARTI, Anjan , DAS, Biswajit , JADHAV, Jitendra, Sambhaji , UPADHYAY, Dilip, J.
发明人： CHAKRABARTI, Anjan , DAS, Biswajit , JADHAV, Jitendra, Sambhaji , UPADHYAY, Dilip, J.
IPC分类号： C07H17/08 , A61K31/7048 , A61P31/04
CPC分类号： C07H17/08
摘要： The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram-positive, gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Propionibeacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译：本发明提供可用作抗菌剂的大环内酯衍生物。本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属，衣原体属。，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，丙酸杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。还提供了制备本文所述化合物的方法，其药物组合物和治疗细菌感染的方法。

12. 发明申请

WO2007060518A3 KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
公开(公告)号：WO2007060518A3
公开(公告)日：2007-05-31
申请号：PCT/IB2006/003298
申请日：2006-11-21
申请人： RANBAXY LABORATORIES LIMITED , DAS, Biswajit , CHAKRABARTI, Anjan , KUMAR, Rajesh , VENKATARAMANAN, Ramadass , HAJARE, Atul Kashinath , BANDYOPADHYAY, Anish , KATOCH, Rita , KAPKOTI, Gobind Singh , SURASE, Yogesh Baban , SALMAN, Mohammad , UPADHYAY, Dilip J.
发明人： DAS, Biswajit , CHAKRABARTI, Anjan , KUMAR, Rajesh , VENKATARAMANAN, Ramadass , HAJARE, Atul Kashinath , BANDYOPADHYAY, Anish , KATOCH, Rita , KAPKOTI, Gobind Singh , SURASE, Yogesh Baban , SALMAN, Mohammad , UPADHYAY, Dilip J.
IPC分类号： C07H17/08 , A61K31/7052 , A61P31/04
摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.

13. 发明申请

WO2006060148A3 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR 审中-公开
标题翻译：与红细胞生成素受体结合的新肽
公开(公告)号：WO2006060148A3
公开(公告)日：2006-10-05
申请号：PCT/US2005041113
申请日：2005-11-11
申请人： AFFYMAX INC , HOLMES CHRISTOPHER P , YIN QUN , ZEMEDE GENET , BHANDARI ASHOK , DONG YAOHUA S , TUMELTY DAVID , LALONDE GUY , PALANI BALU , SCHATZ PETER J , WRIGHTON NICHOLAS C , DOWER WILLIAM J , FREDERICK BRIAN T , CHAKRABARTI ANJAN
发明人： HOLMES CHRISTOPHER P , YIN QUN , ZEMEDE GENET , BHANDARI ASHOK , DONG YAOHUA S , TUMELTY DAVID , LALONDE GUY , PALANI BALU , SCHATZ PETER J , WRIGHTON NICHOLAS C , DOWER WILLIAM J , FREDERICK BRIAN T , CHAKRABARTI ANJAN
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与红细胞产生不足或缺陷有关的病症的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

14. 发明申请

WO2015164308A1 FACTOR XIa INHIBITORS 审中-公开
标题翻译：因子XIA抑制剂
公开(公告)号：WO2015164308A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/026774
申请日：2015-04-21
申请人： MERCK SHARP & DOHME CORP. , LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott, D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda, V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew, M. , YU, Younong , KEVIN, Nancy, J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh, F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph, L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
发明人： LIM, Yeon-Hee , GUO, Zhuyan , ALI, Amjad , EDMONDSON, Scott, D. , LIU, Weiguo , GALLO-ETIENNE, Gioconda, V. , WU, Heping , GAO, Ying-Duo , STAMFORD, Andrew, M. , YU, Younong , KEVIN, Nancy, J. , ANAND, Rajan , SHA, Deyou , NEELAMKAVIL, Santhosh, F. , HUSSAIN, Zahid , KUMAR, Puneet , MONINGKA, Remond , DUFFY, Joseph, L. , XU, Jiayi , JIANG, Yu , SONE, Hiroki , CHAKRABARTI, Anjan
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译：本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

15. 发明申请

WO2008111020A2 MACROLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译： MACROLIDE衍生物作为抗菌剂
公开(公告)号：WO2008111020A2
公开(公告)日：2008-09-18
申请号：PCT/IB2008/050979
申请日：2008-03-14
申请人： RANBAXY LABORATORIES LIMITED , CHAKRABARTI, Anjan , SURASE, Yogesh, Baban , JADHAV, Jitendra, Sambhaji , DAS, Biswajit , UPADHYAY, Dilip
发明人： CHAKRABARTI, Anjan , SURASE, Yogesh, Baban , JADHAV, Jitendra, Sambhaji , DAS, Biswajit , UPADHYAY, Dilip
CPC分类号： C07H17/00 , C07H17/08
摘要： The present invention provides macrolide derivatives, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided, are the processes for preparing the compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
摘要翻译：本发明提供了可用作抗菌剂的大环内酯衍生物。本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧菌引起的疾病或更有针对性地对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉沙拉菌，衣原体属，支原体军团菌属，分枝杆菌属，螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。还提供了用于制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗细菌感染的方法。

16. 发明申请

WO2007060627A3 USE OF MACROLIDE DERIVATIVES FOR TREATING ACNE 审中-公开
公开(公告)号：WO2007060627A3
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054391
申请日：2006-11-22
申请人： RANBAXY LABORATORIES LIMITED , UPADHYAY, Dilip, J. , CHAKRABARTI, Anjan , DAS, Biswajit , GOWRISHANKAR, Radhakrishnan
发明人： UPADHYAY, Dilip, J. , CHAKRABARTI, Anjan , DAS, Biswajit , GOWRISHANKAR, Radhakrishnan
IPC分类号： A61K31/7056 , A61P17/10
摘要： This invention relates to 14-membered macrolides derivatives for treating or preventing acne vulgaris and inflammatory conditions thereof. Also provided herein are pharmaceutical compositions comprising one or more 14-membered macrolides derivatives together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixture thereof, and methods for treating or preventing acne vulgaris and inflammatory condition thereof.

17. 发明申请

WO2007060627A2 USE OF MACROLIDE DERIVATIVES FOR TREATING ACNE 审中-公开
标题翻译： MACROLIDE衍生物用于治疗痤疮的用途
公开(公告)号：WO2007060627A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006054391
申请日：2006-11-22
申请人： RANBAXY LAB LTD , UPADHYAY DILIP J , CHAKRABARTI ANJAN , DAS BISWAJIT , GOWRISHANKAR RADHAKRISHNAN
发明人： UPADHYAY DILIP J , CHAKRABARTI ANJAN , DAS BISWAJIT , GOWRISHANKAR RADHAKRISHNAN
CPC分类号： A61K31/7056
摘要： This invention relates to 14-membered macrolides derivatives for treating or preventing acne vulgaris and inflammatory conditions thereof. Also provided herein are pharmaceutical compositions comprising one or more 14-membered macrolides derivatives together with one or more pharmaceutically acceptable carriers, excipients, diluents or mixture thereof, and methods for treating or preventing acne vulgaris and inflammatory condition thereof.
摘要翻译：本发明涉及用于治疗或预防寻常痤疮及其炎性症状的14-元大环内酯衍生物。本文还提供了包含一种或多种14-元大环内酯衍生物以及一种或多种药学上可接受的载体，赋形剂，稀释剂或其混合物的药物组合物，以及用于治疗或预防寻常痤疮及其炎性病症的方法。

18. 发明申请

WO2007060518A2 KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：胶体衍生物作为抗菌剂
公开(公告)号：WO2007060518A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006003298
申请日：2006-11-21
申请人： RANBAXY LAB LTD , DAS BISWAJIT , CHAKRABARTI ANJAN , KUMAR RAJESH , VENKATARAMANAN RAMADASS , HAJARE ATUL KASHINATH , BANDYOPADHYAY ANISH , KATOCH RITA , KAPKOTI GOBIND SINGH , SURASE YOGESH BABAN , SALMAN MOHAMMAD , UPADHYAY DILIP J
发明人： DAS BISWAJIT , CHAKRABARTI ANJAN , KUMAR RAJESH , VENKATARAMANAN RAMADASS , HAJARE ATUL KASHINATH , BANDYOPADHYAY ANISH , KATOCH RITA , KAPKOTI GOBIND SINGH , SURASE YOGESH BABAN , SALMAN MOHAMMAD , UPADHYAY DILIP J
CPC分类号： C07H17/08
摘要： Provided herein are ketolide derivatives, which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae, Propionibacterium acnes or any combination thereof. Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译：本文提供了可用作抗菌剂的酮内酯衍生物。本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌，衣原体属，支原体，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属，痤疮丙酸杆菌或其任何组合。还提供了制备本文所述的化合物的方法，其药物组合物和治疗细菌感染的方法。

19. 发明申请

WO2006129257A3 KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：胶体衍生物作为抗菌剂
公开(公告)号：WO2006129257A3
公开(公告)日：2007-02-08
申请号：PCT/IB2006051686
申请日：2006-05-26
申请人： RANBAXY LAB LTD , DAS BISWAJIT , CHAKRABARTI ANJAN , KAPKOTI GOBIND SINGH , HAJARE ATUL KASHINATH , KATOCH RITA , RATTAN ASHOK
发明人： DAS BISWAJIT , CHAKRABARTI ANJAN , KAPKOTI GOBIND SINGH , HAJARE ATUL KASHINATH , KATOCH RITA , RATTAN ASHOK
IPC分类号： C07H17/08 , A61K31/7048
CPC分类号： C07H17/08
摘要： The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide. derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections. The compounds have the following structure, Formula (I), wherein R can be Formula (II), (wherein Z i can be hydrogen or melhyl, Z 2 can be hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, amino, nitro, cyano or amido, Z 3 can be hydrogen, fluorine, chlorine, bromine or iodine, X 1 can be CR 4 , CR 4 R' 4 N, NR 4 , O or S, X 2 can be CR 4 or N wherein R 4 and R' 4 independently in each occurrence can be hydrogen or C 1-3 alky, R 2 and R 3 can be independently Formula (III), wherein, X 3 -X 13 can be independenËy C(R 4 ) 0-2 , N(R 4 ) 0-1 , O or S, R 5 -R 10 can be independently hydrogen, halogen, C 1-3 alkyl, C 1-3 alkoxy, amino, nilro, cyano, aryl or heteroaryl), Y is hydrogen or methyl, and is an optional single bond.
摘要翻译：本发明提供可用作抗菌剂的酮内酯衍生物。特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。还提供了制备这种酮内酯的方法。衍生物，其药物组合物，以及治疗细菌感染的方法。这些化合物具有下列结构式（I），其中R可以是式（II），其中Z可以是氢或蜜胺，Z 2可以是氢卤素，C 1-3烷基，C 1-3烷氧基，氨基，硝基，氰基或酰胺基，Z 3可以是氢，氟，氯，溴或碘，X 1可以是CR 4，CR 4 R 4，N， NR 4，O或S，X 2可以是CR 4或N，其中R 4和R' 在每次出现时独立地可以是氢或C 1-3烷基，R 2和R 3可以独立地独立地式（III），其中X 3 -X 13可以独立地是C（R 4）0-2 ，N（R 4）0-1，O或S，R 5 -R 10可以是独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基，氨基，腈基，氰基，芳基或杂芳基），Y是氢或甲基，并且是一个可选单键。

20. 发明申请

WO2006129257A2 KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：胶体衍生物作为抗菌剂
公开(公告)号：WO2006129257A2
公开(公告)日：2006-12-07
申请号：PCT/IB2006/051686
申请日：2006-05-26
申请人： RANBAXY LABORATORIES LIMITED , DAS, Biswajit , CHAKRABARTI, Anjan , KAPKOTI, Gobind, Singh , HAJARE, Atul, Kashinath , KATOCH, Rita , RATTAN, Ashok
发明人： DAS, Biswajit , CHAKRABARTI, Anjan , KAPKOTI, Gobind, Singh , HAJARE, Atul, Kashinath , KATOCH, Rita , RATTAN, Ashok
IPC分类号： C07H17/08 , A61K31/7048
CPC分类号： C07H17/08
摘要： The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.
摘要翻译：本发明提供可用作抗菌剂的酮内酯衍生物。特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，马克拉斯氏菌属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

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