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11. 发明申请

WO1997017018A1 APERIODIC ULTRASOUND PHASED ARRAY 审中-公开
标题翻译： APERIODIC超声波相位阵列
公开(公告)号：WO1997017018A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017964
申请日：1996-11-08
申请人： BRIGHAM & WOMEN'S HOSPITAL , HUTCHINSON, Erin , BUCHANAN, Mark , HYNYNEN, Kullervo
发明人： BRIGHAM & WOMEN'S HOSPITAL
IPC分类号： A61B08/00
CPC分类号： B06B1/0633 , A61B2017/22028 , A61M37/0092 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095 , B06B1/0622 , B06B1/0629
摘要： An apparatus (10) for providing ultrasonic energy for deposition in body tissue (24) including an array (17) of elements (18, 20) having at least two different sizes and at least one element being periodically spaced with respect to the other elements in the array. An amplifier system (12) includes amplifiers (15), and phase shifters (16) each individually controlling each of the elements producing a beam of ultrasonic energy having reduced grating lobes. Reduced grating lobe magnitude permits improved ultrasonic beam focusing and/or the use of larger element sizes.
摘要翻译：一种用于提供用于沉积在身体组织（24）中的超声能量的装置（10），包括具有至少两种不同尺寸的元件（18,20）的阵列（17），并且至少一个元件相对于其它元件周期性间隔开在阵列中。放大器系统（12）包括放大器（15）和移相器（16），每个单独地控制每个元件产生具有减小的栅瓣的超声能量束。减小的光栅大小允许改进的超声波束聚焦和/或使用更大的元件尺寸。

12. 发明申请

WO1996008268A1 INHIBITION OF ENDOTHELIN-1 TO REDUCE INFLAMMATORY PROCESSES 审中-公开
标题翻译：抑制内皮素-1减少炎症过程
公开(公告)号：WO1996008268A1
公开(公告)日：1996-03-21
申请号：PCT/US1995011937
申请日：1995-09-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRIGHAM & WOMEN'S HOSPITAL
发明人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BRIGHAM & WOMEN'S HOSPITAL , RUSSELL, Mary, E. , SAYEGH, Mohamed , WATSCHINGER, Bruno
IPC分类号： A61K38/12
CPC分类号： G01N33/5088 , A61K38/00 , A61K48/00 , C07K14/57536 , C07K14/723 , C07K16/2869 , G01N2333/5754 , G01N2800/245
摘要： The vasoactive and mitogenic peptide, endothelin-1 (ET-1) is upregulated within grafts, and methods of diagnosing and treating graft rejection, arteriosclerosis, and other cell-mediated inflammatory conditions are provided. These methods involve identifying and reducing expression of ET-1.
摘要翻译：血管活性和促有丝分裂肽，内皮素-1（ET-1）在移植物内上调，提供诊断和治疗移植排斥反应，动脉硬化和其他细胞介导的炎性病症的方法。这些方法涉及鉴定和减少ET-1的表达。

13. 发明申请

WO1995012408A1 PLASMIN-INDEPENDENT FIBRINOLYSIS 审中-公开
标题翻译：血浆独立性纤维蛋白溶解
公开(公告)号：WO1995012408A1
公开(公告)日：1995-05-11
申请号：PCT/US1994012583
申请日：1994-11-03
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , SIMON, Daniel, I. , LOSCALZO, Joseph
IPC分类号： A61K38/46
CPC分类号： C12Q1/37 , A61K31/195 , A61K31/405 , A61K31/655 , A61K38/484 , A61K38/55 , A61K38/56 , C07K14/75 , G01N2333/75 , G01N2333/96472 , A61K38/49 , A61K38/48 , A61K2300/00
摘要： Disclosed is a method of dissolving thrombi in blood by introducing into the blood an aspartyl protease which cleaves fibrin or fibrinogen in blood clots.
摘要翻译：本发明公开了一种通过向血液中引入血栓中血栓的方法，该天冬氨酰蛋白酶切割血块中的纤维蛋白或纤维蛋白原。

14. 发明申请

WO1995001179A1 MODULATION OF INFLAMMATION RELATED TO COLUMNAR EPITHELIA 审中-公开
标题翻译：与上海上皮相关的炎症调节
公开(公告)号：WO1995001179A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007333
申请日：1994-06-29
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , MADARA, James, L. , SERHAN, Charles, N. , COLGAN, Sean, P.
IPC分类号： A61K31/557
CPC分类号： A61K31/23 , A61K31/20 , C07C59/42 , C07C59/46 , C07C59/48 , C07C59/56 , C07C59/58 , C07C59/68 , C07C69/732 , C07C69/734 , C07C69/736 , G01N33/5088 , Y02A50/481
摘要： This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods for screening for compounds useful in preventing columnar epithelial inflammation.
摘要翻译：本发明提供含有脂氧素化合物的药物组合物和化合物治疗或预防与柱状上皮炎症相关的疾病或病症的治疗用途。本发明还公开了筛选用于预防柱状上皮炎症的化合物的方法。

15. 发明申请

WO1992018153A1 METHOD OF TREATING GASTROINTESTINAL ULCERS WITH PLATELET DERIVED GROWTH FACTOR 审中-公开
标题翻译：用平板衍生生长因子治疗胃肠功能障碍的方法
公开(公告)号：WO1992018153A1
公开(公告)日：1992-10-29
申请号：PCT/US1992002941
申请日：1992-04-10
申请人： CREATIVE BIOMOLECULES, INC. , BRIGHAM & WOMEN'S HOSPITAL
发明人： CREATIVE BIOMOLECULES, INC. , BRIGHAM & WOMEN'S HOSPITAL , SZABO, Sandor , CHARETTE, Marc, F.
IPC分类号： A61K37/36
CPC分类号： A61K38/1858
摘要： Disclosed is a method for treating ulcers of the gastrointestinal tract in a mammal which includes administering to the mammal a therapeutically effective amount of Platelet-Derived Growth Factor (PDGF) to the gastrointestinal tract of the mammal.
摘要翻译：公开了一种治疗哺乳动物胃肠道溃疡的方法，其包括向哺乳动物施用治疗有效量的血小板衍生生长因子（PDGF）给哺乳动物的胃肠道。

16. 发明申请

WO1992005727A1 INFANT SUPPORT 审中-公开
标题翻译：婴儿支持
公开(公告)号：WO1992005727A1
公开(公告)日：1992-04-16
申请号：PCT/US1991007094
申请日：1991-09-27
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , POPITZ, Michael, D.
IPC分类号： A47C16/00
CPC分类号： A47D15/008 , A47C21/046 , A47C27/144 , A47C27/146 , A47C27/148 , A47C27/15 , A47C27/20 , A47D13/08 , A61G7/065 , A61G13/12 , A61G13/121 , A61G13/1215 , A61G13/1225
摘要： The present invention provides a full body support (10) for an infant which automatically aligns the oropharyngeal, laryngeal, and tracheal axes of the infant's head and neck for airway management. The support (10) includes a first cushion (20) and a second cushion (40), the first cushion (20) having a head receiving opening (25), a body receiving opening (26), and a neck supporting surface (29) to extend beneath the neck of the infant. The second cushion (40) is disposed beneath the first cushion (20) and provides a head supporting surface (44) and a body supporting surface (45) within the head receiving opening (25) and body receiving opening (26), respectively. When an infant is properly positioned on the support (10) the airway axes of the infant's head and neck are automatically opened and aligned for airway management. The support (10) may also be used to provide general comfort to an infant resting thereon during any type of pre or postoperative care.

17. 发明申请

WO1989007957A1 CO2 INDICATOR FOR PLACEMENT OF TRACHEAL TUBES 审中-公开
标题翻译：二氧化碳指示器用于放置管道
公开(公告)号：WO1989007957A1
公开(公告)日：1989-09-08
申请号：PCT/US1989000796
申请日：1989-02-27
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , RAEMER, Daniel, B. , WALT, David, R. , MUNKHOLM, Christianne
IPC分类号： A61M16/00
CPC分类号： G01N31/223 , A61M16/042 , A61M16/0488 , A61M16/085 , A61M2016/0413 , A61M2230/202
摘要： The invention relates to a CO2 detector for the detection of CO2 in respiratory gases. In particular, the invention relates to medical devices which contain a CO2 detector disposed within the devices to allow detection of CO2 within respiratory gases. The invention also relates to a method for determining the proper placement of an intubation device comprising inserting a tracheal tube (28) having a CO2 detector disposed within, and observing whether the CO2 detector changes color in response to the CO2 which is present in respiratory gases. The CO2 detectors (38) of the invention comprise a pH sensitive dye (68) and a solid phase support (64). The CO2 detectors of the invention may further comprise a phase transport enhancer which allows the CO2 detector to respond contemporaneously with the presence or absence of CO2 in a respiratory gas on a breath by breath basis.
摘要翻译：本发明涉及一种用于检测呼吸气体中的二氧化碳的二氧化碳检测器。特别地，本发明涉及包含设置在装置内的CO 2检测器以允许在呼吸气体中检测CO 2的医疗装置。本发明还涉及一种用于确定插管装置的适当放置的方法，包括插入具有设置在其内的CO 2检测器的气管管（28），并观察CO 2检测器是否响应于呼吸气体中存在的CO 2而变色。本发明的CO 2检测器（38）包含pH敏感染料（68）和固相载体（64）。本发明的CO 2检测器还可以包括相转移增强剂，其允许CO 2检测器在呼吸气体呼吸气体中同时响应CO 2的存在或不存在。

18. 发明申请

WO1988001391A1 CREATION AND USE OF MOVING REFERENCE FRAME FOR NMR IMAGING OF FLOW 审中-公开
标题翻译：移动参考框架的流程NMR成像的创建和使用
公开(公告)号：WO1988001391A1
公开(公告)日：1988-02-25
申请号：PCT/US1987001984
申请日：1987-08-14
申请人： BRIGHAM & WOMEN'S HOSPITAL
发明人： BRIGHAM & WOMEN'S HOSPITAL , PATZ, Samuel, H.
IPC分类号： G01R33/20
CPC分类号： G01R33/563
摘要： NMR image in which the individual image element intensities are proportional to the amount of nuclei flowing within a window of velocities. The invention is predicated on the fact that static nuclei in a static reference frame provide the most intense portions of the NMR signal. A moving reference frame for image creation is created moving at the velocity of the nuclei to be imaged. Nuclei moving at the same velocity as the reference frame thus have zero velocity with respect to the reference frame, and hence provide maximum signal intensity. In the described embodiment, the moving reference frame is created by satisfaction of two conditions, which relate to tracking the Larmor frequency and phase of the nuclei of interest moving in a gradient. These conditions may be satisfied by variation of the main NMR magnetic field HO (20) as a function of time. The field may be varied simply by addition of an additional coil (22) to conventional NMR equipment. The invention is applicable to image formation using either steady state free precession techniques or conventional spin echo techniques.
摘要翻译： NMR图像，其中单个图像元素强度与在速度窗口内流动的核的量成比例。本发明基于静态参考系中的静态核提供NMR信号的最强烈部分的事实。创建用于图像创建的移动参考框架以以待成像的核的速度移动。因此，与参考系以相同速度移动的核相对于参考系具有零速度，因此提供最大的信号强度。在所描述的实施例中，通过满足两个条件来创建运动参考系，这两个条件涉及跟踪以梯度移动的感兴趣的核的拉莫尔频率和相位。这些条件可以通过作为时间的函数的主NMR磁场HO（20）的变化来满足。可以简单地通过向常规NMR设备添加额外的线圈（22）来改变场。本发明适用于使用稳态自由进动技术或常规自旋回波技术的图像形成。

19. 发明申请

WO2007061657A2 INTERLEUKIN-10 COMPOSITIONS FOR THE TREATMENT OF ADENOCARCINOMAS 审中-公开
标题翻译：白介素-10组合物治疗腺癌
公开(公告)号：WO2007061657A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/043900
申请日：2006-11-13
申请人： THE BRIGHAM & WOMEN'S HOSPITAL, INC. , HORWITZ, Bruce, H. , ERDMAN, Susan, E. , FOX, James, G. , DAVIDSON, Anne
发明人： HORWITZ, Bruce, H. , ERDMAN, Susan, E. , FOX, James, G. , DAVIDSON, Anne
IPC分类号： A61K39/395 , A61K38/20
CPC分类号： A61K38/2066
摘要： The present invention is directed to methods for the treatment of adenocarcinoma that are characterized by the overexpression of a particular oncogene, Pim-1. The procedur involves administering a therapeutically effective amount of interleukin-10 that has bee coupled to a carrier that increases its circulating plasma half-life.
摘要翻译：本发明涉及用于治疗腺癌的方法，其特征在于过表达特定致癌基因Pim-1。该方法涉及给予治疗有效量的白细胞介素-10，所述白细胞介素-10具有与载体相连的蜂，其增加其循环血浆半衰期。

20. 发明申请

WO2005019984A2 SUPERRESOLUTION ULTRASOUND 审中-公开
标题翻译：超级超声波
公开(公告)号：WO2005019984A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/025077
申请日：2004-08-04
申请人： BRIGHAM & WOMEN'S HOSPITAL, INC. , CLEMENT, Gregory, T. , HYNYNEN, Kullvero, H.
发明人： CLEMENT, Gregory, T. , HYNYNEN, Kullvero, H.
IPC分类号： G06F
CPC分类号： A61B8/08 , A61B8/06 , A61B8/0825
摘要： A computer program product resides on a computer-readable medium and comprises computer-readable, computer-executable instructions for causing a computer to transmit first indicia for an ultrasound propagation arrangement to propagate ultrasound energy toward a focal region containing an object, receive second indicia from a receiver positioned to receive the propagated ultrasound energy after passing at least one of by and through the object and configured to transduce the received ultrasound energy into the second indicia, analyze the second indicia to determine magnitude and phase of the received ultrasound energy, and use the determined magnitude and phase of the received ultrasound energy and knowledge of the ultrasound energy propagated from the propagation arrangement to mathematically propagate indicia of at least one of the received ultrasound energy and the transmitted ultrasound energy to a common location.
摘要翻译：计算机程序产品驻留在计算机可读介质上，并且包括计算机可读的计算机可执行指令，用于使计算机传送超声波传播装置的第一标记以向包含对象的聚焦区域传播超声能量，从第接收器，定位成在通过并通过对象中的至少一个并且被配置为将所接收的超声能量转换成第二标记以接收传播的超声能量，分析第二标记以确定所接收的超声能量的大小和相位，并使用接收的超声能量的确定的幅度和相位以及从传播装置传播的超声能量的知识将数学上将所接收的超声能量和所发送的超声能量中的至少一个的标记传播到公共位置。

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