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11. 发明申请

WO1995028144A1 TEMPORALLY CONTROLLED DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：临时控制的药物输送系统
公开(公告)号：WO1995028144A1
公开(公告)日：1995-10-26
申请号：PCT/IB1995000223
申请日：1995-04-03
申请人： CIBA-GEIGY AG , GIANNOS, Steven, Andrew , MINH DINH, Steven , BERNER, Bret
发明人： CIBA-GEIGY AG
IPC分类号： A61K09/00
CPC分类号： A61K9/7084 , A61K9/0002
摘要： A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking advantage of oscillating chemical systems, one can change the pH of a solution, a drug, enhancer or solubilizer resulting in oscillating the ability of an active ingredient to be delivered transdermally. The pH of a solution can be oscillated over a range of pH values from 2 to 10 by the reduction and oxidation (redox) reactions of salts, such as permanganates, iodates, sulfates, chlorates, or bromates. Upon activation, the delivery system conditions begin to oscillate and with it, the delivery of the active agent oscillates.
摘要翻译：用于药物或活性成分的被动定期释放的递送机制和装置，其避免需要外部电源和/或电子控制器。通过利用振荡化学系统，可以改变溶液，药物，增强剂或增溶剂的pH，导致活性成分经皮递送的能力的振荡。通过盐，如高锰酸盐，碘酸盐，硫酸盐，氯酸盐或溴酸盐的还原和氧化（氧化还原）反应，溶液的pH可以在2至10的pH范围内振荡。在激活时，递送系统条件开始振荡并且随之而起，活性剂的递送振荡。

12. 发明申请

WO2016105582A1 COMPOSITIONS FOR ILEO-JEJUNAL DRUG DELIVERY 审中-公开
标题翻译： ILEO-JEJUNAL DRUG DELIVERY的组合物
公开(公告)号：WO2016105582A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/000515
申请日：2015-12-23
申请人： NUNN, Philip, A. , BERNER, Bret , MASJEDIZADEH, Mohammad, Reza
发明人： NUNN, Philip, A. , BERNER, Bret , MASJEDIZADEH, Mohammad, Reza
IPC分类号： A61K9/00 , A61K9/28 , A61K9/50 , A61K31/519 , A61P35/00
CPC分类号： A61K9/2886 , A61K9/0004 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/5026 , A61K9/5073 , A61K31/519 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/38 , A61P35/00 , A61P35/02
摘要： The current invention affords new formulations which deliver reversible and irreversible covalent kinase inhibitors, in particular BTK inhibitors, into the small intestine and specifically into the ileum and jejunum of the small intestine.
摘要翻译：本发明提供了将可逆和不可逆共价激酶抑制剂特别是BTK抑制剂递送到小肠中并且特异性地递送到小肠回肠和空肠的新配方。

13. 发明申请

WO2016105531A1 SITE SPECIFIC DOSING OF A BTK INHIBITOR 审中-公开
标题翻译： BTK抑制剂的特定剂量
公开(公告)号：WO2016105531A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/000303
申请日：2015-12-23
申请人： NUNN, Philip , BERNER, Bret , MASJEDIZADEH, Mohammad
发明人： NUNN, Philip , BERNER, Bret , MASJEDIZADEH, Mohammad
IPC分类号： A61K9/28 , A61K9/48 , A61K9/50 , A61K31/00
CPC分类号： A61K31/519 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/2886 , A61K9/4808 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5078 , A61K31/506
摘要： Disclosed herein are formulations and methods of site specific administration of Compound (I) or a pharmaceutically acceptable salt thereof. Compound (I) is a potent BTK inhibitor and hence can be useful for the treatment of diseases such as cancer, autoimmune, and inflammatory diseases.
摘要翻译：本文公开了化合物（I）或其药学上可接受的盐的特异性施用的制剂和方法。化合物（I）是有效的BTK抑制剂，因此可用于治疗诸如癌症，自身免疫和炎性疾病的疾病。

14. 发明申请

WO2002096404A1 METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE AND NOCTURNAL ACID BREAKTHROUGH 审中-公开
标题翻译：治疗胃食管反流病和乳头状酸突变的方法
公开(公告)号：WO2002096404A1
公开(公告)日：2002-12-05
申请号：PCT/US2002/016127
申请日：2002-05-20
申请人： DEPOMED DEVELOPMENT LTD , FARA, John, W. , BERNER, Bret , COWLES, Verne, E.
发明人： FARA, John, W. , BERNER, Bret , COWLES, Verne, E.
IPC分类号： A61K31/195
CPC分类号： A61K9/009 , A61K9/0065 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/197
摘要： A method of concurrent treatment for gastroesophageal reflux disease and nocturnal acid breakthrough is described, which comprises the delivery of an GABAb receptor agonist such as 4-amino-3-(4-chlorophenyl) butanoic acid, in the evening, in a gastric retained drug delivery system.
摘要翻译：描述了一种同时治疗胃食管反流疾病和夜间酸突破的方法，其包括在晚上在胃保留药物中递送GABAb受体激动剂如4-氨基-3-（4-氯苯基）丁酸输送系统。

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