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11. 发明申请

WO2011077245A2 COMPOSITIONS 审中-公开
标题翻译：组合物
公开(公告)号：WO2011077245A2
公开(公告)日：2011-06-30
申请号：PCT/IB2010/003447
申请日：2010-12-23
申请人： FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR , RUSSO, Vincenzo , TRAVERSARI, Catia
发明人： RUSSO, Vincenzo , TRAVERSARI, Catia
IPC分类号： A61K45/06
CPC分类号： A61K31/4433 , A61K31/357 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4196 , A61K31/496 , A61K31/575 , A61K39/395 , A61K2300/00
摘要： The invention relates to the discovery that human and murine tumors release LXR ligands (oxysterols) that inhibit CCR7 expression on maturing DC and, therefore, their migration to lymphoid organs. By inhibiting oxysterol synthesis (by Zaragozic Acid, ZA) or by inactivating oxysterols (gene therapy with sulfotransferase SULT2B1 b enzyme) long lasting antigen specific anti-tumor immune response mediated by DC is increased. Surprisingly, we also show that drugs interfering with sterol metabolism (i.e. ZA) in combination with a mAb depleting T regulatory cells potentiate the antitumor effect of the single treatments. This synergic effect is unexpected, providing a new effective combination therapy for the treatment of cancer. The invention also relates to the novel use of LXR ligand inactivators, or of LXR inhibitors/antagonists, for the treatment of cancer. These strategies can also be used in combination with a chemotherapy approach for the treatment of cancer patients.
摘要翻译：本发明涉及人和鼠肿瘤释放在成熟DC上抑制CCR7表达并因此其向淋巴器官迁移的LXR配体（氧固醇）的发现。通过抑制氧固醇合成（通过Zaragozic Acid，ZA）或通过使氧固醇失活（用磺基转移酶SULT2B1b酶进行基因治疗），由DC介导的持久抗原特异性抗肿瘤免疫应答增加。令人惊讶的是，我们还表明，干扰固醇代谢（即ZA）与消耗血清单克隆抗体T调节细胞的组合的药物增强了单次治疗的抗肿瘤作用。这种协同效应是意想不到的，为治疗癌症提供了一种新的有效的联合疗法。本发明还涉及LXR配体灭活剂或LXR抑制剂/拮抗剂在治疗癌症中的新用途。这些策略也可以与化疗方案结合使用，用于治疗癌症患者。

12. 发明申请

WO2010116256A2 THINNING AGENT 审中-公开
标题翻译：细化剂
公开(公告)号：WO2010116256A2
公开(公告)日：2010-10-14
申请号：PCT/IB2010/000963
申请日：2010-04-07
申请人： TAMINCO, NAAMLOZE VENNOOTSCHAP , WILLIAMS, Richard , DECKERS, Tom , ROOSE, Peter , DE SAEGHER, Johan Josef
发明人： WILLIAMS, Richard , DECKERS, Tom , ROOSE, Peter , DE SAEGHER, Johan Josef
IPC分类号： A01N37/44 , A01N37/24 , A01P21/00
CPC分类号： A01N37/44 , A01N37/24 , A01N2300/00
摘要： A composition comprising a compound selected from an auxin, an auxin precursor, an auxin metabolite or a derivative of said auxin, auxin precursor or auxin metabolite or a mixture thereof and acetaminophen or a derivative thereof for use as a chemical thinning agent.
摘要翻译：一种组合物，其包含选自生长素，生长素前体，生长素代谢物或所述生长素，生长素前体或生长素代谢物的衍生物或其混合物和对乙酰氨基酚或其衍生物的化合物，用作化学稀释剂。

13. 发明申请

WO2007072056A2 VECTORS 审中-公开
标题翻译：向量
公开(公告)号：WO2007072056A2
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004917
申请日：2006-12-22
申请人： OXFORD BIOMEDICA (UK) LIMITED , WILKES, Fraser , MISKIN, James , MITROPHANOUS, Kyriacos , KINGSMAN, Susan
发明人： WILKES, Fraser , MISKIN, James , MITROPHANOUS, Kyriacos , KINGSMAN, Susan
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2740/15043 , C12N2740/15052
摘要： A polynucleotide comprising a nucleotide sequence encoding a retroviral gag protein wherein the gag protein comprises a heterologous RNA binding domain capable of recognising a corresponding sequence in an RNA genome to facilitate packaging of the RNA genome into a retroviral vector particle.
摘要翻译：包含编码逆转录病毒gag蛋白的核苷酸序列的多核苷酸，其中所述gag蛋白包含能够识别RNA基因组中的相应序列的异源RNA结合结构域以促进将RNA基因组包装入逆转录病毒载体颗粒

14. 发明申请

WO2006067633A2 CONJUGATION PRODUCT 审中-公开
标题翻译：联合产品
公开(公告)号：WO2006067633A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/004058
申请日：2005-12-21
申请人： MOLMED SPA , FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR , CORTI, Angelo , CURNIS, Flavio
发明人： CORTI, Angelo , CURNIS, Flavio
CPC分类号： C07K14/78 , A61K47/64
摘要： A peptide which selectively inhibits α v β 3 integrin which comprises the deamidation product of a peptide comprising the NGR motif.
摘要翻译：一种肽，其选择性地抑制包含NGR基序的肽的脱酰氨基化产物的3'，3'整联蛋白。

15. 发明申请

WO2004035768A1 ANTIGEN TRANSDUCED T CELLS USED AS A DELIVERY SYSTEM FOR ANTIGENS 审中-公开
标题翻译：用作抗原递送系统的抗原转运T细胞
公开(公告)号：WO2004035768A1
公开(公告)日：2004-04-29
申请号：PCT/IB2003/005109
申请日：2003-10-21
申请人： MOLMED SPA , TRAVERSARI, Catia , BORDIGNON, Claudio
发明人： TRAVERSARI, Catia , BORDIGNON, Claudio
IPC分类号： C12N5/10
CPC分类号： A61K39/245 , A61K39/0011 , A61K39/12 , A61K2039/5156 , A61K2039/5158 , C12N2710/16634
摘要： A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.
摘要翻译：包含T细胞的递送系统，所述T细胞包含至少一种能够将抗原呈递细胞与抗原负载的抗原。

16. 发明申请

WO2004031390A1 VECTOR SYSTEM 审中-公开
标题翻译：矢量系统
公开(公告)号：WO2004031390A1
公开(公告)日：2004-04-15
申请号：PCT/GB2003/004260
申请日：2003-10-03
申请人： OXFORD BIOMEDICA (UK) LIMITED , MAZARAKIS, Nicholas , AZZOUZ, Mimoun , BINLEY, Katie , NAYLOR, Stuart , KINGSMAN, Susan
发明人： MAZARAKIS, Nicholas , AZZOUZ, Mimoun , BINLEY, Katie , NAYLOR, Stuart , KINGSMAN, Susan
IPC分类号： C12N15/49
CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , A61K2121/00 , A61K2123/00 , C12N2740/15043 , C12N2740/15045 , C12N2810/6054 , C12N2810/6081
摘要： Use of a vector system to transduce a target site, wherein the vector system travels to the target site by diffusion, and wherein the vector system is or comprises at least part of a rabies G envelope protein or a mutant, variant, homologue or fragment thereof, or a CVS envelope protein or a mutant, variant, homologue or fragment thereof, and further wherein the target site is at least part of the central nervous system.
摘要翻译：使用载体系统转导靶位点，其中载体系统通过扩散行进到靶位点，并且其中载体系统是或包含狂犬病G包膜蛋白或突变体，变体，同源物或其片段的至少一部分，或CVS包膜蛋白或其突变体，变体，同源物或其片段，并且其中所述靶位点是所述中枢神经系统的至少一部分。

17. 发明申请

WO2003064665A3 VIRAL VECTOR 审中-公开
公开(公告)号：WO2003064665A3
公开(公告)日：2003-08-07
申请号：PCT/GB2003/000418
申请日：2003-02-03
申请人： OXFORD BIOMEDICA (UK) LIMITED , RADCLIFFE, Philippa , MISKIN, James, E. , WILKES, Fraser, J. , MITROPHANOUS, Kyriacos, A.
发明人： RADCLIFFE, Philippa , MISKIN, James, E. , WILKES, Fraser, J. , MITROPHANOUS, Kyriacos, A.
IPC分类号： C12N15/86
摘要： A multicistronic retroviral vector genome comprising a first nucleic acid sequence upstream of an internal regulatory element, such that the level of genomic RNA available for packaging in the absence of rev, or a functional equivalent thereof, is increased. The internal regulatory element can be a promoter or an ires (internal ribosome entry sequence)

18. 发明申请

WO2003011317A1 MODULATORS OF NOTCH SIGNALLING FOR USE IN IMMUNOTHERAPY 审中-公开
标题翻译：免疫信号的免疫调节剂用于免疫治疗
公开(公告)号：WO2003011317A1
公开(公告)日：2003-02-13
申请号：PCT/GB2002/003426
申请日：2002-07-25
申请人： LORANTIS LIMITED , BODMER, Mark, William , BRIEND, Emmanuel, Cyrille, Pascal , CHAMPION, Brian, Robert , YOUNG, Lesley, Lynn
发明人： BODMER, Mark, William , BRIEND, Emmanuel, Cyrille, Pascal , CHAMPION, Brian, Robert , YOUNG, Lesley, Lynn
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K38/17 , C07K2319/30 , G01N33/5047
摘要： The present invention provides new uses of modulators of Notch signalling in therapy and corresponding methods of treatment.
摘要翻译：本发明提供Notch信号传导调节剂在治疗和相应治疗方法中的新用途。

19. 发明申请

WO2010116264A2 SAFENING AGENT 审中-公开
标题翻译：保鲜剂
公开(公告)号：WO2010116264A2
公开(公告)日：2010-10-14
申请号：PCT/IB2010/001034
申请日：2010-04-07
申请人： TAMINCO, NAAMLOZE VENNOOTSCHAP , WILLIAMS, Richard , ROOSE, Peter , DE SAEGHER, Johan Josef
发明人： WILLIAMS, Richard , ROOSE, Peter , DE SAEGHER, Johan Josef
IPC分类号： A01N25/32
CPC分类号： A01N25/32 , A01N37/48 , A01N43/38 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/84 , A01N47/20 , A01N47/30 , A01N57/20 , A01N59/16 , A01N2300/00
摘要： A compound selected from a composition comprising an auxin, an auxin precursor, an auxin metabolite or a derivative of said auxin, auxin precursor or auxin metabolite and acetaminophen or a derivative thereof for use as a plant safener.
摘要翻译：选自包含生长素，生长素前体，生长素代谢物或所述生长素，生长素前体或生长素代谢物的衍生物，对乙酰氨基酚或其衍生物用作植物安全剂的组合物的化合物。

20. 发明申请

WO2010116260A2 POLLINATION IMPROVER 审中-公开
标题翻译：污染改善
公开(公告)号：WO2010116260A2
公开(公告)日：2010-10-14
申请号：PCT/IB2010/000978
申请日：2010-04-07
申请人： TAMINCO, NAAMLOZE VENNOOTSCHAP , WILLIAMS, Richard , ROOSE, Peter , DE SAEGHER, Johan Josef
发明人： WILLIAMS, Richard , ROOSE, Peter , DE SAEGHER, Johan Josef
IPC分类号： A01N43/38 , A01N37/46 , A01N65/00 , A01P21/00
CPC分类号： A01N37/24 , A01N37/44 , A01N43/38 , A01N2300/00 , A01N37/04 , A01N43/08 , A01N43/16 , A01N47/44 , A01N65/08 , A01N65/20 , A01N65/40 , A01N65/44
摘要： A composition suitable for improving seed quality in a plant comprising: (i) a compound selected from an auxin, an auxin precursor, an auxin metabolite or a derivative of said auxin, auxin precursor or auxin metabolite; (ii) acetaminophen or a derivative thereof; and further comprising at least one compound selected from (iiϊ) to (v) wherein: (iii) is a cytokinin, (iv) is another agrochemically acceptable additive, and (v) is a thiosulphate.
摘要翻译：一种适于改善植物种子质量的组合物，其包含：（i）选自生长素，生长素前体，生长素代谢物或所述生长素，生长素前体或生长素代谢物的衍生物的化合物; （ii）对乙酰氨基酚或其衍生物; 并且还包含至少一种选自（ii）至（v）的化合物，其中：（iii）是细胞分裂素，（iv）是另一种农业化学上可接受的添加剂，（v）是硫代硫酸盐。

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