专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2001032003A1 FOR HIGHER BASIDIOMYCETES MUSHROOMS GROWN (AS BIOMASS) IN SUBMERGED CULTURE 审中-公开
标题翻译：用于高等文化遗产的高等生物学家（作为生物量）
公开(公告)号：WO2001032003A1
公开(公告)日：2001-05-10
申请号：PCT/US2000/028251
申请日：2000-10-12
申请人： MEDMYCO, LTD. , KARMALI, Rashida, A. , WASSER, Solomon, P. , RESHETNIKOV, Sergey, V., G. , SOLOMKO, Elvira, F. , BUCHALO, Asya, S. , NEVO, Eviatar
发明人： WASSER, Solomon, P. , RESHETNIKOV, Sergey, V., G. , SOLOMKO, Elvira, F. , BUCHALO, Asya, S. , NEVO, Eviatar
IPC分类号： A01H15/00
CPC分类号： C12R1/645 , A01H15/00 , C12N1/14
摘要： The present invention describes new and distinct horticultural varieties of higher Basidiomycetes mushrooms grown in submerged culture. Specifically, the new varieties of species of the genus Pleurotus offer superior yields of mushroom cell biomass and greater concentrations of the protein rich in essential amino acids, fatty acids, vitamins and minerals.
摘要翻译：本发明描述了在潜水培养中生长的更高的担子菌菌种的新的和不同的园艺品种。具体来说，新品种的Pleurotus品种提供优异的蘑菇细胞生物量和富含必需氨基酸，脂肪酸，维生素和矿物质的蛋白质浓度。

12. 发明申请

WO2013126146A2 METHODS AND COMPOSITIONS FOR ENHANCING SENSITIVITY OF CYTOTOXIC DRUGS WITH TIMELY COMBINATORIAL THERAPY WITH CARBOXYAMIDOTRIAZOLE OROTATE 审中-公开
标题翻译：使用羧甲氧基苯并噻唑的时效组合治疗CYPOTOXIC药物敏感性的方法和组合物
公开(公告)号：WO2013126146A2
公开(公告)日：2013-08-29
申请号：PCT/US2013/000039
申请日：2013-02-19
申请人： TACTICAL THERAPEUTICS, INC
发明人： KARMALI, Rashida, A.
IPC分类号： A61K31/513 , A61K31/506 , A61K31/704 , A61K31/519 , A61P35/00
CPC分类号： A61K31/506 , A61K31/4188 , A61K31/4192 , A61K31/519 , A61K31/704 , A61K2300/00
摘要： This invention relates to enhancing sensitivity of cytotoxic drugs by targeting theit interfering mechanisms induced in the tumor microenvironment which lead to drug resistance, using combinatorial therapy with carboxyamidotriazole orotate. Specific doses of cytotoxic drugs are titrated with carboxyamidotriazole orotate to improve the sensitivity and anticancer activity of cytotoxic drugs.
摘要翻译：本发明涉及通过靶向导致耐药性的肿瘤微环境中诱导的干扰机制，通过使用羧基氨基三唑乳清酸的组合治疗来增强细胞毒性药物的敏感性。特异剂量的细胞毒性药物用羧基氨基三唑乳清滴定，以提高细胞毒性药物的敏感性和抗癌活性。

13. 发明申请

WO2009064385A1 SYSTEM AND METHODS FOR STRESS RELEASE AND ASSOCIATED NITRIC OXIDE RELEASE FOR TREATMENT OF PAIN IN SPECIFIC PARTS OF THE BODY 审中-公开
标题翻译：用于治疗特定部位疼痛的应力释放和相关的氧化氮释放的系统和方法
公开(公告)号：WO2009064385A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/012651
申请日：2008-11-10
申请人： KIERNAN, James, E.
发明人： KIERNAN, James, E.
IPC分类号： A61H1/00
CPC分类号： A61H37/00
摘要： This invention provides unique technology, systems and methods of treatment of stress induced afflictions in the musculoskeletal system, the vascular system or the nervous tissue. More specifically, the systems comprise diagnosis of a stress-induced consistent tightness on the right side of the cranial, cervical, thoracic, lumbar, sacral spine, referred herein as "The Twist", and utilize "Stress Relief Methods" to reduce The Twist to resolve any afflictions associated with it. The invention comprises a coordinated series of untwisting dynamic motions, spinal manipulation and/or motion palpations that result in release of nitric oxide and relief from pain. The systems and methods of the invention therefore provide the benefits of increased nitric oxide release to maintain homeostasis in pulmonary vasculature. The invention also provides methods of training others in the correct use of the Stress Relief Methods to prevent and treat afflictions associated with the Twist.
摘要翻译：本发明提供了独特的技术，系统和治疗肌肉骨骼系统，血管系统或神经组织中的应激诱发疾病的方法。更具体地说，该系统包括在颅，颈，胸，腰，骶骨的右侧应力引起的一致紧度的诊断，这里称为“扭曲”，并利用“应力释放方法”来减少扭曲以解决与之相关的任何困扰。本发明包括协调的一系列解捻动态运动，脊柱手术和/或运动触诊，其导致一氧化氮的释放和缓解疼痛。因此，本发明的系统和方法提供增加的一氧化氮释放以维持肺血管中的体内平衡的益处。本发明还提供了在正确使用压力缓解方法中训练他人以防止和治疗与扭曲相关的折磨的方法。

14. 发明申请

WO2008070169A2 USE OF CARBOXYAMIDOTRIAZOLE (CAI) OROTATE IN MACULAR DEGENERATION 审中-公开
标题翻译：羧甲基三唑（CAI）乳酸盐在心力衰竭中的应用
公开(公告)号：WO2008070169A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/025041
申请日：2007-12-05
申请人： TACTICAL THERAPEUTICS INC , KARMALI, Rashida, A.
发明人： KARMALI, Rashida, A.
IPC分类号： A61K31/4192 , A61K31/513 , A61P27/02
CPC分类号： A61K31/4192 , A61K31/513
摘要： Method and composition of Carboxyamidotriazole orotate for treating age-related macular degeneration and other angiogenesis-dependent diseases.
摘要翻译：用于治疗年龄相关性黄斑变性和其他血管生成依赖性疾病的羧甲基三唑乳清酸盐的方法和组合物。

15. 发明申请

WO2005118145A2 INDUSTRY STANDARD MULTI-WELL PLATES WITH INCREASED CAPACITY AND EFFICIENCY PER WELL 审中-公开
标题翻译：行业标准的多层板具有提高的能力和效率
公开(公告)号：WO2005118145A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/017829
申请日：2005-05-20
申请人： INGENIOUS TARGETING LABORATORY, INC , CHEN, Ellen , HE, Wei , WENG, Wei
发明人： CHEN, Ellen , HE, Wei , WENG, Wei
IPC分类号： B01L9/00
CPC分类号： B01L3/50853 , B01L3/5085 , B01L2300/0809 , B01L2300/0829
摘要： The invention provides for improved multi-well plates and platforms that comprise a plurality of wells having increased volume capacity and clustered in a standard multi-well plate format and dimensions, said multi-well plate format being compatible with auxiliary equipment currently used and designed for the particular multi-well plate format. More particularly, the invention provides improved multi-well plates comprising a base to improve wells having one or more said wells having rectangular configuration, better retention of working materials and tissue culture ingredients than observed in conventional round-shaped wells. A cover is provided for protecting the assembly and cell cultures.
摘要翻译：本发明提供了改进的多孔板和平台，其包括具有增加的体积容量并且以标准多孔板格式和尺寸聚集的多个孔，所述多孔板格式与目前使用和设计的辅助设备兼容特定的多孔板格式。更具体地，本发明提供了改进的多孔板，其包括基底，以改进具有一个或多个所述井的孔，所述孔具有矩形构型，比常规圆形孔中观察到的更好的保留工作材料和组织培养成分。提供了一个保护装置和细胞培养物的盖子。

16. 发明申请

WO2003005819A1 USE OF CROSS-LINKED, COVALENTLY BOUND UROKINASE PLASMINOGEN ACTIVATOR (SCUPA)-UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (SUPAR) COMPLEX AS A FIBRINOLYTIC AGENT 审中-公开
标题翻译：交联的，共价连接的尿激酶激酶（SCUPA）-UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR（SUPAR）COMPLEX AS A FIBRINOLYTIC AGENT
公开(公告)号：WO2003005819A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/020078
申请日：2002-06-24
申请人： THROMBOTECH LTD. , KARMALI, Rashida, A. , HIGAZI, Abd.Al-Roof
发明人： HIGAZI, Abd.Al-Roof
IPC分类号： A01N37/18
CPC分类号： C12N9/6462 , A61K38/00 , C12Y304/21073
摘要： The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.
摘要翻译：本发明涉及交联的scuPA / suPAR复合物和/或tcuPA / suPAR交联复合物，制备具有纤维蛋白溶解活性的共价结合单一化合物的方法和使用交联的scuPA / suPAR或tcuPA / suPAR复合物在预防和/或治疗溶栓性疾病中的作用。本发明还涉及组合组合物和/或治疗方案，其包含交联的scuPA / suPAR复合物或tcuPA / suPAR和一种或多种目前使用的纤溶酶原激活剂以实现改善的治疗功效和/或减少副作用。

17. 发明申请

WO2002102930A2 ENERGY EFFICIENT PROCESSES FOR CONVERTING REFINERY AND PETROLEUM-BASED WASTE TO STANDARD FUELS 审中-公开
标题翻译：将炼油和石油基废物转化为标准燃料的能源有效工艺
公开(公告)号：WO2002102930A2
公开(公告)日：2002-12-27
申请号：PCT/US2002/014089
申请日：2002-05-02
申请人： IPSON LTD. , KARMALI, Rashida, A. , BROHNSHTEIN, Alexander, P. , GEWERTZ, Moshe , ROZHANSKY, Vladimir, M.
发明人： BROHNSHTEIN, Alexander, P. , GEWERTZ, Moshe , ROZHANSKY, Vladimir, M.
IPC分类号： C10G
CPC分类号： B09C1/06 , C10G11/00 , C10G33/04 , C10G33/06
摘要： The present invention is an energy efficient method for processing petroleum-based and other organic waste including sludge or bottoms, by utilizing of heat energy of oil shale ash or of other suitable ashes obtained from burning the solid fuel. The process produces no wasteful by-products like polluted sewage, heavy asphaltenics and tar by-products. Instead, the process eliminates water through selective adsorption by the ashes used as dewatering additives and the process is followed by drying at high temperatures. After skimming the dewatered matter, the remainder is processed by thermo-catalytic cracking by using hot oil shale ash or other ashes as a catalytic active material and as a heat carrier. The process uses equipment that is cost-effective and that is routinely produced. The process and apparatus of the present invention provide a solution for processing refinery and petroleum-based wastes and producing useful and standard liquid fuels.
摘要翻译：本发明是一种通过利用油页岩灰或其它从燃烧固体燃料得到的其它合适的灰分的热能来处理含石油和其它有机废物（包括污泥或底部物质）的能量效率方法。该过程不产生浪费的副产品，如污水，重质沥青质和焦油副产品。相反，该方法通过用作脱水添加剂的灰分的选择性吸附来消除水，并且该过程随后在高温下干燥。在清除脱水物质后，其余部分通过使用热油页岩灰或其它灰分作为催化活性物质和热载体进行热催化裂化处理。该过程使用具有成本效益且经常生产的设备。本发明的方法和装置提供了一种用于加工炼油和石油基废物并生产有用和标准液体燃料的解决方案。

18. 发明申请

WO2011028288A1 NOVEL COMPOSITIONS AND PROCESSES FOR PREPARING 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES AND TRIAZOLE OROTATE FORMULATIONS 审中-公开
标题翻译：用于制备5-氨基或取代的氨基-1,2,3-三唑和三唑制剂的新型组合物和方法
公开(公告)号：WO2011028288A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/002430
申请日：2010-09-03
申请人： TACTICAL THERAPEUTICS, INC , KARMALI, Rashida, A.
发明人： KARMALI, Rashida, A.
IPC分类号： A01N43/82 , A61K31/41
CPC分类号： C07D249/04
摘要： New polymorphs of 5-amino or substituted amino 1, 2, 3-triazole and substituted derivatives thereof, of orotates of the carboxyamidotriazoles, of formulations of the triazoles and orotic acid in the ratio of 1:1 to 1:4 (base:acid) and of safer processes of the preparation of the same are disclosed. The compounds are useful in the control and treatment of diseases including, but not limited to solid cancers, macular degeneration, retinopathy, chronic myeloid leukemia, AIDS and diseases which rely on aberrant signal transduction. The improved processes to prepare the orotate formulations use stable, efficient and safer starting azide intermediate materials in the synthesis of new polymorphs of carboxyamidotriazole.
摘要翻译：三唑和乳清酸的制剂的5-氨基或取代的氨基1,2,3-三唑及其取代的衍生物，羧基氨基三唑的乳清酸的新多晶型物，其比例为1:1至1:4（碱：酸）和其制备方法的更安全的方法。这些化合物可用于控制和治疗疾病，包括但不限于固体癌症，黄斑变性，视网膜病变，慢性骨髓性白血病，艾滋病和依赖于异常信号转导的疾病。制备乳清酸酯制剂的改进方法在合成羧基氨基三唑新型多晶型物时使用稳定，有效和安全的起始叠氮化物中间体材料。

19. 发明申请

WO2008016711A2 COMPOSITIONS AND METHODS OF REDUCING TISSUE LEVELS OF DRUGS WHEN GIVEN AS OROTATE DERIVATIVES 审中-公开
标题翻译：作为齿科衍生物的组合物和减少药物组织水平的方法
公开(公告)号：WO2008016711A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/017458
申请日：2007-08-06
申请人： SAVVIPHARM INC. , KARMALI, Rashida, A.
发明人： KARMALI, Rashida, A.
IPC分类号： A61K38/21 , A61K38/12 , A61K31/7048 , A61K31/704 , A61K31/5415 , A61K31/522 , A61K31/66 , A61K31/60
CPC分类号： C07H15/252 , A61K31/513 , A61K31/522 , A61K31/5415 , A61K31/60 , A61K31/66 , A61K31/7004 , A61K31/704 , A61K31/7048 , A61K38/12 , A61K38/2013
摘要： This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce levels of the pharmaceutical agent in noncancerous tissues. There orotate derivatives are equally efficacious in inhibiting the SCCAKI-I kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with doxorubicin HC1 suggests a reduction in toxicity induced by free radical generation by the anthracyclines.
摘要翻译：本发明属于已知通过产生它们的乳清酸衍生物而引起组织毒性作为副作用的药剂的化学重构领域。更具体地说，它涉及蒽环类衍生物，多柔比星和柔红霉素，其被发现降低非癌组织中药物的水平。乳清酸衍生物在抑制动物中的SCCAKI-1肾肿瘤方面同样有效，与阿霉素盐酸盐相比，阿霉素在心脏组织中的减少提示蒽环类抗生素产生的毒性降低。

20. 发明申请

WO2008013667A2 TECHNOLOGY FOR CULTIVATION OF Porphyra AND OTHER SEAWEEDS IN LAND-BASED PONDS 审中-公开
标题翻译：紫菜和其他海陆地土地利用技术
公开(公告)号：WO2008013667A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/015647
申请日：2007-07-09
申请人： SEAWEED BIO-TECHNOLOGIES INC , LEVY, Israel
发明人： LEVY, Israel
IPC分类号： A01G33/00
CPC分类号： A01G33/00 , Y02A40/88
摘要： The present invention provides unique technology, systems and methods of cultivating different types of seaweeds, including, but not limited to, Porphyra (Nori), Laminaria, Undaria, Eucheuma, Gracillaria, Ulva, Sargassum, Codium, Cladophqra, Ascophyllum, Palmaria, Furcellaria, Fucus or Enteromorpha, in land-based seawater ponds having a climatically suitable and nutrient controlled environment. These land-based ponds may be built in any part of the world with structural engineering and architectural modifications. The land based units for cultivation of seaweeds comprise phycological laboratory facilities, U-shaped sleeves, to allow the maturation of the sporelings; growth tanks, U-shaped cultivation tanks, a plurality of small inoculation tanks aerated with air, and a harvesting unit.
摘要翻译：本发明提供了独特的技术，系统和方法来培育不同类型的海藻，包括但不限于紫菜（Nori），海带（Laminaria），乌尔达里亚（Diaminaria），乌尔代里亚（Eucheuma），格瑞西亚（Gracillaria），乌尔瓦，Fucus或Enteromorpha，在具有气候适宜和营养控制环境的陆地海水池塘中。这些陆基池塘可能在世界任何地方建造，结构工程和建筑改造。用于种植海藻的土地单位包括实验室设施，U形袖子，以使孢子成熟; 生长槽，U形培养槽，多个用空气充气的小型接种罐和收获单元。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式