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11. 发明申请

WO2013095986A1 BILIARY SYSTEM CATHETER 审中-公开
标题翻译：双系统导管
公开(公告)号：WO2013095986A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/068875
申请日：2012-12-11
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： BROWN, Hilbert, D.
IPC分类号： A61M25/00
CPC分类号： A61M25/0028 , A61M25/003 , A61M25/007 , A61M25/0108 , A61M2025/0037 , A61M2025/0081 , A61M2025/0183
摘要： A catheter system and a method for accessing the bile duct are provided. The catheter system includes an elongate shaft having a proximal portion and a distal portion. The catheter also includes a first lumen extending at least partially through the elongate shaft, a distal portion of the first lumen extending generally parallel to a longitudinal axis of the elongate shaft and a distal port operably connected to the first lumen. The catheter system also includes a second lumen extending at least partially through the elongate shaft and a side port operably connected to the second lumen, the side port positioned, proximal to the distal port and operably connected to the second lumen. The second lumen includes an angled wall portion adjacent to the side port. A marker is included on the distal portion of the elongate shaft, the marker configured to indicate the position of the side port.
摘要翻译：提供导管系统和用于接近胆管的方法。导管系统包括具有近端部分和远端部分的细长轴。导管还包括至少部分地延伸穿过细长轴的第一腔，第一内腔的远侧部分大致平行于细长轴的纵向轴线延伸，远端可操作地连接到第一腔。导管系统还包括至少部分延伸穿过细长轴的第二腔和可操作地连接到第二腔的侧端口，侧端口位于远侧端口附近并可操作地连接到第二腔。第二管腔包括与侧端口相邻的成角度的壁部分。标记被包括在细长轴的远端部分上，标记被配置为指示侧面端口的位置。

12. 发明申请

WO2013049300A1 METHOD OF TREATING MUCOEPIDERMOID CARCINOMA 审中-公开
标题翻译：治疗脑积水的方法
公开(公告)号：WO2013049300A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057480
申请日：2012-09-27
申请人： DANA-FARBER CANCER INSTITUTE, INC. , GRIFFIN, James, D. , WU, Lizi , CHEN, Jie
发明人： GRIFFIN, James, D. , WU, Lizi , CHEN, Jie
IPC分类号： A61K31/4015 , A61K31/4745 , A61K47/06 , A61K45/06 , A61P35/00
CPC分类号： C07D471/04 , A61K31/352 , A61K31/4015 , A61K31/4745 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： Imidazoquinolines, as set forth in formula (I), are useful for inhibiting growth or proliferation of mucoepidermoid carcinoma cells. The therapeutic and prophylactic treatments provided by this invention are practiced by administering to a patient in need thereof an amount of a compound of formula (I) that is effective to inhibit growth or proliferation of the mucoepidermoid carcinoma cells.
摘要翻译：如式（I）所示的咪唑并喹啉可用于抑制粘液表皮样癌细胞的生长或增殖。本发明提供的治疗和预防治疗通过向有需要的患者施用一定量的有效抑制粘液表皮样癌细胞生长或增殖的式（I）化合物来实施。

13. 发明申请

WO2013012493A1 CONTROL SYSTEM FOR A STENT DELIVERY SYSTEM 审中-公开
标题翻译：一种STETA交付系统的控制系统
公开(公告)号：WO2013012493A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/042173
申请日：2012-06-13
申请人： COOK MEDICAL TECHNOLOGIES LLC , COSTELLO, Kieran
发明人： COSTELLO, Kieran
IPC分类号： A61F2/84
CPC分类号： A61F2/962 , A61F2/844 , A61F2/95 , A61F2002/9511 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665 , A61F2220/0091 , A61F2230/0058
摘要： A control system (100) for controlling movement of a medical device delivery system (10), a stent delivery system (10) and a method for controlling movement of a medical device delivery system are provided. The control system includes a first extendable arm (102) comprising a plurality of first struts (110) interconnected at intermediate points (121) and end points (123) of the first struts. The first arm is movable between a first position and a second position and the first arm is operably connected to one of a first shaft (22) and the second shaft (24). The control system also includes a first actuator (114) operably connected to the first arm and the first actuator is operable to move the first arm from the first position to the second position. Movement of the first arm moves the first shaft relative to the second shaft to change the position of the second shaft relative to the first shaft.
摘要翻译：提供了一种用于控制医疗装置输送系统（10）的移动的控制系统（100），支架输送系统（10）和用于控制医疗装置输送系统的运动的方法。控制系统包括第一可延伸臂（102），其包括在第一支柱的中间点（121）和端点（123）处互连的多个第一支柱（110）。第一臂可在第一位置和第二位置之间移动，并且第一臂可操作地连接到第一轴（22）和第二轴（24）中的一个。控制系统还包括可操作地连接到第一臂的第一致动器（114），并且第一致动器可操作以将第一臂从第一位置移动到第二位置。第一臂的移动使第一轴相对于第二轴移动，以改变第二轴相对于第一轴的位置。

14. 发明申请

WO2012082453A1 HANDLE CONTROL SYSTEM FOR A STENT DELIVERY SYSTEM 审中-公开
标题翻译：手柄输送系统的手柄控制系统
公开(公告)号：WO2012082453A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/063381
申请日：2011-12-06
申请人： COOK MEDICAL TECHNOLOGIES LLC , RYAN, Michael
发明人： RYAN, Michael
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2002/9517
摘要： A control system (100) for controlling movement of a medical device delivery system, a stent delivery system and a method for controlling movement of a medical device delivery system are provided. The control system includes a rotatable gear (122) operably connected to a first movable member (116) and a second movable member (118) movable by the rotatable gear. The first movable member is operably connected to the first shaft (22) and the second movable member operably connected to the second shaft (24). The first movable member moves the first shaft and the second movable member moves the second shaft to change a position of the first shaft relative to the second shaft and to change a configuration of a medical device operably connected to the first shaft and the second shaft.
摘要翻译：提供了一种用于控制医疗装置输送系统的移动的控制系统（100），用于控制医疗装置输送系统的移动的支架输送系统和方法。控制系统包括可操作地连接到第一可动构件（116）的可旋转齿轮（122）和可由可旋转齿轮移动的第二可动构件（118）。第一可移动构件可操作地连接到第一轴（22），并且第二可移动构件可操作地连接到第二轴（24）。第一可动构件移动第一轴，第二可动构件移动第二轴，以改变第一轴相对于第二轴的位置，并且改变可操作地连接到第一轴和第二轴的医疗装置的构造。

15. 发明申请

WO2012058109A1 ABLATION DEVICE 审中-公开
标题翻译：排除装置
公开(公告)号：WO2012058109A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057249
申请日：2011-10-21
申请人： COOK MEDICAL TECHNOLOGIES LLC , MCHUGO, Vincent
发明人： MCHUGO, Vincent
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00488 , A61B2018/00577
摘要： An ablation device and a method of ablating a tissue are provided. The ablation device includes a mechanically expandable member having a proximal portion, a distal portion and an energy delivery portion. The mechanically expandable member also has an expanded and a collapsed configuration. The ablation device further includes a first elongate shaft having a proximal portion and a distal portion, the distal portion of the mechanically expandable member is operably connected to the distal portion of the first shaft. The ablation device includes a second elongate shaft having a proximal portion and a distal portion, the proximal portion of the mechanically expandable member is operably connected to the distal portion of the second shaft and the second shaft is movable relative to the first shaft. The ablation device includes a handle operably connected to the first elongate shaft and the second elongate shaft.
摘要翻译：提供消融装置和消融组织的方法。消融装置包括具有近端部分，远端部分和能量输送部分的机械可扩张部件。机械可膨胀构件还具有膨胀和收缩构型。消融装置还包括具有近端部分和远侧部分的第一细长轴，机械可扩张构件的远端部分可操作地连接到第一轴的远端部分。消融装置包括具有近端部分和远端部分的第二细长轴，机械可扩张构件的近侧部分可操作地连接到第二轴的远端部分，并且第二轴可相对于第一轴线移动。消融装置包括可操作地连接到第一细长轴和第二细长轴的手柄。

16. 发明申请

WO2012058104A1 TORSION CONSTRAINED STENT DELIVERY SYSTEM 审中-公开
标题翻译：扭转约束式输送系统
公开(公告)号：WO2012058104A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057211
申请日：2011-10-21
申请人： COOK MEDICAL TECHNOLOGIES LLC , MCHUGO, Vincent
发明人： MCHUGO, Vincent
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2002/9511
摘要： A stent delivery system (10) and a method are provided. The stent delivery system includes an inner and outer elongate shaft (22, 24). The outer shaft is coaxially positioned over at least a portion of the inner shaft and the inner shaft is rotatably positionable relative to the outer shaft about a longitudinal axis from a first to a second rotational position. The stent delivery system also includes a stent (28) positioned on at least a portion of the inner shaft and having a constrained and an expanded configuration. Proximal and distal constraining members (44, 46) releasably connected to the stent. The proximal and the distal constraining members cooperatively apply a torsional force to at least a portion of the stent in the constrained configuration and the inner and outer shafts in the first rotational position.
摘要翻译：提供支架输送系统（10）和方法。支架输送系统包括内细长轴和外细长轴（22,24）。外轴同轴地定位在内轴的至少一部分上，并且内轴相对于外轴可旋转地定位成围绕纵向轴线从第一旋转位置到第二旋转位置。支架输送系统还包括定位在内轴的至少一部分上并具有约束和扩张构型的支架（28）。可释放地连接到支架的近端和远端约束构件（44,46）。近端和远端约束构件协同地将扭转力施加到约束构造中的支架的至少一部分，以及在第一旋转位置中的内轴和外轴。

17. 发明申请

WO2011094527A1 MECHANICALLY EXPANDABLE DELIVERY AND DILATION SYSTEMS 审中-公开
标题翻译：机械可扩展的交付和放松系统
公开(公告)号：WO2011094527A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022903
申请日：2011-01-28
申请人： COOK MEDICAL TECHNOLOGIES LLC , MCHUGO, Vincent , NEILAN, John
发明人： MCHUGO, Vincent , NEILAN, John
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2002/9534 , A61F2002/9665
摘要： A stent delivery system, a dilator system and a method for implanting a stent are provided. The stent delivery system includes an elongate shaft including a proximal portion, a distal portion, a lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the shaft. The stent delivery system also includes a stent positioned at the stent receiving portion of the elongate shaft, the stent having a constrained configuration and an expanded configuration. A proximal constraining member and a distal constraining member releasably connected to the stent and having a first position and a second position are also included. The proximal constraining member and the distal constraining member cooperatively apply longitudinal tensile force to at least a portion of the stent with the proximal and distal constraining members each in the first position.
摘要翻译：提供支架输送系统，扩张器系统和植入支架的方法。所述支架输送系统包括细长轴，所述细长轴包括近端部分，远端部分，至少部分地延伸穿过其中的内腔和所述轴的远侧部分上的支架接收部分。支架输送系统还包括定位在细长轴的支架接收部分的支架，支架具有约束构型和扩张构型。还包括近端约束构件和可释放地连接到支架并具有第一位置和第二位置的远端约束构件。近侧约束构件和远侧约束构件协同地将纵向张力施加到支架的至少一部分，其中近侧和远侧约束构件各自处于第一位置。

18. 发明申请

WO2006078743A1 BIOPSY FORCEPS 审中-公开
标题翻译：生物力量
公开(公告)号：WO2006078743A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001775
申请日：2006-01-19
申请人： WILSON-COOK MEDICAL, INC. , SURTI, Vihar, C.
发明人： SURTI, Vihar, C.
IPC分类号： A61B17/28 , A61B10/00 , A61B17/32
CPC分类号： A61B10/06 , A61B17/320016 , A61B2017/2937 , A61B2017/2944
摘要： A biopsy forceps and method of using the biopsy forceps . The biopsy forceps includes a plurality of grasping members (26) extending from an inner shaft (16) . The plurality of grasping members are biased toward an open configuration. Sliding a sheath (18) over the grasping members (26) constrains the grasping members to a closed configuration. A method of performing a tissue biopsy is also disclosed.
摘要翻译：活检钳和使用活检钳的方法。活检钳包括从内轴（16）延伸的多个把持构件（26）。多个把持构件被朝向打开构型偏置。将护套（18）滑过抓持构件（26）将把持构件限制在闭合构型。还公开了进行组织活检的方法。

19. 发明申请

WO2022150457A1 SAMPLE COLLECTION DEVICE AND METHODS OF USE 审中-公开
公开(公告)号：WO2022150457A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011410
申请日：2022-01-06
申请人： QUANTIGEN, LLC , PIONEER HI-BRED INTERNATIONAL, INC.
发明人： BAKSTAD, Martin , ELLIOTT, James , EXELL, Simon , GRABICKI, Rafal , PADGETT, Leah , RAINES, James , REPPE, Christopher , SULLIVAN, Hillary
IPC分类号： A61F13/15 , A61F13/38 , B01L3/00 , F16L15/06 , F16L55/115 , G01N1/02 , G01N33/48
摘要： The present disclosure provides a device for collecting a biological sample. The device may include a tube, a primary cap which engages an open end of the tube, and a secondary cap which engages the primary cap. The device may include a collection member, which may include a swab. Methods of collecting and analyzing samples are also disclosed.

20. 发明申请

WO2020069498A1 SUPAR AND PREDICTION AND TREATMENT OF ACUTE KIDNEY INJURY 审中-公开
公开(公告)号：WO2020069498A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/053802
申请日：2019-09-30
申请人： REISER, Jochen , HAYEK, Salim , QUYYUMI, Arshed, A.
发明人： REISER, Jochen , HAYEK, Salim , QUYYUMI, Arshed, A.
IPC分类号： A61K39/395 , A61P13/12 , C07K14/705 , C07K16/28 , G01N33/53
摘要： Methods and compositions for treating acute kidney injury in a subject are provided. The methods include measuring or having measured a level of soluble urokinase plasminogen activator receptor (suPAR) in a biological sample from the subject, determining or having determined the level of suPAR in the sample compared to a control suPAR level, and administering a therapeutically effective amount of an agent that antagonizes soluble urokinase plasminogen activator receptor (suPAR) to the subject having an elevated level of suPAR relative to the control suPAR level.

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