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11. 发明申请

WO2018102821A1 APPARATUS AND METHOD FOR IDENTIFICATION OF WHEEZING IN AUSCULTATED LUNG SOUNDS 审中-公开
公开(公告)号：WO2018102821A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064537
申请日：2017-12-04
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： SHEKHAR, Raj , KANG, Sukryool , TEACH, Stephen , PATEL, Shilpa , PILLAI, Dinesh
IPC分类号： A61B5/02
摘要： Described herein are a computer enhanced medical method and device for generating an asthmatic condition indication. The apparatus receives a lung signal from a stethoscope, the lung signal having been converted from an analog signal to a digital signal. Furthermore, circuitry included in the apparatus performs, inter alia, the following: displays a patient recording canvas corresponding to physical locations on a body of the patient, the canvas including an anterior patient orientation and a posterior patient orientation, generates a recording process, the recording process including recording, for a predetermined period of time, the detected lung signal, and associates the recording with a marked location. Furthermore, the circuitry merges the recorded lung signal from each marked location on the patent recording canvas as merged information, and applies processing to the merged information to generate the asthmatic condition indication.

12. 发明申请

WO2017075602A1 SOFT SURGICAL TOOLS 审中-公开
标题翻译：软外科手术工具
公开(公告)号：WO2017075602A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059753
申请日：2016-10-31
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： KIM, Peter, C. , OPFERMANN, Justin, D. , KRIEGER, Axel
IPC分类号： A61B1/313 , A61B17/00 , A61B17/28 , B25J9/14 , B25J15/00 , B25J15/12
CPC分类号： A61B1/313 , A61B17/28 , A61B17/320016 , A61B2017/00022 , A61B2017/00526 , A61B2017/00557 , B25J9/142 , B25J15/10 , B25J15/12
摘要： A method is provided for making an appendage of a soft surgical tool, including: receiving a set of mechanical constraints for a surgical procedure; calculating a set of articulation states based on the set of mechanical constraints; generating a plurality of print commands for printing an appendage configured to form the set of articulation states based on the calculation; and printing an appendage based on the plurality of print commands. Multiple printed appendages can be formed into an orienting assembly.
摘要翻译：提供了一种用于制造软手术工具的附肢的方法，包括：接收用于外科手术的一组机械约束; 基于该组机械约束来计算一组关节状态; 基于所述计算生成用于打印被配置为形成所述一组关节状态的附肢的多个打印命令; 以及基于所述多个打印命令打印附属物。多个印刷附件可以形成一个定向组件。

13. 发明申请

WO2017075571A8 GENERATING HPV ANTIGEN-SPECIFIC T CELLS FROM A NAIVE T CELL POPULATION 审中-公开
标题翻译：从无细胞T细胞群体产生HPV抗原特异性T细胞
公开(公告)号：WO2017075571A8
公开(公告)日：2017-05-04
申请号：PCT/US2016/059683
申请日：2016-10-31
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： BOLLARD, Catherine, M. , CRUZ, Conrad , HANLEY, Patrick, J.
IPC分类号： A61K35/12 , A61P37/04 , C12N5/0783 , C12N5/0784
摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.
摘要翻译：用于产生识别人乳头瘤病毒或HPV抗原的抗原特异性T细胞的安全，快速和有效的方法。

14. 发明申请

WO2017075571A1 GENERATING HPV ANTIGEN-SPECIFIC CELLS FROM A NAIVE T CELL POPULATION 审中-公开
标题翻译：从无细胞T细胞群体产生HPV抗原特异性细胞
公开(公告)号：WO2017075571A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059683
申请日：2016-10-31
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： BOLLARD, Catherine, M. , CRUZ, Conrad , HANLEY, Patrick, J.
IPC分类号： A61K35/12 , A61P37/04 , C12N5/0783 , C12N5/0784
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/59 , C12N2502/1121 , C12N2502/1157
摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.
摘要翻译：用于产生识别人乳头瘤病毒或HPV抗原的抗原特异性T细胞的安全，快速和有效的方法。

15. 发明申请

WO2017066444A1 TREATMENT OF LEARNING DISABILITIES AND OTHER NEUROLOGICAL DISORDERS WITH SK CHANNEL INHIBITOR(S) 审中-公开
标题翻译：用SK通道抑制剂治疗学习障碍和其他神经系统疾病（S）
公开(公告)号：WO2017066444A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056835
申请日：2016-10-13
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： HASHIMOTO-TORII, Kazue , TORII, Masaaki , SHAHID, Mohammad , MORIZONO, Hiroki
IPC分类号： A61K38/12 , A61K38/02 , A61K38/04 , A61K38/17 , A61P25/16
CPC分类号： A61K38/02 , A61K38/12 , A61K38/17
摘要： Methods for treating learning disabilities associated with fetal alcohol syndrome and other neurological disorders by administering SK channel blockers, antagonists, inhibitors or modifiers like tamapin.
摘要翻译：通过施用SK通道阻滞剂，拮抗剂，抑制剂或调节剂如塔帕辛（ttaginin）来治疗与胎儿酒精综合征和其他神经疾病相关的学习障碍的方法。

16. 发明申请

WO2017062985A9 APPARATUS AND METHOD FOR PHYSIOLOGIC AND PHARMACODYNAMIC ASSESSMENT AND MONITORING 审中-公开
标题翻译：用于生理和药物动力学评估和监测的装置和方法
公开(公告)号：WO2017062985A9
公开(公告)日：2017-04-13
申请号：PCT/US2016/056420
申请日：2016-10-11
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： FINKEL, Julia, C.
IPC分类号： A61B3/10 , A61B3/11 , A61B3/113 , A61B3/14 , A61B5/16
摘要： Described herein is an apparatus and method for generating a pain score for a patient. The method includes the steps of generating a PLR response signature for each drug of a plurality of drugs and further initiating a light stimulus to the patient, and measuring a corresponding PLR response. The method includes initiating a neuro-stimulus to the patient, the neuro-stimulus being initiated over a set of frequencies, each frequency being associated with a unique intensity, and stimulating a unique nerve fiber type of the patient, and measuring a PRD response of the patient for the initiated neuro-stimulus. Further, the method includes determining, for each nerve fiber type, a threshold response based on the measured PRD, determining a weight for each threshold response based on the PLR response, and combining the determined weight for each threshold response to obtain a pain score for the patient.
摘要翻译：这里描述的是用于为患者产生疼痛评分的装置和方法。该方法包括以下步骤：为多种药物中的每种药物产生PLR应答特征并进一步向患者发起光刺激，并测量相应的PLR应答。该方法包括向患者发起神经刺激，神经刺激在一组频率上发起，每个频率与独特的强度相关联，并且刺激患者的独特的神经纤维类型，并且测量患者的PRD响应引发神经刺激的患者。此外，该方法包括针对每种神经纤维类型基于测量的PRD确定阈值响应，基于PLR响应确定每个阈值响应的权重，并且针对每个阈值响应组合所确定的权重以获得针对每个神经纤维类型的疼痛分数病人。

17. 发明申请

WO2015191874A1 GENERATION OF BROADLY-SPECIFIC, VIRUS-IMMUNE CELLS TARGETING MULTIPLE HIV ANTIGENS FOR PREVENTIVE AND THERAPEUTIC USE 审中-公开
标题翻译：特异性，病毒免疫细胞产生预防和治疗用途的多种艾滋病毒抗原
公开(公告)号：WO2015191874A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035361
申请日：2015-06-11
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： BOLLARD, Catherine, M. , CRUZ, Conrad, Russell, Y. , LAM, Sharon
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N7/00 , A61K45/06 , C12N5/0636 , C12N5/0638 , C12N5/0639 , C12N2501/22 , C12N2501/2301 , C12N2501/2304 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2501/25 , C12N2501/998 , C12N2740/16034
摘要： Compositions for T cell-based immunotherapy of HIV, HIV-associated malignancies, HIV-associated viral infections, or other HIV -related complications. Modified T cells that are resistant to invasion or infection with HIV, such as T-cells modified to decrease or eliminate expression of mannosyl-oligosacharide glucosidase enzyme ("MOGS"). Methods for producing such compositions by expanding HlV-specific T cells from different sources to recognize multiple HIV antigens.
摘要翻译：用于基于T细胞的免疫治疗HIV，HIV相关恶性肿瘤，HIV相关病毒感染或其他HIV相关并发症的组合物。对HIV侵袭或感染有抗性的修饰的T细胞，例如修饰以减少或消除甘露糖基 - 寡糖糖苷酶（“MOGS”）表达的T细胞。通过从不同来源扩增HlV特异性T细胞以识别多种HIV抗原来产生此类组合物的方法。

18. 发明申请

WO2015123700A1 DELIVERY TOOL AND METHOD FOR DEVICES IN THE PERICARDIAL SPACE 审中-公开
标题翻译：交付工具和方法在周边空间设备
公开(公告)号：WO2015123700A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/016360
申请日：2015-02-18
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： BERUL, Charles , OPFERMANN, Justin , KRIEGER, Axel , KIM, Peter
IPC分类号： A61B17/00
CPC分类号： A61B1/05 , A61B1/00154 , A61B1/018 , A61B1/3132 , A61B5/0084 , A61N1/0592
摘要： The present disclosure is a device and method associated with the delivery of medical devices in the pericardial space using a minimally invasive approach with direct visualization. More specifically, the device can be used to deliver permanent pacing, defibrillation and cardiac synchronization leads, as well as leadless pacemakers for cardiac rhythm management to the epicardial surface of the heart. A subxiphoid procedure is proposed as a minimally invasive alternative to thoracotomy, while the delivery tool incorporates a camera for direct visualization of the procedure. The tool also incorporates a steerable catheter to provide selective control of the placement and orientation of the medical device in the pericardial space.
摘要翻译：本公开是与使用具有直接可视化的微创方法在心包空间中递送医疗装置相关联的装置和方法。更具体地说，该装置可以用于向心脏的心外膜表面递送永久性起搏，除颤和心脏同步引线，以及用于心脏节律管理的无引导起搏器。提出了一种亚剑突手术作为开胸手术的微创替代方案，而输送工具包含用于直接观察手术的相机。该工具还包括可导向的导管，用于选择性地控制心包空间中的医疗装置的放置和取向。

19. 发明申请

WO2015042413A1 APPARATUS AND METHOD FOR DETERMINING PHYSIOLOGIC PERTURBATIONS OF A PATIENT 审中-公开
标题翻译：用于确定患者生理刺激的装置和方法
公开(公告)号：WO2015042413A1
公开(公告)日：2015-03-26
申请号：PCT/US2014/056579
申请日：2014-09-19
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： FINKEL, Julia
IPC分类号： A61B3/11
CPC分类号： A61B3/112 , A61B3/0025 , A61B3/11 , A61B3/145 , A61B5/031
摘要： The present disclosure is related to a method and apparatus for determining a physiologic perturbation of a patient including acquiring a video sequence, including a plurality of video frames, of an eye of a patient, selecting at least one parameter of a plurality of parameters including a baseline pupil size, a maximum change in size of a pupil, an average velocity of constriction of the pupil, a maximum velocity of constriction of the pupil, latency of constriction of the pupil, and a velocity of re-dilation of the pupil, determining, using processing circuitry and based on the plurality of video frames, the selected at least one parameter of the plurality of parameters, and determining the physiologic perturbation of the patient based on the determined at least one parameter, where the least one parameter of the plurality of parameters is selected based on which physiologic perturbation of the patient is to be determined.
摘要翻译：本公开涉及一种用于确定患者的生理学扰动的方法和装置，包括获取包括患者眼睛的多个视频帧的视频序列，选择多个参数中的至少一个参数，包括基线瞳孔大小，瞳孔大小的最大变化，瞳孔的平均收缩速度，瞳孔收缩的最大速度，瞳孔收缩的延迟以及瞳孔的再次扩张的速度，确定使用处理电路并且基于所述多个视频帧，所选择的所述多个参数中的至少一个参数，以及基于所确定的至少一个参数来确定所述患者的生理干扰，其中所述多个参数中的至少一个参数根据要确定患者的生理干扰来选择参数。

20. 发明申请

WO2015009830A1 THREE DIMENSIONAL PRINTED REPLICAS OF PATIENT'S ANATOMY FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：患者医疗应用解决方案的三维打印替代品
公开(公告)号：WO2015009830A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046856
申请日：2014-07-16
申请人： CHILDREN'S NATIONAL MEDICAL CENTER
发明人： OLIVIERI, Laura , KRIEGER, Axel , SABLE, Craig , KIM, Peter , KANG, Xin , NATH, Dilip , LOKE, Yue-Hin , COCHENOUR, Carolyn, T.
IPC分类号： G06T17/00
CPC分类号： G06F17/50 , B33Y50/00
摘要： A system and method of creating a 3 -dimensional (3D) replica of a patient's anatomy. The method includes acquiring 3D echo images of the patient's anatomy using ultrasound waves, selecting a filter that reduces noise in the 3D echo images, selecting a segmentation algorithm to segment the filtered 3D echo images, selecting at least one additional segmentation algorithm to subsequently segment the segmented 3D echo images, creating a 3D digital model, and outputting the 3D digital model as the 3D replica of the patient's anatomy. The method also includes acquiring other 3D images using MRI/CT scans, creating another 3D digital model, determining a scaling factor to scale the other 3D digital model to correspond to a size of the 3D digital model created using ultrasound waves, combining the 3D digital model and the other 3D digital model, and outputting the combined 3D digital models.
摘要翻译：创建患者解剖结构的三维（3D）复制品的系统和方法。该方法包括使用超声波获取患者解剖结构的3D回波图像，选择降低3D回波图像中的噪声的滤波器，选择分割算法来分割滤波的3D回波图像，选择至少一个附加分割算法以随后分割分割的3D回波图像，创建3D数字模型，并输出3D数字模型作为患者解剖结构的3D复本。该方法还包括使用MRI / CT扫描获取其他3D图像，创建另一3D数字模型，确定缩放因子以缩放其他3D数字模型以对应于使用超声波创建的3D数字模型的尺寸，将3D数字模型和其他3D数字模型，并输出组合的3D数字模型。

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