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121. 发明申请

WO2017015463A2 INFECTIOUS DISEASE VACCINES 审中-公开
标题翻译：感染性疾病疫苗
公开(公告)号：WO2017015463A2
公开(公告)日：2017-01-26
申请号：PCT/US2016/043348
申请日：2016-07-21
申请人： MODERNATX, INC.
发明人： CIARAMELLA, Giuseppe , HUANG, Eric Yi-Chun , BAHL, Kapil , ZAKS, Tal , HIMANSU, Sunny
CPC分类号： A61K9/0019 , A61K9/5123 , A61K39/12 , A61K2039/505 , A61K2039/5252 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
摘要翻译：本公开的方面涉及核酸疫苗。疫苗包括一种或多种具有编码一种或多种基孔肯雅抗原，一种或多种Zika病毒抗原和一种或多种登革热抗原的开放阅读框的RNA多核苷酸。还描述了制备和使用这种疫苗的方法。

122. 发明申请

WO2016205737A2 TUMOR IMMUNOTHERAPY 审中-公开
标题翻译：肿瘤免疫治疗
公开(公告)号：WO2016205737A2
公开(公告)日：2016-12-22
申请号：PCT/US2016/038222
申请日：2016-06-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： LU, Timothy, Kuan-Ta , NISSIM, Lior , WU, Ming-Ru
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/6845
摘要： Aspects of the present disclosure provide a platform that triggers potent and effective immunotherapy against tumors from within tumors themselves, thus overcoming limitations of existing cancer immunotherapies and tumor-detecting gene circuits.
摘要翻译：本公开的方面提供了一个平台，其触发对肿瘤本身内的肿瘤的有效和有效的免疫治疗，从而克服了现有的癌症免疫疗法和肿瘤检测基因电路的限制。

123. 发明申请

WO2016140726A2 TRIGGERED ASSEMBLY OF METAFLUOROPHORES 审中-公开
标题翻译：触发的金属大会
公开(公告)号：WO2016140726A2
公开(公告)日：2016-09-09
申请号：PCT/US2015/065948
申请日：2015-12-16
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ONG, Luvena, L. , ZHANG, David, Yu , WEI, Diming , JUNGMANN, Ralf , YIN, Peng
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6876 , C07H21/04
摘要： Aspects of the present disclosure relate to systems, kits and methods that comprise a nucleic acid capture strand linked to a first dye molecule, a nucleic acid trigger strand longer than the capture strand and comprising (a) a capture domain that is complementary to the capture strand and (b) at least two concatenated domains, each of which comprises two subdomains, and a partially double-stranded nucleic acid comprising a single- stranded toehold domain having a nucleotide sequence complementary to one of the subdomains of the two subdomains of the concatenated domains, a double-stranded region linked to a second dye molecule and having a nucleotide sequence complementary to the other of the two subdomains of the concatenated domains, and a single- stranded hairpin loop having a nucleotide sequence that is complementary to the single-stranded toehold domain.
摘要翻译：本公开的方面涉及包含与第一染料分子连接的核酸捕获链的系统，试剂盒和方法，比捕获链更长的核酸触发链，并且包含（a）与捕获互补的捕获结构域链和（b）至少两个连接的结构域，每个结构域包含两个亚结构域，以及部分双链核酸，其包含具有与连接的两个亚结构域的子域之一互补的核苷酸序列的单链多肽结构域结构域，连接到第二染料分子并具有与连接结构域的两个亚结构域中的另一个互补的核苷酸序列的双链区域，以及具有与单链互补的核苷酸序列的单链发夹环 toehold域名。

124. 发明申请

WO2016123419A1 MICROSCOPE-FREE IMAGING 审中-公开
标题翻译：显微镜自由成像
公开(公告)号：WO2016123419A1
公开(公告)日：2016-08-04
申请号：PCT/US2016/015503
申请日：2016-01-29
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： SCHAUS, Thomas, E. , CHEN, Xi , YIN, Peng
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12Q1/6841 , C12Q1/6804 , G01N33/5308 , G01N2458/10 , C12Q2521/501 , C12Q2525/161 , C12Q2525/185 , C12Q2525/301 , C12Q2531/113 , C12Q2535/122 , C12Q2563/107 , C12Q2565/601
摘要： Provided herein, in some aspects, are methods of imaging molecules without a microscope or other specialized equipment, referred to herein as "microscope-free imaging (MFI)." Herein, "molecular instruments" (e.g., DNA-based and protein-based molecules) are used, instead of microscopes, in a "bottom-up" approach for inspecting molecular targets.
摘要翻译：在本文中，在一些方面，是在没有显微镜或其他专门设备（本文称为“无显微镜成像（MFI）”的情况下成像分子的方法。本文中，使用“分子仪器”（例如，基于DNA和蛋白质的分子）代替显微镜，以“自下而上”的方式用于检查分子靶标。

125. 发明申请

WO2016123071A1 METHODS OF IDENTIFYING ESSENTIAL PROTEIN DOMAINS 审中-公开
标题翻译：鉴定基因蛋白质域的方法
公开(公告)号：WO2016123071A1
公开(公告)日：2016-08-04
申请号：PCT/US2016/014862
申请日：2016-01-26
申请人： COLD SPRING HARBOR LABORATORY
发明人： VAKOC, Christopher, H. , SHI, Junwei , KINNEY, Justin, B.
IPC分类号： C12N15/63 , C12N15/113 , C12N9/22 , C12N5/078 , C12N5/09
CPC分类号： C12Q1/6876 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2320/12 , C12N2330/31 , C12Q1/6897 , C12Q2600/156 , C12Q2600/178 , G01N33/68 , G01N33/6803
摘要： Provided herein, in some aspects, are methods of determining whether a candidate protein, more specifically a functional domain of a candidate protein, is essential for viability of cells of interest using clustered regularly interspaced short palindromic repeat (CPJSPR)-Cas9 technology which holds great promise for genetic screening and for the discovery of therapeutic targets.
摘要翻译：在本文中，在一些方面，是确定候选蛋白质，更具体地是候选蛋白质的功能结构域是否对于使用聚集的定期交织的短回文重复（CPJSPR）-Cas9技术而言是重要的目的细胞的生存力的方法，其保持很大承诺进行遗传筛选和发现治疗靶点。

126. 发明申请

WO2016089946A1 METHODS AND COMPOSITIONS FOR CONTROLLING ANTIBODY AGGREGATION 审中-公开
标题翻译：用于控制抗体聚集的方法和组合物
公开(公告)号：WO2016089946A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/063339
申请日：2015-12-02
申请人： BIOGEN MA INC.
发明人： WESTOBY, Matthew , BRINKMANN, Alex , HAVERSTOCK, Ryan , ALSTON, Roy
IPC分类号： A61K39/395 , A61K47/02 , A61K47/26 , C07K16/24
CPC分类号： C07K1/34 , A61K39/39591 , C07K16/241 , C07K2317/24
摘要： Disclosed herein are methods of purifying monoclonal antibodies and related compositions.
摘要翻译：本文公开了纯化单克隆抗体和相关组合物的方法。

127. 发明申请

WO2016070037A2 MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR 审中-公开
标题翻译：大型并发组合CRISPR
公开(公告)号：WO2016070037A2
公开(公告)日：2016-05-06
申请号：PCT/US2015/058304
申请日：2015-10-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： LU, Timothy, Kuan-Ta , WONG, Alan Siu, Lun , CHOI, Ching, Gee
IPC分类号： C12N15/10
CPC分类号： C12N15/102 , C12Q2563/179 , C12Q2565/514
摘要： Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.
摘要翻译：本文描述了能够快速产生包含CRISPR指导序列和支架序列的遗传元件的高阶组合的方法和组合物，以及用于快速鉴定编码在单细胞或合并群体内的遗传元件的组合的条形码。本文还描述了表观遗传学基因抑制剂的组合物和用于减少细胞增殖和/或治疗癌症的方法。

128. 发明申请

WO2014153346A1 ENGINEERING A HETEROGENEOUS TISSUE PLURIPOTENT STEM CELLS 审中-公开
标题翻译：工程异构组织细胞干细胞
公开(公告)号：WO2014153346A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/031050
申请日：2014-03-18
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： GUYE, Patrick , WEISS, Ron
IPC分类号： C12N15/85 , G01N33/50
CPC分类号： C12N15/85 , C07K14/4705 , C12N5/0696 , C12N2510/00 , C12N2799/027 , G01N33/5014
摘要： Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem (hiPS) cells.
摘要翻译：本公开的方面涉及用于从人诱导的多能干细胞（hiPS）细胞产生异质组织的方法和组合物。

129. 发明申请

WO2014018675A1 SELF-ASSEMBLY OF NUCLEIC ACID NANOSTRUCTURES 审中-公开
标题翻译：自组装的核酸纳米结构
公开(公告)号：WO2014018675A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051891
申请日：2013-07-24
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： YIN, Peng , SHIH, William, M. , KE, Yonggang , ONG, Luvena, L.
IPC分类号： C12Q1/68
CPC分类号： C07H21/04 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C12Q1/68 , G06F19/16 , C12Q2563/157
摘要： The invention involves the synthesis of nucleic acid structures of controlled size and shape and comprised of a plurality of oligonucleotides. The structures are formed, at least in part, by the self-assembly of single-stranded oligonucleotides. The location of each oligonucleotide in the resultant structure is known. Accordingly, the structures may be modified with specificity.
摘要翻译：本发明涉及受控大小和形状的核酸结构的合成，并且由多个寡核苷酸组成。该结构至少部分地由单链寡核苷酸的自组装形成。所得结构中每个寡核苷酸的位置是已知的。因此，可以特异性地修饰结构。

130. 发明申请

WO2022015813A1 HUMANIZED MOUSE MODELS FOR SARS-COV-2 INFECTION 审中-公开
公开(公告)号：WO2022015813A1
公开(公告)日：2022-01-20
申请号：PCT/US2021/041568
申请日：2021-07-14
申请人： THE JACKSON LABORATORY
发明人： SHULTZ, Leonard, D.
IPC分类号： A01K67/027 , C12N15/90
摘要： The present disclosure provides a transgenic, immunocompromised mouse engineered to express a human angiotensin converting enzyme 2 (huACE2) sequence. The huACE2 sequence may be operably linked to a human keratin 18 (hKRT18) promoter or the endogenous mouse angiotensin converting enzyme 2 (mACE2) promoter. Transgenic immunocompromised mice of the present disclosure may be utilized in methods of evaluating a test agent for reducing or preventing SARS-CoV-2 infection.

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