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121. 发明申请

WO2013076258A3 P450 BM3 MUTANTS AND THEIR USE FOR REGIO- AND STEREOSELECTIVE HYDROXYLATION OF ALPHA-AND BETA-IONONE 审中-公开
标题翻译： P450 BM3突变体及其用于α - 和β - 酮的区域性和立体选择性羟基化的用途
公开(公告)号：WO2013076258A3
公开(公告)日：2013-08-29
申请号：PCT/EP2012073490
申请日：2012-11-23
申请人： DSM IP ASSETS BV
发明人： COMMANDEUR JAN , VENKATARAMAN H M , VERMEULEN NICO
IPC分类号： C12N9/02
CPC分类号： C12N9/0042 , C12N9/0071 , C12Y106/02004 , C12Y114/14001
摘要： Selective hydroxylation is a crucial reaction in the synthesis of fine chemicals like hydroxylated isoprenoids. The present invention discloses cytochrome P450 BM3 mutants able to perform regio- and stereoselective hydroxylation of alpha- and beta-ionone. Therefore, the present invention relates to isolated polypeptides having oxidative activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as a process for the microbiological hydroxylation of isoprenoids, in particular ionones.
摘要翻译：选择性羟基化是合成精细化学品如羟基化异戊二烯的关键反应。本发明公开了能够进行α-和β-紫罗兰酮的区域和立体选择性羟基化的细胞色素P450 BM3突变体。因此，本发明涉及具有氧化活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞，以及类异戊二烯特别是紫罗酮的微生物羟基化方法。

122. 发明申请

WO2013030228A3 DEVICE AND PROCESS FOR CALIBRATING TUBULAR EXTRUDATES 审中-公开
标题翻译：用于校准管状体的装置和方法
公开(公告)号：WO2013030228A3
公开(公告)日：2013-05-10
申请号：PCT/EP2012066770
申请日：2012-08-29
申请人： DSM IP ASSETS BV , GROSS HEINZ , QUAEDFLIEG MATHEUS PIETER , RIJKS LEONARDUS WILHELMUS GUILLAUME
发明人： GROSS HEINZ , QUAEDFLIEG MATHEUS PIETER
IPC分类号： B29C47/90 , B29C47/88 , B29C47/92 , B29C47/94
CPC分类号： B29C47/903 , B29C47/0023 , B29C47/20 , B29C47/34 , B29C47/702 , B29C47/882 , B29C47/8835 , B29C47/8865 , B29C47/8895 , B29C47/90 , B29C47/904 , B29C47/905 , B29C47/907 , B29C47/908 , B29C47/92 , B29C47/94 , B29C2947/92123 , B29C2947/92152 , B29C2947/92428
摘要： The present invention relates to a calibration device for use in a process of making a tubular article comprising a housing (200) and a calibration sleeve (300) providing a vertical pass-way for an extruded tubular extrudate, the housing comprising a bore (210), an upper opening with an upper seal (280)and a lower opening with a lower seal (285); a vacuum channel (215) connecting the bore to a vacuum source; a liquid channel (255) for receiving a flow of liquid and connecting to a reservoir (250) on top of the housing; and an adjustment device (265) for controlling the liquid level in the reservoir; and the calibration sleeve (300) comprising a body with multiple apertures (340) and an inlet flange (330); the calibration sleeve (300) removably positioned in the bore (210) and contacting the housing (200) via the upper (280) and lower (285) seals. This calibration device enables making a tubular article in a very flexible way, specifically on small scale in the laboratory; and can be operated in free or contact calibration mode, both with either dry or wet operation. The invention further relates to an extrusion system for making tubular articles from a polymer composition comprising such calibration device, and to a process applying such device or system.
摘要翻译：本发明涉及一种用于制造管状制品的方法的校准装置，所述管状制品包括壳体（200）和校准套筒（300），所述校准套筒（300）为挤出的管状挤出物提供垂直通行，所述壳体包括孔（210 ），具有上密封件（280）的上开口和具有下密封件（285）的下开口; 将所述孔连接到真空源的真空通道（215）; 液体通道（255），用于接收液体流并连接到壳体顶部的储存器（250）; 以及用于控制所述储存器中的液面的调节装置（265）并且所述校准套筒（300）包括具有多个孔（340）和入口凸缘（330）的主体; 所述校准套筒（300）可移除地定位在所述孔（210）中并且经由所述上部（280）和下部（285）密封件接触所述壳体（200）。该校准装置使得能够以非常灵活的方式制造管状制品，特别是在实验室中小规模; 并且可以在自由或接触校准模式下操作，无论是干法还是湿法操作。本发明还涉及一种用于由包含这种校准装置的聚合物组合物制造管状制品的挤出系统以及应用这种装置或系统的方法。

123. 发明申请

WO2012084624A9 COMPOSITIONS OF FAT-SOLUBLE ACTIVE INGREDIENTS CONTAINING PLANT PROTEIN-SOY POLYSACCHARIDE COMPLEXES 审中-公开
标题翻译：含有植物蛋白多糖复合物的脂肪可溶性活性成分的组合物
公开(公告)号：WO2012084624A9
公开(公告)日：2013-04-25
申请号：PCT/EP2011072690
申请日：2011-12-14
申请人： DSM IP ASSETS BV , DENG WEI , LEUENBERGER BRUNO , VIDONI OLIVIA , YAO PING , YIN BAORU
发明人： DENG WEI , LEUENBERGER BRUNO , VIDONI OLIVIA , YAO PING , YIN BAORU
IPC分类号： A23L1/052 , A23K1/16 , A23L1/275 , A23L1/30 , A23L1/303 , A23L1/305 , A23L2/52 , A23L2/66 , B01J13/14
CPC分类号： A23K20/158 , A23K20/147 , A23K20/174 , A23K20/179 , A23L2/52 , A23L2/66 , A23L5/44 , A23L29/206 , A23L33/115 , A23L33/155 , A23L33/185
摘要： The present invention relates to compositions comprising a) 0.1 to 70 weight-% based on the composition of one or more fat-soluble active ingredients; b) one or more plant protein(s) chosen from the group of proteins suitable for food application; and c) one or more soy soluble polysaccharide(s); wherein the sum of the amount of protein(s) and the amount of polysaccharide(s) represents 10 to 85 weight-% based on the composition in dry matter and, wherein the weight ratio of protein(s) to polysaccharide(s) is chosen like 1 : b with the proviso that b is comprised between 0.5 and 15.
摘要翻译：本发明涉及包含a）基于一种或多种脂溶性活性成分的组合物为0.1-70重量％的组合物; b）一种或多种选自适合食品应用的蛋白质组的植物蛋白质; 和c）一种或多种大豆可溶性多糖; 其中蛋白质的量和多糖的总量相对于干物质中的组成为10〜85重量％，其中蛋白质与多糖的重量比为选择为1：b，条件是b为0.5至15。

124. 发明申请

WO2013000985A3 MODULAR MULTI-STORY PRODUCTION PLANT AND METHODS FOR CONSTRUCTING SAME 审中-公开
标题翻译：多模多用途生产设备及其构造方法
公开(公告)号：WO2013000985A3
公开(公告)日：2013-04-04
申请号：PCT/EP2012062527
申请日：2012-06-28
申请人： DSM IP ASSETS BV , DRIESS MARKUS
发明人： DRIESS MARKUS
IPC分类号： E04H5/02 , A23N17/00 , E04B1/348 , E04H5/08
CPC分类号： E04H5/00 , A23N17/00 , B66B9/00 , E04F11/02 , E04H1/005 , E04H5/02 , E04H5/08 , E04H14/00
摘要： A multistory modular production plant (10) includes a vertical stack (12) of production modules (12-1 through 12-5) for supporting production equipment, and a vertical stack (14) of operator access modules (14-1 through 14-5) adjacently connected to the vertically stacked production modules to allow operator access to the production modules. The adjacently connected vertical stacks of production modules (12) and operator access modules (14) thereby establish multiple stories of the modular production plant. Stairs (30) and/or an elevator (40) may be provided in the vertical stack of operator access modules to allow an operator to ascent/descend between stories of the plant. In especially preferred embodiments, each production module (12) and operator access module (14) is in the form of a rectangular parallelepiped which is sized so as to be accommodated within a standard shipping container. This configuration of modular units thus allows the plant to be more quickly shipped and constructed on site.
摘要翻译：多层模块化生产设备（10）包括用于支撑生产设备的生产模块（12-1至12-5）的垂直堆叠（12）和操作者访问模块（14-1至14- 5）相邻地连接到垂直堆叠的生产模块，以允许操作者访问生产模块。相邻连接的生产模块（12）和操作者访问模块（14）的垂直堆叠由此建立了模块化生产设备的多个故事。楼梯（30）和/或电梯（40）可以设置在操作者访问模块的垂直堆叠中，以允许操作者在工厂的故事之间上升/下降。在特别优选的实施例中，每个生产模块（12）和操作者访问模块（14）是矩形平行六面体的形式，其尺寸被设计成容纳在标准运输容器内。因此，这种模块化设备的配置允许工厂在现场更快地运输和建造。

125. 发明申请

WO2013013208A3 EICOSAPENTAENOIC ACID-PRODUCING MICROORGANISMS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开
标题翻译：生产挥发性微生物的微生物，脂肪酸组合物及其制备方法和用途
公开(公告)号：WO2013013208A3
公开(公告)日：2013-03-28
申请号：PCT/US2012047728
申请日：2012-07-20
申请人： DSM IP ASSETS BV , PFEIFER III JOSEPH W , HANSEN JON MILTON , GARCIA JOSE R , DONG XIAO DANIEL , BEHRENS PAUL WARREN , APT KIRK E
发明人： PFEIFER III JOSEPH W , HANSEN JON MILTON , GARCIA JOSE R , DONG XIAO DANIEL , BEHRENS PAUL WARREN , APT KIRK E
IPC分类号： C12P7/64
CPC分类号： A23K50/00 , A23K1/008 , A23K10/16 , A23K20/158 , A23K50/80 , C11B1/10 , C12N1/12 , C12P7/6427 , C12R1/89
摘要： The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
摘要翻译：本发明涉及分离的微生物及其菌株和突变体，生物质，微生物油，组合物和培养物; 生产微生物油，生物质和突变体的方法; 和使用分离的微生物，生物质和微生物油的方法。

126. 发明申请

WO2012160191A3 USE OF A FEED COMPOSITION FOR REDUCING METHANE EMISSION IN RUMINANTS, AND/OR TO IMPROVE RUMINANT PERFORMANCE 审中-公开
标题翻译：使用饲料组合物降低发酵液中的甲烷排放和/或提高发酵剂性能
公开(公告)号：WO2012160191A3
公开(公告)日：2013-01-31
申请号：PCT/EP2012059826
申请日：2012-05-25
申请人： DSM IP ASSETS BV , DUVAL STEPHANE , IMMIG IRMGARD , KINDERMANN MAIK , WEBER GILBERT
发明人： DUVAL STEPHANE , IMMIG IRMGARD , KINDERMANN MAIK , WEBER GILBERT
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18
CPC分类号： A61K31/21 , A23K20/10 , A23K20/105 , A23K20/195 , A23K50/10 , A61K9/0053 , A61K31/04 , A61K31/215 , A61K31/22 , A61K31/221 , A61K31/23 , A61K31/235 , A61K31/24 , A61K31/255 , A61K31/275 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/44 , A61K31/4406 , A61K45/06 , Y02P60/56
摘要： The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the use of a feed composition or a feed additive comprising at least one antibiotic and at least one organic molecule substituted at any position with at least one nitrooxy group for reducing the production of methane emanating from the digestive activities of ruminants, and/or to improve the ruminant performance.
摘要翻译：本发明涉及反刍动物甲烷排放减少的领域。特别地，本发明涉及使用包含至少一种抗生素和至少一种在任何位置与至少一个硝基氧基取代的有机分子的饲料组合物或饲料添加剂，用于减少由反刍动物的消化活性产生的甲烷的产生，和/或提高反刍动物的表现。

127. 发明申请

WO2012143513A3 YEAST CELL CAPABLE OF CONVERTING SUGARS INCLUDING ARABINOSE AND XYLOSE 审中-公开
标题翻译：酵母细胞能够转化糖，包括阿拉伯糖和木糖
公开(公告)号：WO2012143513A3
公开(公告)日：2012-12-27
申请号：PCT/EP2012057273
申请日：2012-04-20
申请人： DSM IP ASSETS BV , KLAASSEN PAUL , GIELESEN BIANCA ELISABETH MARIA , VAN SUYLEKOM GIJSBERDINA PIETERNELLA , SARANTINOPOULOS PANAGIOTIS , HEIJNE WILBERT HERMAN MARIE , GREEVE ALDO
发明人： KLAASSEN PAUL , GIELESEN BIANCA ELISABETH MARIA , VAN SUYLEKOM GIJSBERDINA PIETERNELLA , SARANTINOPOULOS PANAGIOTIS , HEIJNE WILBERT HERMAN MARIE , GREEVE ALDO
IPC分类号： C07K14/395 , C12N1/36 , C12P7/10 , C12R1/865
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/1205 , C12N9/90 , C12N9/92 , C12P2203/00 , C12R1/865 , C12Y207/01016 , C12Y503/01 , C12Y503/01003 , C12Y503/01005 , Y02E50/16
摘要： Yeast cell belonging to the genus Saccharomyces having introduced into its genome at least one xylA gene and at least one of each of araA, araB and araD genes and that is capable of consuming a mixed sugar mixture comprising glucose, xylose and arabinose, wherein the cell co-consumes glucose and arabinose, has genetic variations obtained during adaptive evolution and has a specific xylose consumption rate in the presence of glucose that is 0.25 g xylose/h, g DM or more.
摘要翻译：属于酵母属的酵母细胞已经在其基因组中引入了至少一个xylA基因和araA，araB和araD基因各自中的至少一个并且能够消耗包含葡萄糖，木糖和阿拉伯糖的混合糖混合物，其中所述细胞共同消耗葡萄糖和阿拉伯糖，在适应性进化过程中获得遗传变异并且在葡萄糖存在下具有特定的木糖消耗速率，所述葡萄糖为0.25g木糖/ h，gDM或更高。

128. 发明申请

WO2011076557A8 USE OF CANTHAXANTHIN AND/OR 25-OH D3 FOR IMPROVED REPRODUCTIVITY AND PERFORMANCE OF ROOSTERS 审中-公开
标题翻译：使用蒽醌和/或25-OH D3改善生殖力和性能
公开(公告)号：WO2011076557A8
公开(公告)日：2012-12-20
申请号：PCT/EP2010069064
申请日：2010-12-07
申请人： DSM IP ASSETS BV , HERNANDEZ JOSE-MARIA
发明人： HERNANDEZ JOSE-MARIA
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A61K31/593 , A23K20/174 , A23K20/179 , A23K50/75 , A61K31/122
摘要： The present invention relates to the use canthaxanthin and/or 25-hydroxy vitamin D3 (25-OH D3) for improving reproductive performance of roosters. More particularly, the invention relates to the use of Canthaxanthin and/or 25-hydroxy canthaxanthin in the manufacture of a food or veterinary composition for improving reproductive performance of roosters.
摘要翻译：本发明涉及使用角黄素和/或25-羟基维生素D3（25-OH D3）来改善雄鸡的繁殖性能。更具体地说，本发明涉及氨茶黄素和/或25-羟基角黄素在制备用于改善雄鸡生殖性能的食品或兽用组合物中的用途。

129. 发明申请

WO2012168282A2 SUNSCREENS 审中-公开
标题翻译：防晒霜
公开(公告)号：WO2012168282A2
公开(公告)日：2012-12-13
申请号：PCT/EP2012060665
申请日：2012-06-06
申请人： DSM IP ASSETS BV , MENDROK-EDINGER CHRISTINE , WESTENFELDER HORST
发明人： MENDROK-EDINGER CHRISTINE , WESTENFELDER HORST
IPC分类号： A61K8/00
CPC分类号： A61K8/496 , A61K8/29 , A61K8/86 , A61K8/896 , A61Q17/04
摘要： The present invention relates to a composition for topical application comprising in a physiologically acceptable medium at least a benzotriazol derivative, a microfine metal oxide particle and a polymeric emulsifier. More specifically, the invention relates to compositions that exhibit a reduced whitening effect on the skin.
摘要翻译：本发明涉及用于局部应用的组合物，其包含在生理学上可接受的培养基中至少一种苯并三唑衍生物，一种微细金属氧化物颗粒和一种聚合乳化剂。更具体地，本发明涉及对皮肤表现出减少的美白效果的组合物。

130. 发明申请

WO2012168276A2 SUNSCREEN 审中-公开
标题翻译：防晒
公开(公告)号：WO2012168276A2
公开(公告)日：2012-12-13
申请号：PCT/EP2012060656
申请日：2012-06-06
申请人： DSM IP ASSETS BV , MENDROK-EDINGER CHRISTINE
发明人： MENDROK-EDINGER CHRISTINE
IPC分类号： A61K8/00
CPC分类号： A61K8/496 , A61K8/678 , A61Q17/00 , A61Q17/04
摘要： The present invention relates to a composition for topical application comprising at least a benzotriazol derivative and vitamin E or a derivative thereof. Furthermore, the invention relates to compositions that prevent staining of clothes and exhibit a reduced sand adherence on skin.
摘要翻译：本发明涉及用于局部应用的组合物，其包含至少一种苯并三唑衍生物和维生素E或其衍生物。此外，本发明涉及防止衣服染色并在皮肤上显示减少的沙附着性的组合物。

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