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101. 发明申请

WO2005112818A3 SONOGRAPHY GUIDED EMBRYO TRANSFER FOR IN VITRO FERTILIZATION 审中-公开
标题翻译： SONOGRAPHY指导胚胎转移用于体外培养
公开(公告)号：WO2005112818A3
公开(公告)日：2006-10-05
申请号：PCT/US2005017520
申请日：2005-05-17
申请人： GERGELY ROBERT
发明人： GERGELY ROBERT
IPC分类号： A61B17/435 , A61B17/43 , A61B19/00 , A61D7/00
CPC分类号： A61B17/435 , A61B34/10 , A61B2090/378
摘要： The present provides novel systems and methods to facilitate embryo transfer, to maximize implantation rates and to improve pregnancy rates resulting from In Vitro fertilization.
摘要翻译：本发明提供了新颖的系统和方法来促进胚胎移植，使植入率最大化并提高由体外受精引起的怀孕率。

102. 发明申请

WO02035982A2 DEVICE FOR TRANS-CERVICAL ARTIFICIAL INSEMINATION AND EMBRYO TRANSFER 审中-公开
标题翻译：用于跨国人造伪造和胚胎转移的设备
公开(公告)号：WO02035982A2
公开(公告)日：2002-05-10
申请号：PCT/US2001/044917
申请日：2001-11-01
IPC分类号： A61B17/43 , A61B17/435 , A61D19/02 , A61D19/04 , A61B
CPC分类号： A61D19/027 , A61B17/43 , A61B17/435 , A61D19/04
摘要： The invention relates to an apparatus (10) and a method useful for non-surgical embryo transfer or artificial insemination of mammals. An apparatus (10) for depositing media (11) into the uterus of a mammal includes a conical chamber (12) that has a plurality of perforations (36) and flaps (36a). An exterior spiral formation (18) is configured for traversing or penetrating cervical passageway. A sheath (20) having a frusto-conical rearward end (22) extends axially from an aft end (16) of the conical chamber (12). A tubular deposing chamber (30) extends axially from the conical chamber (12) to a position beyond a fore end (14) of the conical chamber (12). Coupled to the rearward end (43) of the depositing chamber (30) is an embryo or semen packaging unit (40). The tubular depositing chamber (30) has an end (32) that has an aperture (34) to permit the flow of semen (11) out of the depositing chamber (30) and into the uterus. The invention also involves a method employing the apparatus (10) described.
摘要翻译：本发明涉及一种用于哺乳动物的非手术胚胎移植或人工授精的装置（10）和方法。用于将介质（11）沉积到哺乳动物的子宫中的装置（10）包括具有多个穿孔（36）和襟翼（36a）的锥形室（12）。外部螺旋形结构（18）构造成用于穿过或穿透子宫颈通道。具有截头圆锥形后端（22）的护套（20）从锥形腔（12）的后端（16）轴向延伸。管状脱模室（30）从锥形室（12）轴向延伸到超过锥形室（12）的前端（14）的位置。耦合到沉积室（30）的后端（43）是胚胎或精液包装单元（40）。管状沉积室（30）具有端部（32），其具有孔（34），以允许精液（11）从沉积室（30）流出并进入子宫。本发明还涉及使用所述装置（10）的方法。

103. 发明申请

WO0137719A3 PROGNOSTIC TESTING OF ORGANS INTENDED FOR TRANSPLANTATION 审中-公开
标题翻译：预期用于移植的器官的预后试验
公开(公告)号：WO0137719A3
公开(公告)日：2002-01-03
申请号：PCT/US0041867
申请日：2000-11-03
申请人： BREONICS INC , BRASILE LAUREN
发明人： BRASILE LAUREN
IPC分类号： A01N1/02 , A61B17/435 , A61L33/18 , G01N33/50 , G01N33/70 , A61B17/43
CPC分类号： G01N33/5091 , A01N1/02 , A61B17/435 , A61L33/18 , G01N33/50 , G01N33/70 , G01N2800/245
摘要： The present invention discloses a method of prospectively determining whether an organwill function once it is transplanted. A transplantable organ is perfused in an ex vivo warmperfusion system capable of supporting near normal levels of metabolism by the organ. One ormore parameters related to organ function are measured and evaluated during perfusion. Measurements of perfused organ function are compared to values indicative of normal organfunction to obtain a prediction of whether the organ being perfused will function once it has beentransplanted. A method for calculating a viability index based on the parameters evaluated is also disclosed.
摘要翻译：本发明公开了一种前瞻性地确定器官功能一旦被移植的方法。可移植的器官灌注在体外热灌注系统中，能够支持器官近乎正常的代谢水平。在灌注期间测量和评估与器官功能相关的一个或多个参数。将灌注器官功能的测量值与指示正常器官功能的值进行比较，以获得被灌注器官一旦进行了移植后是否会发挥功能的预测。还公开了基于评估的参数计算生存力指数的方法。

104. 发明申请

WO01074417A2 CATHETER SYSTEM FOR IMPLANTING EMBRYOS 审中-公开
标题翻译：用于植入胚胎的导管系统
公开(公告)号：WO01074417A2
公开(公告)日：2001-10-11
申请号：PCT/US2001/010220
申请日：2001-03-30
IPC分类号： A61B17/42 , A61B17/435 , A61M25/00 , A61M25/01 , A61M
CPC分类号： A61M25/0074 , A61B17/435 , A61B2017/4225 , A61B2090/036 , A61M25/0068 , A61M25/008 , A61M25/0111 , A61M2025/0081 , A61M2210/145
摘要： Described is a catheter system (20) for implanting embryos into a woman's uterus. The catheter system utilizes a protective catheter sleeve (24) for introducing a catheter into the uterus without mucus contamination of an inner catheter (25). Once the sleeve containing the inner catheter is introduced into the uterus, the protected inner catheter, carrying the embryos, is pushed through a swivelable distal end cap (32) on the sleeve to a desired implanting location. The distal end of the inner catheter has a protective cap and a side opening for embryo release. Also, stiffness and indicia features of the outer sleeve and inner catheter assist in the physician's handling of the catheter system and in ensuring a desired uterus location for implanting.
摘要翻译：描述了用于将胚胎植入女性子宫的导管系统（20）。导管系统利用保护导管套管（24），用于将导管引入子宫，而不会导致内导管（25）的粘液污染。一旦将含有内导管的套管引入子宫中，将保护的内导管（携带胚胎）推动穿过套筒上的可旋转远端帽（32）到期望的植入位置。内导管的远端具有保护盖和用于胚胎释放的侧开口。此外，外套筒和内导管的刚度和标记特征有助于医师处理导管系统并且确保用于植入的期望的子宫位置。

105. 发明申请

WO00053108A1 ARRANGEMENT FOR TRANSFERRING AN OVUM FROM A FOLLICLE 审中-公开
标题翻译：从一个方块传输一个OVUM的安排
公开(公告)号：WO00053108A1
公开(公告)日：2000-09-14
申请号：PCT/NL2000/000164
申请日：2000-03-10
IPC分类号： A61B17/435 , A61M1/00
CPC分类号： A61B17/435 , A61B2217/005 , A61B2217/007
摘要： An arrangement for transferring an ovum (9) from a follicle by implementing a technique of simultaneous flushing and aspiration, the arrangement comprising a double lumen needle having an elongate needle body (1) with a cuspidated needle end to be inserted into a follicle, an ovum pick-up lumen (7) for removing an ovum (9) from a follicle and a flushing lumen (11) for inserting a flushing fluid into the follicle, the needle body (1) comprising an outer tube (13) with an inner tube (15) located therein which inner tube (15) extends over at least part of the length of the outer tube (13), the one lumen (11) being bounded by the inside wall of the inner tube (15) and the other lumen (7) by the space between the outside wall of the inner tube (15) and the inside wall of the outer tube (13) and further comprising a connector body (19) a first end (23) of which is connected to the needle end (17) remote from the distal needle end (3). The inner tube (15) has in cross section dimensions which are distinctly smaller than the inside diameter of the outer tube (13), the inner tube (15) is made of a flexible material, the flushing lumen (11) is bounded by the inside wall of the inner tube (15) and the ovum lumen (7) is bounded by the space between the outside wall of the inner tube (15) and the inside wall of the outer tube (13).
摘要翻译：一种用于通过实施同时冲洗和抽吸的技术从卵泡转移卵子（9）的装置，所述装置包括具有细长针体（1）的双腔针，其具有插入到卵泡中的尖头针端，用于从卵泡中除去卵子（9）的卵子吸取腔（7）和用于将冲洗流体插入毛囊的冲洗腔（11），所述针体（1）包括外管（13），所述外管管（15）位于其中，内管（15）在外管（13）的长度的至少一部分上延伸，一个内腔（11）由内管（15）的内壁限定，另一个通过内管（15）的外壁和外管（13）的内壁之间的空间而具有内腔（7），并且还包括连接器主体（19），第一端（23）连接到远离远端针端（3）的针端（17）。内管（15）的横截面尺寸明显小于外管（13）的内径，内管（15）由柔性材料制成，冲洗内腔（11）由内管（15）的内壁和卵腔（7）由内管（15）的外壁和外管（13）的内壁之间的空间界定。

106. 发明申请

WO00038583A1 METHODS AND COMPOSITIONS FOR IMPROVING THE DEVELOPMENTAL ABILITY AND QUALITY OF PRE-IMPLANTATION EMBRYOS 审中-公开
标题翻译：改善植物胚胎发育的能力和质量的方法和组合物
公开(公告)号：WO00038583A1
公开(公告)日：2000-07-06
申请号：PCT/NZ1999/000225
申请日：1999-12-22
IPC分类号： A61B17/435 , C12N15/873 , A61D19/04
CPC分类号： C12N15/873 , A61B17/435 , C12N5/0604 , C12N2500/02
摘要： The present invention provides a method for improving the developmental ability and quality of pre-implantation embryos by partially inhibiting the ability of the embryos to generated ATP by oxidative phosphorylation in in vitro culture.
摘要翻译：本发明提供了通过部分抑制胚胎在体外培养中通过氧化磷酸化产生ATP的能力来提高植入前胚胎的发育能力和质量的方法。

107. 发明申请

WO99037348A1 CATHETER SYSTEM FOR IMPLANTING EMBRYOS 审中-公开
标题翻译：用于植入胚胎的导管系统
公开(公告)号：WO99037348A1
公开(公告)日：1999-07-29
申请号：PCT/US1998/001660
申请日：1998-01-23
IPC分类号： A61B17/435 , A61M25/00 , A61M25/01
CPC分类号： A61M25/0074 , A61B17/435 , A61M25/0068 , A61M25/0111 , A61M2210/145
摘要： Described is a catheter system (20) for implanting embryos into a woman's uterus. The catheter system (20) utilizes a protective catheter sleeve (24) for introducing a catheter (25) into the uterus without mucus contamination of an inner catheter (25). Once the sleeve (24) containing the inner catheter (25) is introduced into the uterus, the protected inner catheter (25), carrying the embryos, is pushed through a swiveled distal end cap (32) on the sleeve (24) to a desired implanting location. The distal end of the inner catheter (25) has a protective cap (44) and a side opening (45) for embryo release. Features of the outer sleeve (24) and inner catheter (25) assist in ensuring a desired uterus location for implanting.
摘要翻译：描述了用于将胚胎植入女性子宫的导管系统（20）。导管系统（20）利用保护导管套管（24）将导管（25）引入子宫，而不会导致内导管（25）的粘液污染。一旦将含有内导管（25）的套管（24）引入到子宫中，则承载胚胎的受保护的内导管（25）被推动穿过套筒（24）上的旋转的远端帽（32）到所需植入位置。内导管（25）的远端具有用于胚胎释放的保护帽（44）和侧开口（45）。外套筒（24）和内导管（25）的特征有助于确保用于植入的期望的子宫位置。

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