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101. 发明申请

WO2007012944A9 METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 审中-公开
标题翻译：疫苗管理方法，新疫苗药物和用于免疫动物疫苗的疫苗和疫苗病毒的治疗方法
公开(公告)号：WO2007012944A9
公开(公告)日：2008-10-16
申请号：PCT/IB2006002018
申请日：2006-07-17
申请人： PFIZER PROD INC , LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBY THOMAS JACK
发明人： LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBY THOMAS JACK
IPC分类号： A61K38/16 , A61K39/12 , A61K48/00 , C07K14/08 , C07K16/10 , C12N15/40
CPC分类号： C07K16/10 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K2317/76 , C12N7/00 , C12N2710/16734 , C12N2750/10034 , C12N2750/14334 , C12N2770/16021 , C12N2770/16022 , C12N2770/16034 , G01N33/56983 , G01N2469/10
摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.
摘要翻译：本发明涉及用于免疫猫对猫科动物病毒的疫苗。本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。该方法包括给予猫治疗有效量的第一和第二FCV疫苗。第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。也可以给予第三次疫苗管理。本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也被称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒称为猫科鼻气管炎病毒。

102. 发明申请

WO2008094674A1 RECOMBINANT BICISTRONIC FLAVIVIRUS VECTORS 审中-公开
标题翻译：重组双歧杆菌FLAVIVIRUS矢量
公开(公告)号：WO2008094674A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/001330
申请日：2008-01-31
申请人： ACAMBIS INC. , DELAGRAVE, Simon , BROWN, Nathan , KLEANTHOUS, Harold , GUIRAKHOO, Farshad , RUMYANTSEV, Alexander, A.
发明人： DELAGRAVE, Simon , BROWN, Nathan , KLEANTHOUS, Harold , GUIRAKHOO, Farshad , RUMYANTSEV, Alexander, A.
IPC分类号： A61K39/12
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/16134 , C12N2770/24143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396
摘要： This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
摘要翻译：本发明涉及双顺反子黄病毒载体，在预防和治疗疾病中使用这些载体的方法，以及制备此类载体的方法。

103. 发明申请

WO2008054612A9 DNA COMPOSITION FOR ELICITING AN IMMUNE RESPONSE AGAINST TUMOR-ASSOCIATED MACROPHAGES 审中-公开
公开(公告)号：WO2008054612A9
公开(公告)日：2008-07-03
申请号：PCT/US2007021414
申请日：2007-10-05
申请人： SCRIPPS RESEARCH INST , REISFELD RALPH A , XIANG RONG , LUO YUNPING
发明人： REISFELD RALPH A , XIANG RONG , LUO YUNPING
IPC分类号： A61K48/00
CPC分类号： C12N9/6472 , A61K39/00 , A61K39/0011 , A61K2039/521 , A61K2039/5254 , A61K2039/53 , A61K2039/542 , A61K2039/645 , C12N9/50
摘要： A DNA composition useful for eliciting an immune response against tumor-associated macrophages comprises a DNA construct that encodes for a cysteine endopeptidase (e.g., legumain) or a polypeptide comprising at least one immunogenic fragment thereof that is overexpressed in tumor-associated cells such as tumor-associated macrophages, or an immunogenic fragment thereof that is expressible in immune cells, and which is incorporated in a pharmaceutically acceptable carrier. In preferred embodiments, the composition encodes a polypeptide comprising a plurality of immunogenic fragments of a tumor associated cysteine endopeptidase (e.g., legumain) joined together serially such that each fragment is connected to at least one other fragment by a linker peptide such as AIaAIaAIa or AlaAlaTyr. In one preferred embodiment, the composition also includes a DNA construct that encodes an immune effector protein, such as a cytokine. The DNA composition of the invention can be used alone or in combination with a chemotherapeutic agent to treat diseases such as tumors and tumor metastases.

104. 发明申请

WO2008057550A2 STABILIZATION OF VACCINES BY LYOPHILIZATION 审中-公开
标题翻译：通过柠檬酸稳定疫苗
公开(公告)号：WO2008057550A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/023421
申请日：2007-11-07
申请人： ACAMBIS INC. , VELLOM, Daniel, C. , DEGEORGE, Paul , CIARAMETARO, Peter
发明人： VELLOM, Daniel, C. , DEGEORGE, Paul , CIARAMETARO, Peter
IPC分类号： C12N7/00
CPC分类号： A61K39/12 , A61K9/19 , A61K2039/5254 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： This invention provides pharmaceutical compositions, such as vaccines, and methods of making and using such compositions.
摘要翻译：本发明提供药物组合物，例如疫苗，以及制备和使用这些组合物的方法。

105. 发明申请

WO2008054612A2 DNA COMPOSITION FOR ELICITING AN IMMUNE RESPONSE AGAINST TUMOR-ASSOCIATED MACROPHAGES 审中-公开
标题翻译：用于激发对肿瘤相关巨噬细胞的免疫应答的DNA组合物
公开(公告)号：WO2008054612A2
公开(公告)日：2008-05-08
申请号：PCT/US2007021414
申请日：2007-10-05
申请人： SCRIPPS RESEARCH INST , REISFELD RALPH A , XIANG RONG , LUO YUNPING
发明人： REISFELD RALPH A , XIANG RONG , LUO YUNPING
IPC分类号： A61K48/00
CPC分类号： C12N9/6472 , A61K39/00 , A61K39/0011 , A61K2039/521 , A61K2039/5254 , A61K2039/53 , A61K2039/542 , A61K2039/645 , C12N9/50
摘要： A DNA composition useful for eliciting an immune response against tumor-associated macrophages comprises a DNA construct that encodes for a cysteine endopeptidase (e.g., legumain) or a polypeptide comprising at least one immunogenic fragment thereof that is overexpressed in tumor-associated cells such as tumor-associated macrophages, or an immunogenic fragment thereof that is expressible in immune cells, and which is incorporated in a pharmaceutically acceptable carrier. In preferred embodiments, the composition encodes a polypeptide comprising a plurality of immunogenic fragments of a tumor associated cysteine endopeptidase (e.g., legumain) joined together serially such that each fragment is connected to at least one other fragment by a linker peptide such as AIaAIaAIa or AlaAlaTyr. In one preferred embodiment, the composition also includes a DNA construct that encodes an immune effector protein, such as a cytokine. The DNA composition of the invention can be used alone or in combination with a chemotherapeutic agent to treat diseases such as tumors and tumor metastases.
摘要翻译：用于引发针对肿瘤相关巨噬细胞的免疫应答的DNA组合物包含编码半胱氨酸内肽酶（例如legumain）的DNA构建体或包含至少一个在肿瘤相关细胞如肿瘤中过表达的免疫原性片段的多肽相关巨噬细胞或其免疫原性片段，其可在免疫细胞中表达，并掺入药学上可接受的载体中。在优选的实施方案中，所述组合物编码多肽，所述多肽包含串联连接在一起的多个肿瘤相关半胱氨酸内肽酶（例如legumain）的免疫原性片段，使得每个片段通过连接肽如AlaAlaAla或AlaAlaTyr连接至少一个其他片段。在一个优选的实施方案中，组合物还包含编码免疫效应蛋白例如细胞因子的DNA构建体。本发明的DNA组合物可以单独使用或与化学治疗剂组合使用以治疗诸如肿瘤和肿瘤转移的疾病。

106. 发明申请

WO2008039267A2 INDUCING CELLULAR IMMUNE RESPONSES TO INFLUENZA VIRUS USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开
标题翻译：使用肽和核酸组合物诱导对流感病毒的细胞免疫应答
公开(公告)号：WO2008039267A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/016529
申请日：2007-07-23
申请人： PHARMEXA INC. , ALEXANDER, Jeffery, L. , SOUTHWOOD, Scott, F. , BILSEL, Pamuk, A. , NEWMAN, Mark, J.
发明人： ALEXANDER, Jeffery, L. , SOUTHWOOD, Scott, F. , BILSEL, Pamuk, A. , NEWMAN, Mark, J.
IPC分类号： C07H21/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55561 , A61K2039/55566 , A61K2039/645 , C12N2760/16022 , C12N2760/16034 , C12N2760/16134
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare influenza virus epitopes, and to develop epitope-based vaccines directed towards influenza virus. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of influenza virus infection.
摘要翻译：本发明使用我们对抗原被T细胞识别和制备流感病毒表位的机制的知识，并开发针对流感病毒的基于表位的疫苗。更具体地说，本申请介绍了我们在预防和治疗流感病毒感染中的药物组合物和使用方法的发现。

107. 发明申请

WO2007143442A3 A NOVEL VIRULENCE DETERMINANT WITHIN THE E2 STRUCTURAL GLYCOPROTEIN OF CLASSICAL SWINE FEVER VIRUS 审中-公开
标题翻译：经典蛇型病毒的E2结构型GLYCOPROTEIN中的新型毒力测定
公开(公告)号：WO2007143442A3
公开(公告)日：2008-03-13
申请号：PCT/US2007069852
申请日：2007-05-29
申请人： US AGRICULTURE , BORCA MANUEL V , RISATTI GUILLERMO R
发明人： BORCA MANUEL V , RISATTI GUILLERMO R
IPC分类号： A61K39/12 , A61K39/00 , C12N15/09 , C12Q1/68
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
摘要： Classical Swine Fever Virus (CSFV) E2 glycoprotein is a major inducer of neutralizing antibodies and protective immunity in swine. E2 mediates virus adsorption to the target cell, and harbors genetic determinants associated with virus virulence. CSFV E2 also contains between residues 829 and 837 a discrete epitope (TAVSPTTLR) recognized by monoclonal antibody (mAb) WH3O3, used to differentiate CSFV from related Pestiviruses Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV). In this report, a CSFV infectious clone of the virulent Brescia isolate (BICv) was used to progressively mutate the mAb WH3O3 epitope of CSFV E2 to the homologous amino acid sequence of BVDV strain NADL E2 (TSFNMDTLA). While the resulting virus mutants TIv (TSFSPTTLR), T2v (TSFNPTTLR), T3v (TSFNMTTLR) demonstrated in vitro growth characteristics similar to those of parental BICv, mutants T4v (TSFNMDTLR) and T5v (TSFNMDTLA) exhibited a 10-fold decrease in virus yield and a significant decrease in plaque size relative to parental BICv. Immunohistochemical reactivity with WH303 was lost only in T3v, T4v and T5v.
摘要翻译：经典猪瘟病毒（CSFV）E2糖蛋白是猪的中和抗体和保护性免疫的主要诱导剂。 E2介导病毒对靶细胞的吸附，并且具有与病毒毒力相关的遗传决定簇。 CSFV E2还包含残基829和837之间由单克隆抗体（mAb）WH3O3识别的离散表位（TAVSPTTLR），用于区分来自相关的病毒性腹泻病毒（BVDV）和边界病病毒（BDV）的CSFV。在本报告中，使用强毒性布雷西亚分离株（BICv）的CSFV感染性克隆逐渐将CSFV E2的mAb WH3O3表位突变为BVDV毒株NADL E2（TSFNMDTLA）的同源氨基酸序列。尽管得到的病毒突变体TIv（TSFSPTTLR），T2v（TSFNPTTLR），T3v（TSFNMTLTLR）证明体外生长特征与亲代BICv相似，但突变体T4v（TSFNMDTLR）和T5v（TSFNMDTLA）的病毒产量降低了10倍相对于亲本BICv，斑块大小明显减少。仅在T3v，T4v和T5v中，与WH303的免疫组织化学反应丧失。

108. 发明申请

WO2007123961A3 PURIFICATION PROCESSES FOR ISOLATING PURIFIED VESICULAR STOMATITIS VIRUS FROM CELL CULTURE 审中-公开
标题翻译：从细胞培养中分离纯化的VESICULAR STOMATITIV病毒的纯化方法
公开(公告)号：WO2007123961A3
公开(公告)日：2008-03-06
申请号：PCT/US2007009510
申请日：2007-04-19
申请人： WYETH CORP , KANG YUN , CUTLER MARK WILLIAM , OUATTARA AMADOU AFFREY , SYVERTSEN KRISTEN ELISSA
发明人： KANG YUN , CUTLER MARK WILLIAM , OUATTARA AMADOU AFFREY , SYVERTSEN KRISTEN ELISSA
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/16222 , C12N2760/20243 , C12N2760/20251 , C12N2760/20252
摘要： Novel purification processes for obtaining vesicular stomatitis virus (VSV) of improved purity from mammalian cell culture are described herein. More particularly, in certain embodiments, a process is described for purifying VSV from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture fluid by low-speed centrifugation and recovering the VSV in the supernatant; filtering the supernatant through a 0.2 to 0.45 µm filter and recovering the VSV in the filtered solution; loading the VSV filtered solution onto a anion exchange membrane adsorber equilibrated with a first pH buffered salt solution, eluting the VSV from the anion exchange membrane adsorber with a second pH buffered salt solution and recovering the eluted VSV fractions; purifying the recovered VSV by tangential flow filtration (TFF) using a TFF membrane having a molecular weight cutoff between 300 kDa and 1,000 kDa and recovering the VSV in the retentate, and filtering the VSV retentate through a 0.2 to 0.22 µm filter and recovering the VSV in the filtered solution.
摘要翻译：本文描述了从哺乳动物细胞培养物获得改善纯度的水泡性口炎病毒（VSV）的新型纯化方法。更具体地，在某些实施方案中，描述了用于从感染VSV的哺乳动物细胞培养物的细胞培养液中纯化VSV的方法，该方法包括：通过低速离心澄清细胞培养液并回收上清液中的VSV; 通过0.2至0.45μm的过滤器过滤上清液并在过滤的溶液中回收VSV; 将VSV过滤的溶液加载到用第一pH缓冲盐溶液平衡的阴离子交换膜吸附器上，用第二pH缓冲盐溶液从阴离子交换膜吸附器洗脱VSV并回收洗脱的VSV级分; 通过切向流过滤（TFF），使用分子量截止值在300kDa至1,000kDa之间的TFF膜来纯化回收的VSV，并回收渗余物中的VSV，并通过0.2至0.22μm的过滤器过滤VSV滞留物并回收VSV 在过滤的溶液中。

109. 发明申请

WO2007123961A2 PURIFICATION PROCESSES FOR ISOLATING PURIFIED VESICULAR STOMATITIS VIRUS FROM CELL CULTURE 审中-公开
标题翻译：从细胞培养中分离纯化的VESICULAR STOMATITIV病毒的纯化方法
公开(公告)号：WO2007123961A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009510
申请日：2007-04-19
申请人： WYETH , KANG, Yun , CUTLER, Mark, William , OUATTARA, Amadou, Affrey , SYVERTSEN, Kristen, Elissa
发明人： KANG, Yun , CUTLER, Mark, William , OUATTARA, Amadou, Affrey , SYVERTSEN, Kristen, Elissa
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/16222 , C12N2760/20243 , C12N2760/20251 , C12N2760/20252 , Y02A50/464
摘要： Novel purification processes for obtaining vesicular stomatitis virus (VSV) of improved purity from mammalian cell culture are described herein. More particularly, in certain embodiments, a process is described for purifying VSV from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture fluid by low-speed centrifugation and recovering the VSV in the supernatant; filtering the supernatant through a 0.2 to 0.45 µm filter and recovering the VSV in the filtered solution; loading the VSV filtered solution onto a anion exchange membrane adsorber equilibrated with a first pH buffered salt solution, eluting the VSV from the anion exchange membrane adsorber with a second pH buffered salt solution and recovering the eluted VSV fractions; purifying the recovered VSV by tangential flow filtration (TFF) using a TFF membrane having a molecular weight cutoff between 300 kDa and 1,000 kDa and recovering the VSV in the retentate, and filtering the VSV retentate through a 0.2 to 0.22 µm filter and recovering the VSV in the filtered solution.
摘要翻译：本文描述了从哺乳动物细胞培养物获得改善纯度的水泡性口炎病毒（VSV）的新型纯化方法。更具体地，在某些实施方案中，描述了用于从感染VSV的哺乳动物细胞培养物的细胞培养液中纯化VSV的方法，该方法包括：通过低速离心澄清细胞培养液并回收上清液中的VSV; 通过0.2至0.45μm的过滤器过滤上清液并在过滤的溶液中回收VSV; 将VSV过滤的溶液加载到用第一pH缓冲盐溶液平衡的阴离子交换膜吸附器上，用第二pH缓冲盐溶液从阴离子交换膜吸附器洗脱VSV并回收洗脱的VSV级分; 通过切向流过滤（TFF），使用分子量截止值在300kDa至1,000kDa之间的TFF膜来纯化回收的VSV，并回收渗余物中的VSV，并通过0.2至0.22μm的过滤器过滤VSV滞留物并回收VSV 在过滤的溶液中。

110. 发明申请

WO2007064742B1 IDENTIFICATION OF PROTECTIVE ANTIGENIC DETERMINANTS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) AND USES THEREOF 审中-公开
标题翻译：鉴定番茄生殖和呼吸道综合症病毒（PRRSV）的保护性抗原决定因子及其用途
公开(公告)号：WO2007064742B1
公开(公告)日：2007-10-04
申请号：PCT/US2006045758
申请日：2006-11-29
申请人： UNIV IOWA STATE RES FOUND INC , HARRIS DELBERT LINN , ERDMAN MATTHEW M
发明人： HARRIS DELBERT LINN , ERDMAN MATTHEW M
IPC分类号： A61K39/12 , C07K14/08 , C07K16/10
CPC分类号： C07K14/005 , A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , C12N2770/10022 , C12N2770/10034 , G01N33/56983
摘要： The invention relates to a polypeptide of a protective antigenic determinant (PAD polypeptide) of porcine reproductive and respiratory syndrome virus (PRRSV) and nucleic acids encoding a PAD polypeptide. The PAD is generated by a heterodimer consisting of the GP 5 protein and the M protein of PRRSV wherein the ectodomain of GP 5 has different N-glycosylated states. The PAD polypeptide and nucleic acids encoding a PAD polypeptide are useful in the development of antibodies directed to PAD, vaccines effective in providing protection against PRRSV infection, and diagnostic assays detecting the presence of PAD antibodies generated by a PAD-specific vaccine. The invention also discloses methods of generating antibodies to PAD, for vaccinating a pig to provide protection from PRRSV infections, a method of preparing the vaccine, a method of treating PRRSV infections in a pig, and a method of detecting antibodies to PAD of PRRSV.
摘要翻译：本发明涉及猪繁殖与呼吸综合征病毒（PRRSV）的保护性抗原决定簇（PAD多肽）多肽和编码PAD多肽的核酸。 PAD由由GP5蛋白和PRRSV的M蛋白组成的异源二聚体产生，其中GP 5的胞外域具有不同的N-糖基化状态。编码PAD多肽的PAD多肽和核酸可用于开发针对PAD的抗体，有效提供针对PRRSV感染的保护的疫苗以及检测由PAD特异性疫苗产生的PAD抗体的存在的诊断测定。本发明还公开了产生PAD抗体的方法，用于疫苗接种猪以提供针对PRRSV感染的保护，制备疫苗的方法，治疗猪中PRRSV感染的方法和检测PRRSV的PAD抗体的方法。

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