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101. 发明申请

WO1998013489A1 NUCLEIC ACID MOLECULES CODING FOR TUMOR SUPPRESSOR PROTEINS AND METHODS FOR THEIR ISOLATION 审中-公开
标题翻译：肿瘤抑制蛋白的核酸分子编码及其分离方法
公开(公告)号：WO1998013489A1
公开(公告)日：1998-04-02
申请号：PCT/EP1997005198
申请日：1997-09-22
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SPENGLER, Dietmar , JOURNOT, Laurent
发明人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/12
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/4705
摘要： Described are novel proteins having the biological activity of a tumor suppressor protein and nucleic molecules coding for such proteins. Methods for the isolation of nucleic acid molecules encoding tumor suppressor proteins as well as nucleic acid molecules obtainable by said method are also provided. Further, vectors comprising said nucleic molecules wherein the nucleic acid molecules are operatively linked to regulatory elements allowing expression in prokaryotic or eukaryotic host cells can be used for the production of polypeptides encoded by said nucleic acid molecules which have tumor suppressor activity. Pharmaceutical and diagnostic compositions are provided comprising the nucleic acid molecules of the invention and/or comprising a nucleic acid molecule which is complementary to such a nucleic acid molecule. Described are also compositions which comprise polypeptides encoded by the described nucleic acid molecules which have tumor suppressor activity and/or an antibody specifically recognizing such polypeptides.
摘要翻译：描述了具有肿瘤抑制蛋白的生物活性和编码这种蛋白质的核酸分子的新型蛋白质。还提供了分离编码肿瘤抑制蛋白的核酸分子的方法以及通过所述方法可获得的核酸分子。此外，包含所述核酸分子的载体，其中所述核酸分子可操作地连接到允许在原核或真核宿主细胞中表达的调节元件，可用于产生由具有肿瘤抑制活性的所述核酸分子编码的多肽。提供了包含本发明的核酸分子和/或包含与这种核酸分子互补的核酸分子的药物和诊断组合物。还描述了包含由具有肿瘤抑制活性的所述核酸分子编码的多肽的组合物和/或特异性识别这些多肽的抗体。

102. 发明申请

WO1998002455A2 TRANSCRIPTIONAL INTERMEDIARY FACTOR-2 审中-公开
标题翻译：转录中间因子-2
公开(公告)号：WO1998002455A2
公开(公告)日：1998-01-22
申请号：PCT/US1997012100
申请日：1997-07-11
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR , BRISTOL-MYERS SQUIBB COMPANY
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR , BRISTOL-MYERS SQUIBB COMPANY , CHAMBON, Pierre , GRONEMEYER, Hinrich , VOEGEL, Johannes , LUTZ, Yves
IPC分类号： C07K14/00
CPC分类号： C07K14/4702
摘要： The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
摘要翻译：本发明涉及核受体（NR）转录介体。更具体地，提供编码转录中介因子-2（TIF2）的分离的核酸分子。还提供了用于制备TIF2多肽的重组方法，如TIF2抗体。还提供筛选方法用于鉴定核受体的激活功能AF-2的激动剂和拮抗剂，用于鉴定TIF2的AD1活化域活性的激动剂和拮抗剂，以及用于鉴定TIF2的AD2活化域活性的激动剂和拮抗剂。

103. 发明申请

WO1997043660A1 METHOD AND DEVICE FOR LOCATING A SOURCE PROVIDED WITH A MICROWAVE TRANSMITTER 审中-公开
标题翻译：用于定位由微波发射器提供的源的方法和装置
公开(公告)号：WO1997043660A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997002425
申请日：1997-05-12
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEROY, Yves , BERLARBI-DELAI, Aziz , COVILLERS, Jean-Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01S05/06
CPC分类号： G01S5/06
摘要： A device and a method for locating a source (1) provided with a microwave transmitter, particularly over short distances in a portion of a plane or space, are disclosed. The location method comprises using at least two antenna pairs (2, 3) positioned outside the area in which the source (1) is moving, positioning the source transmitter in such a way that the antenna pairs (2, 3) pick up the signal therefrom, measuring, for each antenna pair (2, 3), the phase shift between the signals received by each of the antennas (5, 6, 8, 9) of said pair (2, 3), determining the equation of the hyperboloid of revolution representing the locus of points where wave transmission identical to that of the source (1) would correspond to the phase shift ( phi 1, phi 2) measured by each antenna pair (2, 3), and determining the intersection of the hyperboloids of revolution in order to locate the source accurately and with a single solution. Said device and said method are useful for location and detection over short distances.
摘要翻译：公开了一种用于定位设置有微波发射器的源（1）的装置和方法，特别是在平面或空间的一部分中的短距离处。定位方法包括使用位于源（1）移动的区域外的至少两个天线对（2,3），以使得天线对（2,3）拾取信号的方式定位源发射机对于每个天线对（2,3），测量由所述对（2,3）中的每个天线（5,6,8,9）接收的信号之间的相移，确定双曲面的方程表示与源（1）的波传播相同的波传播的点的轨迹的旋转对应于由每个天线对（2,3）测量的相移（phi 1，phi 2），并且确定双曲面的交点的革命，以便准确地定位源，并使用单一解决方案。所述装置和所述方法对于在短距离上的定位和检测是有用的。

104. 发明申请

WO1997042253A1 SULPHONATED POLYIMIDES, MEMBRANES AND FUEL CELL 审中-公开
标题翻译：硫化聚合物，膜和燃料电池
公开(公告)号：WO1997042253A1
公开(公告)日：1997-11-13
申请号：PCT/FR1997000804
申请日：1997-05-06
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , FAURE, Sylvain , PINERI, Michel , ALDEBERT, Pierre , MERCIER, Régis , SILLION, Bernard
发明人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C08G73/10
CPC分类号： C08J5/2256 , C08G73/10 , C08G73/1042 , C08J2379/08 , H01M8/1027 , H01M8/103
摘要： The invention relates to sulphonated polyimides, in particular of formula (I). The invention also features an ion-exchanger membrane containing such a polyimide and a fuel cell containing such a membrane. The membranes of the invention have excellent durability and low cost and the fuel cells can be used particularly in electric vehicles.
摘要翻译：本发明涉及磺化聚酰亚胺，特别是式（I）。本发明还具有含有这种聚酰亚胺和含有这种膜的燃料电池的离子交换膜。本发明的膜具有优异的耐久性和低成本，并且燃料电池可以特别用于电动车辆。

105. 发明申请

WO1997041061A1 NEW CARBONS CONTAINING FLUORINE, METHOD OF PREPARATION THEREOF AND USE AS ELECTRODE MATERIAL 审中-公开
标题翻译：含有氟的新型碳，其制备方法和用作电极材料
公开(公告)号：WO1997041061A1
公开(公告)日：1997-11-06
申请号：PCT/FR1997000710
申请日：1997-04-21
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , YAZAMI, Rachid , HAMWI, André , HANY, Pascal
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C01B31/00
CPC分类号： H01M4/583 , C01B32/00 , H01M4/133 , H01M4/622 , H01M4/623 , H01M4/625 , H01M10/05 , H01M10/052 , H01M10/0525 , H01M10/0569
摘要： The invention relates to new carbons containing fluorine. The carbons containing fluorine are obtained from a graphite or a mosaic textured graphitisable compound containing carbon. As a first step, the graphite or the carbon containing compound is reacted with a gaseous mixture (HF+F2) in presence of a MFn fluoride at a temperature range between 15 DEG C and 80 DEG C, M representing an element selected among I, Cl, Br, Re, W, Mo, Nb, Ta, B, Ti, P, As, Sb, S, Se, Te, Pt, Ir, and Os and n representing the valency of the element M, with n
摘要翻译：本发明涉及含氟的新碳。含氟的碳由石墨或含有碳的马赛克有机化的石墨化合物得到。作为第一步，在15℃至80℃的温度范围内，在MFn氟化物存在下，将石墨或含碳化合物与气体混合物（HF + F2）反应，M表示选自I， Cl，Br，Re，W，Mo，Nb，Ta，B，Ti，P，As，Sb，S，Se，Te，Pt，Ir和Os，n表示元素M的化合价， = 7。作为第二步，将第一步骤中得到的化合物与氟反应，在20〜400℃的温度范围内与氟反应1〜20小时。本发明可用作活性电极材料。

106. 发明申请

WO1997032057A1 METHOD FOR FORMING Ti1-xAlxN COATINGS 审中-公开
标题翻译：形成Ti1-xAlxN涂层的方法
公开(公告)号：WO1997032057A1
公开(公告)日：1997-09-04
申请号：PCT/FR1997000336
申请日：1997-02-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MADAR, Roland , ROUAULT, Alain , BLANQUET, Elisabeth , BERNARD, Claude , DUTRON, Anne-Marie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C23C16/34
CPC分类号： C23C16/4488 , C23C16/34
摘要： A method for forming a Ti1-xAlxN coating on a part, wherein a chemical vapour deposition chamber is heated to 250-500 DEG C; the part to be coated is heated to 550-650 DEG C and placed in said chamber; and a mixture of titanium and aluminium chlorides, NH3 and H2 is injected into the chamber. The molar amount of NH3 is greater than the molar amount of chlorides, and the molar amount of hydrogen is over five times greater than the molar amount of chlorides.
摘要翻译：在部件上形成Ti1-xAlxN涂层的方法，其中化学气相沉积室被加热到250-500℃; 将待涂覆的部分加热至550-650℃并放置在所述室中; 并将钛和氯化铝的混合物NH 3和H 2注入室中。 NH 3的摩尔量大于氯化物的摩尔量，氢的摩尔量比氯化物的摩尔量高五倍以上。

107. 发明申请

WO1997009303A1 ALPHA-HYDRAZINO ACID DERIVATIVES AND METHOD FOR MAKING SAME 审中-公开
标题翻译： ALPHA-HYDRAZINO酸衍生物及其制备方法
公开(公告)号：WO1997009303A1
公开(公告)日：1997-03-13
申请号：PCT/FR1996001349
申请日：1996-09-04
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COLLET, André , VIDAL, Joëlle , HANNACHI, Jean-Christophe , GUY, Laure
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07C281/02
CPC分类号： C07D233/64 , C07C281/02 , C07C317/48 , C07D209/20 , C07K1/1072 , Y02P20/55
摘要： An alpha -hydrazino acid derivative of general formula (I) is described, wherein R1, R2, R3 are hydrogen or a carbon radical, such that when R2 and R3 are different, C* is an asymmetric carbon of L, D or DL configuration, and R4 and R5 are a protecting group, characterised in that R4 is a benzyl ArCH2 radical of formula (a), wherein Ar is a phenyl radical or phenyl substituted by one or more X groups; X being hydrogen, halogen, a nitro or alkyl radical; and in that R5 is a Y-O-CO group, where Y is a carbon radical different from R4.
摘要翻译：描述了通式（I）的α-肼基衍生物，其中R 1，R 2，R 3是氢或碳基，使得当R 2和R 3不同时，C *是L，D或DL构型的不对称碳，R4和R5是保护基，其特征在于R4是式（a）的苄基ArCH 2基团，其中Ar是苯基或被一个或多个X基取代的苯基; X为氢，卤素，硝基或烷基; 并且其中R 5是Y-O-CO基团，其中Y是不同于R 4的碳基团。

108. 发明申请

WO1997009295A1 MESOGENIC METALLIC COMPLEXES, PROCESS FOR POLYMERIZING THESE COMPLEXES AND ANISOTROPIC POLYMERS OBTAINED THEREBY 审中-公开
标题翻译：异构金属复合物，用于聚合这些复合物的方法和获得的各向异性聚合物
公开(公告)号：WO1997009295A1
公开(公告)日：1997-03-13
申请号：PCT/FR1996001370
申请日：1996-09-06
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MARCOT, Laurence , MALDIVI, Pascale , MARCHON, Jean-Claude
发明人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07C65/21
CPC分类号： C07C65/21 , C07C69/92 , C08F30/04 , C09K19/40
摘要： The invention concerns novel mesogenic metallic complexes which can be polymerized photochemically in their liquid crystalline state and correspond to formula (I), in which at least one of the two R groups is a group which can be polymerized photochemically and M is a metal, in particular zinc. The invention also concerns a process for photochemically polymerizing these complexes, and the resultant columnar anisotropic liquid-crystalline polymers containing one metallic centre per monomer unit.
摘要翻译：本发明涉及可以在其液晶状态下光化学聚合并对应于式（I）的新型介晶金属配合物，其中两个R基团中的至少一个是可以光化学聚合的基团，M是金属，在特别是锌。本发明还涉及一种用于光化学聚合这些络合物的方法，并且所得的柱状各向异性液晶聚合物每单体单元含有一个金属中心。

109. 发明申请

WO1997005113A1 4-ARYL-THIO-PYRIDIN-2(1H)-ONES, DRUGS CONTAINING SAME, AND USES THEREOF FOR TREATING HIV-RELATED DISEASES 审中-公开
标题翻译： 4-ARYL-THIO-PYRIDIN-2（1H）-ONES，含有它们的药物及其用于治疗HIV相关疾病的用途
公开(公告)号：WO1997005113A1
公开(公告)日：1997-02-13
申请号：PCT/FR1996001204
申请日：1996-07-30
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BISAGNI, Emile , DOLLE, Valérie , NGUYEN, Chi, Hung , LEGRAVEREND, Michel , AUBERTIN, Anne-Marie , KIRN, André , ANDREOLA, Marie, Line , TARRAGO-LITVAK, Laura , VENTURA, Michel
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07D213/70
CPC分类号： C07D213/70 , C07D213/74 , C07D213/75 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (3), wherein each of R1 and R2, which are the same or different, is a hydrogen atom, an aliphatic group or an alkyloxyalkyl group in which the alkyl chains have 1-4 carbon atoms or together form an aromatic ring; R3 is a hydrogen atom or a group NHR5 where R5 is a hydrogen atom or a group COR6 where R6 is an aliphatic or aromatic group, or a group NO2, or a group COOR7 where R7 is an aliphatic group; and R4 is a phenyl group or heterocycle. Said compounds may be used for treating HIV-related diseases.
摘要翻译：式（3）的化合物，其中相同或不同的R 1和R 2各自是烷基链具有1-4个碳原子或一起形成芳环的氢原子，脂族基团或烷氧基烷基 ; R3是氢原子或其中R5是氢原子的基团NHR5或R6是脂族或芳族基团的基团COR6或基团NO2或其中R7是脂族基团的基团COOR7; R4是苯基或杂环。所述化合物可用于治疗HIV相关疾病。

110. 发明申请

WO1996031872A1 PERSONAL ACTIVE NOISE CANCELLATION METHOD AND DEVICE HAVING INVARIANT IMPULSE RESPONSE 审中-公开
标题翻译：个人主动噪声消除方法和具有不确定冲突响应的装置
公开(公告)号：WO1996031872A1
公开(公告)日：1996-10-10
申请号：PCT/FR1996000508
申请日：1996-04-03
申请人： TECHNOFIRST , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CARME, Christian , ROURE, Alain
发明人： TECHNOFIRST , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G10K11/178
CPC分类号： G10K11/178 , G10K2210/128 , G10K2210/30232 , G10K2210/3031 , G10K2210/3033 , G10K2210/3041 , G10K2210/3219 , G10K2210/3221
摘要： A selected electrical signal is first applied to the input of a source (30) to determine at least the impulse response (H), over a predetermined time, between the source output and the input of sensors (20). The values of the active cancellation control signal are determined in real time according to a predetermined law established in accordance with the previously determined impulse response (H), whereby the energy of the output signal from the sensors is minimised. The acoustic structure (2) is arranged so that the space (534) containing the sensors (20) and the source (30) is invariant at least during the determination of the active cancellation control signal and in the presence of a person, whereby the impulse response (H) between the output of the source (30) and the input of the sensors (20) may remain invariant.
摘要翻译：首先将选择的电信号施加到源（30）的输入端，以在源极输出和传感器（20）的输入之间的预定时间内至少确定脉冲响应（H）。主动取消控制信号的值根据根据先前确定的脉冲响应（H）建立的预定定律实时确定，由此来自传感器的输出信号的能量最小化。声学结构（2）被布置成使得包含传感器（20）和源（30）的空间（534）至少在确定主动取消控制信号期间和在人的存在下是不变的，由此源（30）的输出与传感器（20）的输入之间的脉冲响应（H）可以保持不变。

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