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    • 100. 发明申请
    • PROCESS FOR PREPARING SNUFF COMPOSITION
    • 制备SNUFF组合物的方法
    • WO2010031552A1
    • 2010-03-25
    • PCT/EP2009/006714
    • 2009-09-17
    • NicoNovum ABAXELSSON, AndersKRISTENSEN, Arne
    • AXELSSON, AndersKRISTENSEN, Arne
    • A61K9/00A24B15/14A61K31/465
    • A61K9/0056A24B15/16A61K9/009A61K9/146
    • A method for the preparation of a nicotine-cellulose combination, the method comprising simultaneous loading of the nicotine on the cellulose and agglomeration of the particles so as to obtain a suitably loaded combination with a mean particle size that is suitable for use e.g. in snuff compositions packed in pouches of gauze or other materials with opening. The invention further relates to the use of such a nicotine-cellulose combination for the preparation of a snuff composition for achievement of a fast onset of action of nicotine after application of the snuff composition to the oral cavity of a subject, wherein the composition has a high release rate so that when subjected to an in vitro dissolution test about 45% or more of the total content of nicotine is released within 30 minutes. Moreover, the invention relates to an improved snuff composition for application to the oral cavity.
    • 一种制备尼古丁 - 纤维素组合的方法,所述方法包括同时将尼古丁加载到纤维素上并使颗粒附聚,以获得适合加载的组合,其平均粒度适合于例如使用。 包装在纱布或其他材料开口的鼻烟组合物中。 本发明还涉及这样的尼古丁 - 纤维素组合在制备鼻烟组合物中的用途,其用于在将鼻烟组合物施用于受试者的口腔之后实现尼古丁的快速起效,其中该组合物具有 高释放速率使得当进行体外溶出试验时,在30分钟内释放出大约45%或更多的尼古丁总含量。 此外,本发明涉及用于口腔的改进的鼻烟组合物。