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91. 发明申请

WO00004925A1 SLOW RELEASE FORMULATIONS COMPRISING ANIONIC POLYSACCHARIDE 审中-公开
标题翻译：包含阴离子多糖的缓释制剂
公开(公告)号：WO00004925A1
公开(公告)日：2000-02-03
申请号：PCT/IE1999/000069
申请日：1999-07-21
IPC分类号： A61K31/715 , A01N43/04 , A61C8/00 , A61K6/00 , A61K6/097 , A61K8/72 , A61K8/96 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/50 , A61K9/52 , A61K9/64 , A61K9/70 , A61K31/00 , A61K31/4164 , A61K31/70 , A61K31/7048 , A61K31/717 , A61K31/718 , A61K31/722 , A61K31/74 , A61K31/78 , A61K31/785 , A61K38/00 , A61K38/16 , A61K47/18 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61L15/16 , A61L15/28 , A61L27/00 , A61P1/04 , A61P3/06 , A61P7/04 , A61P11/00 , A61P17/00 , A61P31/04 , A61P31/12 , A61P35/00 , C01D15/08 , C08B20060101 , C08B15/00 , C08B31/00 , C08B37/00 , C08J5/10 , C08J9/00 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00
CPC分类号： A61K9/02 , A61K8/65 , A61K8/73 , A61K8/731 , A61K8/736 , A61K8/737 , A61K8/8158 , A61K9/0034 , A61K9/12 , A61K9/16 , A61K9/1617 , A61K9/1635 , A61K9/2027 , A61K9/2054 , A61K31/715 , A61K31/785 , A61K47/38 , A61K2800/5424 , A61K2800/5426 , A61Q19/00
摘要： A slow release formulation includes a biocompatible anionic polysaccharide material containing glucuronic acid in the polymer chain.
摘要翻译：缓释制剂包括在聚合物链中含有葡萄糖醛酸的生物相容性阴离子多糖物质。

92. 发明申请

WO00004907A1 AN ANTILIPEMIC FORMULATION 审中-公开
标题翻译：抗生素配方
公开(公告)号：WO00004907A1
公开(公告)日：2000-02-03
申请号：PCT/IE1999/000070
申请日：1999-07-21
IPC分类号： A61K31/715 , A01N43/04 , A61C8/00 , A61K6/00 , A61K6/097 , A61K8/72 , A61K8/96 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/50 , A61K9/52 , A61K9/64 , A61K9/70 , A61K31/00 , A61K31/4164 , A61K31/70 , A61K31/7048 , A61K31/717 , A61K31/718 , A61K31/722 , A61K31/74 , A61K31/78 , A61K31/785 , A61K38/00 , A61K38/16 , A61K47/18 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61L15/16 , A61L15/28 , A61L27/00 , A61P1/04 , A61P3/06 , A61P7/04 , A61P11/00 , A61P17/00 , A61P31/04 , A61P31/12 , A61P35/00 , C01D15/08 , C08B20060101 , C08B15/00 , C08B31/00 , C08B37/00 , C08J5/10 , C08J9/00 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00
CPC分类号： A61K9/02 , A61K8/65 , A61K8/73 , A61K8/731 , A61K8/736 , A61K8/737 , A61K8/8158 , A61K9/0034 , A61K9/12 , A61K9/16 , A61K9/1617 , A61K9/1635 , A61K9/2027 , A61K9/2054 , A61K31/715 , A61K31/785 , A61K47/38 , A61K2800/5424 , A61K2800/5426 , A61Q19/00
摘要： An antilipemic composition, particularly to achieve a lowering of cholesterol levels comprises a biocompatible anionic polysaccharide material containing non-sulphated glucuronic acid.
摘要翻译：特别是为了降低胆固醇水平的抗血脂组合物包含含有非硫酸化葡萄糖醛酸的生物相容性阴离子多糖物质。

93. 发明申请

WO99031141A2 METHOD FOR PRODUCING REGULAR POROUS CELLULOSE PEARLS, CORRESPONDING CELLULOSE PEARLS AND USE THEREOF 审中-公开
标题翻译：制备定期多孔细胞的方法，细胞周期蛋白及其使用
公开(公告)号：WO99031141A2
公开(公告)日：1999-06-24
申请号：PCT/DE1998/003657
申请日：1998-12-09
IPC分类号： A61K31/717 , A61P17/02 , B01D15/08 , B01J2/06 , C08B1/00 , C08B16/00 , C08J3/14 , C08J3/16 , C08J9/16 , C08J9/28 , G01N33/548 , C08B
CPC分类号： C08J9/16 , B01D15/08 , B01J2/06 , C08B1/003 , C08B16/00 , C08J3/14 , C08J3/16 , C08J9/28 , C08J2301/02 , G01N33/548
摘要： The invention relates to a method for producing regular porous pearls of cellulose with a particle size of 2 to 1000 mu m, comprising the following steps: a) a cellulose with a degree of polymerisation of 150 to 2000 is dissolved in a solvent to form a 0.5 to 25 mass % solution, b) the cellulose solution is reduced to fine particles and dispersed in a dispersion agent which does not mix with the cellulose solution and which has a degree of viscosity of 10 to 8000 mPa.s, c) the disperse particles of the solution are solidified into regular pearl particles 1) after the dispersion has been cooled to below the melting temperature of the cellulose solution and the hardened particles of cellulose solution have been separated from the dispersion agent or 2) directly in the solution by precipitation with a precipitating agent which mixes with the solvent, and d) the pearl particles are separated from the liquid mixture of the solvent, the precipitating agent and optionally, the dispersing agent.
摘要翻译：一种用于与颗粒尺寸范围生产规则多孔珍珠纤维素从2至1000微米，其包括a）将具有在150至2000溶解在溶剂中的范围内的聚合度的质量溶液中以形成0.5〜25％的纤维素处理，b）精细分割的纤维素溶液和可混溶于一个与它分散在范围内的粘度为10至80,000毫帕·秒冷却所述分散液低于纤维素溶液的熔融温度和分离后具有分散剂，c）该分散液中的粒子1）固化Celluloselösungsteilchen分散剂或2）直接在分散体与用所述溶剂液体沉淀剂定期Perlteilchen，和d混溶的溶剂凝固通过沉淀）从溶剂的液体混合物中分离出Perlteilchen，沉淀剂和可能的。分散剂。

94. 发明申请

WO99007417A1 HEMOSTATIC TISSUE SEALANTS 审中-公开
公开(公告)号：WO99007417A1
公开(公告)日：1999-02-18
申请号：PCT/US1998/016410
申请日：1998-08-06
IPC分类号： A61L27/00 , A61K9/16 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/00 , A61L24/04 , A61L26/00 , A61L31/06 , A61L31/14 , C08G63/64 , C08G63/676 , C08G65/00 , C08G85/00 , A61L25/00
CPC分类号： C08G63/676 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/404 , A61K31/717 , A61K31/722 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , A61L2300/418 , A61L2400/04 , C08G63/64 , C08L67/04
摘要： A method of controlling hemostasis by applying a hemostatic agent in a tissue sealant composition. The tissue sealant is a biodegradable, biocompatible synthetic polymer that may not intrinsically possess strong hemostatic properties. Inclusion of a hemostatic material in the tissue sealant can control bleeding at the site and may also provide improved adherence of the sealant to tissue and provide shorter healing times.
摘要翻译：一种通过在组织密封剂组合物中应用止血剂来控制止血的方法。组织密封剂是可生物降解的，生物相容的合成聚合物，其本身不具有强的止血性能。将止血材料包括在组织密封剂中可以控制该部位的渗血并且还可以提供密封剂对组织的改善的粘附并且提供更短的愈合时间。

95. 发明申请

WO98030247A1 A METHOD AND COMPOSITION FOR CANCER TREATMENT BY ENZYMATIC CONVERSION OF SOLUBLE RADIOACTIVE TOXIC AGENTS 审中-公开
标题翻译：通过可溶性放射性毒性剂的酶转化进行癌症治疗的方法和组合物
公开(公告)号：WO98030247A1
公开(公告)日：1998-07-16
申请号：PCT/US1998/000511
申请日：1998-01-13
IPC分类号： A61K45/00 , A61K31/717 , A61K31/722 , A61K31/74 , A61K38/00 , A61K49/00 , A61K51/04 , A61P35/00 , C07K16/00 , A61K51/00 , A61M36/14
CPC分类号： A61K51/0497 , A61K2039/505 , C07K2317/31 , Y02P20/582
摘要： A method for the treatment of cancer is disclosed which is capable of directing supralethal doses of radiation, called Hot-Spots, virtually exclusively to the cancer. The present invention involves a multi-step therapy process and includes a class of novel chemical agents. In accordance with the present invention, it was discovered that soluble precipitable materials can be made to accumulate as non-digestible precipitates in targeted cells as a result of enzyme action within the targeted cells. Accumulation is achieved by administering to the living host a soluble binary reagent made by attaching a targeting agent to a novel chemical agent which is a soluble precipitable material. The binary reagent binds to antigenic receptors on targeted cells which endocytose binary reagent and transport it into the lysosomes where enzymes detach the soluble precipitable material from the targeting agent, causing it to precipitate, accumulate, and be retained in the cells. Increasing amounts of precipitate can be made to accumulate in cells by continuing the administration of the binary reagent. The accumulated precipitate is relocated to the extra-cellular fluid by selectively killing a fraction of cancer cells. Now relocated in the extra-cellular fluid of the cancer, the precipitate is used as a "platform" from which to generate Hot-Spots. A bispecific reagent with a non-mammalian enzyme moiety is made to bind to the precipitate. A soluble radioactive material is administered which is converted by the enzyme moiety of the bound bispecific reagent into a new form which is retained adjacent to the precipitate for an extended period of time, thereby generating Hot-Spots which non-selectively kill all cells adjacent to the precipitate in the extra-cellular fluid of the cancer.
摘要翻译：公开了一种治疗癌症的方法，其能够将超临界剂量的辐射（称为热点）几乎专门用于癌症。本发明涉及多步骤治疗方法并且包括一类新型化学试剂。根据本发明，发现可溶性沉淀物质作为目标细胞中的酶作用的结果，可以在靶细胞中作为不可消化的沉淀物积累。通过向活体宿主施用通过将靶向剂附着到作为可溶性可沉淀材料的新型化学试剂而制备的可溶性二元试剂来实现累积。二元试剂结合靶向细胞上的抗原受体，其内吞胞外二元试剂并将其转运到溶酶体中，其中酶将可溶性可沉淀物质从靶向剂中分离出来，导致其沉淀，积聚并保留在细胞中。通过继续施用二元试剂，可以增加沉淀物的积累量。通过选择性地杀死一部分癌细胞，将累积的沉淀物重新定位到细胞外液体。现在迁移到细胞外的细胞液中，沉淀物被用作产生热点的“平台”。使具有非哺乳动物酶部分的双特异性试剂与沉淀物结合。施用可溶性放射性物质，其由结合的双特异性试剂的酶部分转化为与沉淀物相邻保留较长时间段的新形式，从而产生热点，其不选择性地杀死所有细胞癌细胞中细胞液中的沉淀。

96. 发明申请

WO2023028664A1 INJECTABLE COMPOSITION 审中-公开
公开(公告)号：WO2023028664A1
公开(公告)日：2023-03-09
申请号：PCT/AU2022/051077
申请日：2022-09-02
申请人： THE UNIVERSITY OF QUEENSLAND , BULUGUDU LIMITED
发明人： MARTIN, Darren, James , GRIFFITHS, Ian
IPC分类号： A61L27/20 , A61L27/52 , A61L27/58 , C08J3/09 , A61K31/717 , A61K47/02 , A61K47/18 , A61K8/04 , A61K8/23 , A61K8/42 , A61K8/73 , A61K9/00 , A61K9/06 , A61P19/02 , A61Q19/08 , C08B15/00
摘要： Disclosed are injectable compositions. Such compositions may be formed from cellulosic fibers and a deep eutectic solvent. Also disclosed are methods of preparing an injectable composition, which comprises: (i) contacting cellulosic fibers with a deep eutectic solvent to provide deep eutectic solvent treated cellulosic fibers; (ii) washing the deep eutectic solvent treated cellulosic fibers; and (iii) homogenizing or mechanically refining the washed deep eutectic solvent treated cellulosic fibers to thereby provide the injectable composition. Also disclosed are uses of the compositions and methods involving the compositions.

97. 发明申请

WO2021248197A1 HAEMOSTATIC MATERIAL 审中-公开
公开(公告)号：WO2021248197A1
公开(公告)日：2021-12-16
申请号：PCT/AU2021/050591
申请日：2021-06-10
申请人： THE AUSTRALIAN NATIONAL UNIVERSITY
发明人： TSUZUKI, Takuya , COUPLAND, Lucy Anne , MOHAMED, Elmira
IPC分类号： A61L15/28 , A61F13/00 , A61L26/00 , C08L97/02 , A61F13/00063 , A61F13/20 , A61F2013/00106 , A61F2013/0011 , A61F2013/00463 , A61K31/717 , A61K9/70 , A61L15/44 , A61L2300/418 , A61L2400/04 , A61L2400/12 , A61P7/04 , C08B37/003 , C08L1/02 , C08L5/08 , C08L5/10 , D21C9/007 , D21H15/00 , D21H21/52
摘要： The present invention provides a composition for controlling bleeding, said composition comprising a non-acidic meshed network of fibrous material, wherein the network comprises fibres with a mean diameter (D50) no greater than 1µm, an aspect ratio (mean fibre length/ mean fibre diameter) of at least 100, and wherein said meshed network has a specific surface area of at least 10m2/g, and a gel point no greater than 3g/L. The present invention also contemplates methods for controlling bleeding from a surface, said method comprising applying to said surface a composition according to the invention.

98. 发明申请

WO2021245568A1 PERMANENT MAGNET ELECTRIC MACHINE WITH MULTIPLE COAXIAL ROTORS 审中-公开
公开(公告)号：WO2021245568A1
公开(公告)日：2021-12-09
申请号：PCT/IB2021/054831
申请日：2021-06-02
申请人： RICCIARDI, Francesco
发明人： RICCIARDI, Francesco
IPC分类号： H02K16/00 , H02K21/12 , H02K29/06 , H02K29/12 , A61K31/717 , A61K31/722 , A61K31/734 , A61K33/06 , A61K47/183 , A61K47/24 , A61K47/34 , A61P17/02 , A61P31/04 , A61P31/10
摘要： An electric machine with permanent magnets comprises at least two rotors (2-5) mutually coaxial and each provided with two or more permanent magnetic poles associated with their side wall, at least one stator (10-12) provided with windings with respective electrical output contacts (13-15) and interposed between two of said rotors (2-5) to be powered with current and generate a rotating electromagnetic field adapted to put into rotation the corresponding rotors (2-5), a transmission shaft (16) mechanically connected to said rotors (2-5) to be driven into rotation upon the rotation of said rotors (2-5) promoted by said at least one stator (10-12).

99. 发明申请

WO2021180293A1 A COMPOSITION FOR NORMALIZING BLOOD LIPID LEVEL 审中-公开
公开(公告)号：WO2021180293A1
公开(公告)日：2021-09-16
申请号：PCT/EA2021/000001
申请日：2021-03-10
申请人： DIKOVSKIY, Aleksander Vladimirovich
发明人： SERGEEV, Artemiy Aleksandrovich , NIKITINA, Anna Aleksandrovna , SELEZNEV, Andrey Vladimirovich , SCHANKINA, Vera Gennadevna , PRYAKHINA, Ekaterina Sergeevna
IPC分类号： A61K31/704 , A61K31/715 , A61K31/717 , A61K35/00 , A61P3/06 , A61P7/00 , A61P9/10 , A61P43/00 , A61K9/00 , A23L2/00
摘要： The invention relates to a composition suitable for normalizing the lipid level in blood, including low-density lipoproteins, cholesterol and triglycerides, comprising glycyrrhizic acid in the form of its pharmaceutically acceptable salt in combination with hydrolysis lignin in effective amounts that provide for a therapeutically effective daily dose of the composition, and also to a dietary supplement and a product for therapeutic and preventive dietary nutrition. The effect consists in achieving an unexpected synergistic effect by implementing the mechanism of simultaneous action on the functions of the liver and intestines from the side of glycyrrhizic acid in the claimed effective amounts in combination with the pronounced adsorption and antioxidant activity of hydrolytic lignin in the form of a ligninocellulose complex in the claimed effective amounts.

100. 发明申请

WO2021126221A1 COMPOSITIONS COMPRISING A PARTICULAR RATIO OF INSOLUBLE TO SOLUBLE FIBRE FOR USE IN THE TREATMENT OF E.G. ANXIETY 审中-公开
公开(公告)号：WO2021126221A1
公开(公告)日：2021-06-24
申请号：PCT/US2019/067568
申请日：2019-12-19
申请人： HILL'S PET NUTRITION, INC.
发明人： EPHRAIM, Eden , JEWELL, Dennis
IPC分类号： A23K10/30 , A23K20/158 , A23K50/42 , A61K31/202 , A23K20/163 , A61K31/355 , A61K31/375 , A61K31/717 , A61P25/00 , A61P25/22 , A23K20/174 , A23K50/40
摘要： Compositions and methods of treating anxiety or stress in an animal are disclosed. Compositions and methods of reducing or preventing elevated levels of 4-EPS are disclosed. Compositions and methods for promoting growth of beneficial microbes in an animal's microbiome and inhibiting growth of non-beneficial microbes are disclosed. The methods comprise administering to the animal an effective amount of n-3 fatty acids, antioxidants, insoluble fiber and soluble fiber in an effective ratio of insoluble fiber and soluble fiber. Compositions comprise effective amounts of n-3 fatty acids, antioxidants, insoluble fiber and soluble fiber in an effective ratio of insoluble fiber and soluble fiber.

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