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91. 发明申请

WO02041752A2 METHOD AND SYSTEM FOR INSTANT BIOPSY SPECIMEN ANALYSIS 审中-公开
标题翻译：用于生物样本分析的方法和系统
公开(公告)号：WO02041752A2
公开(公告)日：2002-05-30
申请号：PCT/US2001/043244
申请日：2001-11-20
IPC分类号： A61B8/08 , A61B10/00 , A61B19/00 , G01N29/06 , G01N29/22 , G01N29/28 , G01S7/52 , G01S15/89 , A61B
CPC分类号： G01S15/8993 , A61B8/0833 , A61B10/0096 , A61B2090/378 , G01N29/0609 , G01N29/223 , G01N29/28 , G01N2291/02466 , G01S7/52017
摘要： According to a preferred embodiment, a specimen 102 containing the tumor is extracted from the patient and suspended in a container 108 holding an acoustically conductive fluid. An ultrasound probe is brought into acoustic communication with the fluid and scan the specimen 108, preferably at an acoustic power setting higher than a maximum ultrasonic power permitted on live human tissue. The resulting two-dimensional or three dimensional ultrasound images of the specimen, which have a higher quality due to the increased acoustic power of the sc, are viewed on an output display for examining whether any portion of the tumor comes into contact with surfaace of the specimen. Preferably, the ultrasound images are segmented and processed by the ultrasound system in a manner that further assists in the determination of whether the specimen contains the entire tumor.
摘要翻译：根据优选实施例，从患者中提取含有肿瘤的标本102并悬浮在保持声导电液体的容器108中。使超声波探头与流体进行声学连通并扫描样本108，优选地在高于活人体组织上允许的最大超声功率的声功率设定。在输出显示器上观察由于sc增加的声功率而具有较高质量的所得到的样本的二维或三维超声图像，用于检查肿瘤的任何部分是否与标本。优选地，超声图像被分段和超声系统处理，以进一步有助于确定样本是否包含整个肿瘤的方式。

92. 发明申请

WO0015097A3 METHODS FOR USING RESONANT ACOUSTIC ENERGY TO DETECT OR EFFECT STRUCTURES 审中-公开
标题翻译：使用共振能量来检测或影响结构的方法
公开(公告)号：WO0015097A3
公开(公告)日：2000-07-06
申请号：PCT/US9920776
申请日：1999-09-10
申请人： BERKSHIRE LAB INC , BROOKS JULIANA H J , ABEL ALBERT E
发明人： BROOKS JULIANA H J , ABEL ALBERT E
IPC分类号： A01G7/04 , A01C1/00 , A01C1/08 , A01M1/00 , A01M29/00 , A61B5/05 , A61B8/00 , A61L2/02 , A61L2/08 , A61M1/36 , A61N5/00 , A61N5/02 , A61N7/00 , C12M1/34 , C12M1/42 , C12Q1/02 , C12Q1/06 , C12Q1/70 , G01N29/032 , G01N29/036 , G01N29/12 , A61B17/22 , A61B6/00
CPC分类号： A61B5/05 , A61B5/0093 , A61B5/415 , A61B5/417 , A61B8/00 , A61L2/0029 , A61L2/08 , A61N5/00 , A61N7/00 , C12M47/06 , G01N29/032 , G01N29/036 , G01N2291/014 , G01N2291/02466
摘要： The present invention makes use of resonant acoustic and/or acousto-EM energy applied to inorganic or biologic structures for the detection and/or identification, and for augmentation and/or disruption of function within the biologic structure. In particular, the invention provides a method of generating resonant acoustic and/or acousto-EM energy in biologic structures such as virus, bacteria, fungi, worms and tumors for the detection and disruption of these structures. Moreover, the invention provides a method of augmenting functions of biologic structures such as bone through the generation of resonant acoustic and/or acousto-EM energy in the structure. Systems are also provided for the generation and detection of resonant acoustic and/or resonant acousto-EM energy.
摘要翻译：本发明利用应用于无机或生物结构的共振声和/或声 - 电能用于检测和/或识别生物结构内的功能的增加和/或破坏。特别地，本发明提供了一种在诸如病毒，细菌，真菌，蠕虫和肿瘤的生物结构中产生共振声和/或声 - 电能的方法，用于检测和破坏这些结构。此外，本发明提供了一种通过在结构中产生共振声和/或声 - EM能量来增强诸如骨之类的生物结构功能的方法。还提供用于产生和检测谐振声和/或谐振声 - 电能的系统。

93. 发明申请

WO00015097A2 METHODS FOR USING RESONANT ACOUSTIC AND/OR RESONANT ACOUSTO-EM ENERGY TO DETECT AND/OR EFFECT STRUCTURES 审中-公开
标题翻译：使用共振声和/或共振触发能量来检测和/或影响结构的方法
公开(公告)号：WO00015097A2
公开(公告)日：2000-03-23
申请号：PCT/US1999/020776
申请日：1999-09-10
IPC分类号： A01G7/04 , A01C1/00 , A01C1/08 , A01M1/00 , A01M29/00 , A61B5/05 , A61B8/00 , A61L2/02 , A61L2/08 , A61M1/36 , A61N5/00 , A61N5/02 , A61N7/00 , C12M1/34 , C12M1/42 , C12Q1/02 , C12Q1/06 , C12Q1/70 , G01N29/032 , G01N29/036 , G01N29/12 , A61B
CPC分类号： A61B5/05 , A61B5/0093 , A61B5/415 , A61B5/417 , A61B8/00 , A61L2/0029 , A61L2/08 , A61N5/00 , A61N7/00 , C12M47/06 , G01N29/032 , G01N29/036 , G01N2291/014 , G01N2291/02466
摘要： The present invention makes use of resonant acoustic and/or acousto-EM energy applied to inorganic or biologic structures for the detection and/or identification, and for augmentation and/or disruption of function within the biologic structure. In particular, the invention provides a method of generating resonant acoustic and/or acousto-EM energy in biologic structures such as virus, bacteria, fungi, worms and tumors for the detection and disruption of these structures. Moreover, the invention provides a method of augmenting functions of biologic structures such as bone through the generation of resonant acoustic and/or acousto-EM energy in the structure. Systems are also provided for the generation and detection of resonant acoustic and/or resonant acousto-EM energy.
摘要翻译：本发明利用应用于无机或生物结构的共振声和/或声 - 电能用于检测和/或识别生物结构内的功能的增加和/或破坏。特别地，本发明提供了一种在诸如病毒，细菌，真菌，蠕虫和肿瘤的生物结构中产生共振声和/或声 - 电能的方法，用于检测和破坏这些结构。此外，本发明提供了一种通过在结构中产生共振声和/或声 - EM能量来增强诸如骨之类的生物结构功能的方法。还提供用于产生和检测谐振声和/或谐振声 - 电能的系统。

94. 发明申请

WO2017189512A1 RESONATOR FOR DETECTING SINGLE MOLECULE BINDING 审中-公开
标题翻译：检测单分子结合的谐振器
公开(公告)号：WO2017189512A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/029311
申请日：2017-04-25
申请人： QORVO US, INC.
发明人： WEBSTER, James
IPC分类号： G01N15/10 , G01H1/14 , G01H13/00 , G01N29/02
CPC分类号： G01N29/022 , G01H1/06 , G01H13/00 , G01N5/02 , G01N29/036 , G01N29/2443 , G01N33/557 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , G01N2291/106
摘要： Various embodiments of an apparatus for measuring binding kinetics of an interaction of an analyte material present in a fluid sample are disclosed. The apparatus includes a sensing resonator having at least one binding site for the analyte material; actuation circuitry adapted to drive the sensing resonator into an oscillating motion; measurement circuitry coupled to the sensing resonator and adapted to measure an output signal of the sensing resonator representing resonance characteristics of the oscillating motion of the sensing resonator; and a controller coupled to the actuation and measurement circuitry, wherein the controller is adapted to detect an individual binding event between the at least one binding site and a molecule of the analyte material.
摘要翻译：公开了用于测量流体样品中存在的分析物材料的相互作用的结合动力学的装置的各种实施例。该设备包括具有用于分析物材料的至少一个结合位点的感测谐振器; 致动电路，其适于将所述感测谐振器驱动为振荡运动; 测量电路，耦合到感测谐振器并且适于测量表示感测谐振器的振荡运动的谐振特性的感测谐振器的输出信号; 以及耦合到所述致动和测量电路的控制器，其中所述控制器适于检测所述至少一个结合位点与所述分析物材料的分子之间的个体结合事件。

95. 发明申请

WO2017023721A8 DETECTION OF BACTERIA USING BACTERIOPHAGE 审中-公开
标题翻译：用细菌检测细菌
公开(公告)号：WO2017023721A8
公开(公告)日：2017-03-23
申请号：PCT/US2016044621
申请日：2016-07-29
申请人： UNIV OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , DUQUESNE UNIV
发明人： KELLUM JOHN ALSTON , HEMPEL JOHN D , EDGAR ROBERT HUGH , VIATOR JOHN ANDREW
IPC分类号： C12Q1/06 , C12N7/00 , G01N15/14 , G01N29/24
CPC分类号： C12N7/00 , C12N2795/10321 , C12N2795/10331 , C12Q1/04 , G01N15/10 , G01N29/2425 , G01N2015/1006 , G01N2291/02466
摘要： A method of detecting a species, strain or type of bacteria includes mixing a labeled bacteriophage including a label that is detectible via a detection system with a bacterial culture including the species, strain or type of bacteria to which the labeled bacteriophage selectively binds and using the detection system to detect the labeled bacteriophage bound to the species, strain or type of bacteria.
摘要翻译：检测细菌种类，菌株或类型的方法包括将包含可通过检测系统检测的标记的标记噬菌体与包括标记噬菌体选择性结合的细菌种类，菌株或细菌类型的细菌培养物混合，并使用检测系统来检测结合到物种，菌株或细菌类型的标记的噬菌体。

96. 发明申请

WO2017023721A1 DETECTION OF BACTERIA USING BACTERIOPHAGE 审中-公开
标题翻译：使用细菌检测细菌
公开(公告)号：WO2017023721A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044621
申请日：2016-07-29
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , DUQUESNE UNIVERSITY
发明人： KELLUM, John, Alston , HEMPEL, John, D. , EDGAR, Rober, Hugh , VIATOR, John, Andrew
IPC分类号： C12Q1/06 , G01N15/14 , G01N29/24 , C12N7/00
CPC分类号： C12N7/00 , C12N2795/10321 , C12N2795/10331 , C12Q1/04 , G01N15/10 , G01N29/2425 , G01N2015/1006 , G01N2291/02466
摘要： A method of detecting a species, strain or type of bacteria includes mixing a labeled bacteriophage including a label that is detectible via a detection system with a bacterial culture including the species, strain or type of bacteria to which the labeled bacteriophage selectively binds and using the detection system to detect the labeled bacteriophage bound to the species, strain or type of bacteria.
摘要翻译：检测细菌的种类，菌株或类型的方法包括将包括可通过检测系统检测的标记的标记噬菌体与包括标记噬菌体选择性结合的物种，菌株或细菌类型的细菌培养物混合，并使用检测系统检测标记的噬菌体结合物种，菌株或细菌类型。

97. 发明申请

WO2016156446A1 ULTRASOUND SYSTEM AND METHOD OF VESSEL IDENTIFICATION 审中-公开
标题翻译：超声波系统及船舶识别方法
公开(公告)号：WO2016156446A1
公开(公告)日：2016-10-06
申请号：PCT/EP2016/056984
申请日：2016-03-31
申请人： KONINKLIJKE PHILIPS N.V.
发明人： CHEN, Jiangang , RAJU, Balasundar Iyyavu , LEYVI, Evgeniy
IPC分类号： A61B8/06 , A61B8/08 , A61B8/14 , A61B8/00
CPC分类号： A61B8/06 , A61B8/085 , A61B8/0891 , A61B8/14 , A61B8/4494 , A61B8/469 , A61B8/481 , A61B8/488 , A61B8/5223 , A61B8/523 , A61B8/5246 , A61B8/5284 , G01B17/00 , G01N29/2406 , G01N29/2437 , G01N2291/017 , G01N2291/02466
摘要： The present invention proposes an ultrasound system and method of identifying a vessel of a subject. The ultrasound system comprises: an ultrasound probe configured to simultaneously acquire a sequence of ultrasound blood flow data frames (such as a sequence of ultrasound Doppler data frames) and a sequence of ultrasound B-mode data frames of a region of interest including the vessel over a predetermined time period; a blood flow region selecting unit configured to select a blood flow region in the sequence of blood flow data frames; and a vessel segmenting unit configured to segment the vessel in at least one frame of the sequence of ultrasound B-mode data frames based on the selected blood flow region. Since there is no need to manually place any seed point for vessel segmentation any more, the user dependency is reduced and a fast measurement is made possible. Furthermore, since the segmentation of the vessel in a B-mode data frame makes use of information from multiple blood flow data frames, more robust, reliable segmentation can be achieved.
摘要翻译：本发明提出了一种识别受试者的血管的超声系统和方法。所述超声系统包括：超声探头，被配置为同时获取超声血流数据帧序列（例如超声多普勒数据帧序列）以及所述感兴趣区域的超声B模式数据帧序列，包括所述血管预定时间段; 血流区域选择单元，其构成为以血流数据帧的顺序选择血流区域; 以及血管分割单元，其被配置为基于所选择的血流区域在所述超声B模式数据帧序列的至少一帧中分割血管。由于不需要手动放置用于血管分割的任何种子点，因此减少了用户依赖性，并且可以进行快速测量。此外，由于B模式数据帧中的血管的分割利用来自多个血流数据帧的信息，因此可以实现更加鲁棒，可靠的分割。

98. 发明申请

WO2016030147A1 A BLOOD PROCESSING APPARATUS COMPRISING A HOLDER DEVICE FOR A MEASUREMENT DEVICE 审中-公开
标题翻译：包含用于测量装置的支架装置的血液加工装置
公开(公告)号：WO2016030147A1
公开(公告)日：2016-03-03
申请号：PCT/EP2015/067813
申请日：2015-08-03
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： SCHMIDT, Frank , STERNHEIMER, Ilka , MEISBERGER, Artur , MICHEL, Lars
IPC分类号： A61M1/02 , A61M1/36 , A61B5/145 , G01N29/00 , G01N33/49
CPC分类号： A61M1/0281 , A61B5/14535 , A61B5/4836 , A61B2560/0437 , A61M1/0209 , A61M1/0259 , A61M1/36 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M2205/12 , A61M2205/121 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , G01N29/024 , G01N29/222 , G01N2015/0065 , G01N2015/0092 , G01N2291/02466 , G01N2291/044
摘要： A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.
摘要翻译：血液处理装置（1）包括具有用于接收血液流体的至少一个腔室元件（80,81）的测量装置（8），其中所述至少一个腔室元件（80,81）沿着纵向轴线（L ），并且包括围绕所述纵向轴线（L）延伸的圆周壁（804,814），底壁（803,813）和顶壁（805,815），所述顶壁共同限定流动室（802,812），所述at 最后一个腔室元件（80,81）还包括用于允许血液流体流入所述流动室（802,812）的入口端口（800,810）和出口端口（801,811），用于允许血液流出流动室（802,812）。血液处理装置（1）还包括用于保持测量装置（8）的保持装置（9），保持装置（9）包括具有用于接收测量装置（8）的接收开口（900）的基座（90））和可移动地布置在基座（90）上的用于将测量装置（8）锁定在接收开口（900）中的插入位置的闭合元件（91）。保持器装置（9）的超声波传感器元件（92,93）布置在基座（90）上并且适于产生用于测量流动室中的血液流体的血细胞比容值（802）的超声波传感器信号（P），812）。这里，在测量装置（8）的插入位置的超声波传感器元件（92,93）面向用于传送超声信号的至少一个室元件（80,81）的底壁（803,813）（P）通过底壁（803,813）进入流动室（802,812）。以这种方式，提供了一种包括用于测量装置的保持装置的血液处理装置，其允许容易地将测量装置插入保持装置中，并且允许可靠地测量特别是通过测量的血流量的血细胞比容值设备。

99. 发明申请

WO2016030145A1 A BLOOD PROCESSING APPARATUS COMPRISING A MEASUREMENT DEVICE 审中-公开
标题翻译：包含测量装置的血液加工装置
公开(公告)号：WO2016030145A1
公开(公告)日：2016-03-03
申请号：PCT/EP2015/067811
申请日：2015-08-03
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： MEISBERGER, Artur , FAHRENDORFF, Melanie , STERNHEIMER, Ilka , MICHEL, Lars , SCHMIDT, Frank
IPC分类号： A61M1/02 , A61M1/36 , G01N29/00 , G01N33/49
CPC分类号： A61M1/3609 , A61M1/0209 , A61M1/025 , A61M1/0259 , A61M1/0281 , A61M1/36 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M2205/12 , A61M2205/121 , A61M2205/3313 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , G01N21/85 , G01N29/02 , G01N33/49 , G01N33/4915 , G01N2291/02466
摘要： A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.
摘要翻译：血液处理装置（1）包括具有用于测量血液流体的血细胞比容值的第一腔室元件（80）的测量装置（8），所述第一腔室元件（80）包括第一入口（800）用于允许从第一储存容器（2）流入第一室元件（80）的第一储存容器（2）和用于允许流出第一室元件（80）的第一出口（801）第二室元件（81）包括用于允许流入第二室元件（81）的第二入口（810）和可连接到第二储存容器（3）的第二出口（811），用于允许流出第二室元件（81）朝向第二储存容器（3）。血液处理装置还包括：第一泵机构（600），其用于从第一储存容器（2）向血液处理装置（1）向流动方向（F1）泵送血液流体;以及第二泵机构（610）用于从血液处理装置（1）朝向第二储存容器（2）将流体流（F2）的血液泵送。这里，第一泵机构（600）位于第一室元件（80）的第一入口（800）的上游，并且第二泵机构（610）位于第二泵机构（600）的第二入口端口（810）的上游室元件（81）。以这种方式，提供了包括测量装置的血液处理装置，其以容易且可靠的方式允许特别地测量进入的血流中的血细胞比容值以及输出的血流量。

100. 发明申请

WO2015110955A1 DEVICE FOR ULTRASOUND TESTS 审中-公开
标题翻译：用于超声测试的设备
公开(公告)号：WO2015110955A1
公开(公告)日：2015-07-30
申请号：PCT/IB2015/050434
申请日：2015-01-20
申请人： PROMEDICA BIOELECTRONICS S.R.L. , BARBATO, Gaetano , IMAGE GUIDED THERAPY SA
发明人： BARBATO, Gaetano , CATALLO, Nadia , CORSO, Cristiano , SCOARUGHI, Gian Luca , DUMONT, Erik
IPC分类号： C12M1/42 , A61K41/00 , G01N29/22
CPC分类号： G01N29/27 , C12M35/04 , G01N29/222 , G01N29/346 , G01N29/348 , G01N33/4833 , G01N2291/02466
摘要： A device (1) for ultrasound tests, comprising one or more transducers (4) for generating ultrasound beams with different powers and/or frequencies to be projected in direction of a plurality of targets (11), guaranteeing the separate control of the temperature both of the targets and of the transducers and it allows performing several tests contemporarily, by optimizing the functionality and the efficiency of the device, at the same time by guaranteeing results comparable therebetween for each test, and to this purpose it comprises: a first supporting structure (3) having at least a closed chamber (7; 23) receiving the body of said one or more transducers (4) and it is isolated from a propagation liquid medium, by leaving exposed each respective vibrating surface in contact with said liquid medium at a prefixed distance from the respective targets (11), the closed chamber containing a thermorefrigerating fluid in contact with the body of said one or more transducers; a second supporting structure (10) for said targets (11); means for refrigerating, through said thermorefrigerating fluid, the body of said one or more transducers (4); and means for keeping the liquid medium, which dampens said targets (11), at a predetermined temperature.
摘要翻译： 1.一种用于超声波测试的装置（1），包括用于产生具有不同功率和/或频率的超声波束的多个换能器（4），以在多个目标（11）的方向上投射，保证了两者的温度的单独控制的目标和传感器，并且它允许通过优化设备的功能和效率同时执行几个测试，同时通过保证每个测试的可比性，并且为此目的，它包括：第一支撑结构（3）至少具有接收所述一个或多个换能器（4）的主体的封闭腔（7; 23），并且通过使每个相应的振动表面与所述液体介质接触而将其与传播液体介质隔离距离各个目标（11）的预定距离，所述封闭室包含与所述一个或多个换能器的主体接触的热致冷流体; 用于所述目标（11）的第二支撑结构（10）; 用于通过所述制冷剂流体冷却所述一个或多个换能器（4）的主体的装置; 以及用于保持将所述目标（11）抑制在预定温度的液体介质的装置。

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