专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明申请

WO0009757A9 OPTICALLY CHARACTERIZING POLYMERS 审中-公开
标题翻译：光学表征聚合物
公开(公告)号：WO0009757A9
公开(公告)日：2000-10-12
申请号：PCT/US9918438
申请日：1999-08-13
申请人： US GENOMICS INC , UNIV PRINCETON
发明人： TEGENFELDT JONAS O , AUSTIN ROBERT H , CHAN EUGENE Y
IPC分类号： G01N31/20 , C12Q1/68 , G01N21/64 , G01N27/02 , G01N27/416 , G01N27/447 , G01N33/44 , G01N33/50 , G01N33/58 , G01N37/00
CPC分类号： G01N21/648 , B82Y20/00 , G01N21/6428 , G01N33/442 , G01N2021/6441
摘要： The invention is a system for optically characterizing polymers. Preferably the system is used to perform linear analysis of the polymers.
摘要翻译：本发明是用于光学表征聚合物的系统。优选地，该系统用于对聚合物进行线性分析。

92. 发明申请

WO00012759A1 BIOCHIP DETECTION SYSTEM 审中-公开
标题翻译：生物检测系统
公开(公告)号：WO00012759A1
公开(公告)日：2000-03-09
申请号：PCT/US1999/019759
申请日：1999-08-25
IPC分类号： G01N21/64 , G01N33/53 , G01N33/566 , G01N33/58 , G01N37/00 , C12Q1/68 , G01N33/543
CPC分类号： G01N21/6452 , B01J2219/00274 , G01N2021/6419 , G01N2021/6441
摘要： A biochip detection system detects and locates samples that are labeled with multiple fluorescent tags and are located on a biochip. This biochip detection system includes a charge coupled device (CCD) sensor, a broad spectrum light source, a lens, a light source filter, and a sensor filter. The CCD sensor comprises two dimensional CCD arrays to simultaneously detect light waves from at least a substantial portion of the biochip. The broad spectrum light source is optically coupled to the CCD sensor and is configured to be utilized with a variety of different fluorescent tags which have differing excitation wavelengths. The lens and the CCD sensor are optimized and matched to each other such that the sensor operates at or below the diffraction rating of the lens. Further, the resolution of the CCD sensor is matched to the samples on the biochip such that the CCD sensor oversamples each of the samples a sufficient number of times. Additionally, the lens is configured to frame at least a substantial portion of the biochip. The biochip detection system is optimized to provide a higher dynamic range, increased sensitivity, and faster throughput compared to system utilizing laser scanners. Further, the biochip detection system is capable of utilizing a same broad spectrum light source to excite samples labeled with a variety of fluorescent tags.
摘要翻译：生物芯片检测系统检测并定位标有多个荧光标签并位于生物芯片上的样品。该生物芯片检测系统包括电荷耦合器件（CCD）传感器，广谱光源，透镜，光源滤光器和传感器滤光器。 CCD传感器包括二维CCD阵列，以同时检测至少大部分生物芯片的光波。广谱光源光学耦合到CCD传感器，并且被配置为与具有不同激发波长的各种不同的荧光标签一起使用。透镜和CCD传感器被优化并彼此匹配，使得传感器在等于或低于透镜的衍射等级下工作。此外，CCD传感器的分辨率与生物芯片上的样本相匹配，使得CCD传感器对每个样本进行过采样足够的次数。另外，透镜配置成框架生物芯片的至少大部分。与使用激光扫描仪的系统相比，生物芯片检测系统被优化以提供更高的动态范围，增加的灵敏度和更快的吞吐量。此外，生物芯片检测系统能够利用相同的广谱光源来激发用各种荧光标签标记的样品。

93. 发明申请

WO98035012A2 METHODS AND PRODUCTS FOR ANALYZING POLYMERS 审中-公开
标题翻译：分析聚合物的方法和产品
公开(公告)号：WO98035012A2
公开(公告)日：1998-08-13
申请号：PCT/US1998/003024
申请日：1998-02-11
IPC分类号： G01N33/50 , B01L3/00 , C12N15/09 , C12Q1/68 , G01N21/03 , G01N21/05 , G01N21/64 , G01N21/78 , C12M1/34
CPC分类号： C12Q1/6869 , B01J2219/00707 , B01L3/5027 , C12Q1/6809 , G01N21/05 , G01N21/6428 , G01N33/48721 , G01N2021/0346 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , Y10S435/97 , Y10S435/973 , C12Q2565/631
摘要： Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.
摘要翻译：提供了分析聚合物的方法和产品。该方法包括确定聚合物各种其它结构性质的方法。

94. 发明申请

WO1994018547A1 APPARATUS FOR QUANTITATIVE IMAGING OF MULTIPLE FLUROPHORES 审中-公开
标题翻译：用于定量成像多种植物的设备
公开(公告)号：WO1994018547A1
公开(公告)日：1994-08-18
申请号：PCT/IB1994000019
申请日：1994-02-01
申请人： ASLUND, Nils, R., D. , CARLSSON, Kjell, S.
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6408 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6423 , G01N2021/6441
摘要： A quantitative fluorometer for multiple fluorophores having a separate time-modulated beam of excitation light for each fluorescent target (26). Each beam is synchronized with one or more detectors (114 and 116) and separate lock-in amplifiers (30 and 32). The fluorophores are simultaneously excited and the combined fluorescent emission is resolved into components corresponding to each fluorophore. Confocal scanning means (24) are used to excite and detect fluorescent emission from locations throughout a volume. The location specific output of each amplifier is stored in a computer (34) which resolves the emission into the components corresponding to each fluorophore. The location specific data may be further processed or visually displayed to provide simultaneously fluorescence lifetime images of two fluorophores with this frequency domain method. Multiple amplifiers for each detector channel allow phase discrimination in each channel so that prompt and delayed fluorescence may be measured, allowing use of multiple fluorophores in each detector channel.
摘要翻译：用于多个荧光团的定量荧光计，其具有用于每个荧光靶（26）的单独的时间调制的激发光束。每个光束与一个或多个检测器（114和116）和分离的锁定放大器（30和32）同步。荧光团同时被激发，并且组合的荧光发射被分解成对应于每个荧光团的组分。共焦扫描装置（24）用于激发和检测整个体积中的位置的荧光发射。每个放大器的位置特定输出被存储在计算机（34）中，该计算机将发射分解成对应于每个荧光团的组分。位置特定数据可以进一步处理或视觉显示，以提供具有该频域方法的两个荧光团的荧光寿命图像。每个检测器通道的多个放大器允许每个通道中的相位辨别，从而可以测量即时和延迟的荧光，从而允许在每个检测器通道中使用多个荧光团。

95. 发明申请

WO1992013264A1 METHOD OF MEASURING LUMINESCENCE IN AN ASSAY BY LUMINESCENCE 审中-公开
标题翻译：通过荧光测定测定中的发光的方法
公开(公告)号：WO1992013264A1
公开(公告)日：1992-08-06
申请号：PCT/FR1992000069
申请日：1992-01-27
申请人： CIS BIO INTERNATIONAL , MABILE, Michel , MATHIS, Gérard , JOLU, Etienne, Jean-Pierre , POUYAT, Dominique
发明人： CIS BIO INTERNATIONAL
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/274 , G01N33/582 , G01N2021/6421 , G01N2021/6441 , Y10S435/962 , Y10S435/968 , Y10S435/973 , Y10S436/825 , Y10T436/13
摘要： A method for measuring luminescence in an assay by luminescence is described wherein certain disturbances due to the measuring medium can be corrected. The method is characterized in that it employs at least one luminescent tracer compound and a luminescent compound used as an internal reference which, when exposed to the same excitation wavelength, are capable of emission at different wavelengths, μ2 et μ1 respectively, either by direct luminescence or by induction of luminescent emission, and that the measurement of tracer compound luminescence at wavelength μ2 is corrected on the basis of the measurement of reference compound luminescence at wavelength μ1. The use of the method in a homogeneous analyte detection and/or determination process, and a device for its implementation, are also described.

96. 发明申请

WO1992004618A1 SELF-COMPENSATING FOCS AND OTHER CHEMICAL SENSORS 审中-公开
标题翻译：自我补偿和其他化学传感器
公开(公告)号：WO1992004618A1
公开(公告)日：1992-03-19
申请号：PCT/US1991004212
申请日：1991-06-13
申请人： FIBERCHEM, INC.
发明人： FIBERCHEM, INC. , KLAINER, Stanley, M. , GOSWANI, Kisholoy
IPC分类号： G01N21/76
CPC分类号： G01N21/7703 , G01J3/427 , G01N21/648 , G01N2021/6421 , G01N2021/6432 , G01N2021/6434 , G01N2021/6441 , G01N2021/7786
摘要： A chemical sensor, such as a fiber optic chemical sensor, is self-calibrated by measuring two output values which behave differently in response to an analyte, and forming a ratio between the two measured output values to cancel out effects of variations in external factors such as temperature variations differences between coatings, light (illuminator) variations, fouling, bleaching, leaching or the like. An indicator material may be used which produces both fluorescence and phosphorence, both monomer and aggregate emission or absorption bands, emission or absorption bands with or without an isosbestic point, emission peaks at one wavelength at two different excitation bands, or emission peaks at two wavelengths for excitation at two wavelengths.

97. 发明申请

WO2017172005A2 SINGLE MOLECULE TIMERS AND CLOCKS 审中-公开
标题翻译：单分子计时器和时钟
公开(公告)号：WO2017172005A2
公开(公告)日：2017-10-05
申请号：PCT/US2017/015057
申请日：2017-01-26
申请人： DANA-FARBER CANCER INSTITUTE, INC.
发明人： JOHNSON-BUCK, Alexander, E. , SHIH, William, M. , NATHWANI, Bhavik
CPC分类号： C12Q1/682 , C12Q1/6853 , G01N21/6428 , G01N21/6458 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , C12Q2525/301 , C12Q2525/307 , C12Q2531/119 , C12Q2563/107 , C12Q2565/601
摘要： The present disclosure provides, in some aspects, single-molecule timers and clocks, systems and methods for kinetically encoded imaging.
摘要翻译：在一些方面，本公开提供了用于动力学编码成像的单分子定时器和时钟，系统和方法。

98. 发明申请

WO2017112634A1 SPECTRALLY AND SPATIALLY MULTIPLEXED FLUORESCENT PROBES FOR IN SITU CELL LABELING 审中-公开
标题翻译：用于原位细胞标记的光谱和空间复合荧光探针
公开(公告)号：WO2017112634A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067684
申请日：2016-12-20
申请人： VERILY LIFE SCIENCES LLC
发明人： WU, Cheng-Hsun , ACOSTA, Victor, Marcel , PEIKON, lan , LEBEL, Paul , SCHWARTZ, Jerrod, Joseph
IPC分类号： G01J3/02 , G01J3/18 , G02B21/36 , G02B5/18 , G02B26/08 , G01N21/64
CPC分类号： G01N21/6458 , G01J3/0208 , G01J3/021 , G01J3/0224 , G01J3/0229 , G01J3/0237 , G01J3/08 , G01J3/14 , G01J3/18 , G01J3/2823 , G01J3/32 , G01J3/4406 , G01J2003/1213 , G01J2003/2826 , G01N21/6408 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463 , G01N2201/0633 , G01N2201/0675 , G02B5/1828 , G02B21/16 , G02B21/361 , G02B21/367 , G02B26/0808 , G02B26/0833 , G02F1/29 , G02F2201/34 , G02F2203/12 , G06T7/90 , G06T2207/10004 , G06T2207/10056
摘要： Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.
摘要翻译：提供了用于识别生物环境中的空间和光谱复用探针的方法。这些探针通过探针的荧光团的排序和颜色来识别。所提供的装置和方法便于确定这种荧光团的位置和颜色，从而可以识别探针。在一些实施例中，通过将来自目标环境的光施加到可用于控制检测到的光的色散的方向和大小的空间光调制器来识别探针; 对应于多个不同空间光调制器设置的目标的多个图像可被解卷积并用于确定荧光团的颜色和位置。在一些实施例中，来自目标区域的光可以同时在空间和光谱上成像。随着时间的推移空间和光谱图像之间的相关性可用于确定目标中荧光团的颜色。

99. 发明申请

WO2017093266A2 METHOD FOR DETERMINING HAEMOSTASIS UNDER SHEAR 审中-公开
标题翻译：确定血液回流的方法
公开(公告)号：WO2017093266A2
公开(公告)日：2017-06-08
申请号：PCT/EP2016/079159
申请日：2016-11-29
申请人： UNIVERSITEIT MAASTRICHT , ACADEMISCH ZIEKENHUIS MAASTRICHT
发明人： VERDOOLD, Remco , WITT, DE, Susanne , COSEMANS, Judith , HEEMSKERK, Johan
IPC分类号： G01N21/64 , G01N33/86 , G01N21/05
CPC分类号： G01N21/6428 , G01N21/05 , G01N33/86 , G01N2021/056 , G01N2021/6441 , G01N2021/7763 , G01N2021/7786 , G01N2021/7793
摘要： The present invention relates to a method for monitoring of coagulation status and haemostasis in the perioperative setting. The invention also relates to an apparatus for applying said method, and to a cartridge applicable in said method, wherein said cartridge is a flow cell. Furthermore, the invention relates to the use of said method, said apparatus and said cartridge for assessing coagulation status or thrombus formation in a whole blood sample. In addition, the invention relates to a kit of parts comprising disposables required for applying said method of the invention with the apparatus of the invention.
摘要翻译：本发明涉及一种监测围手术期凝血状态和止血的方法。本发明还涉及一种用于应用所述方法的设备，并且涉及一种适用于所述方法的盒，其中所述盒是流动池。此外，本发明涉及所述方法，所述设备和所述盒的用途，用于评估全血样品中的凝血状态或血栓形成。另外，本发明涉及一套包括用于将本发明的所述方法应用于本发明的设备所需的一次性部件的套件。

100. 发明申请

WO2017079688A1 SYSTEMS AND METHODS FOR OPTOGENETIC IMAGING 审中-公开
标题翻译：用于OPTOGENETIC成像的系统和方法
公开(公告)号：WO2017079688A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/060717
申请日：2016-11-04
申请人： INSCOPIX, INC.
发明人： TRULSON, Mark, O. , STAMATAKIS, Alice , VISSCHER, Koen
IPC分类号： G01N21/25 , G01N21/64 , G02B21/16 , G02B27/02
CPC分类号： G01N21/6458 , A61B5/0059 , A61B5/0071 , A61B5/04001 , G01N2021/6439 , G01N2021/6441 , G02B3/14 , G02B21/025 , G02B21/06 , G02B21/16
摘要： Provided herein are systems and methods for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.
摘要翻译：本文提供了使用显微镜系统同时成像和刺激的系统和方法。与普通显微镜系统相比，显微镜系统可以具有相对较小的尺寸。显微镜可以部分包括成像光源和刺激光源。来自成像光源和刺激光源的光可以在光谱上分离以减少刺激光和成像光之间的串扰。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式