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    • 93. 发明申请
    • METHOD OF PREPARING A POLYVINYLPYRROLIDONE-HALOGEN COMPLEX OF IMPROVED STABILITY
    • 制备改进稳定性的聚乙烯吡咯烷酮 - 卤化物复合物的方法
    • WO1987006134A1
    • 1987-10-22
    • PCT/US1987000526
    • 1987-03-13
    • GAF CORPORATION
    • GAF CORPORATIONBARABAS, Eugene, S.
    • A61K31/79
    • A01N59/12
    • Process for making a highly stable polyvinylpyrrolidone-halogen complex by forming a reaction solution in a diffusion zone containing a 3 to 9 percent aqueous solution of polyvinylpyrrolidone and halogen dissolved in an alcohol solution wherein the concentration of alcohol is not less than 40 % of the total solutions and wherein a portion of the halogen requirement, up to 35 %, may be in the form of hydrogen halide or a salt thereof; reacting the polypyrrolidone and halogen components and forming a water/alcohol azeotrope simultaneously with the corresponding polyvinylpyrrolidone-halogen complex; subjecting the reacted mixture to azeotropic distillation to remove an aqueous alcohol distillate; recycling the distillate to the halogen solubilizing or diffusion zone and subjecting the remaining liquid product solution, containing not more than about 35 % solids, to spray drying to recover the polyvinylpyrrolidone/halogen product in the form of a particulate solid wherein each particle is of a uniform brownish yellow color throughout.
    • 通过在含有3〜9%聚乙烯吡咯烷酮水溶液和溶解在醇溶液中的卤素的扩散区中形成反应溶液来制备高度稳定的聚乙烯吡咯烷酮 - 卤素络合物的方法,其中酒精浓度不低于总量的40% 溶液,其中卤素需求的一部分高达35%可以​​是卤化氢或其盐的形式; 使聚吡咯烷酮和卤素组分反应,并与相应的聚乙烯吡咯烷酮 - 卤素络合物同时形成水/醇共沸物; 对反应后的混合物进行共沸蒸馏以除去醇酒精馏出物; 将馏出物再循环到卤素增溶或扩散区,并使含有不超过约35%固体的剩余液体产物溶液喷雾干燥以回收颗粒状固体形式的聚乙烯吡咯烷酮/卤素产物,其中每个颗粒为 均匀的棕黄色贯穿整个颜色。