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91. 发明申请

WO1996010563A1 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS 审中-公开
标题翻译： 2-ARYL-4-QUINOLONES作为抗菌化合物
公开(公告)号：WO1996010563A1
公开(公告)日：1996-04-11
申请号：PCT/US1995012589
申请日：1995-09-28
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEE, Kuo-Hsiung , KUO, Sheng-Chu , WU, Tian-Shung , WANG, Hui, Kang , LI, Leping
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , A61K31/47 , A61K31/4709 , A61K31/5377
摘要： A method of inhibiting tumor-cell growth in a mammalian subject, by administering a therapeutically effective amount of selected 2-phenyl-4-quinolone compounds represented by formula (5), wherein X is selected from the group consisting of H, F, C1, Br, I, CH3, CF3, OH, OCH3, OCF3, OCH2CH3, NH2, NHCH3, N(CH3)2, O-benzyl, -C(=O)-R0, -C(=O)-OR0, where R0 is a lower alkyl group; and where R1 and R2 (i) are lower alkyl groups or (ii) taken together, form a chain having the form -(CH2)m Y(CH2)n-, where Y is CH2, O, or S; m and n are each greater than 1; and the sum of m and n is between 3 and 6.
摘要翻译：一种抑制哺乳动物受试者肿瘤细胞生长的方法，通过施用治疗有效量的由式（5）表示的选择的2-苯基-4-喹诺酮化合物，其中X选自H，F，C 1 ，Br，I，CH3，CF3，OH，OCH3，OCF3，OCH2CH3，NH2，NHCH3，N（CH3）2，O-苄基，-C（= O）-R0，-C（= O）-OR0， R 0是低级烷基; 并且其中R 1和R 2（i）是低级烷基或（ii）一起形成具有 - （CH 2）m Y（CH 2）n - 形式的链，其中Y是CH 2，O或S; m和n分别大于1; m和n之和在3和6之间。

92. 发明申请

WO1995035115A1 DNA ENCODING AN 18 Kd CDK6 INHIBITING PROTEIN 审中-公开
标题翻译：编码18Kd CDK6抑制蛋白的DNA
公开(公告)号：WO1995035115A1
公开(公告)日：1995-12-28
申请号：PCT/US1995007816
申请日：1995-06-20
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , THE UNIVERSITY OF MICHIGAN , XIONG, Yue , GUAN, Kunliang
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , THE UNIVERSITY OF MICHIGAN
IPC分类号： A61K38/18
CPC分类号： C12N9/12 , A61K38/00 , C07K14/4738
摘要： A nucleic acid encoding a CDK inhibiting protein, particularly a CDK6 inhibiting protein, is selected from the group consisting of: (a) DNA having the nucleotide sequence given herein as SEQ ID NO:1 (which encodes the protein having the amino acid sequence given herein as SEQ ID NO:2), and which are referred to as p18 ; (b) nucleic acids which hybridize to DNA of (a) above and which encode a CDK inhibiting protein; and (c) nucleic acids which differs from the DNA of (a) or (b) above due to the degeneracy of the genetic code, and which encodes a CDK inhibiting protein encoded by a DNA of (a) or (b) above. Constructs containing such DNA, cells containing such constructs, proteins encoded by such DNA, antibodies which bind thereto, antisense oligonucleotides corresponding to such DNA, and methods of using the same are also disclosed.
摘要翻译：编码CDK抑制蛋白质，特别是CDK6抑制蛋白质的核酸选自：（a）具有本文给出的核苷酸序列的SEQ ID NO：1的DNA（其编码具有给定氨基酸序列的蛋白质）本文作为SEQ ID NO：2），其被称为p18 ; （b）与上述（a）的DNA杂交并编码CDK抑制蛋白质的核酸; 和（c）由于遗传密码的简并性而编码由上述（a）或（b）的DNA编码的CDK抑制蛋白的上述（a）或（b）的DNA不同的核酸。还公开了含有此类DNA的构建体，含有此类构建体的细胞，由此DNA编码的蛋白质，与其结合的抗体，对应于该DNA的反义寡核苷酸及其使用方法。

93. 发明申请

WO1994022927A1 SYNTHESIS OF AMINATED PVCS BY CONTROLLED REACTION WITH PIPERAZINE 审中-公开
标题翻译：通过与哌嗪的控制反应合成胺化PVCS
公开(公告)号：WO1994022927A1
公开(公告)日：1994-10-13
申请号：PCT/US1994003751
申请日：1994-04-06
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , KUSY, Robert, P. , COSOFRET, Vasile, V. , WHITLEY, John, Q. , LINDNER, Erno , BUCK, Richard, P.
IPC分类号： C08F08/30
CPC分类号： H01M2/1653 , C08F8/30 , G01N31/221 , C08F114/06 , C08F214/08
摘要： Disclosed are a copolymer composition comprising a substituted halo-polymer wherein from about 0.01 % to about 20 % by weight of the halo moieties therein are replaced with piperazine, and a flexible plastic film made from the copolymer. The copolymer is inherently conductive.
摘要翻译：公开了包含取代的卤代聚合物的共聚物组合物，其中约0.01％至约20％重量的其中的卤素部分被哌嗪代替，以及由共聚物制成的柔性塑料膜。共聚物固有导电性。

94. 发明申请

WO1994020840A1 TWO DIMENSIONAL SEPARATION SYSTEM 审中-公开
标题翻译：两维分离系统
公开(公告)号：WO1994020840A1
公开(公告)日：1994-09-15
申请号：PCT/US1994001863
申请日：1994-02-22
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , JORGENSON, James, W. , LEMMO, Anthony, V.
IPC分类号： G01N27/26
CPC分类号： G01N30/38 , G01N27/44743 , G01N27/44773 , G01N30/02 , G01N30/461 , G01N30/463 , G01N2030/027 , G01N2030/383
摘要： The system comprises a flow gating interface having an effluent channel and a gating channel (36) formed therein. The gating channel (36) transversely intersects the efluent channel at an intersection portion so that the channels are in fluid communication with one another. The intersection portion divides the effluent channel into an upstream portion and a downstream portion, and divides the gating channel (36) into an upstream portion and a dowstream portion. A liquid chromatography column (34) is inserted into the effluent channel upstream portion and an electrophoresis capillary (35) is inserted into the effluent channel downstream portion. A flush solution inlet line (44) is connected to the gating cahanel upstream portion, and a flush solution outlet line (45) is connected to the gating channel downstream portion. A valve (41) regulates the flow of flush solution from flush solution inlet line (44) to the gating channel upstream portion.
摘要翻译：该系统包括具有流出通道的流动门控接口和其中形成的门控通道（36）。门控通道（36）在交叉部分处与流出液通道横向相交，使得通道彼此流体连通。交叉部分将流出通道分成上游部分和下游部分，并将浇口通道（36）分成上游部分和下游部分。将液相色谱柱（34）插入流出物通道上游部分，并将电泳毛细管（35）插入流出物通道下游部分。冲洗溶液入口管线（44）连接到门控上游部分，并且冲洗出口管线（45）连接到门控通道下游部分。阀（41）调节冲洗溶液从冲洗溶液入口管线（44）到浇口通道上游部分的流动。

95. 发明申请

WO1994006150A1 METHOD FOR PLASMA PROCESSING AT HIGH PRESSURES 审中-公开
标题翻译：高压等离子体处理方法
公开(公告)号：WO1994006150A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008202
申请日：1993-08-31
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , HOOKE, William, M. , BOZEMAN, Steven, P.
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： H01J37/32
CPC分类号： H01J37/32357
摘要： A method for plasma processing includes using a relatively high magnetic field and a relatively high pressure to create a first plasma region adjacent a window of a processing chamber having a lower radiation absorption and a second plasma region adjacent a substrate holder having a higher radiation absorption. Accordingly, a cooler plasma region is created adjacent the window to prevent contaminants from being etched from the window and adjacent chamber surface, and hotter plasma region is created adjacent the substrate to increase the processing rate. Additionally, the relatively high pressure of the processing gas, preferably greater than about 10 Torr and more preferably greater than about 100 Torr, increases the density of the plasma thereby increasing the processing rate. Alternatively, a high magnetic field and a high pressure create a radiation absorption region which is on the order of centimeters thick, for example 5-10 centimeters thick. Preferably, a uniform magnetic field creates uniform absorption in the absorption region.
摘要翻译：一种用于等离子体处理的方法包括使用相对高的磁场和相对高的压力来产生邻近具有较低辐射吸收的处理室的窗口的第一等离子体区域和与具有较高辐射吸收的衬底保持器相邻的第二等离子体区域。因此，在窗口附近产生较冷的等离子体区域，以防止污染物从窗口和相邻的室表面被蚀刻，并且在衬底附近产生较热的等离子体区域以增加处理速率。此外，加工气体的较高压力，优选大于约10托，更优选大于约100托，增加了等离子体的密度，从而提高了加工速率。或者，高磁场和高压产生约为厘米厚的辐射吸收区域，例如5-10厘米厚。优选地，均匀的磁场在吸收区域中产生均匀的吸收。

96. 发明申请

WO1993023997A1 PHARMACEUTICALLY ACCEPTABLE FIXED-DRIED HUMAN BLOOD PLATELETS 审中-公开
标题翻译：药物可接受的固定式人体血液平板
公开(公告)号：WO1993023997A1
公开(公告)日：1993-12-09
申请号：PCT/US1993004142
申请日：1993-04-28
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , EAST CAROLINA UNIVERSITY , READ, Marjorie, S. , REDDICK, Robert, L. , BODE, Arthur, P.
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , EAST CAROLINA UNIVERSITY
IPC分类号： A01N01/02
CPC分类号： A61L27/50 , A01N1/0221 , A01N1/0231 , A61K35/19 , A61K38/1858 , A61L15/40 , A61L17/005 , A61L26/0047 , A61L26/0057 , A61L26/0066 , A61L27/227 , A61L27/3804 , A61L27/60 , A61L2300/414 , A61L2300/418 , A61L2300/602 , A61L2300/64 , A61L2400/04
摘要： Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
摘要翻译：公开了固定干燥的人血小板及其制备方法。重建后的血小板：粘附于血栓形成的表面; 不粘附于非血栓形成的表面; 在粘附于血栓形成的表面时经历形状变化（扩散）; 彼此粘附以在粘附于血栓形成表面时形成止血塞; 并释放其颗粒内容。还公开了含有该制剂的药物制剂。血小板优选通过固定剂如甲醛，多聚甲醛或戊二醛固定，或通过高锰酸盐固定物固定。血小板优选通过冻干干燥。

97. 发明申请

WO1993019166A1 SMALL ANIMAL MODEL FOR STUDYING CHOLESTEROL METABOLISM 审中-公开
标题翻译：用于研究胆固醇代谢的小动物模型
公开(公告)号：WO1993019166A1
公开(公告)日：1993-09-30
申请号：PCT/US1993002542
申请日：1993-03-22
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , MAEDA, Nobuyo , SMITHIES, Oliver
IPC分类号： C12N05/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0362 , A61K38/00 , A61K49/0008 , C07K14/775
摘要： Mouse animal models are provided for studying lipid metabolism defects and the indications resulting therefrom. Specific genes associated with lipid metabolism are targeted for inactivation by homologous recombination, particularly apoE, apoAI, apoB, apoCIII and hepatic lipase, and homozygous mice are produced, competent to retain the defect in the germ line. The resulting mice may be used for the study of lipid metabolic disorders, as well as the effect of drugs on the disorders and the genetic defect.
摘要翻译：提供小鼠动物模型用于研究脂质代谢缺陷及其引起的适应症。与脂质代谢相关的特定基因是通过同源重组，特别是apoE，apoAI，apoB，apoCIII和肝脂肪酶进行失活的靶向，并且产生纯合小鼠，能够在胚系中保留缺陷。所得到的小鼠可用于研究脂代谢紊乱，以及药物对疾病和遗传缺陷的影响。

98. 发明申请

WO1992020437A1 MICROELECTROSPRAY METHOD AND APPARATUS 审中-公开
标题翻译：微电子方法和装置
公开(公告)号：WO1992020437A1
公开(公告)日：1992-11-26
申请号：PCT/US1992004015
申请日：1992-05-14
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , JORGENSON, James, W. , DOHMEIER, Daniel, M.
IPC分类号： B01D59/44
CPC分类号： H01J49/165 , G01N30/72
摘要： A method of generating an electrospray from a solution is disclosed which is useful for electrospraying at low flow rates, for electrospraying directly into a vacuum, or both. The method comprises the steps of causing the solution to flow through a capillary tube (10) to an outlet opening (14) formed in the terminal portion (13) thereof. The capillary tube terminal portion has an inner diameter of not more than 50 micrometers and an outer diameter of not more than 150 micrometers. An electrical potential difference is provided between the capillary tube terminal portion (13) and a conductor (26) spaced from said terminal portion, with the potential sufficient to cause the solution to electrospray from the capillary outlet.

99. 发明申请

WO1991008289A1 SPERM SPECIFIC NUCLEAR AUTOANTIGENIC PROTEIN 审中-公开
标题翻译： SPERM特异性核自动蛋白
公开(公告)号：WO1991008289A1
公开(公告)日：1991-06-13
申请号：PCT/US1990006869
申请日：1990-11-23
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , O'RAND, Michael, G. , ZIMMERMAN, Lisa, J. , WELCH, Jeffrey, E.
IPC分类号： C12N15/12
CPC分类号： G01N33/689 , C07K14/4713 , G01N33/564 , G01N2800/367
摘要： Disclosed is a DNA sequence which codes for Sperm Nuclear Autoantigenic Protein (SNAP) or a fragment thereof. Essentially pure SNAP is also disclosed. The DNA sequence which codes for human SNAP and the DNA sequence which codes for rabbit SNAP are specifically disclosed. SNAP is useful as an immunocontraceptive agent and in the diagnosis of autoimmune infertility.
摘要翻译：公开了编码精子核自身抗原蛋白（SNAP）或其片段的DNA序列。也披露了基本纯SNAP。具体公开编码人SNAP的DNA序列和编码兔SNAP的DNA序列。 SNAP可用作免疫避孕药和自身免疫性不孕症的诊断。

100. 发明申请

WO1990009788A1 ETOPOSIDE ANALOGUES 审中-公开
公开(公告)号：WO1990009788A1
公开(公告)日：1990-09-07
申请号：PCT/US1990000842
申请日：1990-02-23
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEE, Kuo-Hsiung , WANG, Zhe, Qing , CHENG, Yung-Chi , LIU, Su-Ying , IMAKURA, Yasuhiro , HARUNA, Mitsumasa , BEERS, Scott, A. , THURSTON, Lee, S. , DAI, Hua-Juan , CHEN, Chung-Hsiung , BOWEN, Phillip, J. , SCHNUR, Dora, M. , KUO, Yao, Haur , MORI, Masami
IPC分类号： A61K31/34
CPC分类号： C07D493/04
摘要： Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have formula (I), where R1 is beta -OCH2CH2NH2, beta -NHCH(CH3)CH2OH, beta -NHCH2CH(CH3)OH, beta -Cl, beta -Br, beta -OH, alpha -OH, beta -NH2, alpha -NH2, beta -NHCH2CH2OH, alpha -NHCH2CH2OH, beta -NHCH2CH2CH3, beta -NHCH2CH2OCH3, beta -NHCH2CH=CH2, beta -NHCH2CH(OH)CH3, beta -NHCH2CH2CH2OH, beta -OCH2CH2OH, (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p), (q), (r), (s), (t), (u), (v) or (w). R2 is H, or Br; R3 is H, or Br; R4 is H, or Br; R5 is H, or Br; and R6 is H, or -CH3.
摘要翻译：公开了依托泊苷的类似物并表现出抗肿瘤活性的化合物。本发明的化合物具有式（I），其中R 1为β-OCH 2 CH 2 NH 2，β-NHCH（CH 3）CH 2 OH，β-NHCH 2 CH（CH 3）OH，β-Cl，β-B，β-OH，α-OH ，β-NH 2，α-NH 2，β-NHCH 2 CH 2 OH，α-NHCH 2 CH 2 OH，β-NHCH 2 CH 2 CH 3，β-NHCH 2 CH 2 OCH 3，β-NHCH 2 CH = CH 2，β-NHCH 2 CH（OH），（c），（d），（e），（f），（g），（h），（i），（j），（k），（l），（m） n），（o），（p），（q），（r），（s），（t），（u），（v）或（w）。 R2是H或Br; R3是H或Br; R4是H或Br; R5是H或Br; 且R6为H或-CH3。

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