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91. 发明申请

WO2010082030A3 METHODS OF DESIGNING TREATMENT FLUIDS BASED ON SOLID-FLUID INTERACTIONS 审中-公开
公开(公告)号：WO2010082030A3
公开(公告)日：2010-07-22
申请号：PCT/GB2010/000060
申请日：2010-01-15
申请人： HALLIBURTON ENERGY SERVICES, INC. , HARRIS, Phillip, C. , HEATH, Stanley, J. , WALTERS, Harold, G. , CURTIS, Philip, Anthony
发明人： HARRIS, Phillip, C. , HEATH, Stanley, J. , WALTERS, Harold, G.
IPC分类号： C09K8/04 , C09K8/42 , C09K8/66 , C09K8/68 , C09K8/80 , E21B43/04
摘要： Methods that comprise selecting proppant for use in a fracturing fluid based on one or more factors, wherein the one or more factors comprise an interaction between the proppant and the fracturing fluid. Methods that comprise designing a treatment fluid that comprises a gelled base fluid and a particulate based on one or more factors, wherein the one or more factors comprise an interaction between the particulate and the gelled base fluid.

92. 发明申请

WO2010070284A1 METHODS AND COMPOSITIONS FOR STABILIZING UNCONSOLIDATED PARTICULATES IN A SUBTERRANEAN FORMATION 审中-公开
标题翻译：用于稳定亚硫酸盐形成中不连续颗粒的方法和组合物
公开(公告)号：WO2010070284A1
公开(公告)日：2010-06-24
申请号：PCT/GB2009/002896
申请日：2009-12-16
申请人： HALLIBURTON ENERGY SERVICES, INC. , NGUYEN, Philip, Duke , RICKMAN, Richard, D , DUSTERHOFT, Ronald, G , CURTIS, Philip, Anthony
发明人： NGUYEN, Philip, Duke , RICKMAN, Richard, D , DUSTERHOFT, Ronald, G
IPC分类号： C09K8/50 , C09K8/508 , C09K8/512 , C09K8/516 , C09K8/80 , C09K8/575 , E21B33/138
CPC分类号： C09K8/50 , C09K8/5086 , C09K8/512 , C09K8/516 , C09K8/575 , C09K8/80 , E21B43/025
摘要： Methods and compositions for stabilizing portions of a subterranean formation that comprise unconsolidated particulates are provided. In one embodiment, a method of treating a subterranean formation includes introducing a pre-flush fluid into a subterranean formation comprising unconsolidated particulates; introducing a foamed consolidation fluid comprising an aqueous base fluid, an emulsified resin, a hardening agent, a silane coupling agent, and a surfactant into the subterranean formation subsequent to the pre-flush fluid; wherein the emulsified resin is emulsified prior to being introduced into the aqueous base fluid; and allowing the resin to cure to at least partially consolidate the unconsolidated particulates.
摘要翻译：提供了用于稳定包括未固结颗粒的地下部分部分的方法和组合物。在一个实施方案中，处理地下地层的方法包括将预冲洗流体引入到包含未固结颗粒的地下地层中; 在预冲洗流体之后将包含含水基础流体，乳化树脂，硬化剂，硅烷偶联剂和表面活性剂的泡沫固结流体引入地层; 其中所述乳化树脂在被引入所述含水基础液体之前被乳化; 并使树脂固化以至少部分地固结未固结的颗粒。

93. 发明申请

WO2010061182A3 PROCESS FOR PREPARING ZANAMIVIR AND INTERMEDIATES FOR USE IN THE PROCESS 审中-公开
公开(公告)号：WO2010061182A3
公开(公告)日：2010-06-03
申请号：PCT/GB2009/002744
申请日：2009-11-24
申请人： CIPLA LIMITED , PHULL, Manjinder, Singh , KANKAN, Rajendra, Narayanrao , RAO, Dharmaraj, Ramachandra , SAWANT, Ashwini, Amol , THOPPIL, Sanoj , CURTIS, Philip, Anthony
发明人： PHULL, Manjinder, Singh , KANKAN, Rajendra, Narayanrao , RAO, Dharmaraj, Ramachandra , SAWANT, Ashwini, Amol , THOPPIL, Sanoj
IPC分类号： C07D309/28
摘要： The present invention provides a process for preparing methyl 5-acetamido-4-amino-6- (1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2- carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminium hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.

94. 发明申请

WO2010052475A1 PROCESS FOR RESOLVING ZOPICLONE 审中-公开
标题翻译：解决ZOPICLONE的过程
公开(公告)号：WO2010052475A1
公开(公告)日：2010-05-14
申请号：PCT/GB2009/002628
申请日：2009-11-06
申请人： CIPLA LIMITED , RAO, Dharamaraj, Ramchandra , KANKAN, Rajendra, Narayanrao , GHAGARE, Maruti, Ganpati , SAROJ, Sunilkumar, Parasnath , CURTIS, Philip, Anthony
发明人： RAO, Dharamaraj, Ramchandra , KANKAN, Rajendra, Narayanrao , GHAGARE, Maruti, Ganpati , SAROJ, Sunilkumar, Parasnath
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04
摘要： The present invention provides a process for the preparation of the dextrorotatory isomer of zopiclone (eszopiclone). The present invention also provides eszopiclone di-p-anisolyl-L-tartrate and eszopiclone diacetyl-L-tartrate, which are useful as intermediates in a process for preparing eszopiclone.
摘要翻译：本发明提供了一种制备佐匹克隆（右倍他默）的右旋异构体的方法。本发明还提供左旋对茴香酰基-L-酒石酸左美托洛尔和二乙酰基-L-酒石酸左旋异丙托铵，其用作制备右佐匹克隆的方法中的中间体。

95. 发明申请

WO2009083724A1 PROCESSES FOR THE PREPARATION OF THALIDOMIDE 审中-公开
标题翻译：制备噻吗二胺的方法
公开(公告)号：WO2009083724A1
公开(公告)日：2009-07-09
申请号：PCT/GB2008/004290
申请日：2008-12-24
申请人： CIPLA LIMITED , CURTIS, Philip, Anthony , RAO, Dharmaraj, Ramachandra , KANKAN, Rajendra, Narayanrao , SURVE, Manohar , BIRARI, Dilip
发明人： RAO, Dharmaraj, Ramachandra , KANKAN, Rajendra, Narayanrao , SURVE, Manohar , BIRARI, Dilip
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention provides a process for the preparation of thalidomide (I) comprising: i) reacting a compound of formula (II), where one of R represents -OH or -NH 2 and the other of R represents -NH 2 or -OH, respectively, with a phthaloylating agent in the presence of a base and a a non-polar organic solvent to obtain a phthaloyl derivative where R have the same meanings as above; and ii) dehydrating the phthaloyl derivative using a dehydrating agent selected from an acid anhydride, an acid halide, an ion exchange resin or a molecular sleve to obtain thalidomide (I).
摘要翻译：本发明提供了一种制备沙利度胺（I）的方法，包括：i）使式（II）化合物与其中R表示-OH或-NH 2，另一个R表示-NH 2或-OH的化合物反应与邻苯二甲酰化剂在碱和非极性有机溶剂的存在下反应得到邻苯二甲酰基衍生物，其中R具有与上述相同的含义; 和ii）使用选自酸酐，酰卤，离子交换树脂或分子式的脱水剂使邻苯二甲酰基衍生物脱水，得到沙利度胺（I）。

96. 发明申请

WO2008135770A2 PROCESS FOR PREPARING DORZOLAM IDE 审中-公开
标题翻译：制备DORZOLAM IDE的方法
公开(公告)号：WO2008135770A2
公开(公告)日：2008-11-13
申请号：PCT/GB2008/001592
申请日：2008-05-07
申请人： CIPLA LIMITED , CURTIS, Philip, Anthony , KANKAN, Rajendra, Narayanrao , RAO, Dhanmaraj, Ramachandra , MUDGAL, Shrikant, Suresh
发明人： KANKAN, Rajendra, Narayanrao , RAO, Dhanmaraj, Ramachandra , MUDGAL, Shrikant, Suresh
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： There is provided a process for preparing dorzolamide and processes for preparing intermediates useful in the preparation of dorzolamide. In particular, there is provided a process for preparing an acetoamido sulfone of formula (viii) comprising oxidation of a hydroxysulfonamide of formula (vii) in the presence of an oxidizing agent selected from the group consisting of: a peracid, tert-butyl hydroperoxide, dimethyl dioxirane, selenium dioxide, m-phenanthroline di-N-oxide, nitric acid and hydrogen peroxide. There is also provided a process for preparing an acetoamidosulfone of formula (ix-a) comprising converting a hydroxysulfone of formula (viii) to the acetoamidosulfone of formula (ix-a) in the presence of acetonitrile and an acid. There is also provided a process for separating the cis- and trans-isomers of dorzolamide from a mixture of the trans-isomer of dorzolamide and the cis-isomer of dorzolamide comprising reacting the mixture of isomers with a carboxylic acid.
摘要翻译：提供了制备多佐胺的方法和制备可用于制备多佐胺的中间体的方法。特别地，提供了制备式（viii）的乙酰胺基砜的方法，包括在选自以下的氧化剂的存在下氧化式（vii）的羟基磺酰胺：过酸，叔丁基过氧化氢，二氧杂环己烷，二氧化硒，间二菲咯啉二-N-氧化物，硝酸和过氧化氢。还提供了制备式（ix-a）的乙酰氨基砜的方法，包括在乙腈和酸存在下将式（Ⅸ）的羟基砜转化成式（ix-a）的乙酰胺基砜。还提供了从多佐胺的反式异构体和多佐胺的顺式异构体的混合物中分离多佐胺的顺式和反式异构体的方法，包括使异构体的混合物与羧酸反应。

97. 发明申请

WO2014125270A1 PROCESS FOR PREPARING ATAZANAVIR SULPHATE 审中-公开
标题翻译：制备阿扎伐他汀硫酸钠的方法
公开(公告)号：WO2014125270A1
公开(公告)日：2014-08-21
申请号：PCT/GB2014/050404
申请日：2014-02-12
申请人： CIPLA HOUSE , COTTRILL, Emily Elizabeth Helen
发明人： KANKAN, Rajendra Narayanrao , PATHI, Srinivas Laxminarayan , CHINIMILLI, Venugopalarao
IPC分类号： C07D213/42 , A61K31/44
CPC分类号： C07D213/58 , C07D213/42
摘要： The present invention relates to a process for the preparation of Compound (A): (Formula (A)) wherein the process comprises contacting atazanavir base (Compound (II)) with sulphuric acid in a combination of two or more solvents and isolating compound (A). The present invention also relates to substantially pure Compound (A), and to Compound (A) devoid of mesityl oxide impurity. Mesityl oxide has the following formula: (Formula (B)).
摘要翻译：本发明涉及一种制备化合物（A）：（式（A））的方法，其中所述方法包括使阿扎那韦碱（化合物（II））与两种或更多种溶剂的组合中的硫酸接触并分离化合物一个）。本发明还涉及基本上纯的化合物（A）和不含有均三氧化物杂质的化合物（A）。甲硅烷氧基氧化物具有下式：（式（B））。

98. 发明申请

WO2012164242A1 PROCESS FOR THE PREPARATION OF PALIPERIDONE 审中-公开
标题翻译：制备PALIPERIDONE的方法
公开(公告)号：WO2012164242A1
公开(公告)日：2012-12-06
申请号：PCT/GB2012/000480
申请日：2012-05-30
申请人： CIPLA LIMITED , PUPPALA, Ravikumar , PATHI, Srinivas, Laxminarayan , KANKAN, Rajendra, Narayanrao , COTTRILL, Emily, Elizabeth, Helen
发明人： PUPPALA, Ravikumar , PATHI, Srinivas, Laxminarayan , KANKAN, Rajendra, Narayanrao , COTTRILL, Emily, Elizabeth, Helen
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a process for the preparation of paliperidone or a pharmaceutically acceptable salt thereof, wherein the process comprises condensing a compound of formula (II) with a compound of formula (III) or a salt thereof, in a suitable solvent and a base, in the presence of a catalyst and an inhibiting agent, wherein the inhibiting agent is added to the reaction system before the compound of formula (II) and compound of formula (III) have reacted or as the reaction of the compound of formula (II) and compound of formula (III) is initiated, and optionally converting the paliperidone to a salt thereof, wherein X is a suitable leaving group. The present invention also provides substantially pure paliperidone or a salt thereof, paliperidone or a salt thereof as prepared by the process and uses of the paliperidone or salt thereof.
摘要翻译：本发明提供了一种制备普利培酮或其药学上可接受的盐的方法，其中所述方法包括在合适的溶剂和碱中将式（II）化合物与式（III）化合物或其盐缩合在催化剂和抑制剂的存在下，其中在式（II）化合物和式（III）化合物已经反应之前或作为式（II）化合物的反应之前将该抑制剂加入到反应体系中）和式（III）的化合物引发，并且任选地将帕培酮转化成其盐，其中X是合适的离去基团。本发明还提供了通过普利培酮或其盐的方法和用途制备的基本上纯的利培酮或其盐，普利培酮或其盐。

99. 发明申请

WO2012156663A1 SETTABLE COMPOSITIONS CONTAINING METAKAOLIN HAVING REDUCED PORTLAND CEMENT CONTENT 审中-公开
标题翻译：含有具有降低的波特兰水泥含量的甲基纤维素的可固化组合物
公开(公告)号：WO2012156663A1
公开(公告)日：2012-11-22
申请号：PCT/GB2012/000430
申请日：2012-05-11
申请人： HALLIBURTON ENERGY SERVICES INC , SANTRA, Ashok K. , RAVI, Krishna M. , KEYS, Crystal L. , IVERSON, Benjamin John , PATIL, Rahul , PATIL, Sandip , COTTRILL, Emily Elizabeth Helen
发明人： SANTRA, Ashok K. , RAVI, Krishna M. , KEYS, Crystal L. , IVERSON, Benjamin John , PATIL, Rahul , PATIL, Sandip
IPC分类号： C04B28/02 , C04B28/22 , C09K8/42 , C09K8/467 , C09K8/473 , E21B33/13
CPC分类号： C09K8/473 , C04B28/021 , C04B28/18 , C04B2111/1037 , C04B2111/2015 , C04B2111/2092 , C04B2111/22 , C04B2111/23 , C09K8/426 , C09K8/467 , Y02W30/92 , Y02W30/94 , Y02W30/95 , C04B14/041 , C04B14/047 , C04B14/28 , C04B18/08 , C04B18/141 , C04B18/162 , C04B40/0263 , C04B2103/12 , C04B2103/22 , C04B2103/40 , C04B2103/44 , C04B2103/46 , C04B14/106
摘要： Of the many compositions and methods provided herein, one method includes providing a settable fluid that comprises an aqueous-based medium, a lime composition, and a cementitious blend that comprises metakaolin particulates and aluminosilicate particulates, wherein the cementitious blend is essentially free of Portland cement; introducing the settable fluid into a wellbore penetrating a subterranean formation that comprises a corrosive component; and allowing the settable fluid to set therein.
摘要翻译：在本文提供的许多组合物和方法中，一种方法包括提供包含水性介质，石灰组合物和包含偏高岭土颗粒和铝硅酸盐颗粒的水泥混合物的可固化流体，其中所述水泥混合物基本上不含波特兰水泥 ; 将可固化流体引入渗透包括腐蚀性成分的地下地层的井眼; 并允许可固化流体置于其中。

100. 发明申请

WO2012146895A1 TREATMENT FLUIDS CONTAINING BIODEGRADABLE CHELATING AGENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：含有可生物降解螯合剂的处理液及其使用方法
公开(公告)号：WO2012146895A1
公开(公告)日：2012-11-01
申请号：PCT/GB2012/000385
申请日：2012-04-26
申请人： HALLIBURTON ENERGY SERVICES, INC. , REYES, Enrique A. , WELTON, Thomas D. , COTTRILL, Emily Elizabeth Helen
发明人： REYES, Enrique A. , WELTON, Thomas D.
IPC分类号： C09K8/528 , C09K8/68 , C09K8/78 , C02F5/12 , E21B43/04
CPC分类号： C09K8/528 , C02F5/12 , C09K8/68 , C09K8/74 , C09K8/78 , C09K8/845 , C09K8/86 , Y02W10/37
摘要： Treatment fluids containing biodegradable chelating agents and methods for use thereof are described. The methods can comprise providing a treatment fluid that comprises an aqueous base fluid and a chelating agent composition, and introducing the treatment fluid into at least a portion of a subterranean formation. The treatment fluids can also be used for treatment of pipes or tubing such as, for example, well bore pipes or tubing penetrating a subterranean formation and above-ground pipelines. Illustrative biodegradable chelating agents include, but are not limited to, glutamic acid diacetic acid, methylglycine diacetic acid, β-alanine diacetic acid, S,S-ethylenediaminedisuccinic acid, iminodisuccinic acid, hydroxyiminodisuccinic acid, any salt thereof, any derivative thereof, and any combination thereof. The treatment fluids can optionally comprise an acid, which can include hydrofluoric acid or a hydrofluoric acid generating compound.
摘要翻译：描述含有可生物降解的螯合剂的处理液及其使用方法。所述方法可以包括提供包含含水基础液和螯合剂组合物的处理流体，并将处理流体引入至地下地层的至少一部分中。处理流体还可以用于管道或管道的处理，例如井眼管道或穿透地下地层和地上管道的管道。示例性可生物降解的螯合剂包括但不限于谷氨酸二乙酸，甲基甘氨酸二乙酸，β-丙氨酸二乙酸，S，S-乙二胺二琥珀酸，亚氨基二琥珀酸，羟基亚氨基二琥珀酸，其任何盐，其任何衍生物和任何其组合。处理流体可以任选地包含酸，其可以包括氢氟酸或产生氢氟酸的化合物。

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