专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010011357A3 DETECTION OF PROSTATE CANCER USING PSA GLYCOSYLATION PATTERNS 审中-公开
标题翻译：应用PSA糖基化模式检测前列腺癌
公开(公告)号：WO2010011357A3
公开(公告)日：2010-05-06
申请号：PCT/US2009004365
申请日：2009-07-27
申请人： UNIV JOHNS HOPKINS , ZHANG HUI , MEANY DANNI LI , CHAN DANIEL WAN-YUI , ZHANG ZHEN , LI YAN , SOKOLL LORI J
发明人： ZHANG HUI , MEANY DANNI LI , CHAN DANIEL WAN-YUI , ZHANG ZHEN , LI YAN , SOKOLL LORI J
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： G01N33/57434 , G01N2333/4724 , G01N2400/00
摘要： The present invention features novel methods for determining if a subject has prostate caner. The present invention is based on the development of lectin immunosorbant assays which analyze a2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and a2,3 -linked sialylation of total and free serum PSA. These novel assays were used then to conduct a clinical investigation of the potential role of glycoprotein analysis in improving PSA's cancer specificity. The present invention also features kits for determining if a subject has prostate cancer comprising one or more lectins and a PSA specific antibody and instructions for use.
摘要翻译：本发明提出了用于确定受试者是否具有前列腺癌的新颖方法。本发明基于凝集素免疫吸附测定法的发展，其通过接骨木霉黑素凝集素（SNA）和全部和游离血清PSA的2,3-连接唾液酸化来分析总血清PSA的2,6-连接唾液酸化。然后使用这些新型测定来进行糖蛋白分析在改善PSA的癌症特异性中的潜在作用的临床研究。本发明还提供了用于确定受试者是否患有包含一种或多种凝集素和PSA特异性抗体的前列腺癌的试剂盒以及使用说明书。

2. 发明申请

WO2012129408A3 BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER 审中-公开
标题翻译：生物标志物用于肿瘤前列腺癌
公开(公告)号：WO2012129408A3
公开(公告)日：2013-01-31
申请号：PCT/US2012030129
申请日：2012-03-22
申请人： UNIV JOHNS HOPKINS , ZHANG HUI , TIAN YUAN , CHAN DANIEL W , CHEN JING
发明人： ZHANG HUI , TIAN YUAN , CHAN DANIEL W , CHEN JING
IPC分类号： G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/57434
摘要： The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).
摘要翻译：本发明涉及生物标记领域，更具体地涉及可用于诊断侵略性前列腺癌的生物标志物。在具体实施方案中，用于诊断患者中侵袭性前列腺癌的方法包括（a）测量从患者收集的样品中的一种或多种生物标志物的水平; 和（b）将一种或多种生物标志物的水平与与具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平和与不具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平进行比较，其中相关性到其中一个预定义的级别提供诊断。在一个具体的实施方案中，一种或多种生物标志物可以包含组织蛋白酶-L（CTSL），骨膜素，微原纤维相关蛋白4（MFAP4），胶原XII，起泡蛋白，聚集蛋白，嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL），上皮细胞活化分子 EpCAM），前列腺特异性抗原（PSA），膜金属内肽酶（MME）和阿泊菌（ASPN）。

3. 发明申请

WO2009073412A3 METHODS OF CLEANING WELLBORES AND ANALYZING WELLBORE FLUIDS 审中-公开
标题翻译：清洁井和分析井筒流体的方法
公开(公告)号：WO2009073412A3
公开(公告)日：2009-08-27
申请号：PCT/US2008084367
申请日：2008-11-21
申请人： MI LLC , DAKIN EUGENE , ZHANG HUI , PRASEK BETHICIA B
发明人： DAKIN EUGENE , ZHANG HUI , PRASEK BETHICIA B
IPC分类号： G01N33/30 , G01N31/00
CPC分类号： C09K8/524
摘要： A method of analyzing a wellbore fluid that includes treating a wellbore fluid with an emulsifying fluid, the emulsifying fluid comprising: a hydroxylated ether; an amphoteric chemotrope; and testing the treated wellbore fluid for at least one of turbidity and total suspended solids is disclosed. Methods of cleaning wellbores are also disclosed.
摘要翻译：一种分析井眼流体的方法，包括用乳化液处理井筒流体，所述乳化流体包含：羟基化醚; 两性化合物; 并且公开了用于浊度和总悬浮固体中的至少一种的经处理的井筒流体的测试。还公开了清洗井筒的方法。

4. 发明申请

WO2008070049A3 PEPTIDE AND TREATMENT FOR HIV-1 INFECTION 审中-公开
标题翻译：艾滋病毒1感染的肽和治疗
公开(公告)号：WO2008070049A3
公开(公告)日：2009-01-29
申请号：PCT/US2007024790
申请日：2007-12-04
申请人： UNIV JEFFERSON , OYAGEN INC , ZHANG HUI , SMITH HAROLD C
发明人： ZHANG HUI , SMITH HAROLD C
IPC分类号： A61K38/00 , A61K38/10 , A61K39/395 , C07K5/00 , C07K7/00 , C07K9/00
CPC分类号： C07K14/00 , A61K38/162 , A61K45/06 , A61K2300/00
摘要： A compound of the formula X1 -M-SEQ ID NO.l, or a derivative thereof, is provided, wherein X1 -M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.
摘要翻译：提供式X1-M-SEQ ID NO.1或其衍生物的化合物，其中X1-M-表示任选的基团，其包含与氨基酸序列SEQ ID NO的N末端缀合的蛋白质转导结构域 NO：1。还提供了包含使用该化合物的药物组合物和治疗方法。

5. 发明申请

WO2008066629A3 METHODS FOR QUANTITATIVE PROTEOME ANALYSIS OF GLYCOPROTEINS 审中-公开
标题翻译：糖蛋白定量蛋白质分析方法
公开(公告)号：WO2008066629A3
公开(公告)日：2008-10-16
申请号：PCT/US2007022624
申请日：2007-10-24
申请人： INST SYSTEMS BIOLOGY , AEBERSOLD RUDOLF H , ZHANG HUI , HOOD LEROY E , SUN BINGYUN
发明人： AEBERSOLD RUDOLF H , ZHANG HUI , HOOD LEROY E , SUN BINGYUN
IPC分类号： C07K1/00 , C12Q1/34 , C12Q1/37 , G01N33/68
CPC分类号： C12Q1/34 , C12Q1/37 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6848 , G01N33/6851 , Y10T436/13
摘要： The invention provides a method for identifying and quantifying polyglycopeptides in a sample. The method can include the steps of immobilizing glycopolypeptides to a solid support; cleaving the immobilized glycopolypeptides, thereby releasing non-glycosylated peptides and retaining immobilized glycopeptides; releasing the glycopeptides from the solid support; and analyzing the released glycopeptides. The method can further include the step of identifying one or more glycopeptides, for example, using mass spectrometry.
摘要翻译：本发明提供了用于鉴定和定量样品中的聚糖肽的方法。该方法可以包括将糖多肽固定到固体支持物上的步骤; 切割固定的糖多肽，从而释放非糖基化的肽并保留固定的糖肽; 从固体载体释放糖肽; 并分析释放的糖肽。该方法可以进一步包括例如使用质谱法鉴定一种或多种糖肽的步骤。

6. 发明申请

WO2005114188A3 CUL4 E3 LIGASE MEDIATORS AS REGULATORS OF P53 审中-公开
标题翻译：作为P53的调节剂的CUL4 E3辅助介质
公开(公告)号：WO2005114188A3
公开(公告)日：2006-05-18
申请号：PCT/US2005014615
申请日：2005-04-27
申请人： UNIV YALE , ZHANG HUI , BANKS DAMON POWELL , HIGA LEIGH ANN AKI
发明人： ZHANG HUI , BANKS DAMON POWELL , HIGA LEIGH ANN AKI
IPC分类号： G01N33/53 , C12Q1/25
CPC分类号： C12Q1/25 , G01N2333/9015 , G01N2500/02
摘要： The invention relates to assays for identifying modulators of p53ubiquitination by CUL4 E3 ligase complexes. This assays allows detection of agents and compounds that affect p53 ubiquitination and thus, cell cycle regulation and cell survival in cells. In some assays, an increase in ubiquitination, in comparison to a test sample lacking a test compound, indicates a stimulation of p53 ubiquitination activity, whereas a reduction in p53 ubiquitination indicates an inhibitor of activity. The assays provided may be suited, for example, for high-throughput screening of agents. The invention further relates to methods of modulating p53 activity in a cell, such as a cell of a mammal, by administering agents which decrease expression or activity of a member of a CUL4 E3 ligase complex, or which block the binding of p53 to a CUL4 E3 ligase complex.
摘要翻译：本发明涉及用于鉴定CUL4 E3连接酶复合物的p53泛素化调节剂的测定法。该测定允许检测影响p53泛素化的因子和化合物，从而检测细胞中的细胞周期调节和细胞存活。在一些测定中，与缺乏测试化合物的测试样品相比，泛素化的增加表明刺激p53泛素化活性，而p53泛素化的减少表示活性抑制剂。所提供的测定可能适合于例如用于药物的高通量筛选。本发明还涉及通过施用降低CUL4 E3连接酶复合物成员的表达或活性或阻断p53与CUL4的结合的药剂来调节细胞例如哺乳动物细胞中p53活性的方法 E3连接酶复合物。

7. 发明申请

WO2013009510A3 CALIBRATION AND TRANSFORMATION OF A CAMERA SYSTEM'S COORDINATE SYSTEM 审中-公开
标题翻译：摄像机系统坐标系的校准与转换
公开(公告)号：WO2013009510A3
公开(公告)日：2013-05-02
申请号：PCT/US2012045202
申请日：2012-07-02
申请人： RESTORATION ROBOTICS INC , TENNEY JOHN A , BURD ERIK R , ZHANG HUI , BIRO ROBERT F
发明人： TENNEY JOHN A , BURD ERIK R , ZHANG HUI , BIRO ROBERT F
IPC分类号： A61B5/00 , A61F2/10
CPC分类号： G06T7/80 , A61B34/30 , B25J9/1697 , G05B19/4086 , G05B2219/39022 , G05B2219/39045 , G06T7/12 , G06T7/73 , G06T7/85 , G06T2207/10012 , G06T2207/30004 , G06T2207/30208 , G06T2207/30244 , H04N7/181 , H04N13/02
摘要： Systems and methods are disclosed that determine a mapping between a first camera system's coordinate system and a second camera system's coordinate system; or determine a transformation between a robot's coordinate system and a camera system's coordinate system, and/or locate, in a robot's coordinate system, a tool extending from an arm of the robot based on the tool location in the camera's coordinate system. The disclosed systems and methods may use transformations derived from coordinates of features found in one or more images. The transformations may be used to interrelate various coordinate systems, facilitating calibration of camera systems, including in robotic systems, such as an image- guided robotic systems for hair harvesting and/or implantation.
摘要翻译：公开了确定第一相机系统的坐标系和第二相机系统的坐标系之间的映射的系统和方法; 或确定机器人坐标系和照相机系统坐标系之间的变换，和/或基于在照相机坐标系中的工具位置在机器人的坐标系中定位从机器人的臂延伸的工具。所公开的系统和方法可以使用从在一个或多个图像中找到的特征的坐标导出的变换。这些变换可用于使各种坐标系相互关联，便于照相机系统的校准，包括机器人系统，例如用于头发收获和/或植入的图像引导机器人系统。

8. 发明申请

WO2012071469A2 HISTONE DEMETHYLASE INHIBITORS AND USES THEREOF FOR TREATMENT O F CANCER 审中-公开
标题翻译： HISTONE DEMETHYLASE抑制剂及其用于治疗的用途
公开(公告)号：WO2012071469A2
公开(公告)日：2012-05-31
申请号：PCT/US2011061954
申请日：2011-11-22
申请人： NEVADA CANCER INST , SHENZHEN GRADUATE SCHOOL OF PEKING UNIVERSITY , ZHANG HUI , YE TAO , QUAN JUNMIN , WANG JING
发明人： ZHANG HUI , YE TAO , QUAN JUNMIN , WANG JING
IPC分类号： C07D403/02 , A61K31/496
CPC分类号： C07D295/215 , A61K31/496 , C07D211/46 , C07D211/58 , C07D211/62
摘要： A compound of formula I: or a pharmaceutically acceptable salt, Ri is an optionally substituted heterocyclic group; R and R' are independently H, CH3, NO2, SO2N(CH3)2, SO2N((CH3)SO2), COOH, COOCH3, CO(N(CH3)), alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, heteroaryl, heterocycloalkyl, alkoxy, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, alkylaminocarbonyl, aralkylaminocarbonyl, alkenylaminocarbonyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, alkenylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylthiocarbonyl, trifluoromethyl, pentafluoroethyl, halogen, cyano, thio, amido, ether, ester, hydroxyl, hydroxyalkyl, saturated or unsaturated fatty acids, azido, phosphonamido, sulfonamido, lactam, phosphate, phosphonato, phosphinato, amino, acylamino, amidino, imino, guanidino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, cyano, or azido; m and n are independently integers from 1 to 4; T, U, V, and Z are independently CH, N, or CR; L is NH, CH2, O, S, or SO2; X is N or CH; Y and Y' are independently O or S; and R3 is an optionally substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl group.
摘要翻译：式I化合物或其药学上可接受的盐，R 1是任选取代的杂环基; R和R'独立地是H，CH 3，NO 2，SO 2 N（CH 3）2，SO 2 N（（CH 3）SO 2），COOH，COOCH 3，CO（N（CH 3）），烷基，烯基，炔基，芳基，芳烷基，环烷基，杂芳基，杂环烷基，烷氧基，烷基羰基氧基，芳基羰基氧基，烷氧基羰基氧基，芳氧基羰基氧基，羧酸酯，烷基羰基，烷基氨基羰基，芳烷基氨基羰基，烯基氨基羰基，烷基羰基，芳基羰基，芳烷基羰基，烯基羰基，烷氧羰基，氨基羰基，烷硫基羰基，三氟甲基，五氟乙基，卤素，氰基，醚，酯，羟基，羟基烷基，饱和或不饱和脂肪酸，叠氮基，酰基氨基，亚磺酰氨基，内酰胺，磷酸酯，膦酰基，次膦酸酯基，氨基，酰氨基，脒基，亚氨基，胍基，巯基，烷硫基，芳硫基，硫代羧酸酯，硫酸酯，烷基亚磺酰基，磺酸基，氨磺酰基，亚磺酰氨基，硝基，氰基或叠氮基; m和n独立地为1至4的整数; T，U，V和Z独立地为CH，N或CR; L是NH，CH 2，O，S或SO 2; X为N或CH; Y和Y'独立地为O或S; 并且R 3是任选取代的芳基，杂芳基，环烷基或杂环烷基。

9. 发明申请

WO2011124166A2 SESSION TRANSFER METHOD, APPLICATION SERVER AND COMMUNICATION SYSTEM 审中-公开
标题翻译：会话传输方法，应用服务器和通信系统
公开(公告)号：WO2011124166A2
公开(公告)日：2011-10-13
申请号：PCT/CN2011073900
申请日：2011-05-10
申请人： HUAWEI TECH CO LTD , ZHANG HUI
发明人： ZHANG HUI
IPC分类号： H04L29/06
CPC分类号： H04L45/00 , H04L65/1016 , H04L65/1083 , H04L65/1093 , H04L67/148
摘要： The embodiments of the present invention provide a session transfer method, an application server and a communication system, which relate to communication field and can realize the cross-network session transfer between the Circuit Switch (CS) domain and the IP Multimedia Subsystem (IMS) domain. The method includes the following steps: after receiving a session transfer request sent by the user B or user C in the IMS domain, sending a release message to the user B of the current call to terminate the session between the user A in the CS domain and the user B; and negotiating the multimedia information of the user A and that of the user C so as to set up a session between the user A and user C. The embodiments of the present invention can be applied in cross-network session between the CS domain and the IMS domain.
摘要翻译：本发明的实施例提供了一种会话转移方法，应用服务器和通信系统，其涉及通信领域，并且可以实现电路交换（CS）域和IP多媒体子系统（IMS）之间的跨网络会话传送，域。该方法包括以下步骤：在接收到IMS域中的用户B或用户C发送的会话转移请求后，向当前呼叫的用户B发送释放消息以终止CS域中的用户A之间的会话和用户B; 以及协商用户A和用户C的多媒体信息，以便在用户A和用户C之间建立会话。本发明的实施例可以应用于CS域和网络中的跨网络会话 IMS域。

10. 发明申请

WO2009051660A3 COMPOUNDS FOR ACTIVATING TGF-BETA SIGNALING 审中-公开
标题翻译：活化TGF-β信号的化合物
公开(公告)号：WO2009051660A3
公开(公告)日：2009-08-13
申请号：PCT/US2008011648
申请日：2008-10-10
申请人： UNIV LELAND STANFORD JUNIOR , WYSS-CORAY ANTON , ZHANG HUI , TANGA MARY J
发明人： WYSS-CORAY ANTON , ZHANG HUI , TANGA MARY J
IPC分类号： C07D209/16 , A61K31/4045 , A61P25/28 , C07D405/12 , C07D409/12
CPC分类号： C07D405/12 , C07D209/16 , C07D409/12
摘要： Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-ß signaling are described.
摘要翻译：描述了用于治疗和预防特征在于TGF-β信号减少的病症和病症的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式