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    • 4. 发明申请
    • METHODS FOR ALTERING VIRUS REPLICATION
    • 改变病毒复制的方法
    • WO2013166264A3
    • 2014-01-16
    • PCT/US2013039234
    • 2013-05-02
    • UNIV GEORGIA
    • TRIPP RALPH ATOMPKINS STEPHEN MBAKRE ABHIJEET
    • C12N15/113
    • A61K48/00C12N15/1137C12N2310/141C12N2320/11C12N2320/12C12N2760/16122C12N2760/18022
    • Provided herein are methods for altering viral replication in a cell. The virus may be a member of the family Orthomyxoviridae, such as an influenza virus, or a member of the family Paramyxoviridae, such as human respiratory syncytial virus. Altering viral replication is accomplished through the use of polynucleotides. In one embodiment, a polynucleotide decreases expression of a polypeptide, such as a protease or a kinase. In one embodiment, a polynucleotide is an miRNA or an miRNA inhibitor. In some embodiments viral replication is decreased, and in other embodiments viral replication is increased. Also included are methods for treating a subject, and genetically modified cells having the characteristic of altered virus replication compared to a control cell.
    • 本文提供了改变细胞中病毒复制的方法。 病毒可以是正粘病毒科的一个成员,例如流感病毒,或副粘病毒科的成员,例如人呼吸道合胞病毒。 通过使用多核苷酸来改变病毒复制。 在一个实施方案中,多核苷酸降低多肽如蛋白酶或激酶的表达。 在一个实施方案中,多核苷酸是miRNA或miRNA抑制剂。 在一些实施方案中,病毒复制减少,并且在其它实施方案中病毒复制增加。 还包括用于治疗受试者的方法,以及具有与对照细胞相比改变的病毒复制特征的遗传修饰的细胞。