专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013166264A3 METHODS FOR ALTERING VIRUS REPLICATION 审中-公开
标题翻译：改变病毒复制的方法
公开(公告)号：WO2013166264A3
公开(公告)日：2014-01-16
申请号：PCT/US2013039234
申请日：2013-05-02
申请人： UNIV GEORGIA
发明人： TRIPP RALPH A , TOMPKINS STEPHEN M , BAKRE ABHIJEET
IPC分类号： C12N15/113
CPC分类号： A61K48/00 , C12N15/1137 , C12N2310/141 , C12N2320/11 , C12N2320/12 , C12N2760/16122 , C12N2760/18022
摘要： Provided herein are methods for altering viral replication in a cell. The virus may be a member of the family Orthomyxoviridae, such as an influenza virus, or a member of the family Paramyxoviridae, such as human respiratory syncytial virus. Altering viral replication is accomplished through the use of polynucleotides. In one embodiment, a polynucleotide decreases expression of a polypeptide, such as a protease or a kinase. In one embodiment, a polynucleotide is an miRNA or an miRNA inhibitor. In some embodiments viral replication is decreased, and in other embodiments viral replication is increased. Also included are methods for treating a subject, and genetically modified cells having the characteristic of altered virus replication compared to a control cell.
摘要翻译：本文提供了改变细胞中病毒复制的方法。病毒可以是正粘病毒科的一个成员，例如流感病毒，或副粘病毒科的成员，例如人呼吸道合胞病毒。通过使用多核苷酸来改变病毒复制。在一个实施方案中，多核苷酸降低多肽如蛋白酶或激酶的表达。在一个实施方案中，多核苷酸是miRNA或miRNA抑制剂。在一些实施方案中，病毒复制减少，并且在其它实施方案中病毒复制增加。还包括用于治疗受试者的方法，以及具有与对照细胞相比改变的病毒复制特征的遗传修饰的细胞。

IPRDB

热门服务

关于我们

友情链接

联系方式