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1. 发明申请

WO2019096904A1 MIXING AND/OR RECONSTITUTION SYSTEM 审中-公开
公开(公告)号：WO2019096904A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081369
申请日：2018-11-15
申请人： SANOFI
发明人： SCHABBACH, Michael , HARVEY, Charlotte Emma , HUANG, Congyi , FREARSON, Timothy Charles , NORMAN, Alexander David , POTTER, Andrew Robert , STACEY, Gary
IPC分类号： A61M5/178
CPC分类号： A61M5/1782 , A61J1/2096 , A61M5/19 , A61M5/20 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/31596 , A61M5/445 , A61M2005/2013 , A61M2005/2474 , A61M2005/3128 , A61M2005/31598 , A61M2005/3267 , A61M2205/0272 , A61M2209/04 , A61M2209/045
摘要： The invention refers to a mixing and/or reconstitution system which reduces the possibility of user error and provides an easy and automatic operation comprising -a device(300, 400) containing a first material within a first chamber (305, 405), further comprising a housing (301, 401) and a plunger (307, 407), -a vial (308, 408) containing a second material within a second chamber (309, 409), wherein at least one of the first material and the second material is a fluid, -a base station (350, 450) comprising at least one drive unit (370, 470), a first slide (374) and a driver, and -a needle (302, 402), wherein the device (300, 400) and the vial (308, 408) are attachable to the base station in an initial position in which the device (300, 400) and the vial (308, 408) have a pre-defined distance to each other, wherein the needle (302, 402) is attached to the device (300, 400) and fluidly connected with the first chamber (305, 405) of the device (300, 400), wherein in the initial position the at least one drive unit (370, 470) is connected to the first slide (374) that moves the vial (308, 408) and/or the housing (301, 401) of the device (300, 400) relative to each other in an axial direction of the device (300, 400) along a pre-defined distance into an activated position, in which the needle (302, 402) is fluidly connected with the second chamber (309, 409) and wherein in the activated position the at least one drive unit (370, 470) is connected to the driver that moves the plunger (307, 407) in the axial direction of the device (300, 400) along a pre- defined distance such that during fluid connection of the needle (302, 402) with the second chamber (309, 409) the first material is expelled from the first chamber (305, 405) of the device into the second chamber (309, 409) of the vial (308, 408) or the second material is expelled from the second chamber (309, 409) of the vial (308, 408) into the first chamber (305, 405) of the device (300, 400). The invention further refers to a base station thereto, a supporting unit and a respective mixing and/or reconstitution method.

2. 发明申请

WO2019096913A1 MIXING AND/OR RECONSTITUTION SYSTEM AND RESPECTIVE METHOD 审中-公开
公开(公告)号：WO2019096913A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081386
申请日：2018-11-15
申请人： SANOFI
发明人： SCHABBACH, Michael , KADEREIT, Dieter , HEIBERGER, Andrea , GEIGER, Claus , HARVEY, Charlotte Emma , HUANG, Congyi , FREARSON, Timothy Charles , NORMAN, Alexander David
IPC分类号： A61M5/19 , A61M5/315
CPC分类号： A61M5/31596 , A61J1/2096 , A61M5/1782 , A61M5/19 , A61M5/20 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/445 , A61M2005/2013 , A61M2005/2474 , A61M2005/3128 , A61M2005/31598 , A61M2005/3267 , A61M2205/0272 , A61M2209/04
摘要： The invention refers to a mixing and/or reconstitution system which reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time comprising -a device (200), for example a cartridge, a syringe or an autoinjector, containing a first material within a first chamber (205), a housing (201) and a plunger (207), wherein the plunger (207) comprises a second chamber (209) containing a second material, wherein one of the first and the second material is a fluid, and a movable element (210) with an electric, magnetic or paramagnetic characteristic, wherein the second chamber (209) is initially closed, -a base unit (250) comprising an recess (265) for accommodation of the device (200), a control unit (270), and an electromagnetic unit (260) which is adapted to produce an electromagnetic field penetrating the recess (265), wherein the control unit (270) electrically operates the electromagnetic unit (260), wherein the base unit (250) is adapted such that after accommodation of the device (200) within the recess (265) and after user activation of the base unit (250) the control unit (270) operates the electromagnetic unit (260) such that the element (210) contained in the second chamber (209) moves in a direction of the device (200) determined by the electromagnetic field and thereby opens a path providing a fluid communication between the first chamber (205) and the second chamber (209). The invention also refers to a respective device (200) and a respective mixing and/or reconstitution method.

3. 发明申请

WO2019096908A1 DEVICE AND MIXING AND/OR RECONSTITUTION METHOD 审中-公开
公开(公告)号：WO2019096908A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081375
申请日：2018-11-15
申请人： SANOFI
发明人： SCHABBACH, Michael , GEIGER, Claus , HEIBERGER, Andrea , KADEREIT, Dieter , HARVEY, Charlotte Emma , HUANG, Congyi , FREARSON, Timothy Charles , NORMAN, Alexander David
IPC分类号： A61M5/20 , A61J1/20 , A61M5/19
CPC分类号： A61M5/19 , A61J1/1406 , A61J1/16 , A61J1/201 , A61J1/2093 , A61J1/2096 , A61J2205/60 , A61M5/1782 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/31596 , A61M5/445 , A61M2005/2013 , A61M2005/2474 , A61M2005/3128 , A61M2005/31598 , A61M2005/3267 , A61M2205/0272 , A61M2209/045
摘要： The invention refers to a device (100, 500, 510), for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution, comprising: - a first chamber (105, 505) within the housing, wherein the first chamber (105, 505) contains a first material, - a second chamber (109, 509) comprising a first piston (112, 512) and a second piston (111, 511), wherein the first piston (112, 512) and the second piston (111, 511) are axially moveable within the second chamber (109, 509), and - a second fluid material initially contained within the second chamber (109, 509) between the first piston (112, 512) and the second piston (111, 511 ), wherein the device is adapted such that activation of the device (100, 500, 510) causes movement one of the first piston (112, 512) and the second piston (111, 511 ) in an axial direction of the device thereby - moving the other one of the first piston (112, 512) and the second piston (111, 511 ) into the same axial direction of the device, - opening a fluid communication path between the second chamber (109, 509) and the first chamber (105, 505) and - expelling the second material from the second chamber (109, 509) into the first chamber (105, 505) via the fluid communication path. The invention is further directed to a respective mixing and/or reconstitution method.

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