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1. 发明申请

WO2023281514A1 NUCLEIC ACID MOLECULE AND ITS USE 审中-公开
公开(公告)号：WO2023281514A1
公开(公告)日：2023-01-12
申请号：PCT/IL2022/050735
申请日：2022-07-07
申请人： RNA MORPH LTD
发明人： LEV, Eitan
IPC分类号： C12N15/113
摘要： Nucleobases-comprising complex having two nucleobase strands linked by a common backbone structure common to the two strands. The common backbone structure may be formed by coupling two backbones, one of each of the strands, by molecular (e.g., covalent) bonding or other type of bonding; or may be a single backbone structure for the two strands. The first nucleic acid strand is, typically, such that it can specifically hybridize to a nucleotide target sequence, which may be a coding DNA sequence or an mRNA sequence and is typically complementary to that sequence. The second nucleic acid strand remains exposed after hybridization and has a sequence such so as to permit interaction with certain agents in the environment. The first strand may such that can specifically hybridize to a mutated target sequence and the second strand is such so that after the first strand hybridizes to the target sequence, the exposed, second sequence, together with the non-hybridized portions of the full sequence, display a correct, non- mutated sequence.

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