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1. 发明申请

WO2005012491A3 SURFACE EXPRESSION OF BIOLOGICALLY ACTIVE PROTEINS IN BACTERIA 审中-公开
标题翻译：生物活性蛋白在细菌中的表面表达
公开(公告)号：WO2005012491A3
公开(公告)日：2007-01-04
申请号：PCT/US2004002460
申请日：2004-01-28
申请人： OSEL INC , CHANG CHIA-HWA , LIU XIAOWEN , LEWICKI JOHN A , XU QIANG
发明人： CHANG CHIA-HWA , LIU XIAOWEN , LEWICKI JOHN A , XU QIANG
IPC分类号： C12P21/06 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/195 , C07K14/335 , C12N20060101 , C12N1/00 , C12N1/21 , C12N1/22 , C12N15/74
CPC分类号： C12N15/746 , A61K35/747 , A61K38/00 , A61K38/162 , C07K14/335 , C07K14/70514 , C07K2319/035 , C12N15/62 , A61K2300/00
摘要： Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.
摘要翻译：提供了将异源多肽靶向细菌细胞壁的方法和组合物。

2. 发明申请

WO2006083516A9 MODIFIED CYANOVIRIN-N POLYPEPTIDE 审中-公开
标题翻译：改性氰尿苷-N多肽
公开(公告)号：WO2006083516A9
公开(公告)日：2007-03-22
申请号：PCT/US2006001107
申请日：2006-01-12
申请人： OSEL INC , LIU XIAOWEN , ESSENMACHER KIRSTEN , SIMPSON DAVID A , XU QIANG
发明人： LIU XIAOWEN , ESSENMACHER KIRSTEN , SIMPSON DAVID A , XU QIANG
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C07K14/195 , A61K9/0034 , A61K38/164 , C07K2319/02
摘要： This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.
摘要翻译：本公开涉及能够重组表达该修饰蛋白质的氰尿素-N蛋白和转化的乳杆菌属细菌的修饰版本。进一步公开的是编码改性氰尿素-N蛋白的多核苷酸序列，允许修饰蛋白表达的表达盒，以及修饰蛋白以及转化的乳杆菌属细菌的制备和使用方法。此外，本公开描述了两种起源于延髓酵母的新型启动子，其能够在乳杆菌属细菌中指导高水平的基因表达。还描述了一种表达盒，其包含新型启动子之一，含有表达盒的经遗传修饰的乳杆菌属细菌，使用该新颖启动子在乳杆菌属细菌中重组基因表达的方法，以及将具有所需生物学活性的蛋白质递送至人体粘膜表面。

3. 发明申请

WO2006083516A3 MODIFIED CYANOVIRIN-N POLYPEPTIDE 审中-公开
标题翻译：修饰的Cyanovirin-N多肽
公开(公告)号：WO2006083516A3
公开(公告)日：2007-05-10
申请号：PCT/US2006001107
申请日：2006-01-12
申请人： OSEL INC , LIU XIAOWEN , ESSENMACHER KIRSTEN , SIMPSON DAVID A , XU QIANG
发明人： LIU XIAOWEN , ESSENMACHER KIRSTEN , SIMPSON DAVID A , XU QIANG
IPC分类号： A61K39/00 , A61K39/02 , A61K39/295 , A61K39/385
CPC分类号： C07K14/195 , A61K9/0034 , A61K38/164 , C07K2319/02
摘要： This disclosure relates to a modified version of cyanovirin-N protein and a transformed Lactobacillus bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed Lactobacillus bacterium. In addition, this disclosure describes two novel promoters originated from L. jensenii, which are capable of directing a high level of gene expression in Lactobacillus bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified Lactobacillus bacterium containing the expression cassette, a method for recombinant gene expression in Lactobacillus bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.
摘要翻译：本公开内容涉及能够重组表达该修饰的蛋白质的氰基维生素-N蛋白质和转化的乳酸杆菌属细菌的修饰形式。还公开了编码修饰的cyanovirin-N蛋白的多核苷酸序列，允许表达修饰的蛋白的表达盒，以及制备和使用修饰的蛋白以及转化的乳杆菌属细菌的方法。此外，本公开内容描述了源自詹氏乳杆菌的两种新型启动子，其能够指导乳酸杆菌属细菌中高水平的基因表达。还描述了包含新启动子之一的表达盒，含有该表达盒的遗传修饰的乳酸杆菌属细菌，使用该新启动子在乳杆菌属细菌中重组基因表达的方法，以及将具有所需生物学活性的蛋白质递送至人体内的粘膜表面。

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