专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010136598A1 A COLLECTION AND METHODS FOR ITS USE 审中-公开
标题翻译：其使用的收集和方法
公开(公告)号：WO2010136598A1
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057507
申请日：2010-05-29
申请人： MorphoSys AG , ENZELBERGER, Markus , PRASSLER, Josef , URLINGER, Stefanie , HERRMANN, Tanja , TILLER, Thomas
发明人： ENZELBERGER, Markus , PRASSLER, Josef , URLINGER, Stefanie , HERRMANN, Tanja , TILLER, Thomas
IPC分类号： C12N15/10 , C07K16/00 , C40B30/02 , C40B40/08 , C40B50/06
CPC分类号： C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
摘要： The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
摘要翻译：本公开使得能够鉴定人免疫谱中的VH和VL类对的方法，确定最普遍的VH和VL类对以及具有有利的生物物理性质的那些。更具体地，本公开的集合包含具有高度多样化的CDR的最普遍和/或优选的VH和VL类配对。

2. 发明申请

WO2010130824A3 COLLECTIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2010130824A3
公开(公告)日：2010-11-18
申请号：PCT/EP2010/056637
申请日：2010-05-14
申请人： MORPHOSYS AG , ENZELBERGER, Markus , PRASSLER, Josef , URLINGER, Stefanie
发明人： ENZELBERGER, Markus , PRASSLER, Josef , URLINGER, Stefanie
IPC分类号： C07K16/00
摘要： The present disclosure relates to synthetic collections of candidate proteinaceous binding molecules, for example, antibodies, wherein one or more candidate proteinaceous binding molecules comprise an optimized property as compared to a parental proteinaceous binding molecule. In particular, the collections of candidate proteinaceous binding molecules are made by gene synthesis, and are based upon the sequence of the parental proteinaceous binding molecule, for example, antibody, therefore a custom collection of candidate proteinaceous binding molecules can be made specifically for one parental proteinaceous binding molecules. The present disclosure also relates to methods of making and using such collections for optimizing parental proteinaceous binding molecules, for example, antibodies. The present disclosure also relates to the candidate proteinaceous binding molecules of the synthetic collections comprising optimized properties.

3. 发明申请

WO2010052244A1 DECONVOLUTION METHOD 审中-公开
标题翻译：解卷方法
公开(公告)号：WO2010052244A1
公开(公告)日：2010-05-14
申请号：PCT/EP2009/064625
申请日：2009-11-04
申请人： ENZELBERGER, Markus , MorphoSys AG
发明人： ENZELBERGER, Markus
IPC分类号： C12Q1/68
CPC分类号： G01N33/6845 , C40B30/04
摘要： The present invention relates generally to novel applications in combating infectious disease, cancer, allergy and autoimmune diseases. In one aspect, the invention relates to identifying one or more protein binding moieties of interest. In another aspect, the present invention relates to identifying one or more candidate vaccines.
摘要翻译：本发明一般涉及抗感染性疾病，癌症，变态反应和自身免疫性疾病的新型应用。一方面，本发明涉及鉴定感兴趣的一种或多种蛋白质结合部分。另一方面，本发明涉及鉴定一种或多种候选疫苗。

4. 发明申请

WO2008053275A2 NOVEL COLLECTION OF HCDR3 REGIONS AND USES THEREFOR 审中-公开
标题翻译： HCDR3地区的新收藏品及其用途
公开(公告)号：WO2008053275A2
公开(公告)日：2008-05-08
申请号：PCT/IB2006/004301
申请日：2006-12-15
申请人： MORPHOSYS AG , ENZELBERGER, Markus , THIEL, Stefanie
发明人： ENZELBERGER, Markus , THIEL, Stefanie
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/565
摘要： The present invention is directed to the preparation and use of a collection of antibody heavy chain complementarity determining region 3 (HCDR3) members, where diversity of the collection is a function of the length of the HCDR3 members. The diversity of the collection of HCDR3 regions substantially represents the natural amino acid distribution of HCDR3 in the human repertoire. This natural amino acid distribution can be represented by biasing the complete random distribution of amino acids, accordingly, in the HCDR3 encoding DNA sequence by using trinucleotide mutagenesis (TRIM) technology. A collection of HCDR3 members of the invention each can be comprised within a variable region of an antibody (or fragment thereof) to form a library of synthetic antibodies or antibody fragments. Synthetic antibody libraries of the present invention may be designed to include modular features, such as chemically synthesized "master gene" framework regions, which may contain unique restriction sites flanking one or more CDR regions, including an HCDR3 region prepared as described herein. The invention also provides nucleic acid molecules encoding such diverse collection and methods of making and using the same.
摘要翻译：本发明涉及抗体重链互补决定区3（HCDR3）成员集合的制备和应用，其中集合的多样性是HCDR3成员长度的函数。 HCDR3区域集合的多样性基本上代表了HCDR3在人类库中的天然氨基酸分布。这种天然氨基酸分布可以通过使用三核苷酸诱变（TRIM）技术偏置氨基酸的完全随机分布来表示，因此在HCDR3编码DNA序列中。本发明的HCDR3成员的集合可以各自包含在抗体（或其片段）的可变区内以形成合成抗体或抗体片段的文库。本发明的合成抗体文库可以被设计为包括模块化特征，例如化学合成的“主基因” 框架区，其可以包含侧接一个或多个CDR区的独特限制性位点，包括如本文所述制备的HCDR3区。本发明还提供了编码这些不同收集物的核酸分子以及制备和使用它们的方法。

5. 发明申请

WO2009100896A1 METHODS FOR IDENTIFICATION OF AN ANTIBODY OR A TARGET 审中-公开
标题翻译：用于鉴定抗体或靶标的方法
公开(公告)号：WO2009100896A1
公开(公告)日：2009-08-20
申请号：PCT/EP2009/000953
申请日：2009-02-11
申请人： MORPHOSYS AG , ENZELBERGER, Markus
发明人： ENZELBERGER, Markus
IPC分类号： G01N33/53 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/6854 , C12N15/1034 , C12N15/1089
摘要： This disclosure relates to methods for identifying an antibody, a target molecule, or an agent by analyzing the immunoglobulin repertoire sequence data in a sample and by determining the most dominant VH and VL chains present in said sample, as well as materials used therewith.
摘要翻译：本公开涉及通过分析样品中的免疫球蛋白序列数据和确定存在于所述样品中的最显着的VH和VL链以及与其一起使用的材料来鉴定抗体，靶分子或试剂的方法。

6. 发明申请

WO2008071749A2 INTERNALIZATION 审中-公开
标题翻译：国际接轨
公开(公告)号：WO2008071749A2
公开(公告)日：2008-06-19
申请号：PCT/EP2007/063843
申请日：2007-12-12
申请人： MORPHOSYS AG , ENZELBERGER, Markus
发明人： ENZELBERGER, Markus
IPC分类号： C12Q1/68
CPC分类号： C12N15/1037
摘要： A target internalized within a cell (and a binding member that specifically binds thereto) can be identified in an efficient manner by segregating (or substantially segregating) genetic material encoding the binding member from genetic material encoding a binding member that binds to a target that is not internalized. This can be achieved by employing a display library of binding members having a genotype/phenotype linkage via a non-fusion protein format, whereby genetic material encoding non-internalized targets can be segregated (or substantially segregated) without lysing the cells. Internalized genetic material subsequently can be isolated and amplified.
摘要翻译：通过将编码结合成员的遗传物质与编码结合成分的结合成员的遗传物质分离（或基本上分离），可以以有效的方式鉴定内细胞内（特异性结合于其的结合成员）的靶标没有内化。这可以通过使用具有通过非融合蛋白质形式具有基因型/表型连接的结合成员的显示文库来实现，由此编码非内化靶的遗传物质可以在不裂解细胞的情况下被分离（或基本上分离）。随后可以分离和扩增内源遗传物质。

7. 发明申请

WO2010089387A1 PRODUCTION OF OLIGOCLONAL MIXTURES OF IMMUNOGLOBULINS IN SINGLE CELLS 审中-公开
标题翻译：在单细胞中产生免疫球蛋白的寡糖混合物
公开(公告)号：WO2010089387A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/051469
申请日：2010-02-08
申请人： MORPHOSYS AG , ENZELBERGER, Markus
发明人： ENZELBERGER, Markus
IPC分类号： C12N15/63 , C12N15/79 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505
摘要： The present invention provides methods to produce mixtures of exogenous proteins in single cells. Preferably said exogenous proteins are heteromeric and multimeric proteins, such as immunoglobulins. The method enables the controlled expression of proteins, thereby allowing the correct formation and assembly of multimeric proteins, such as immunoglobulins.
摘要翻译：本发明提供在单细胞中产生外源蛋白质的混合物的方法。优选地，所述外源蛋白质是异聚和多聚体蛋白质，例如免疫球蛋白。该方法能够控制蛋白质的表达，从而允许多聚体蛋白质如免疫球蛋白的正确形成和装配。

8. 发明申请

WO2009087230A1 DISPLAY VECTORS AND METHODS AND USES THEREOF 审中-公开
标题翻译：显示向量及其方法及其用途
公开(公告)号：WO2009087230A1
公开(公告)日：2009-07-16
申请号：PCT/EP2009/050237
申请日：2009-01-09
申请人： MorphoSys AG , ENZELBERGER, Markus , YODER, Stephen , NEUN, Rüdiger , THIEL, Philippe , PETERS, Solveig
发明人： ENZELBERGER, Markus , YODER, Stephen , NEUN, Rüdiger , THIEL, Philippe , PETERS, Solveig
IPC分类号： C12N15/79
CPC分类号： C12N15/1037
摘要： The present invention relates, in one aspect, to a vector comprising (a) a first polynucleotide capable of encoding a first (poly)peptide comprising at least one cysteine residue, and (b) a second polynucleotide capable of encoding a second (poly)peptide which is a cell surface anchor comprising at least one cysteine residue, wherein the vector is operable in a eukaryotic host cell to express and to cause or allow the attachment of said first (poly)peptide to said second (poly)peptide by formation of a disulfide bond between said cysteine residues comprised within said first (polypeptide and said second (poly)peptide, respectively, wherein said first (poly)peptide is exhibited at the surface of a eukaryotic host cell.
摘要翻译：本发明在一个方面涉及载体，其包含（a）能够编码包含至少一个半胱氨酸残基的第一（多）肽的第一多核苷酸，和（b）能够编码第二（多聚）肽，其是包含至少一个半胱氨酸残基的细胞表面锚，其中所述载体可在真核宿主细胞中操作以表达并引起或允许所述第一（多）肽通过形成所述第二（多）肽而形成分别包含在所述第一（多肽和所述第二（多））肽内的所述半胱氨酸残基之间的二硫键，其中所述第一（多）肽显示在真核宿主细胞的表面。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式