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1. 发明申请

WO2004066808A2 GLYCAN MARKERS FOR DIAGNOSING AND MONITORING DISEASE 审中-公开
标题翻译：用于诊断和监测疾病的GLYCAN标记
公开(公告)号：WO2004066808A2
公开(公告)日：2004-08-12
申请号：PCT/US2003/040547
申请日：2003-12-19
申请人： MOMENTA PHARMACEUTICALS, INC. , SHRIVER, Zachary , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Mallikarjun
发明人： SHRIVER, Zachary , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Mallikarjun
IPC分类号： A61B
CPC分类号： G01N33/574 , G01N33/57473 , G01N33/57476 , G01N2400/10 , G06F19/28
摘要： The present invention provides ultra-sensitive methods for detecting changes in glycosylation that are correlated with pre-cancerous or early cancerous states. Because the chance of complete recovery is increased with earlier detection of cancer, the present invention provides therapeutically useful methods of early detection, diagnosis, staging and prognostication.
摘要翻译：本发明提供了用于检测与癌前或早期癌症状态相关的糖基化变化的超灵敏方法。因为随着癌症的早期检测，完全恢复的机会增加，本发明提供治疗有用的早期检测，诊断，分期和预后的方法。

2. 发明申请

WO2003090696A2 METHODS AND PRODUCTS FOR MUCOSAL DELIVERY 审中-公开
标题翻译：用于粘膜递送的方法和产品
公开(公告)号：WO2003090696A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/013085
申请日：2003-04-25
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SHRIVER, Zachary , SUNDARAM, Malikarjun , SASISEKHARAN, Ram , RICHARDSON, Thomas , QI, Yiwei
发明人： VENKATARAMAN, Ganesh , SHRIVER, Zachary , SUNDARAM, Malikarjun , SASISEKHARAN, Ram , RICHARDSON, Thomas , QI, Yiwei
IPC分类号： A61K
CPC分类号： C08B37/0078 , C07H1/00 , C07H5/04 , C12P19/26
摘要： The invention features methods and products associated with non-invasive delivery of polysaccharide preparations.
摘要翻译：本发明涉及与多糖制剂的非侵入性递送相关的方法和产品。

3. 发明申请

WO2003090696A3 METHODS AND PRODUCTS FOR MUCOSAL DELIVERY 审中-公开
公开(公告)号：WO2003090696A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/013085
申请日：2003-04-25
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SHRIVER, Zachary , SUNDARAM, Malikarjun , SASISEKHARAN, Ram , RICHARDSON, Thomas , QI, Yiwei
发明人： VENKATARAMAN, Ganesh , SHRIVER, Zachary , SUNDARAM, Malikarjun , SASISEKHARAN, Ram , RICHARDSON, Thomas , QI, Yiwei
IPC分类号： C07H1/00
摘要： The invention features methods and products associated with non-invasive delivery of polysaccharide preparations.

4. 发明申请

WO2003078960A2 ANALYSIS OF SULFATED POLYSACCHARIDES 审中-公开
标题翻译：硫化多糖的分析
公开(公告)号：WO2003078960A2
公开(公告)日：2003-09-25
申请号：PCT/US2003/007208
申请日：2003-03-11
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
发明人： VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
IPC分类号： G01N
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译：本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法被描述。

5. 发明申请

WO2004083807A2 METHODS OF EVALUATING GLYCOMOLECULES FOR ENHANCED ACTIVITIES 审中-公开
标题翻译：评估增强型活性糖蛋白的方法
公开(公告)号：WO2004083807A2
公开(公告)日：2004-09-30
申请号：PCT/US2004/004423
申请日：2004-02-13
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram , WHORISKEY, Susan, K.
发明人： VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram , WHORISKEY, Susan, K.
IPC分类号： G01N
CPC分类号： C07H1/00 , C08B37/00 , C08H1/00 , G01N2400/00
摘要： Methods to evaluate and rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, saccharide moiety. The method includes: determining the chemical composition and structure of all or a portion of the second, saccharide moiety, and evaluating or screening the molecule, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a ploysaccharide.
摘要翻译：已经开发了评估并快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。所述方法包括产生分子，例如治疗分子，其包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二糖部分。该方法包括：确定第二糖部分的全部或部分的化学组成和结构，以及评估或筛选分子，例如生物活性或其它化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库 ploysaccharide。

6. 发明申请

WO2003078960A3 ANALYSIS OF SULFATED POLYSACCHARIDES 审中-公开
公开(公告)号：WO2003078960A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/007208
申请日：2003-03-11
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
发明人： VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
IPC分类号： G01N33/53
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.

7. 发明申请

WO2004062592A2 2-O SULFATASE COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译： 2-O硫酸盐组合物及相关方法
公开(公告)号：WO2004062592A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000332
申请日：2004-01-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SASISEKHARAN, Ram , MYETTE, James, R. , SHRIVER, Zachary , VENKATARAMAN, Ganesh
发明人： SASISEKHARAN, Ram , MYETTE, James, R. , SHRIVER, Zachary , VENKATARAMAN, Ganesh
IPC分类号： A61K
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译：本发明涉及2-O硫酸酯酶及其用途。特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAGS）。例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

8. 发明申请

WO2003025133A2 METHODS OF MAKING GLYCOLMOLECULES WITH ENHANCED ACTIVITIES AND USES THEREOF 审中-公开
标题翻译：制备具有增强活性的甘油分子的方法及其用途
公开(公告)号：WO2003025133A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029285
申请日：2002-09-16
申请人： MIMEON, INC. , VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram
发明人： VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram
IPC分类号： C12N
CPC分类号： C08B37/00 , C12P21/005 , G01N2400/00
摘要： Methods to rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide.
摘要翻译：已经开发了快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。所述方法包括产生分子，例如包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二多糖部分的治疗分子。该方法包括：确定第二部分的全部或部分的化学组成和结构，修饰第二部分的结构以提供修饰的第二部分，以及评估或筛选具有修饰的第二部分的分子，例如，用于生物活性或其他化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库多糖。

9. 发明申请

WO2011003100A2 COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING INFLUENZA INFECTION 审中-公开
标题翻译：诊断和/或治疗流感感染的组合物和方法
公开(公告)号：WO2011003100A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040978
申请日：2010-07-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JAYARAMAN, Akila , VISWANATHAN, Karthik , RAMAN, Rahul , SHRIVER, Zachary, H. , SASISEKHARAN, Ram
发明人： JAYARAMAN, Akila , VISWANATHAN, Karthik , RAMAN, Rahul , SHRIVER, Zachary, H. , SASISEKHARAN, Ram
IPC分类号： A61K39/12 , C07K14/00 , A61K38/16 , A61P31/16 , C12Q1/70
CPC分类号： G01N33/56983 , C07K14/005 , C12N2760/16122 , G01N2333/11 , G01N2800/50
摘要： [00336] The present invention provides HA polypeptides (e.g., Hl HA polypeptides) that bind to umbrella- topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., Hl HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., Hl HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.
摘要翻译：本发明提供了结合伞形拓扑聚糖的HA多肽（例如H1HA多肽），以及与其相关的试剂和方法。本发明提供了结合HA多肽（例如H1HA多肽）的结合剂，以及与其相关的试剂和方法。本发明提供了抑制HA多肽（例如H1HA多肽）与HA受体结合的干扰剂，以及与其相关的试剂和方法。本发明提供了利用HA多肽，HA多肽结合剂，HA多肽干扰剂和/或包含上述任一种的疫苗组合物治疗，预防和/或诊断流感感染的组合物和方法。

10. 发明申请

WO2015102738A9 MULTIVALENT ANTIVIRAL COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF 审中-公开
公开(公告)号：WO2015102738A9
公开(公告)日：2015-07-09
申请号：PCT/US2014/061400
申请日：2014-10-20
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSITY OF CALIFORNIA, SANTA BARBARA (UCSB) , UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , COMOLLI, James , FINBERG, Robert , FYGENSON, Deborah K. , SHRIVER, Zachary , SASISEKHARAN, Ram , WANG, Jennifer , VISWANATHAN, Karthik
发明人： COMOLLI, James , FINBERG, Robert , FYGENSON, Deborah K. , SHRIVER, Zachary , SASISEKHARAN, Ram , WANG, Jennifer , VISWANATHAN, Karthik
IPC分类号： A61K31/702 , A61K31/715 , A61P31/12
摘要： This disclosure provides compositions, kits, and methods useful for treating or preventing viral infection. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide composition.

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