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1. 发明申请

WO03094950A2 A METHOD OF INHIBITING THE EMIGRATION OF CELLS FROM THE INTRAVASCULAR COMPARTMENT INTO TISSUES 审中-公开
标题翻译：抑制细胞从体外组织中分离出组织的方法
公开(公告)号：WO03094950A2
公开(公告)日：2003-11-20
申请号：PCT/EP0304872
申请日：2003-05-09
申请人： IPF PHARMACEUTICALS GMBH , FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
发明人： FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
IPC分类号： A61K31/00 , A61K31/557 , A61K38/07 , A61K38/17 , A61K38/19 , A61P29/00 , A61P37/06
CPC分类号： A61K38/195 , A61K31/00 , A61K31/557 , Y10S514/825 , Y10S514/826 , Y10S514/886
摘要： A method of inhibiting the emigration of cells from the intravascular compartment into tissues (or through any membrane limiting any body compartment from another) by confronting the cells with an agonist specific for receptors involved with migration of said cells via a receptor thereby making the cell unresponsive to further activation.
摘要翻译：通过使细胞与受到参与所述细胞经受体迁移的受体特异性的激动剂相对，从而抑制细胞从血管内隔室迁移到组织中（或通过任何限制任何身体隔室的膜）的方法，从而使细胞无反应进一步激活。

2. 发明申请

WO03094950A3 A METHOD OF INHIBITING THE EMIGRATION OF CELLS FROM THE INTRAVASCULAR COMPARTMENT INTO TISSUES 审中-公开
标题翻译：抑制细胞从体外组织中分离出组织的方法
公开(公告)号：WO03094950A3
公开(公告)日：2004-02-26
申请号：PCT/EP0304872
申请日：2003-05-09
申请人： IPF PHARMACEUTICALS GMBH , FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
发明人： FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
IPC分类号： A61K31/00 , A61K31/557 , A61K38/07 , A61K38/17 , A61K38/19 , A61P29/00 , A61P37/06
CPC分类号： A61K38/195 , A61K31/00 , A61K31/557 , Y10S514/825 , Y10S514/826 , Y10S514/886
摘要： A method of inhibiting the emigration of cells from the intravascular compartment into tissues (or through any membrane limiting any body compartment from another) by confronting the cells with an agonist specific for receptors involved with migration of said cells via a receptor thereby making the cell unresponsive to further activation.
摘要翻译：通过使细胞与受到参与所述细胞经受体迁移的受体特异性的激动剂相对，从而抑制细胞从血管内隔室迁移到组织中（或通过任何限制任何身体隔室的膜）的方法，从而使细胞无反应进一步激活。

3. 发明申请

WO03094950A8 A METHOD OF INHIBITING THE EMIGRATION OF CELLS FROM THE INTRAVASCULAR COMPARTMENT INTO TISSUES 审中-公开
标题翻译：一种抑制细胞从组织内迁移到组织中的方法
公开(公告)号：WO03094950A8
公开(公告)日：2004-01-15
申请号：PCT/EP0304872
申请日：2003-05-09
申请人： IPF PHARMACEUTICALS GMBH , FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
发明人： FORSSMANN ULF , ELSNER JOERN , ESCHER SYLVIA , SPODSBERG NIKOLAJ
IPC分类号： A61K31/00 , A61K31/557 , A61K38/07 , A61K38/17 , A61K38/19 , A61P29/00 , A61P37/06
CPC分类号： A61K38/195 , A61K31/00 , A61K31/557 , Y10S514/825 , Y10S514/826 , Y10S514/886
摘要： A method of inhibiting the emigration of cells from the intravascular compartment into tissues (or through any membrane limiting any body compartment from another) by confronting the cells with an agonist specific for receptors involved with migration of said cells via a receptor thereby making the cell unresponsive to further activation.
摘要翻译：一种抑制细胞从血管内隔室向组织中迁移（或通过任何限制任何身体隔室与另一个隔膜的细胞膜）的方法，通过使细胞与特异于涉及所述细胞通过受体迁移的受体的激动剂相对抗，从而使细胞不响应以进一步激活。

4. 发明申请

WO0172830A3 DIAGNOSTIC AND MEDICAMENT FOR ANALYSING THE CELL SURFACE PROTEOME OF TUMOUR AND INFLAMMATORY CELLS AND FOR TREATING TUMOROUS AND INFLAMMATORY DISEASES, PREFERABLY USING A SPECIFIC CHEMOKINE RECEPTOR ANALYSIS AND THE CHEMOKINE RECEPTOR-LIGAND INTERACTION 审中-公开
标题翻译：诊断及药物调查肿瘤和炎症细胞的ZELLOBERFLÄCHENPROTEOMS和治疗肿瘤疾病和炎症性疾病优选比趋化因子受体分析与趋化因子受体配体相互作用的帮助
公开(公告)号：WO0172830A3
公开(公告)日：2002-06-20
申请号：PCT/EP0103708
申请日：2001-04-02
申请人： IPF PHARMACEUTICALS GMBH , FORSSMANN ULF , FORSSMANN WOLF-GEORG , ADERMANN KNUT , HEITLAND ALEKSANDRA , SPODSBERG NIKOLAJ
发明人： FORSSMANN WOLF-GEORG , ADERMANN KNUT , HEITLAND ALEKSANDRA , SPODSBERG NIKOLAJ
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/00 , A61P5/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P17/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K14/52 , C07K16/28 , C12P21/08 , C12Q1/68 , C07K14/54
CPC分类号： C07K14/522 , A61K38/00 , C07K16/2866
摘要： The invention relates to the production of a medicament and a diagnostic agent, obtained by a proteome analysis, preferably containing at least two different chemokine receptor ligands or chemokine receptor antibodies and in addition, to the use of at least two different chemokine receptor ligands, chemokine receptor antibodies and/or two different chemokine receptors. The medicament preferably contains as inhibitors, ligands or antibodies of at least two chemokine receptors or of the related algorithms of the surface chemokine receptor proteome. The invention also relates to at least one chemokine receptor ligand and/or a chemokine receptor, peptides and antibodies and to the use of the same for diagnosing and treating tumorous and inflammatory diseases. Similarly, clusters of analysed tumour cell surface proteomes, such as ectoproteases, adhesion molecules or different receptor types can be used. The invention relates to a method for diagnostic and therapeutic purposes and for the medicinal and commercial use of chemokines and their corresponding receptors and their antagonists including antibodies, for inhibiting cancer growth and its metastatic spread and for repressing inflammatory and auto-immune diseases. The method is based on the finding that chemokines act on specific tumour and inflammatory cells in an autocrine, paracrine and endocrine manner by means of the disease-specific constellation of chemokine receptor proteome. Primary and secondary tumours and specific inflammatory cells are controlled in their migration and proliferation behaviour. The diagnostic detection of a local increase in expressed and regulated chemokines and of the presence of the chemokine receptor compositions allows the significant repression or complete prevention of cancer growth, tumour metastatic spread and both inflammatory and auto-immune diseases.
摘要翻译：本发明是一种药物的制备，并通过蛋白质组获得的诊断剂，优选含有至少两个不同的趋化因子受体配体或Chemokinrezeptorantikörper，并且进一步使用至少两种不同的趋化因子受体配体，Chemokinrezeptorantikörper和/或两种不同的趋化因子受体。所述药物含有作为抑制剂优选配体或至少两种趋化因子受体的抗体或表面Chemokinrezeptorproteoms的相关算法和使用至少一种趋化因子受体配体和/或趋化因子受体，肽和抗体的以及它们用于肿瘤性疾病和炎症性疾病的诊断和治疗中的用途，以类似的方式簇分析Tumorzelloberflächenproteomen的verwendbar.Die作为Ektoproteasen，粘附分子或各种受体类型的本发明涉及一种用于诊断和治疗的目的以及医学和商业使用趋化因子和它们相应的受体，它们的拮抗剂，包括抗体，癌生长抑制转移和包括以抑制炎症和自身免疫性疾病。该方法是基于以下发现，即通过在Chemokinrezeptorproteoms的特定肿瘤和炎症细胞疾病特定星座自分泌，旁分泌和内分泌途径趋化因子的行为。原发性和继发性肿瘤，以及特定的炎性细胞被控制在它们的迁移和增殖特性。由所表达的局部增加的和调节的趋化因子的诊断性检测以及趋化因子受体的组合物的存在下产生的肿瘤生长，肿瘤转移和炎症和自身免疫疾病的可能性抑制基本上或完全阻止。

5. 发明申请

WO2011080267A3 GH61 POLYPEPTIDES HAVING DETERGENCY ENHANCING EFFECT 审中-公开
标题翻译： GH61多糖具有除臭效果
公开(公告)号：WO2011080267A3
公开(公告)日：2011-09-29
申请号：PCT/EP2010070795
申请日：2010-12-28
申请人： NOVOZYMES AS , ALLESEN-HOLM MARIE , ANDERSON LARS , SCHNORR KIRK MATTHEW , SPODSBERG NIKOLAJ , HARRIS PAUL
发明人： ALLESEN-HOLM MARIE , ANDERSON LARS , SCHNORR KIRK MATTHEW , SPODSBERG NIKOLAJ , HARRIS PAUL
IPC分类号： C11D3/386 , C07K14/37 , C12N9/24 , C12N9/30
CPC分类号： C12N9/242 , C11D3/3869
摘要： The present invention relates to the use of glycosyl hydrolase family 61 polypeptides as enhancers of enzyme benefits in detergents as well as a detergent composition comprising glycosyl hydrolase family 61 polypeptides in combination with detergency enzymes.
摘要翻译：本发明涉及糖基水解酶家族61多肽作为洗涤剂中酶有益效果的增强剂的用途，以及包含糖基水解酶家族61多肽与去污力酶的洗涤剂组合物的用途。

6. 发明申请

WO2012030858A3 POLYPEPTIDES HAVING HEMICELLULOLYTIC ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有抗细胞活性的多肽和编码其的多核苷酸
公开(公告)号：WO2012030858A3
公开(公告)日：2012-06-07
申请号：PCT/US2011049785
申请日：2011-08-30
申请人： NOVOZYMES AS , NOVOZYMES INC , SPODSBERG NIKOLAJ , STRINGER MARY , DING HANSHU
发明人： SPODSBERG NIKOLAJ , STRINGER MARY , DING HANSHU
IPC分类号： C12N9/42 , A01H5/00 , C12N15/82 , C12P7/00
CPC分类号： C12N9/2437 , C12N9/2434 , C12N9/2477
摘要： The present invention relates to isolated polypeptides having hemicellulolytic activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有半纤维素分解活性的分离多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

7. 发明申请

WO2013019827A2 POLYPEPTIDES HAVING XYLANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有木聚糖酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2013019827A2
公开(公告)日：2013-02-07
申请号：PCT/US2012049096
申请日：2012-08-01
申请人： NOVOZYMES AS , NOVOZYMES INC , SPODSBERG NIKOLAJ
发明人： SPODSBERG NIKOLAJ
IPC分类号： C12N9/24
CPC分类号： C12N9/2482 , C12N9/248 , C12P19/02 , C12P19/14 , C12Y302/01008
摘要： The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有木聚糖酶活性的分离的多肽和编码该多肽的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

8. 发明申请

WO2014066141A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维增强活性的多肽和编码其的多核苷酸
公开(公告)号：WO2014066141A3
公开(公告)日：2014-07-17
申请号：PCT/US2013065485
申请日：2013-10-17
申请人： NOVOZYMES AS , NOVOZYMES INC , SPODSBERG NIKOLAJ , SHAGHASI TARANA , SWEENEY MATT , XU FENG , SCHNORR KIRK
发明人： SPODSBERG NIKOLAJ , SHAGHASI TARANA , SWEENEY MATT , XU FENG , SCHNORR KIRK
IPC分类号： C12N9/42 , C07K14/00 , C12N5/00 , C12P7/10 , C12P19/14
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity, catalytic domains, cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or cellulose binding domains.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽，催化结构域，纤维素结合结构域和编码多肽，催化结构域或纤维素结合结构域的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽，催化结构域或纤维素结合结构域的方法。

9. 发明申请

WO2013019780A2 POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有内切酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2013019780A2
公开(公告)日：2013-02-07
申请号：PCT/US2012048950
申请日：2012-07-31
申请人： NOVOZYMES AS , NOVOZYMES INC , SPODSBERG NIKOLAJ
发明人： SPODSBERG NIKOLAJ
IPC分类号： C12N9/24
CPC分类号： C12N9/2437 , C12Y302/01004
摘要： The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有内切葡聚糖酶活性的分离多肽和编码该多肽的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

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