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1. 发明申请

WO2007015824A2 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：WO2007015824A2
公开(公告)日：2007-02-08
申请号：PCT/US2006027738
申请日：2006-07-17
申请人： INTERMUNE INC , ARRAY BIOPHARMA INC , SEIWERT SCOTT D , BLATT LAWRENCE M , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BARNETT BRADLEY R , EARY TODD C , KAUS ROBERT , KERCHER TIMOTHY , LIU WEIDONG , LYON MICHAEL , NICHOLS PAUL , WANG BIN , SAMMAKIA TAREK , KENNEDY APRIL , JIANG YUTONG
发明人： SEIWERT SCOTT D , BLATT LAWRENCE M , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BARNETT BRADLEY R , EARY TODD C , KAUS ROBERT , KERCHER TIMOTHY , LIU WEIDONG , LYON MICHAEL , NICHOLS PAUL , WANG BIN , SAMMAKIA TAREK , KENNEDY APRIL , JIANG YUTONG
IPC分类号： C07K5/12 , A61K38/00 , A61P31/14 , C07C231/02 , C07C269/00 , C07D207/16 , C07D209/44
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式（I）至通式（VIII）的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

2. 发明申请

WO2008137779A3 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：WO2008137779A3
公开(公告)日：2009-01-08
申请号：PCT/US2008062552
申请日：2008-05-02
申请人： INTERMUNE INC , ARRAY BIOPHARMA INC , BLATT LAWRENCE M , PAN LIN , SEIWERT SCOTT , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BEIGELMAN LEONID , LIU JYANWEI , CONDROSKI KEVIN , JIANG YUTONG , KAUS ROBERT , KENNEDY APRIL , KERCHER TIMOTHY , LYON MICHAEL , WANG BIN
发明人： BLATT LAWRENCE M , PAN LIN , SEIWERT SCOTT , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BEIGELMAN LEONID , LIU JYANWEI , CONDROSKI KEVIN , JIANG YUTONG , KAUS ROBERT , KENNEDY APRIL , KERCHER TIMOTHY , LYON MICHAEL , WANG BIN
IPC分类号： C07D487/04 , A61K31/407 , A61P31/12 , C08H1/00
CPC分类号： C07D487/04
摘要： The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供了通式I的大环化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

3. 发明申请

WO2005049614A3 PROCESSES FOR PREPARING TETRAHYDROBIOPTERIN, AND ANALOGS OF TETRAHYDROBIOPTERIN 审中-公开
标题翻译：制备四氢生物素的方法和四氢生物素的类似物
公开(公告)号：WO2005049614A3
公开(公告)日：2007-03-08
申请号：PCT/US2004038313
申请日：2004-11-17
申请人： BIOMARIN PHARM INC , MERCK EPROVA AG , MOSER RUDOLF , GROEHN VIOLA , SCHUMACHER ANDREAS , MARTIN PIERRE , SPIELVOGEL DIRK
发明人： MOSER RUDOLF , GROEHN VIOLA , SCHUMACHER ANDREAS , MARTIN PIERRE , SPIELVOGEL DIRK
IPC分类号： C07D475/04 , A61K31/505 , C07D487/14
CPC分类号： C07D487/14 , C07D475/04
摘要： Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
摘要翻译：从新喋呤和/或6-取代蝶呤制备四氢生物喋呤的方法，其具有提高的产率和高立体选择性。本文还公开了在制备四氢生物蝶呤（例如可用于制备四氢生物蝶呤的选择性保护的新蝶呤）中制备的新的单个中间体。

4. 发明申请

WO2004089920A3 AMINE-SUBSTITUTED DIPHENYLDIPHOSPHINES AND THE USE THEREOF IN METAL COMPLEXES FOR ASYMMETRIC ADDITION REACTIONS 审中-公开
标题翻译：氨基取代的二苯基二苯膦及其在不对称合成金属配合物中的应用
公开(公告)号：WO2004089920A3
公开(公告)日：2005-03-17
申请号：PCT/EP2004050439
申请日：2004-04-05
申请人： SOLVIAS AG , PUGIN BENOIT , MARTIN PIERRE , MUELLER MARKUS , NAUD FREDERIC , SPINDLER FELIX , THOMMEN MARC , MELONE GIANPIETRO , KESSELGRUBER MARTIN
发明人： PUGIN BENOIT , MARTIN PIERRE , MUELLER MARKUS , NAUD FREDERIC , SPINDLER FELIX , THOMMEN MARC , MELONE GIANPIETRO , KESSELGRUBER MARTIN
IPC分类号： B01J31/18 , B01J31/24 , C07B53/00 , C07D265/36 , C07F9/50 , C07F9/653 , C07F9/6533 , C07F15/00
CPC分类号： C07B53/00 , B01J31/1865 , B01J31/1875 , B01J31/2409 , B01J2231/323 , B01J2231/44 , B01J2231/643 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D265/36 , C07F9/5027 , C07F9/65324 , C07F9/65335 , C07F15/0033 , C07F15/004 , C07F15/0073 , C07F15/008
摘要： The invention relates to the 1,1'-diphenyl-2,2'-diphosphines of formulae (Ia), (Ib), having at least one amine substituent in para position to the phosphine group. These novel compounds are ligands for metal complexes that are catalysts for asymmetric addition reactions of prochiral organic compounds and whose catalytic properties can be adjusted in a substrate-specific manner via the substitution of the amino group.
摘要翻译： 1,1'-二苯基-2,2'-二膦具有在对位上的至少一个胺取代基具有下式的用于金属配合物的配体通过胺基的取代作为催化剂前手性有机化合物的不对称加成反应，以及它们的催化性能的膦基团可以专门针对基材进行调整。

5. 发明申请

WO9746569A3 2'-SUBSTITUTED NUCLEOSIDES AND OLIGONUCLEOTIDE DERIVATIVES 审中-公开
标题翻译： 2'-取代的核苷酸和寡核苷酸衍生物
公开(公告)号：WO9746569A3
公开(公告)日：1998-02-19
申请号：PCT/EP9702738
申请日：1997-05-27
申请人： CIBA GEIGY AG , CUENOUD BERNARD , ALTMANN KARL HEINZ , MARTIN PIERRE , MOSER HEINZ
发明人： CUENOUD BERNARD , ALTMANN KARL-HEINZ , MARTIN PIERRE , MOSER HEINZ
IPC分类号： C12N15/09 , C07H21/00 , A61K31/70 , C07H19/04
CPC分类号： C07H21/00
摘要： The invention relates to an oligonucleotide derivative which comprises at least one nucleoside building block of the formula (I). The invention furthermore relates to nucleoside building blocks, intermediates and processes for preparing the oligonucleotide derivatives and the nucleoside building blocks. The invention also relates to pharmaceutical compositions and to uses of the oligonucleotide derivatives and the nucleoside building blocks.

6. 发明申请

WO2011063976A2 THREADED CONNECTION 审中-公开
标题翻译：螺纹连接
公开(公告)号：WO2011063976A2
公开(公告)日：2011-06-03
申请号：PCT/EP2010007191
申请日：2010-11-26
申请人： VALLOUREC MANNESMANN OIL & GAS , SUMITOMO METAL IND , MAILLON BERTRAND , MARTIN PIERRE , DURIVAULT JEROEME
发明人： MAILLON BERTRAND , MARTIN PIERRE , DURIVAULT JEROEME
IPC分类号： F16L15/06 , E21B17/042 , E21B17/08 , F16L15/04
CPC分类号： F16L15/06 , E21B17/042
摘要： A threaded connection 1 used in the exploration and operation of hydrocarbon wells comprises a first and a second tubular component, the first component comprising a male end 3 comprising a threaded zone 5 disposed on its external peripheral surface, the second component comprising a female end 2 comprising a threaded zone 4 disposed on its internal peripheral surface, the threaded zone 5 of the male end being threaded up into the threaded zone 4 of the female end, the threaded zones comprising respective male and female threads 40, 50, the threads 40, 50 comprising a root, a crest, a stabbing flank and a load flank, a groove being provided in the load flank of the threaded zone 40 of the female end and/or the male end respectively, adjacent to the root, and a boss being provided which projects axially from the load flank of the threaded zone 50 of the male end and/or respectively from the female end adjacent to the crest, the boss comprising a convex surface and a concave surface, the boss being housed in the groove with, in the connected state, a radial clearance subsisting between the concave surface and the groove and an axial clearance subsisting between the end of the boss and the bottom of the groove.
摘要翻译：用于勘探和操作烃井的螺纹连接件1包括第一和第二管状部件，第一部件包括阳端3，阳端3包括设置在其外周表面上的螺纹区5，第二部分包括阴端2 包括设置在其内周表面上的螺纹区域4，阳端的螺纹区域5螺纹连接到阴端的螺纹区域4中，螺纹区域包括相应的阳螺纹40和内螺纹螺纹40，螺纹40， 50，其包括根部，顶部，刺入侧面和负载侧面，槽分别设置在与根部相邻的阴端部和/或阳端部的螺纹区域40的负载侧面中，并且凸起部其设置在从阳端的螺纹区域50的负载侧面和/或分别从与凸起相邻的阴端部轴向突出的位置，凸台包括凸面和凹面，凸台在连接状态下容纳在凹槽中，其中凹部表面和凹槽之间存在径向间隙，并且在凸起的端部和凹槽的底部之间存在轴向间隙。

7. 发明申请

WO2004049274A3 2'-0-TRISUBSTITUTED SILYLOXYMETHYL-RIBONUCLEOSIDE-DERIVATIVE AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译： 2'-O-三取代的硅氧基甲基 - 赖氨酸衍生物及其制备方法
公开(公告)号：WO2004049274A3
公开(公告)日：2004-07-15
申请号：PCT/EP0313113
申请日：2003-11-21
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , NATT FRANCOIS JEAN-CHARLES , HUNZIKER JUERG , HALL JONATHAN , MARTIN PIERRE
发明人： NATT FRANCOIS JEAN-CHARLES , HUNZIKER JUERG , HALL JONATHAN , MARTIN PIERRE
IPC分类号： C07F7/18 , C07H19/00 , C07H21/00
CPC分类号： C07H21/00 , C07H19/00 , Y02P20/55
摘要： The invention provides ribonucleoside derivatives with novel protecting groups and methods for the preparation of such ribonucleoside derivatives. The general formula (I) of the ribonucleoside derivatives is: wherein R1 is a base of the purine- or pyrimidine-family or a derivative of such a base or any other residue with serves as a nucleobase surrogate, R2 is a proton or a substituted derivative of phosphonic acid, R3 is a proton or a protection-group for the oxygen atom in 5'-position, R4, R5 and R6 are independently alkyl or aryl or a combination of alkyl and aryl or heteroatom, R4, R5 or R6 may also be cyclically connected to each other; and wherein at least one of the R4, R5 or R6 substituents comprises a tertiary C-atom or a heteroatom vicinal to the Si-atom.
摘要翻译：本发明提供具有新保护基的核糖核苷衍生物和制备这种核糖核苷衍生物的方法。核糖核苷衍生物的通式（I）是：其中R1是嘌呤或嘧啶族的碱基或这种碱的衍生物或用作核碱基替代物的任何其它残基，R2是质子或取代的膦酸的衍生物，R3是5'-位上的氧原子的质子或保护基，R4，R5和R6独立地是烷基或芳基或烷基和芳基或杂原子的组合，R4，R5或R6可以也循环连接; 并且其中R 4，R 5或R 6取代基中的至少一个包含与叔原子相邻的叔C原子或杂原子。

8. 发明申请

WO2004089920A8 AMINE-SUBSTITUTED DIPHENYLDIPHOSPHINES AND THE USE THEREOF IN METAL COMPLEXES FOR ASYMMETRIC SYNTHESES 审中-公开
标题翻译：阿明 - 取代diphenyldiphosphines及它们在金属络合物不对称合成
公开(公告)号：WO2004089920A8
公开(公告)日：2005-05-26
申请号：PCT/EP2004050439
申请日：2004-04-05
申请人： SOLVIAS AG , PUGIN BENOIT , MARTIN PIERRE , MUELLER MARKUS , NAUD FREDERIC , SPINDLER FELIX , THOMMEN MARC , MELONE GIANPIETRO , KESSELGRUBER MARTIN
发明人： PUGIN BENOIT , MARTIN PIERRE , MUELLER MARKUS , NAUD FREDERIC , SPINDLER FELIX , THOMMEN MARC , MELONE GIANPIETRO , KESSELGRUBER MARTIN
IPC分类号： B01J31/18 , B01J31/24 , C07B53/00 , C07D265/36 , C07F9/50 , C07F9/653 , C07F9/6533 , C07F15/00
CPC分类号： C07B53/00 , B01J31/1865 , B01J31/1875 , B01J31/2409 , B01J2231/323 , B01J2231/44 , B01J2231/643 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D265/36 , C07F9/5027 , C07F9/65324 , C07F9/65335 , C07F15/0033 , C07F15/004 , C07F15/0073 , C07F15/008
摘要： The invention relates to the 1,1'-diphenyl-2,2'-diphosphines of formulae (Ia), (Ib), having at least one amine substituent in para position to the phosphine group. These novel compounds are ligands for metal complexes that are catalysts for asymmetric addition reactions of prochiral organic compounds and whose catalytic properties can be adjusted in a substrate-specific manner via the substitution of the amino group.
摘要翻译： 1,1'-二苯基-2,2'-二膦具有在对位上的至少一个胺取代基具有下式的用于金属配合物的配体通过胺基的取代作为催化剂前手性有机化合物的不对称加成反应，以及它们的催化性能的膦基团可以具体调整到基材上。

9. 发明申请

WO2011060894A2 THREADED CONNECTION 审中-公开
标题翻译：螺纹连接
公开(公告)号：WO2011060894A2
公开(公告)日：2011-05-26
申请号：PCT/EP2010006823
申请日：2010-11-09
申请人： VALLOUREC MANNESMANN OIL & GAS , SUMITOMO METAL IND , MARTIN PIERRE , MAILLON BERTRAND
发明人： MARTIN PIERRE , MAILLON BERTRAND
IPC分类号： F16L15/06 , E21B17/08
CPC分类号： E21B17/042 , F16L15/004 , F16L15/06
摘要： A threaded connection 1 comprising a first and a second tubular component, the first component comprising a male end comprising a distal surface and a threaded zone 5 disposed on its external peripheral surface, the second component comprising a female end comprising a distal surface and a threaded zone 4 disposed on its internal peripheral surface, the threaded zone 5 of the male end being threaded up into the threaded zone 4 of the female end, the threaded zones 4, 5 comprising respective male and female threads 40, 50 having a width which increases from the distal surface, the threads comprising load flanks having negative angles over at least a portion of their radial dimension, and stabbing flanks, with a radial clearance subsisting in the connected state between the crests of the male threads and the roots of the female threads and/or between the crests of the female threads and the roots of the male threads, with an axial clearance subsisting in the connected state between the stabbing flanks of the male and female threads, and the distal surface of the male end and/or female end being brought into axial abutting contact against a corresponding abutment surface.
摘要翻译：螺纹连接件1，包括第一和第二管状部件，第一部件包括阳端，其包括远侧表面和设置在其外周表面上的螺纹区域5，第二部件包括阴端，其包括远端表面和螺纹区域4设置在其内周表面上，阳端的螺纹区域5被螺纹连接到阴端的螺纹区域4中，螺纹区域4,5包括相应的阳螺纹40和内螺纹50，其宽度增加从远端表面，包括负载侧面的螺纹在其径向尺寸的至少一部分上具有负角并且刺入侧面，其中在阳螺纹的顶部和阴螺纹的根部之间的连接状态下保持的径向间隙和/或在内螺纹的顶部和阳螺纹的根部之间，轴向间隙在s之间的连接状态下保持阳螺纹和阴螺纹的凸舌侧面，并且阳端和/或阴端的远端表面与相应的邻接表面轴向抵靠接触。

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