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1. 发明申请

WO2019121934A1 A METHOD AND A SYSTEM FOR ANALYSIS OF CARDIOMYOCYTE FUNCTION 审中-公开
公开(公告)号：WO2019121934A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085868
申请日：2018-12-19
申请人： IMEC VZW , KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： BRAEKEN, Dries , PAUWELYN, Thomas , LAGAE, Liesbet
IPC分类号： G01N33/543 , C12M3/00 , H04L29/08
CPC分类号： G01N33/543 , C12M3/00 , H04L29/08 , H04L67/12
摘要： A method for analysis of cardiomyocyte function comprises: receiving (302) in a measurement position a substrate (110) carrying cardiomyocytes on a cell culturing surface; recording (304) electrical signals from the cardiomyocytes; simultaneously with said recording, acquiring (306) a sequence of images of the cardiomyocytes on the cell culturing surface based on detecting light wavefront information of reflected light; determining (308) an electrical representation relating to an intracellular and/or extracellular action potential, and/or an impedimetric electrical image of a cardiomyocyte based on the recorded electrical signals; and determining (310) a contractile representation relating to cellular deformation during contractility action of a group of cardiomyocytes based on the acquired sequence of images, wherein the electrical representation and the contractile representation apply to a common period of time.

2. 发明申请

WO2013083815A1 ANALYSIS AND SORTING OF OBJECTS IN FLOW 审中-公开
标题翻译：流量对象分析与分类
公开(公告)号：WO2013083815A1
公开(公告)日：2013-06-13
申请号：PCT/EP2012/074865
申请日：2012-12-07
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： LAGAE, Liesbet , PEUMANS, Peter , VERSTREKEN, Kris , VERCRUYSSE, Dries , LIU, Chengxun
IPC分类号： G01N15/14
CPC分类号： G06T7/0012 , G01N15/1434 , G01N15/1436 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1445 , G01N2015/149 , G03H1/0443 , G03H1/22 , G03H2001/0033 , G03H2001/005 , G03H2001/0447 , G03H2222/33 , G03H2226/13 , G06K9/46 , G06K9/6267 , G06T7/20 , G06T2207/30004
摘要： A device (1) for sorting objects immersed in a flowing medium is described. The device comprises a holographic imaging unit comprising a plurality of holographic imaging elements (2), a fluid handling unit comprising a plurality of microfluidic channels (3) for conducting flowing medium along a corresponding holographic imaging element (2) and comprising a microfluidic switch (5) arranged downstream of an imaging region in the microfluidic channel for controllably directing each object in the flowing medium into a selected one of a plurality of outlets (6). The device also comprises a processing unit (7) adapted for real-time characterization of the holographic diffraction image obtained for each of the objects thereby taking into account at least one predetermined object type signature. The processing unit (7) furthermore is adapted for controlling the microfluidic switch (5) in response to the characterization.
摘要翻译：描述了用于分选浸在流动介质中的物体的装置（1）。该装置包括全息成像单元，该全息成像单元包括多个全息成像元件（2），流体处理单元包括多个微流体通道（3），用于沿对应的全息成像元件（2）传导流动介质，并包括微流体开关 5），其布置在微流体通道中的成像区域的下游，用于可控地将流动介质中的每个物体引导到多个出口（6）中的选定的一个出口。该装置还包括适于对每个对象获得的全息衍射图像进行实时表征的处理单元（7），从而考虑到至少一个预定的对象类型签名。处理单元（7）还适于响应于表征来控制微流体开关（5）。

3. 发明申请

WO2010066794A1 SINGLE MOLECULE OPTICAL SPECTROSCOPY IN SOLID-STATE NANOPORES IN A TRANSMISSION-BASED APPROACH 审中-公开
标题翻译：基于传输方式的固体纳米光子中的单分子光学光谱
公开(公告)号：WO2010066794A1
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066737
申请日：2009-12-09
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , IMEC , VAN DORPE, Pol , DE VLAMINCK, Iwijn , LAGAE, Liesbet , BORGHS, Gustaaf
发明人： VAN DORPE, Pol , DE VLAMINCK, Iwijn , LAGAE, Liesbet , BORGHS, Gustaaf
IPC分类号： G01N21/64
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： Methods and apparatus in the field of single molecule sensing are described, e.g. for molecular analysis of analytes such as molecular analytes, e.g. nucleic acids, proteins, polypeptides, peptides, lipids and polysaccharides. Molecular spectroscopy on a molecule translocating through a solid-state nanopore is described. Optical spectroscopic signals are enhanced by plasmonic field-confinement and antenna effects and probed in transmission by plasmon-enabled transmission of light through an optical channel that overlaps with the physical channel.
摘要翻译：描述了单分子感测领域的方法和装置，例如用于分析物如分子分析物的分子分析。核酸，蛋白质，多肽，肽，脂质和多糖。描述了通过固态纳米孔易位的分子的分子光谱。光谱信号通过等离激元场约束和天线效应增强，并通过等离子体激发的光透过与物理信道重叠的光信道进行传输。

4. 发明申请

WO2010133576A1 PATTERNING AND CONTACTING OF MAGNETIC LAYERS 审中-公开
标题翻译：磁性层的绘图与接触
公开(公告)号：WO2010133576A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/056785
申请日：2010-05-18
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN , OP DE BEECK, Maria , LAGAE, Liesbet , CORNELISSEN, Sven
发明人： OP DE BEECK, Maria , LAGAE, Liesbet , CORNELISSEN, Sven
IPC分类号： H01L43/12
CPC分类号： H01L43/12
摘要： A method according to embodiments of the present invention comprises providing a magnetic stack comprising a magnetic layer sub-stack comprising magnetic layers (41) and a bottom conductive electrode (43) and a top conductive electrode (44) electrically connecting the magnetic layer sub-stack at opposite sides thereof; providing a sacrificial pillar (46) on top of the magnetic stack, the sacrificial pillar (46) having an undercut with respect to an overlying second sacrificial material (45) and a sloped foot with increasing cross-sectional dimension towards the magnetic stack, using the sacrificial pillar for patterning the magnetic stack, depositing an insulating layer (70) around the sacrificial pillar (46), selectively removing the sacrificial pillar, thus creating a contact hole (80) towards the patterned magnetic stack, and filling the contact hole with electrically conductive material (81).
摘要翻译：根据本发明的实施例的方法包括提供包括磁层子堆叠的磁性堆叠，磁层子层包括磁性层（41）和底部导电电极（43），以及顶部导电电极（44）在其相对侧堆叠; 在所述磁性堆叠的顶部提供牺牲柱（46），所述牺牲柱（46）相对于上覆的第二牺牲材料（45）具有底切，并且具有朝着所述磁性堆叠的横截面尺寸增加的倾斜脚用于图案化磁性堆叠的牺牲柱，在牺牲柱（46）周围沉积绝缘层（70），选择性地去除牺牲柱，从而产生朝向图案化磁性堆叠的接触孔（80），并且向导电材料（81）。

5. 发明申请

WO2010066795A2 A METHOD FOR FORMING A NANOSTRUCTURE PENETRATING A LAYER 审中-公开
标题翻译：一种形成层状纳米结构的方法
公开(公告)号：WO2010066795A2
公开(公告)日：2010-06-17
申请号：PCT/EP2009/066739
申请日：2009-12-09
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D , CHENG, Kai , VAN DORPE, Pol , LAGAE, Liesbet , BORGHS, Gustaaf , CHEN, Chang
发明人： CHENG, Kai , VAN DORPE, Pol , LAGAE, Liesbet , BORGHS, Gustaaf , CHEN, Chang
IPC分类号： G01N21/64
CPC分类号： B82Y15/00 , B82Y20/00 , B82Y40/00 , G01N21/554 , G01N21/648 , G01N21/658 , G01N33/48721 , G01N2021/653 , Y10S977/724 , Y10S977/924
摘要： The device comprises a substrate, a layer present thereon and a nanostructure penetrating said layer, which nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through the passageway, wherein the nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterisation of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.
摘要翻译：该装置包括基底，存在于其上的层和穿透所述层的纳米结构，该纳米结构限定了待分析的分子穿过该通道的纳米级通道，其中纳米结构在横截面图中具有基本上三角形形状。通过具有限定纳米结构的倾斜侧壁的晶面的外延层的生长，特别地实现了这种形状。它非常适合用于分子结构的光学表征，特别是用于表面等离子体增强透射光谱。

6. 发明申请

WO2011076951A1 PLASMONIC FORCE MANIPULATION IN NANOSTRUCTURES 审中-公开
标题翻译：纳米结构中的等离子体力学调控
公开(公告)号：WO2011076951A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070733
申请日：2010-12-24
申请人： IMEC , KATHOLIEKE UNIVERSITEIT LEUVEN , CHEN, Chang , VAN DORPE, Pol , CHENG, Kai , STAKENBORG, Tim , LAGAE, Liesbet
发明人： CHEN, Chang , VAN DORPE, Pol , CHENG, Kai , STAKENBORG, Tim , LAGAE, Liesbet
IPC分类号： G01N33/487 , C12Q1/68
CPC分类号： B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N33/538 , Y10T436/143333 , C12Q2565/631 , C12Q2565/607
摘要： A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.
摘要翻译：描述了用于表征和/或操纵分子的系统（100）。该系统可以特别适用于生物分子，尽管本发明不限于此。该系统（100）包括一个衬底（110），该衬底（110）包括适合于通过纳米结构（120）的分子易位的纳米结构（120）。它还包括用于使分子转移通过纳米结构（120）的装置（210）和适于通过在纳米结构（120）处施加等离子体力场来影响颗粒的易位速度的等离子体激元场产生装置（130）。还描述了相应的方法。

7. 发明申请

WO2016083337A1 A FLUID ANALYSIS DEVICE 审中-公开
标题翻译：流体分析装置
公开(公告)号：WO2016083337A1
公开(公告)日：2016-06-02
申请号：PCT/EP2015/077439
申请日：2015-11-24
申请人： IMEC VZW
发明人： PEUMANS, Peter , LAGAE, Liesbet , FIORINI, Paolo
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/10 , B01L2300/041 , B01L2300/044 , B01L2300/046 , B01L2300/0627 , B01L2300/0645 , B01L2300/0672 , B01L2300/0816 , B01L2300/0825 , B01L2300/0848 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2400/0406 , B01L2400/049 , B01L2400/0683 , B01L2400/086 , G01N1/14 , G01N1/38 , G01N33/49 , G01N2001/386
摘要： A fluid analysis device Presented is a fluid analysis device 1 which comprises a sensing device 100 for analyzing a fluid sample, the sensing device comprising a micro-fluidic component 4 for propagating the fluid sample and a microchip 103 configured for sensing the fluid sample in the micro-fluidic component 4; a sealed fluid compartment 6 containing a further fluid, the compartment 6 being fluid-tight connected to the sensing device 100 and adapted for providing the further fluid to the micro-fluidic component 4 when the sealed fluid compartment 6 is opened; and an inlet 7 for providing the fluid sample to the micro-fluidic component 4. Further, a method for sensing a fluid sample using the fluid analysis device 1 is presented.
摘要翻译：流体分析装置提供了一种流体分析装置1，其包括用于分析流体样品的感测装置100，该感测装置包括用于传播流体样品的微流体部件4和被构造用于感测流体样品中的流体样品的微芯片103 微流体组分4; 密封的流体隔室6包含另外的流体，隔间6与传感装置100流体密封连接，并且适于在密封的流体隔室6打开时向微流体部件4提供另外的流体; 以及用于将流体样品提供给微流体部件4的入口7.此外，提供了使用流体分析装置1感测流体样品的方法。

8. 发明申请

WO2017029789A1 MICRO ANALYSIS CHIP AND FABRICATION METHOD THEREOF 审中-公开
标题翻译：微分析芯片及其制造方法
公开(公告)号：WO2017029789A1
公开(公告)日：2017-02-23
申请号：PCT/JP2016/003655
申请日：2016-08-08
申请人： PANASONIC CORPORATION , IMEC VZW
发明人： SATO, Shuji , OKUMURA, Yasuaki , NISHIYAMA, Yukari , KAWAMURA, Tatsurou , JONES, Ben , LAGAE, Liesbet , STAKENBORG, Tim
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/041 , B01L2300/0809 , B01L2300/0816 , B01L2300/0851 , B01L2300/0861 , B01L2400/0406 , B01L2400/0688 , G01N21/03 , G01N27/416 , G01N33/54386
摘要： The present invention provides a novel micro analysis chip and a fabrication method thereof. The micro analysis chip comprises an inlet and a fluid flow path which communicates thereto. The fluid flow path comprises a first flow path, a second flow path, and a third flow path which are arranged continuously along a longitudinal direction of the fluid flow path. An antibody is bound on at least one peripheral surface selected from the group consisting of a peripheral surface of the second flow path and a peripheral surface of the third flow path. A cross-sectional area of the third flow path is constant or increased monotonically along a direction X from the second flow path toward the third flow path. A cross-sectional area of the second flow path is increased monotonically along the direction X from the one end to the other end of the second flow path. A cross-sectional area of the first flow path is larger than a cross-sectional area at the one end of the second flow path.
摘要翻译：本发明提供了一种新颖的微分析芯片及其制造方法。微分析芯片包括与其通信的入口和流体流动路径。流体流动路径包括沿着流体流动路径的纵向方向连续布置的第一流动路径，第二流动路径和第三流动路径。抗体结合在选自第二流路的外周表面和第三流路的外周表面的至少一个外周表面上。第三流路的横截面积沿着从第二流路朝向第三流路的方向X单调地恒定或增加。第二流路的截面积从第二流路的一端向另一端沿方向X单调增加。第一流路的截面积大于第二流路一端的截面积。

9. 发明申请

WO2017001534A1 BLEACHING OF DYES IN LUMINESCENT DETECTION 审中-公开
标题翻译：染发剂中染色剂的漂白
公开(公告)号：WO2017001534A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/065229
申请日：2016-06-30
申请人： IMEC VZW
发明人： PEUMANS, Peter , LAGAE, Liesbet , VAN ROY, Willem , STAKENBORG, Tim , VAN DORPE, Pol
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6408 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/648 , G01N2021/6413 , G01N2021/6439
摘要： A sensor device (100) for quantifying luminescent targets. The device comprises a light source (111) for exciting the targets, thus generating luminescence signals and a detector (120) for detecting these signals, resulting in a detected signal which comprises a desired signal (310) originating from the targets and a background signal (320). It moreover comprises a bleaching device (135) for bleaching of at least part of the sources generating the background signal (320) and a processor (140) configured to trigger the bleaching device (135) to start bleaching, and to trigger the light source (111) for exciting the remaining luminescent targets which are not bleached, and to trigger the detector (120) for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.
摘要翻译：一种用于量化发光靶的传感器装置（100）。该装置包括用于激发目标的光源（111），从而产生发光信号，以及用于检测这些信号的检测器（120），产生检测信号，该检测信号包括源自目标的期望信号（310）和背景信号（320）。它还包括漂白装置（135），用于漂白产生背景信号的源的至少一部分（320）和配置成触发漂白装置（135）开始漂白的处理器（140），并触发光源（111），用于激发未漂白的剩余发光靶，并且触发检测器（120）以检测剩余的发光靶的发光信号，以产生代表发光靶的量化的测量信号。

10. 发明申请

WO2016083550A1 COMPACT GLASS-BASED FLUID ANALYSIS DEVICE AND METHOD TO FABRICATE 审中-公开
标题翻译：基于玻璃的基于玻璃的流体分析装置和方法
公开(公告)号：WO2016083550A1
公开(公告)日：2016-06-02
申请号：PCT/EP2015/077855
申请日：2015-11-26
申请人： IMEC VZW
发明人： PEUMANS, Peter , LAGAE, Liesbet , FIORINI, Paolo
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , A61K9/0014 , B01L3/5027 , B01L3/50273 , B01L3/50857 , B01L3/565 , B01L9/527 , B01L2200/10 , B01L2300/0645
摘要： The present invention relates to a device (100) for analyzing a fluid sample. The device (100) comprises a fluidic substrate (101) comprising a micro- fluidic component (102) embedded therein, for propagating a fluid sample; a means for providing the fluid sample which is fluidically connected to the micro-fluidic component (102); a lid (103) attached to the fluidic substrate (101) thereby at least partly covering the fluidic substrate (101) and at least partly closing the micro-fluidic component (102); wherein the fluidic substrate (101) is a glass fluidic substrate and wherein the lid is a microchip (103). The present invention also relates to a method for fabricating a fluid analysis device (100). The method comprises providing a fluidic substrate (101); providing a lid (103); attaching the lid (103) to the fluidic substrate (101) to close the fluidic substrate (101) at least partly.
摘要翻译：本发明涉及一种用于分析流体样品的装置（100）。装置（100）包括流体衬底（101），其包括嵌入其中的微流体组分（102），用于传播流体样品; 用于提供流体连接到微流体组件（102）的流体样品的装置; 附接到所述流体基底（101）的盖（103），从而至少部分地覆盖所述流体基底（101）并且至少部分地封闭所述微流体部件（102）; 其中所述流体基底（101）是玻璃流体基底，并且其中所述盖子是微芯片（103）。本发明还涉及一种用于制造流体分析装置（100）的方法。该方法包括提供流体基底（101）; 提供盖（103）; 将盖（103）附接到流体基板（101）以至少部分地关闭流体基板（101）。

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