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1. 发明申请

WO2017083187A1 ELECTROSPINNING 审中-公开
标题翻译：静电纺丝
公开(公告)号：WO2017083187A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/060494
申请日：2016-11-04
申请人： ELEKTROFI, INC
发明人： COFFMAN, Chase
IPC分类号： D01D5/00
CPC分类号： D01D5/0069 , D01D5/0092
摘要： Among other things, fibers are electrospun using an electrospinning structure comprising a base and at least one emitting element on the base, a first electrode arranged at a distance from the free end of the at least one emitting element, and optionally a collection element between the at least one emitting element and the first electrode, the collection element being configured to collect the fibers. The at least one emitting element has a projecting free end. At least a portion of the base, the at least one emitting element, or both include a porous material. The first electrode is configured to cause fibers to be produced from the free end of the at least one emitting element.
摘要翻译：其中，纤维是使用静电纺丝结构进行电纺丝的，所述静电纺丝结构包含基底和在基底上的至少一个发光元件，第一电极布置在距所述至少一个发光元件的自由端以及任选地在所述至少一个发射元件与所述第一电极之间的收集元件，所述收集元件被配置为收集所述纤维。该至少一个发光元件具有突出的自由端。基座的至少一部分，至少一个发光元件或两者包括多孔材料。第一电极被配置为使纤维从至少一个发光元件的自由端产生。

2. 发明申请

WO2019023392A1 FORMATION OF PARTICLES INCLUDING AGENTS 审中-公开
公开(公告)号：WO2019023392A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043774
申请日：2018-07-25
申请人： ELEKTROFI, INC.
发明人： COFFMAN, Chase , CHARLES, Lyndon , BROWN, Paul , DADON, Daniel Benjamin , LIU, Lisa , ROBINSON, Cory , THOMAS, Dale Arlington, III
IPC分类号： C08J9/28 , B01J2/06 , B01J2/08 , B01J2/16 , B01J2/30
摘要： The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

3. 发明申请

WO2019226969A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2019226969A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033875
申请日：2019-05-24
申请人： ELEKTROFI, INC.
发明人： COFFMAN, Chase , CHARLES, Lyndon , BROWN, Paul , DADON, Daniel, Benjamin , LIU, Lisa , SHADBAR, Sadiqua , SUDRIK, Chaitanya
IPC分类号： A61K9/51
摘要： The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

4. 发明申请

WO2018098376A1 PARTICLES COMPRISING A THERAPEUTIC OR DIAGNOSTIC AGENT AND SUSPENSIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2018098376A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/063150
申请日：2017-11-22
申请人： ELEKTROFI, INC.
发明人： COFFMAN, Chase , CHARLES, Lyndon , BROWN, Paul , DADON, Daniel, Benjamin , LIU, Lisa , ROBINSON, Cory
IPC分类号： B01J13/04 , B05B5/00 , B05B5/025
摘要： The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

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