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1. 发明申请

WO2020075069A1 AN RF-ION GUIDE WITH IMPROVED TRANSMISSION OF ELECTRONS 审中-公开
公开(公告)号：WO2020075069A1
公开(公告)日：2020-04-16
申请号：PCT/IB2019/058559
申请日：2019-10-08
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： RYUMIN, Pavel , BABA, Takashi
IPC分类号： H01J49/00 , H01J49/06
摘要： An electron-ion interaction module for use in a mass spectrometer, having a plurality of rod sets arranged relative to one another such that said rod sets share a common longitudinal axis and each of said rod sets is longitudinally separated from an adjacent rod set by a gap, each of said rod sets comprising a plurality of rods arranged around said common longitudinal axis. The module further includes at least one magnet disposed around said rod sets so as to at least partially surround one or more of said plurality of rod sets and configured to generate a static magnetic field along said longitudinal axis. The rod sets are configured to receive electrons from an electron source and ions from an ion source within an interaction volume defined by the rods. One or more RF voltage sources coupled to the plurality of rod sets applies voltages to the rods.

2. 发明申请

WO2020075068A1 ELECTRON BEAM THROTTLING FOR ELECTRON CAPTURE DISSOCIATION 审中-公开
公开(公告)号：WO2020075068A1
公开(公告)日：2020-04-16
申请号：PCT/IB2019/058558
申请日：2019-10-08
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , RYUMIN, Pavel
IPC分类号： H01J49/00 , H01J49/06
摘要： In one aspect, an electron-ion reaction module, e.g., an electron capture dissociation module, for use in a mass spectrometer is disclosed, which comprises a chamber, an electron source for generating electrons and introducing the electrons into the chamber, a gate electrode positioned relative to the electron source and the chamber, and a DC voltage source operatively coupled to the gate electrode for applying control voltages to the gate electrode. The electron-ion interaction module can further include a controller operably coupled to the DC voltage source and configured for adjusting the DC voltage applied to the gate electrode to adjust flow of electrons into the chamber.

3. 发明申请

WO2019197983A1 TOP-DOWN ANALYSIS OF ANTIBODIES IN MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2019197983A1
公开(公告)日：2019-10-17
申请号：PCT/IB2019/052906
申请日：2019-04-09
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , RYUMIN, Pavel , LOYD, William M.
IPC分类号： G01N33/68 , G16B40/10 , G16B30/00
摘要： A separation device separates an unknown intact mAb or reduced mAb subunits of a known mAb class from a sample. An ion source device ionizes the mAb. A mass spectrometer fragments the ionized mAb using an ECD device and mass analyzes resulting product ions using a mass analyzer, producing one or more product ion spectra. Theoretical product ion peaks are calculated for one or more constant portions of the mAb class. The theoretical product ion peaks are removed from the one or more product ion spectra, producing one or more difference product ion spectra. De novo sequencing is applied to the one or more difference product ion spectra, producing one or more candidate sequences for one or more variable portions of the mAb. A genome database is searched for matches to the one or more candidate sequences, producing one or more matched sequences for the one or more variable portions.

4. 发明申请

WO2018087634A1 SPATIAL, MASS AND ENERGY FOCUSED ION INJECTION METHOD AND DEVICE 审中-公开
标题翻译：空间质量和能量聚焦离子注入方法和装置
公开(公告)号：WO2018087634A1
公开(公告)日：2018-05-17
申请号：PCT/IB2017/056819
申请日：2017-11-02
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi
IPC分类号： H01J49/42
摘要： In one aspect, an ion trap is disclosed, which includes a curved linear ion trap having a plurality of electrodes arranged around a central curved axis so as to provide a volume for trapping ions, said plurality of electrodes comprising at least one inner electrode and at least one outer electrode radially separated from said inner electrode. The ion trap further includes a pair of inner and outer ion guide electrodes providing a volume therebetween for receiving ions ejected from said curved ion trap and guiding the ejected ions to one or more spatial locations along a focal line, said inner and outer ion guide electrodes being positioned external to said ion trapping volume and in proximity of said at least inner and outer electrodes of the curved ion trap, respectively, wherein a DC voltage is applied between said ion guide electrodes to provide an electric filed therebetween for guiding the ejected ions to said spatial locations.
摘要翻译：在一个方面，公开了一种离子阱，其包括弯曲的线性离子阱，该弯曲的线性离子阱具有布置在中心弯曲轴周围的多个电极以便提供用于俘获离子的体积，所述多个电极包括至少一个内电极和与所述内电极径向分开的至少一个外电极。离子阱进一步包括一对内部和外部离子引导电极，在其间提供体积用于接收从所述弯曲离子阱射出的离子并且将所喷射的离子引导到沿着焦线的一个或多个空间位置，所述内部和外部离子引导电极位于所述离子俘获体积的外部并分别靠近所述弯曲离子阱的所述至少内部电极和外部电极，其中在所述离子引导电极之间施加直流电压以在其间提供电场以将所述喷射离子引导至说空间位置。

5. 发明申请

WO2017093860A1 OPTIMIZED ELECTROMAGNETIC FIELD ON SIDE-ON FT-ICR MASS SPECTROMETERS 审中-公开
标题翻译：侧入式FT-ICR质谱仪的优化电磁场
公开(公告)号：WO2017093860A1
公开(公告)日：2017-06-08
申请号：PCT/IB2016/057082
申请日：2016-11-24
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/4255 , H01J49/38 , H01J49/424
摘要： Improvements to a side-on Penning trap include a feedback system for stabilizing the magnetic field. This system includes a magnetic sensor that measures the magnetic field and a solenoid coil that in response to the magnetic field measurements increases or decreases the overall magnetic field. Improvements also include a number of different configurations of the two sets of PCB electrodes used to produce the quadrupole electric field. Dimensions of the PCB electrodes are optimized, an equipotential surface electrode is added, and additional ring electrodes are added to produce a purer quadrupole field. A central disk electrode is segmented to direct charged particles to the trap center to make the trap useful for applications other than mass spectrometry. Finally, outer ring electrodes are segmented to increase the path of charged particles, thereby increasing sensitivity.
摘要翻译：
侧入Penning陷阱的改进包括用于稳定磁场的反馈系统。该系统包括一个测量磁场的磁性传感器和一个响应磁场测量增加或减少总磁场的电磁线圈。改进还包括用于产生四极电场的两组PCB电极的许多不同配置。优化PCB电极的尺寸，添加等电位表面电极，并添加额外的环形电极以产生更纯的四极场。将中心圆盘电极分段以将带电粒子引导至陷阱中心，以使该陷阱可用于除质谱之外的应用。最后，外环电极被分段以增加带电粒子的路径，从而提高灵敏度。

6. 发明申请

WO2015097503A1 SIMULTANEOUS POSITIVE AND NEGATIVE ION ACCUMULATION IN AN ION TRAP FOR MASS SPECTROSCOPY 审中-公开
标题翻译：用于大量光谱的离子阱同时积极和负离子累积
公开(公告)号：WO2015097503A1
公开(公告)日：2015-07-02
申请号：PCT/IB2014/002482
申请日：2014-11-18
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi
IPC分类号： H01J49/26 , H01J3/00
CPC分类号： H01J49/0095 , H01J49/0072 , H01J49/062 , H01J49/4225 , H01J49/4295
摘要： An ion reaction device is provided having an ion injection inlet for receiving a plurality of ions and an ion ejection outlet through which ions can exit the device. The reaction device includes a plurality of non-linear rods disposed relative to one another so as to provide an axial region configured to receive a plurality of anions and cations via said ion injection inlet, and a plurality of trapping regions in communication with the axial region in which said anions and cations can be confined. A DC voltage source is adapted to apply a DC voltage across at least two of said rods so as to generate an electric field within at least a portion of said axial region for spatially separating the received anions and cations and guiding the anions into one of said trapping regions and the cations into another one of said trapping regions.
摘要翻译：提供了一种离子反应装置，其具有用于接收多个离子的离子注入口和离子可以离开装置的离子喷射出口。反应装置包括相对于彼此设置的多个非线性杆，以提供构造成经由所述离子注入口接收多个阴离子和阳离子的轴向区域，以及与轴向区域连通的多个捕获区域其中阴离子和阳离子可以被限制。直流电压源适于跨所述杆中的至少两个施加直流电压，以便在所述轴向区域的至少一部分内产生电场，用于空间分离所接收的阴离子和阳离子，并将阴离子引导到所述捕获区域和阳离子到另一个所述捕获区域。

7. 发明申请

WO2022053950A1 REDUCTION OF INTERNAL FRAGMENTATION IN ELECTRON ACTIVATED DISSOCIATION DEVICES AND METHODS 审中-公开
公开(公告)号：WO2022053950A1
公开(公告)日：2022-03-17
申请号：PCT/IB2021/058171
申请日：2021-09-08
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi
IPC分类号： H01J49/00 , H01J49/06
摘要： An ion sequestering apparatus and methods or systems using one or more auxiliary electrodes in an ion reaction instrument having RF electrodes adapted to guide positively-charged precursor ions along a first axis, and an electron source for introduction of an electron beam along a second axis transverse to the first axis such that electron activated dissociation of the precursor ions into reaction products can occur, the auxiliary electrode configured to apply a supplemental AC signal to permit selective extraction of reaction products while sequestering precursor ions along the second central axis. For example, the supplemental AC signal can comprises an notched white noise signal with a notch that suppresses frequencies at which the precursor ions (and/or charge reduced species that have the same molecular mass but have a different charge state) would otherwise be excited.

8. 发明申请

WO2022013715A1 ELECTRON ACTIVATION DISSOCIATION REACTION DEVICE WITH ION ISOLATION FUNCTIONALITY IN MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2022013715A1
公开(公告)日：2022-01-20
申请号：PCT/IB2021/056257
申请日：2021-07-12
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , GODBEHERE, Grant
IPC分类号： H01J49/00 , H01J49/42
摘要： In one aspect, a method of performing mass spectrometry is disclosed, which comprises ionizing a sample to generate a plurality of precursor ions, passing the precursor ions through a mass filter to select at least one subset of the ions, introducing the selected ions into a branched radiofrequency (RF) ion trap and subjecting at least a portion of said selected precursor ions to fragmentation within the ion trap so as to generate a first plurality of fragment ions. The method can further include isolating at least a portion of the first plurality of fragment ions in at least one branch of the branched RF ion trap, removing unwanted fragment ions, releasing the remaining ions from said at least one branch and subjecting at least a portion thereof to fragmentation so as to generate a second plurality of fragment ions. Any combination of collision induced dissociation (CID) and electron activation dissociation (EAD) can be employed for fragmenting the ions.

9. 发明申请

WO2019003188A1 APPARATUS AND METHOD FOR GLYCOPEPTIDE ANALYSIS 审中-公开
公开(公告)号：WO2019003188A1
公开(公告)日：2019-01-03
申请号：PCT/IB2018/054823
申请日：2018-06-28
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi , LEBLANC, Yves
IPC分类号： H01J49/42 , G01N33/68
摘要： A system and method is described for characterizing glycopeptides which includes a first quadrupole mass filter, a multipole rod set of an ion guide, a lens electrode, an ExD device and a mass analyzer. The multipole rod set is adapted to receive a radial radio frequency (RF) trapping voltage and a radial dipole direct current (DC) voltage The lens electrode is adapted to receive an axial trapping alternating current (AC) voltage and a DC voltage. The ExD device performs electron capture dissociation or electron transfer dissociation, the ExD device being positioned so that an entrance of the ExD device is disposed on the other side of the lens electrode opposite the multipole rod set. The mass analyzer is positioned at an exit of the ExD device for receiving ions from the ExD device.

10. 发明申请

WO2017130070A1 ION INJECTION METHOD INTO SIDE-ON FT-ICR MASS SPECTROMETERS 审中-公开
标题翻译：离子注入法在侧入式FT-ICR质谱分析仪上的应用
公开(公告)号：WO2017130070A1
公开(公告)日：2017-08-03
申请号：PCT/IB2017/050107
申请日：2017-01-10
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： BABA, Takashi
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/38
摘要： Improvements to a side-on Penning trap include methods to stabilize ions in the trap. The ions are stabilized by injecting ions in the focusing region of the non-uniform DC fields produced by the pad electrodes of the trap. Ions are injected along an injection axis shifted from the central axis of a gap between a positively biased electrode pad and negatively biased electrode pad of the trap. Improvements also include methods to compensate for the Lorentz force that is produced when ions are injected into a side-on Penning trap. Electrodes of an ion injection device are DC biased so that the electrodes produce an electric field along the axis of the device that compensates for the Lorentz force. Finally, methods are provided to increase the m/z range of ions injected into a side-on Penning trap by pre-trapping ions just before injection of the ions into the trap.
摘要翻译：改进侧入式潘宁阱包括稳定阱中离子的方法。通过将离子注入由陷阱的焊盘电极产生的非均匀DC场的聚焦区域中来稳定离子。沿着注入轴注入离子，注入轴从阱的正偏置电极焊盘和负偏置电极焊盘之间的间隙的中心轴偏移。改进还包括补偿在将离子注入侧向Penning阱时产生的洛伦兹力的方法。离子注入装置的电极被直流偏置，使得电极沿着装置的轴线产生补偿洛伦兹力的电场。最后，通过在将离子注入阱之前预先俘获离子来提供方法以增加注入到侧入式Penning阱中的离子的m / z范围。

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