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1. 发明申请

WO2006119115A2 ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：抗IL-6抗体，组合物，方法和用途
公开(公告)号：WO2006119115A2
公开(公告)日：2006-11-09
申请号：PCT/US2006016457
申请日：2006-04-28
申请人： CENTOCOR INC , APPLIED MOLECULAR EVOLUTION , CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
发明人： CHEN YAN , GARDNER DEBRA , KNIGHT DAVID M , LARK MICHAEL W , LIANG BAILIN , SHEALY DAVID J , SONG XIAO-YU R , STOJANOVIC-SUSULIC VEDRANA , SWEET RAYMOND W , TAM SUSAN H , WU SHENG-JIUN , YANG JING , MARQUIS DAVID MATTHEW , SMITH ERIC MICHAEL , VASSEROT ALAIN PHILIPPE
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法在诊断和/或治疗组合物中的应用，方法和设备。

2. 发明申请

WO2004098502A3 CNGH0010 SPECIFIC POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES. 审中-公开
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途。
公开(公告)号：WO2004098502A3
公开(公告)日：2006-03-23
申请号：PCT/US2004013211
申请日：2004-04-30
申请人： CENTOCOR INC , SONG XIAO-YU R , HUANG CHRIS , MA KEYING , LIANG BAILIN , NASO MICHAEL
发明人： SONG XIAO-YU R , HUANG CHRIS , MA KEYING , LIANG BAILIN , NASO MICHAEL
IPC分类号： A61K20060101 , A61K38/00 , C07K14/47 , C07H21/04 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/02
CPC分类号： C07K14/47 , A61K45/06
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

3. 发明申请

WO2008052111A3 RESISTIN ANTAGONISTS AND THEIR USE 审中-公开
标题翻译：电阻拮抗剂及其使用
公开(公告)号：WO2008052111A3
公开(公告)日：2008-11-13
申请号：PCT/US2007082521
申请日：2007-10-25
申请人： CENTOCOR INC , BLAKE SIMON , CARTON JILL , LEE JENNY , MA KEYING , MARSTERS PAUL , PICHA KRISTEN , SONG XIAO-YU R , FARRELL FRANCIS , MURRAY LYNNE , TEPLYAKOV ALEXEY , ORT TATIANA
发明人： BLAKE SIMON , CARTON JILL , LEE JENNY , MA KEYING , MARSTERS PAUL , PICHA KRISTEN , SONG XIAO-YU R , FARRELL FRANCIS , MURRAY LYNNE , TEPLYAKOV ALEXEY , ORT TATIANA
IPC分类号： C07K16/00 , A61K39/395 , C07K14/00
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译：公开了抗性拮抗剂，包括与限定的表位反应的抗体。还公开了可用于提高抗人抵抗素抗体的抗原。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

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