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    • 1. 发明申请
    • DRY POWDER INHALERS
    • 干粉吸入
    • WO2008110809A3
    • 2008-12-31
    • PCT/GB2008000886
    • 2008-03-13
    • CAMBRIDGE CONSULTANTSSMITH SIMON JAMESTANG LAI CHIU
    • SMITH SIMON JAMESTANG LAI CHIU
    • A61M15/00
    • A61M15/0045A61M15/0025A61M15/0036A61M15/0041A61M15/0048A61M15/0081A61M15/0096A61M2202/064
    • A dry powder inhaler comprises a mouthpiece (12) through which in use a user can inhale a powdered medicament. A mouthpiece obstruction or cover (6, 8) is arranged to prevent a user properly inhaling through the mouthpiece. A plurality of medicament doses are provided in individually sealed compartments (24). The inhaler has means (48, 50) for breaching the seal (25) of one of said compartments (24) to establish a pathway between that compartment and the mouthpiece, wherein the mouthpiece obstruction or cover is mechanically coupled to the seal breaching means so as to operate the latter when the mouthpiece obstruction or cover is opened. The inhaler further comprises one or more piercers (52, 54). The piercers are so shaped and arranged that upon penetration of the sealing member they form a hollow tube therewith for communicating with the interior of the compartment.
    • 干粉吸入器包括接口(12),使用者可以在使用中吸入粉末状药物。 喉舌阻塞物或盖子(6,8)被布置成防止使用者通过吸嘴适当吸入。 在单独密封的隔室(24)中提供多个药物剂量。 吸入器具有用于破坏其中一个隔室(24)的密封件(25)的装置(48,50),以在该隔室和接口管之间建立通道,其中,接口阻塞物或盖机械地联接到密封件破裂装置 以便在打开喉舌阻塞物或盖子时操作后者。 吸入器还包括一个或多个穿孔器(52,54)。 穿孔器是这样的形状和布置,使得在密封构件穿透时,它们形成中空管,用于与隔间的内部连通。
    • 2. 发明申请
    • DRY POWDER INHALERS
    • 干粉吸入器
    • WO2007144607A3
    • 2008-02-21
    • PCT/GB2007002190
    • 2007-06-13
    • CAMBRIDGE CONSULTANTSSMITH SIMON JAMESHARRIS DAVID STUARTSTRIEBIG RACHEL VICTORIAPEARL JULIE SUZANNE
    • SMITH SIMON JAMESHARRIS DAVID STUARTSTRIEBIG RACHEL VICTORIAPEARL JULIE SUZANNE
    • A61M15/00
    • A61M15/0028A61M15/0008A61M15/002A61M15/0021A61M15/0026A61M15/0036A61M15/0043A61M15/0045A61M15/0065A61M2202/064A61M2205/195A61M2205/197A61M2206/16
    • A dry powder inhaler comprises: a cyclone chamber having a cyclone chamber outlet (20) extending substantially axially therefrom; a mouthpiece channel (26) having a central axis; and a plenum portion (58) connecting said cyclone chamber outlet (20) and said mouthpiece channel, the mouthpiece channel axis A m being offset from, and making a non-parallel angle with, the axis of the cyclone outlet A c such that in use air exits the cyclone outlet (20) at least partly tangentially into the mouthpiece (28). Also disclosed is a blister pack (200) for use with a dry powder inhaler and including a dose of powder for inhalation, the blister comprising: a base part (202) comprising at least one chamber (204,206); a grommet cover (208) extending partly over said chamber and defining an aperture (212, 214) above the chamber; and a protective layer (210) covering at least said aperture, wherein the edge of the grommet cover (208) defining the aperture (212, 214) is compliant so as in use to form a seal around a tube passing through the aperture.
    • 干粉吸入器包括:旋风室,其具有从其基本轴向延伸的旋风室出口(20); 具有中心轴线的接口通道(26); 以及连接所述旋风室出口(20)和所述接口通道的增压室(58),所述接口通道轴线A M m从所述旋转室出口(20)和所述接口通道的轴线偏移,并且与 旋风出口A ,使得在使用中,空气至少部分切向地离开旋风出口(20)进入吹口(28)。 还公开了一种与干粉吸入器一起使用并且包括一定剂量的用于吸入的粉末的泡罩包装(200),所述泡罩包括:包括至少一个室(204,206)的基部(202); 在所述腔室上部分地延伸并且在所述腔室上方限定孔(212,214)的垫圈盖(208) 以及覆盖至少所述孔的保护层(210),其中限定孔(212,214)的索环盖(208)的边缘是柔顺的,以便在使用中形成围绕穿过孔的管的密封。
    • 4. 发明申请
    • PRESSURISED INHALERS
    • 加压吸入器
    • WO2004041339A3
    • 2004-07-29
    • PCT/GB0304751
    • 2003-11-04
    • CAMBRIDGE CONSULTANTSBURGE SIMONISAACS WARREN PAULSMITH SIMON JAMESTUCKWELL JONATHAN DAVID
    • BURGE SIMONISAACS WARREN PAULSMITH SIMON JAMESTUCKWELL JONATHAN DAVID
    • A61M15/00
    • A61M15/0091A61M15/0068A61M15/0073A61M15/009A61M15/0096
    • A pressurised medicament canister (4) has a valve (2) which dispenses a metered dose upon being released from a depressed condition. An inhaler device adapted for use with the canister has a breath-actuated latch mechanism (60, 62; 208, 216) arranged in use to latch the canister (4) in a depressed condition and further to release the latch (60, 62; 208, 216) in response to inhalation through the inhaler by a user. Also disclosed is a dose counter for counting the number of doses dispensed from the canister comprising a counter member (240) having a helical toothed track (238) which is incrementally advanced each time a dose is dispensed from the canister (4). Also disclosed is a valve for the canister comprising a sliding seal (136) delimiting the metering chamber and slidable relative to a nozzle member, said sliding seal (136) being biased in use to reduce the volume of the metering chamber (146) substantially to zero once the metering chamber (146) has been vented to the atmosphere.
    • 加压药剂罐(4)具有阀(2),其在从沮丧状态释放时分配计量剂量。 适于与该罐一起使用的吸入器装置具有一个呼吸致动的锁定机构(60,62; 208,216),该锁定机构设置在使用中以将凹槽(4)锁定在凹陷状态,并进一步释放闩锁(60,62; 208,216)。 208,116),以响应于使用者通过吸入器的吸入。 还公开了一种用于计数从罐分配的剂量数量的剂量计数器,其包括具有螺旋齿状轨迹(238)的计数器构件(240),每当从罐(4)分配剂量时,其逐渐前进。 还公开了一种用于罐的阀,其包括限定计量室并相对于喷嘴构件可滑动的滑动密封件(136),所述滑动密封件(136)在使用中被偏压以将计量腔室(146)的体积基本上减小到 一旦计量室(146)已经排放到大气中,则为零。