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1. 发明申请

WO2009065142A2 USE OF NITRITE SALTS IN CHRONIC ISCHEMIA 审中-公开
标题翻译：硝酸盐在慢性疾病中的使用
公开(公告)号：WO2009065142A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083830
申请日：2008-11-17
申请人： BIOMEDICAL RESEARCH FOUNDATION OF NORTHWEST LOUISIANA , LOUISIANA STATE UNIVERSITY , THE UAB RESEARCH FOUNDATION , KEVIL, Christopher , LEFER, David , PATEL, Rakesh
发明人： KEVIL, Christopher , LEFER, David , PATEL, Rakesh
IPC分类号： A61K33/14 , A61K33/06 , A61P7/06
CPC分类号： A61K33/06 , A61K33/00 , A61K45/06

2. 发明申请

WO2021046371A1 TREATMENT AND PREVENTION OF PULMONARY INJURY 审中-公开
公开(公告)号：WO2021046371A1
公开(公告)日：2021-03-11
申请号：PCT/US2020/049436
申请日：2020-09-04
申请人： THE UAB RESEARCH FOUNDATION
发明人： MATALON, Sadis , AGGARWALL, Saurabh , JILLING, Tamas , PATEL, Rakesh
IPC分类号： A61K38/16 , A61K38/46 , A61K38/48 , A61P11/00 , A61P29/00 , A61K38/17
摘要： Hemopexin, salubrinal, aurothioglucose, and nitrite find uses in treating pulmonary injury from several causes, alone and in combination. Methods of treatment, methods of prevention, and pharmaceutical compositions are provided with those components.

3. 发明申请

WO2010118228A1 DRUG DELIVERY COMPOSITION 审中-公开
标题翻译：药物输送组合物
公开(公告)号：WO2010118228A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/030387
申请日：2010-04-08
申请人： ELAN PHARMA INTERNATIONAL LIMITED , RUDDY, Stephen, B. , MCGURK, Simon, L. , PATEL, Rakesh , BULLOCK, John , KEWALRAMANI, Raj
发明人： RUDDY, Stephen, B. , MCGURK, Simon, L. , PATEL, Rakesh , BULLOCK, John , KEWALRAMANI, Raj
IPC分类号： A61K9/50
CPC分类号： A61K9/5078 , A61K9/5047 , A61K31/167 , A61K31/185 , A61K31/403 , A61K31/436 , A61K31/551 , A61K31/5513 , A61K47/20 , Y02A50/402
摘要： A composition for delivery of a drug is disclosed. The composition has a semipermeable coating, particles of a medicament having an effective average particle size of less than or about 2 μm and at least one surface stabilizer adsorbed on the surface of the medicament particles, and a solubilizing agent.
摘要翻译：公开了用于递送药物的组合物。该组合物具有半透性涂层，具有小于或约2μm的有效平均粒度的药物颗粒和吸附在药物颗粒表面上的至少一种表面稳定剂和增溶剂。

4. 发明申请

WO2009056993A2 A PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES 审中-公开
标题翻译：一个合成中间体及其中间体的方法
公开(公告)号：WO2009056993A2
公开(公告)日：2009-05-07
申请号：PCT/IB2008/003894
申请日：2008-11-03
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , VASOYA, Snjay, L. , PATEL, Rakesh , JADAV, Arpan, M.
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , VASOYA, Snjay, L. , PATEL, Rakesh , JADAV, Arpan, M.
CPC分类号： C07D307/93
摘要： A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.
摘要翻译：用于制备在该方法中有用的拉米尔顿和中间体的方法。适用于工业规模的方法通过较少的工艺步骤提供增加的产率和/或更高的纯度。

5. 发明申请

WO2007053723A3 PROCESS FOR THE PREPARATION OF CEFDINIR 审中-公开
公开(公告)号：WO2007053723A3
公开(公告)日：2007-05-10
申请号：PCT/US2006/042745
申请日：2006-10-31
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh , WIZEL, Shlomit
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh , WIZEL, Shlomit
IPC分类号： C07D513/04
摘要： The invention relates to processes for preparing cefdinir via its potassium and cesium salts.

6. 发明申请

WO2007053722A3 CRYSTALLINE FORM OF CEFDINIR CESIUM SALT 审中-公开
公开(公告)号：WO2007053722A3
公开(公告)日：2007-05-10
申请号：PCT/US2006/042743
申请日：2006-10-31
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh
发明人： KANSAL, Vinod, Kumar , MISTRY, Dhirenkumar, N. , PANDEY, Saurabh , PATEL, Rakesh
IPC分类号： C07D513/04
摘要： Provided is the cesium salt of cefdinir, processes for its preparation and its use in the preparation of cefdinir.

7. 发明申请

WO2014012110A2 MULTIMODAL IMAGING FOR THE DETECTION OF TISSUE STRUCTURE AND COMPOSITION 审中-公开
标题翻译：多模式成像检测组织结构和组成
公开(公告)号：WO2014012110A2
公开(公告)日：2014-01-16
申请号：PCT/US2013/050535
申请日：2013-07-15
申请人： UNIVERSITY OF MASSACHUSETTS , YAROSLAVKSY, Anna, N. , GILES, Robert, H. , JOSEPH, Cecil, S. , PATEL, Rakesh
发明人： YAROSLAVKSY, Anna, N. , GILES, Robert, H. , JOSEPH, Cecil, S. , PATEL, Rakesh
IPC分类号： A61B5/1455
CPC分类号： A61B5/0035 , A61B5/004 , A61B5/0064 , A61B5/0507 , A61B5/443 , A61B5/444 , A61B5/4872 , A61B5/7246 , A61B5/7278 , A61B5/7282 , A61B2576/02 , G01N21/21 , G01N21/3581
摘要： The present invention relates to the use of optical and terahertz imaging of tissue for measuring characteristics to assist in diagnosis. A light delivery and collection system is used that can aid in the detection of tumor margins, for example. A data processor processes the image data to determine characteristics of a region of tissue.
摘要翻译：本发明涉及使用组织的光学和太赫兹成像来测量特征以辅助诊断。例如，使用光递送和收集系统，其可以帮助检测肿瘤边缘。数据处理器处理图像数据以确定组织区域的特征。

8. 发明申请

WO2013033832A1 SIGNAL ROUTER 审中-公开
标题翻译：信号路由器
公开(公告)号：WO2013033832A1
公开(公告)日：2013-03-14
申请号：PCT/CA2012/000840
申请日：2012-09-07
申请人： EVERTZ MICROSYSTEMS LTD. , PATEL, Rakesh
发明人： PATEL, Rakesh
IPC分类号： H04L12/56 , H04N7/26
CPC分类号： H04Q11/0062 , H04H20/69 , H04L12/00 , H04M3/56
摘要： A plurality of signal routing systems are disclosed. In various embodiments, the routing systems include both a crosspoint switch or switching fabric for coupling input ports to one or more output ports, thereby allowing an input signal received at one of the input ports to be transported to one or more of the output ports. The system also includes aggregation or compression modules to allow multiple input signals to be combined into compressed signal, which may be transmitted converted into optical signals for transmission to a communication network. In some embodiments, the communication network may include a packet switched router which extracts some of the input signals from the optical signals and produced packetized signals corresponding to the original input signals. The packetized signals may be coupled to output ports to which external devices are coupled. In various embodiments, the routing system may include only a packet switched router. In various embodiments, the routing system may be configured to receive various input signals including optical signals and to decompress or deaggregate such signals to form individual signals which may then be coupled to various output ports.
摘要翻译：公开了多个信号路由系统。在各种实施例中，路由系统包括用于将输入端口耦合到一个或多个输出端口的交叉点交换机或交换结构，从而允许在一个输入端口接收的输入信号被传送到一个或多个输出端口。该系统还包括聚合或压缩模块，以允许将多个输入信号组合成压缩信号，该压缩信号可被转换成光信号以传输到通信网络。在一些实施例中，通信网络可以包括从光信号中提取一些输入信号并且产生对应于原始输入信号的分组化信号的分组交换路由器。分组信号可以耦合到外部设备耦合到的输出端口。在各种实施例中，路由系统可以仅包括分组交换路由器。在各种实施例中，路由系统可以被配置为接收包括光信号的各种输入信号，并且解压缩或解聚集这些信号以形成单独的信号，然后可以将其耦合到各种输出端口。

9. 发明申请

WO2012112911A2 DEVICES AND METHODS FOR OPTICAL PATHOLOGY 审中-公开
标题翻译：用于光学病理学的装置和方法
公开(公告)号：WO2012112911A2
公开(公告)日：2012-08-23
申请号：PCT/US2012/025678
申请日：2012-02-17
申请人： UNIVERSITY OF MASSACHUSETTS - LOWELL , YAROSLAVSKY, Anna, N. , PATEL, Rakesh , WIRTH, Dennis
发明人： YAROSLAVSKY, Anna, N. , PATEL, Rakesh , WIRTH, Dennis
IPC分类号： C12Q1/00 , G06T7/40
CPC分类号： A61B5/0071 , A61B5/0068 , A61B5/0091 , A61B5/742 , A61M5/007 , A61M31/005 , G06T7/0012 , G06T7/90 , G06T2207/10064 , G06T2207/10152 , G06T2207/20221 , G06T2207/30096
摘要： Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.
摘要翻译：目前绝大多数癌症，包括乳腺癌，都是在没有任何术中保证金控制的情况下被移除的。术后检查方法检查手术切缘的1-2％，易出现抽样误差。本发明涉及一种光学成像系统，其将能够实时评估手术边界。本发明提供了同时的荧光和荧光偏振成像。使用批准用于患者诊断的荧光剂可以增强获取图像的对比度。由于荧光图像的染色模式与组织学类似，并且与正常细胞相比，癌症中的荧光偏振值显着更高，因此本发明为诊断方法提供了进一步的改进。该系统和方法可以应用于手术中癌组织的描绘。

10. 发明申请

WO2016012985A1 SOLID PHARMACEUTICAL COMPOSITION COMPRISING PI3K-INHIBITOR 审中-公开
标题翻译：包含PI3K抑制剂的固体药物组合物
公开(公告)号：WO2016012985A1
公开(公告)日：2016-01-28
申请号：PCT/IB2015/055622
申请日：2015-07-24
申请人： NOVARTIS AG , DESAI, Dipen , GALLI, Bruno , PATEL, Rakesh , SANCHEZ-FELIX, Manuel Vincente , SEILER, Frank Hans , SHAH, Navnit H. , VERMA, Daya D. , WIDMER, Toni , MEYER, Stefanie , IYER, Raman , SERREAU, Severine , GRANDOLINI, Simone , GRANER, Oliver
发明人： DESAI, Dipen , GALLI, Bruno , PATEL, Rakesh , SANCHEZ-FELIX, Manuel Vincente , SEILER, Frank Hans , SHAH, Navnit H. , VERMA, Daya D. , WIDMER, Toni , MEYER, Stefanie , IYER, Raman , SERREAU, Severine , GRANDOLINI, Simone , GRANER, Oliver
IPC分类号： A61K9/14 , A61K9/20 , A61K9/48 , A61K31/5377
CPC分类号： A61K31/5377 , A61K9/146 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/2077 , A61K9/4825 , A61K9/4833 , A61K9/4866
摘要： The application relates to solid pharmaceutical compositions suitable for oral administration comprising an PI3K inhibitor, processes for their production and uses of the pharmaceutical compositions in the treatment of cancer.
摘要翻译：本申请涉及适用于口服给药的固体药物组合物，其包含PI3K抑制剂，其制备方法和药物组合物用于治疗癌症的用途。

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