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1. 发明申请

WO2006058723A8 NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES 审中-公开
标题翻译：新的吡啶并吡啶衍生物
公开(公告)号：WO2006058723A8
公开(公告)日：2007-07-12
申请号：PCT/EP2005012773
申请日：2005-11-30
申请人： ALMIRALL LAB , PAGES SANTACANA LLUIS MIQUEL , TALTAVULL MOLL JOAN , GRACIA FERRER JORDI
发明人： PAGES SANTACANA LLUIS MIQUEL , TALTAVULL MOLL JOAN , GRACIA FERRER JORDI
IPC分类号： C07D495/22 , A61K31/519 , A61P11/06
CPC分类号： C07D495/22 , A61K31/519
摘要： Use of a pyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivative of formula (I), wherein n is an integer selected from 0 or 1 R 1 and R 2 are independently selected from hydrogen atoms and C 1-4 alkyl groups R 3 represents a group selected from alkyl, amino, monoalkylamino, dialkylamino, aryl, heteroaryl and saturated N-containing heterocyclyl groups bound through the nitrogen atom to the piridine ring, all of them being optionally substituted by one or more substituents selected from the group consisting of halogen atoms and alkyl, alkoxyalkyl, arylalkyl, R 6 000-, alkoxy, R 6 R 7 N-CO-, -CN, -CF 3 , -NR 6 R 7 , -SR 6 and - SO 2 NH 2 groups wherein R 6 and R 7 are independently selected from hydrogen atoms and C 1-4 alkyl groups R 4 and R 5 are independently selected from the group consisting of hydrogen atoms, alkyl groups and groups of formula (II): wherein p and q are integers selected from 1, 2 and 3; A is either a direct bond or a group selected from -CONR 12 -, -NR 12 CO-, -O-, -COO-, -OCO-, -NR 12 COO-, -OCONR 12 -, -NR 12 CONR 13 -, -S-, -SO-, -SO 2 -, -COS- and -SCO-; and G 2 is a group selected from aryl, heteroaryl or heterocyclyl; wherein the alkyl groups and the group G 2 are optionally substituted by one or more substuents selected from group consisting of halogen atoms and alkyl, alkoxyalkyl, arylalkyl, R 14 OCO-, hydroxy, alkoxy, oxo, R 14 R 15 N-CO-, -CN, -CF 3 , -NR 14 R 15 , -SR 14 and -SO 2 NH 2 groups; wherein the groups R 8 to R 15 are independently selected from hydrogen atoms and C 1
摘要翻译：使用式（I）的吡啶并[3'，2'：4,5]噻吩并[3,2-d]嘧啶衍生物，其中n是选自0或1个R 1 R 2和R 2独立地选自氢原子，C 1-4烷基R 3表示选自烷基，氨基，单烷基氨基，通过氮原子与吡啶环结合的二烷基氨基，芳基，杂芳基和饱和的含N的杂环基，它们全部被任选地被一个或多个选自卤素原子和烷基，烷氧基烷基，芳基烷基， SO 6，N，CO，-CN，-CF 3 - ， - SO 2 - ， - R 6，R 6，-SR 6和-S SO 2 NH 2基团其中R 6和R 7独立地选自氢原子和C 1-4烷基R 4和 R 5独立地选自氢原子，烷基g （II）的基团：其中p和q是选自1,2和3的整数; A是直接键或选自-CONR 12 - ， - NR 12 - ， - O - ， - COO - ， - OCO - ， - NR C 12 -C 12 - ， - CONR 12 - ， - NR 12 - ， - SO - ， - S - ， - SO - ，-SO 2 - ， - COS-和-SCO-; 和G 2是选自芳基，杂芳基或杂环基的基团; 其中烷基和基团G 2任选被一个或多个选自以下的取代基取代：卤素原子和烷基，烷氧基烷基，芳基烷基，R 14 OCO-，羟基，烷氧基，氧代，R 14，R 15，N-CO-，-CN，-CF 3，-NR 14， 15个，-SR 14和-SO 2个NH 2基团; 其中基团R 8至R 15独立地选自氢原子和C 1〜

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