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    • 1. 发明申请
    • HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS
    • 生物组织的杂交光谱测量监测
    • WO2012096825A2
    • 2012-07-19
    • PCT/US2012/020319
    • 2012-01-05
    • O2 MEDTECH INC.ZHANG, WeiYU, ZengpinWANG, Shih-ping
    • ZHANG, WeiYU, ZengpinWANG, Shih-ping
    • A61B5/1455
    • A61B5/1455
    • Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.
    • 基于相位调制分光光度法(PMS)和连续波分光光度法(CWS)的混合组合,用于非侵入式近红外分光光度计(NIRS)监测总血红蛋白水平和/或其他血液成分水平的系统,方法和相关计算机程序产品, 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的幅度和相位信息的PMS测量,以计算至少部分代表散射特性的PMS衍生的中间信息。 结合PMS派生的中间信息来处理包括振幅信息的基于CWS的测量,以计算吸收特性的脉冲分量。 代表至少一个生色团水平的度量,例如总血液血红蛋白水平,是根据至少三个波长的吸收特性的脉动分量来计算的,并显示在输出显示器上。
    • 5. 发明申请
    • HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS
    • 生物组分的混合分光光度法监测
    • WO2012096825A3
    • 2012-09-07
    • PCT/US2012020319
    • 2012-01-05
    • O2 MEDTECH INCZHANG WEIYU ZENGPINWANG SHIH-PING
    • ZHANG WEIYU ZENGPINWANG SHIH-PING
    • A61B5/1477
    • A61B5/1455
    • Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.
    • 基于相位调制分光光度法(PMS)和连续波分光光度法(CWS)的混合组合,用于非侵入式近红外分光光度(NIRS)监测总血红蛋白水平和/或其他血液成分水平的系统,方法和相关计算机程序产品, 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的振幅和相位信息的基于PMS的测量值,以计算至少部分表示散射特性的PMS导出的中间信息。 结合PMS导出的中间信息处理包括幅度信息的基于CWS的测量值,以计算吸收特性的脉动分量。 从至少三个波长处的吸收特性的脉动分量计算代表至少一个发色团水平的量度,例如总血红蛋白水平,并显示在输出显示器上。
    • 7. 发明申请
    • BREAST ULTRASOUND SCANNING PROMOTING PATIENT COMFORT AND IMPROVED IMAGING NEAR CHEST WALL
    • 乳房超声波扫描促进患者舒适和改进的近似壁面成像
    • WO2005120357A1
    • 2005-12-22
    • PCT/US2005/018316
    • 2005-05-23
    • U-SYSTEMS, INC.WANG, Shih-PingZHANG, WeiCHEN, JiayuYU, Zengpin
    • WANG, Shih-PingZHANG, WeiCHEN, JiayuYU, Zengpin
    • A61B8/00
    • A61B8/0825A61B8/406A61B8/4218A61B8/4281A61B8/483A61B8/54
    • An apparatus and related methods for scanning a breast are described, the apparatus comprising a frame defining an orifice shaped to allow the breast to be received therein, a compressive member secured to the frame across the orifice that compresses the received breast toward the patient's chest wall, and a transducer positioned in acoustic communication with the compressive member for imaging the breast therethrough. The frame holds a reservoir of acoustically conductive fluid that maintains the transducer in acoustic communication with the compressive member. In different preferred embodiments having different advantages, the compressive member comprises a flexible elastic membrane, a flexible inelastic membrane, or a rigid sonolucent plastic preformed into the shape of a chestwardly-compressed breast. Where the transducer comprises one or more linear array probes, various probe orientations and trajectories are described for generating a three-dimensional volumetric representation of the breast having reduced nipple shadow effects.
    • 描述了一种用于扫描乳房的装置和相关方法,所述装置包括限定形状以允许乳房被容纳在其中的孔口的框架;压缩构件,其被固定到穿过所述孔口的框架,所述压缩构件将接收的乳房压缩到患者的胸壁 以及与所述压缩构件声学连通的换能器,用于使乳房通过其成像。 框架保持导电流体的储存器,其将换能器保持与压缩构件声学连通。 在具有不同优点的不同优选实施例中,压缩构件包括柔性弹性膜,柔性非弹性膜或预先形成胸部压缩乳房形状的刚性声光塑料。 在换能器包括一个或多个线性阵列探针的情况下,描述了用于产生具有降低的乳头阴影效应的乳房的三维体积表示的各种探针取向和轨迹。
    • 9. 发明申请
    • FULL-FIELD BREAST IMAGE DATA PROCESSING AND ARCHIVING
    • 全场BREAST图像数据处理和存档
    • WO2004051405A2
    • 2004-06-17
    • PCT/US0337600
    • 2003-11-25
    • U SYSTEMS INCYU ZENGPINWANG SHIH-PING
    • YU ZENGPINWANG SHIH-PING
    • A61B6/00A61B8/00A61B8/08G06F
    • A61B8/5215A61B6/463A61B6/502A61B6/5241A61B6/5247A61B6/563A61B8/0825A61B8/406A61B8/4281A61B8/4405A61B8/463A61B8/464A61B8/465A61B8/466A61B8/467A61B8/5238A61B8/565
    • A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment. Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.
    • 描述了用于获得,处理和/或归档全场乳房图像数据(例如全场乳房超声(FFBU)数据)的系统,计算机程序产品和相关方法,以促进与当前的现场集成的方式 基于x射线乳腺X线摄影的乳腺癌筛查方法,可替代地可用于支持全场纯环境。 使用从三维数据体积计算的二维厚片图像来促进乳房成像会话的有效归档,对应于乳房的板状子体积的二维厚片图像。 减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。 存档空间也得到保留,同时仍然提供足够的信息数据以备将来参考。 还描述了相关的辅助全字段工作流程方法。 所描述的实施例可应用于FFBU成像和其他全场乳房成像模式,例如MRI,CT,PET等。
    • 10. 发明申请
    • APPARATUS AND METHOD FOR FULL-FIELD BREAST ULTRASOUND SCANNING
    • 用于全场乳腺超声扫描的装置和方法
    • WO2004030523A2
    • 2004-04-15
    • PCT/US2003/031434
    • 2003-10-01
    • U-SYSTEMS, INC.ANDERSON, Tor, C.HAUTALA, Reino, E.CHIN, DonaldMAR, Janet, B.YU, Zengpin
    • ANDERSON, Tor, C.HAUTALA, Reino, E.CHIN, DonaldMAR, Janet, B.YU, Zengpin
    • A61B
    • A61B6/463A61B6/5247A61B8/0825A61B8/4281A61B8/4405A61B8/462A61B8/463A61B8/5238
    • A full-field breast ultrasound (FFBU) scanning apparatus and related methods are described for compressing and ultrasonically scanning a breast. A first surface of an at least partially conformable, substantially taut membrane or film sheet compresses one side of the breast, and the other side of the breast is compressed by a compression assembly comprising a rigid compression plate and an inflatable air bladder. A transducer translation mechanism holds a transducer surface against a second surface of the film sheet while translating the transducer thereacross to scan the breast. An irrigation system automatically maintains a continuous supply of coupling agent at an interface between the transducer surface and the film sheet as the transducer is translated. A recycling system collects used coupling agent for re-use by the irrigation system. The transducer is housed in a substantially closed environment to prevent evaporative acoustic couplant loss and to allow scanning at many different angles without couplant loss. A variety of other usability, patient comfort, and safety features are also described.
    • 描述了用于压缩和超声扫描乳房的全场乳房超声(FFBU)扫描装置及相关方法。 至少部分贴合的,基本上拉紧的膜或膜片的第一表面压缩乳房的一侧,并且乳房的另一侧被包括刚性压缩板和可充气气囊的压缩组件压缩。 换能器平移机构将换能器表面保持抵靠薄膜片的第二表面,同时在其上平移换能器以扫描乳房。 当换能器被平移时,灌溉系统在换能器表面和薄膜片之间的界面处自动维持耦合剂的连续供应。 回收系统收集使用的偶联剂以供灌溉系统重复使用。 传感器容纳在基本封闭的环境中以防止蒸发声耦合剂损失,并允许在许多不同角度进行扫描而没有耦合剂损失。 还描述了各种其他可用性,患者舒适和安全特征。