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1. 发明申请

WO2012149356A3 ANTI-CD40 ANTIBODIES AND METHODS OF USE 审中-公开
公开(公告)号：WO2012149356A3
公开(公告)日：2012-11-01
申请号：PCT/US2012/035502
申请日：2012-04-27
申请人： APEXIGEN, INC. , ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
发明人： ZHANG, Yongke , YU, Guo-Liang , ZHU, Weimin
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , A61P35/00
摘要： The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

2. 发明申请

WO2007123765A3 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
公开(公告)号：WO2007123765A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/008021
申请日：2007-03-30
申请人： HUMAN GENOME SCIENCES INC. , YU, Guo-liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen , CHEVRIER, Marc
发明人： YU, Guo-liang , EBNER, Reinhard , NI, Jian , ROSEN, Craig, A. , ULLRICH, Stephen , CHEVRIER, Marc
IPC分类号： C12N5/20 , C07K16/00 , G01N33/53
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

3. 发明申请

WO03013227A9 YIELD-RELATED POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS 审中-公开
标题翻译：植物相关多核苷酸和多糖
公开(公告)号：WO03013227A9
公开(公告)日：2003-07-03
申请号：PCT/US0225805
申请日：2002-08-09
申请人： MENDEL BIOTECHNOLOGY INC , RATCLIFFE OLIVER , RIECHMANN JOSE LUIS , ADAM LUC J , DUBELL ARNOLD N , HEARD JACQUELINE E , PILGRIM MARSHA L , JIANG CAI-ZHONG , REUBER T LYNNE , CREELMAN ROBERT A , PINEDA OMAIRA , YU GUO-LIANG , BROUN PIERRE E
发明人： RATCLIFFE OLIVER , RIECHMANN JOSE LUIS , ADAM LUC J , DUBELL ARNOLD N , HEARD JACQUELINE E , PILGRIM MARSHA L , JIANG CAI-ZHONG , REUBER T LYNNE , CREELMAN ROBERT A , PINEDA OMAIRA , YU GUO-LIANG , BROUN PIERRE E
IPC分类号： A01H5/10 , C07K14/415 , C12N15/29 , C12N15/82 , A01H
CPC分类号： A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
摘要： The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
摘要翻译：本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自各种植物物种的同系物，以及使用多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法，并且也被公开。

4. 发明申请

WO03014327A3 STRESS-RELATED POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS 审中-公开
标题翻译：植物中与应激有关的多核苷酸和多肽
公开(公告)号：WO03014327A3
公开(公告)日：2003-05-30
申请号：PCT/US0226966
申请日：2002-08-09
申请人： MENDEL BIOTECHNOLOGY INC , REUBER T LYNNE , RIECHMANN JOSE LUIS , HEARD JACQUELINE E , JIANG CAI-ZHONG , ADAM LUC J , DUBELL ARNOLD N , RATCLIFFE OLIVER , PINEDA OMAIRA , YU GUO LIANG , BROUN PIERRE E
发明人： REUBER T LYNNE , RIECHMANN JOSE LUIS , HEARD JACQUELINE E , JIANG CAI-ZHONG , ADAM LUC J , DUBELL ARNOLD N , RATCLIFFE OLIVER , PINEDA OMAIRA , YU GUO LIANG , BROUN PIERRE E
IPC分类号： A01H5/10 , C07K14/415 , C12N15/29 , C12N15/82 , A01H1/00 , A01H5/00 , C07H21/04 , C12N5/04
CPC分类号： A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
摘要： The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
摘要翻译：本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自多种植物物种的同源物，以及使用该多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法中，并且也被公开。

5. 发明申请

WO2003014327A2 STRESS-RELATED POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS 审中-公开
标题翻译：在植物中的应力相关多核苷酸和多肽
公开(公告)号：WO2003014327A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/026966
申请日：2002-08-09
申请人： MENDEL BIOTECHNOLOGY, INC. , REUBER, T., Lynne , RIECHMANN, Jose Luis , HEARD, Jacqueline, E. , JIANG, Cai-Zhong , ADAM, Luc, J. , DUBELL, Arnold, N. , RATCLIFFE, Oliver , PINEDA, Omaira , YU, Guo, Liang , BROUN, Pierre, E.
发明人： REUBER, T., Lynne , RIECHMANN, Jose Luis , HEARD, Jacqueline, E. , JIANG, Cai-Zhong , ADAM, Luc, J. , DUBELL, Arnold, N. , RATCLIFFE, Oliver , PINEDA, Omaira , YU, Guo, Liang , BROUN, Pierre, E.
IPC分类号： C12N
CPC分类号： A01H5/10 , C07K14/415 , C12N15/8247 , C12N15/8261 , C12N15/8262 , C12N15/827 , C12N15/8271 , C12N15/8273 , C12N15/8275 , C12N15/8282 , Y02A40/146
摘要： The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
摘要翻译：本发明涉及植物转录因子多肽，编码它们的多核苷酸，来自各种植物物种的同系物，以及使用多核苷酸和多肽产生与参照植物相比具有有利特性的转基因植物的方法。与这些多核苷酸和多肽相关的序列信息也可以用于生物信息学检索方法，并且也被公开。

6. 发明申请

WO0196528A3 HUMAN TUMOR NECROSIS FACTOR DELTA AND EPSILON 审中-公开
标题翻译：人类肿瘤坏死因子DELTA和EPSILON
公开(公告)号：WO0196528A3
公开(公告)日：2002-08-08
申请号：PCT/US0119026
申请日：2001-06-14
申请人： HUMAN GENOME SCIENCES INC , YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
发明人： YU GUO-LIANG , NI JIAN , GENTZ REINDER L , DILLON PATRICK J , HILBERT DAVID
IPC分类号： A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K16/28 , G01N33/564 , C12Q1/68 , A61K38/00 , C07H21/02
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

7. 发明申请

WO0050620A3 HUMAN ENDOKINE ALPHA AND METHODS OF USE 审中-公开
标题翻译：人类内啡肽和使用方法
公开(公告)号：WO0050620A3
公开(公告)日：2000-11-30
申请号：PCT/US0004722
申请日：2000-02-25
申请人： HUMAN GENOME SCIENCES INC , YU GUO LIANG , NI JIAN , ROSEN CRAIG A
发明人： YU GUO-LIANG , NI JIAN , ROSEN CRAIG A
IPC分类号： A61K38/00 , C07K14/525 , C07K14/52 , A61K38/16 , A61K38/19 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/19 , C12N15/63
CPC分类号： C07K14/5255 , A61K38/00
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及肿瘤坏死因子（TNF）家族细胞因子的新成员。具体而言，提供了编码内因子α蛋白的分离的核酸分子。还提供了内因子α多肽，如载体，宿主细胞和用于生产它们的重组方法。还提供了关于TNF家族相关疾病的诊断和治疗方法。

8. 发明申请

WO1998007749A1 NOVEL HUMAN GROWTH FACTORS 审中-公开
标题翻译：新的人类成长因素
公开(公告)号：WO1998007749A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014139
申请日：1997-08-22
申请人： HUMAN GENOME SCIENCES, INC. , YU, Guo-Liang , DILLON, Patrick, J. , EBNER, Reinhard , ENDRESS, Gregory, A.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00 , C12N2799/026
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. These proteins share homology with the XAG protein of Xenopus laevis and can be found in colon tissue. huXAG-1 is specifically found in cancerous colon cells and may therefore be a growth factor for colon cancer. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity as well as diagnostic and therapeutic uses of the proteins.
摘要翻译：本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。这些蛋白质与非洲爪蟾的XAG蛋白质具有同源性，并且可以在结肠组织中发现。 huXAG-1特异性地存在于癌性结肠细胞中，因此可能是结肠癌的生长因子。特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂以及蛋白质的诊断和治疗用途的筛选方法。

9. 发明申请

WO1997034997A1 HUMAN ENDOMETRIAL SPECIFIC STEROID-BINDING FACTOR I, II AND III 审中-公开
标题翻译：人类内分泌特异性STEROID-BINDING因子I，II和III
公开(公告)号：WO1997034997A1
公开(公告)日：1997-09-25
申请号：PCT/US1996003857
申请日：1996-03-21
申请人： HUMAN GENOME SCIENCES, INC. , NI, Jian , YU, Guo-Liang , GENTZ, Reiner, L.
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N01/20
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及hESF I，II和III多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，以及多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

10. 发明申请

WO1997027747A1 CYTOSTATIN I 审中-公开
公开(公告)号：WO1997027747A1
公开(公告)日：1997-08-07
申请号：PCT/US1996001640
申请日：1996-02-05
申请人： HUMAN GENOME SCIENCES, INC. , NI, Jian , GENTZ, Reiner, L. , YU, Guo-Liang , ROSEN, Craig, A. , SU, Jeffrey
发明人： HUMAN GENOME SCIENCES, INC.
IPC分类号： A01N37/18
CPC分类号： C07K14/475 , A61K38/00 , C12N2799/026
摘要： The invention relates to cytostatin I polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及细胞抑制剂I多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

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