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1. 发明申请

WO2008127526A2 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS 审中-公开
标题翻译：生物标志物和确定血管内皮生长因子受体2调节因子灵敏度的方法
公开(公告)号：WO2008127526A2
公开(公告)日：2008-10-23
申请号：PCT/US2008003258
申请日：2008-03-12
申请人： SQUIBB BRISTOL MYERS CO , WU SHUJIAN , AYERS MARK DAVID , HAN XIA , YOGANATHAN SUGANTHY , FARGNOLI JOSEPH
发明人： WU SHUJIAN , AYERS MARK DAVID , HAN XIA , YOGANATHAN SUGANTHY , FARGNOLI JOSEPH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the VEGFR-2 modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a VEGFR-2 modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
摘要翻译：可用于鉴定和监测将对治疗癌症的治疗方法进行治疗的哺乳动物的方法中的VEGFR-2生物标志物，其包括施用VEGFR-2调节剂，其中所述方法包括（a）将哺乳动物暴露于VEGFR-2调节剂和（ b）在哺乳动物中测量至少一种生物标志物的水平，其中在（b）中测量的至少一种生物标志物水平的差异与尚未暴露于VEGFR的哺乳动物中的生物标志物的水平相比较 -2调节剂表明哺乳动物将对治疗癌症的方法进行治疗反应;（c）其中暴露于VEGFR-2调节剂后哺乳动物中生物标志物的水平表明哺乳动物对治疗癌症的方法有治疗反应。

2. 发明申请

WO2007117439A2 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO MICROTUBULE-STABILIZING AGENTS 审中-公开
公开(公告)号：WO2007117439A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008269
申请日：2007-03-30
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEE, Hyerim , CLARK, Edwin, A. , WU, Shujian , XU, Li-An
发明人： LEE, Hyerim , CLARK, Edwin, A. , WU, Shujian , XU, Li-An
IPC分类号： G01N33/574 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N2800/52
摘要： Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.

3. 发明申请

WO2002094999A2 POLYNUCLEOTIDE ENCODING A NOVEL TRP CHANNEL FAMILY MEMBER, TRP-PLIK2, AND SPLICE VARIANTS THEREOF 审中-公开
标题翻译：多核苷酸编码一个新的TRP通道家族成员，TRP-PLIK2及其SPLICE变量
公开(公告)号：WO2002094999A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/016164
申请日：2002-05-22
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEE, Ning , CHEN, Jian , FEDER, John , WU, Shujian , CHANG, Han , LEE, Liana , BLANAR, Michael , BOL, David
发明人： LEE, Ning , CHEN, Jian , FEDER, John , WU, Shujian , CHANG, Han , LEE, Liana , BLANAR, Michael , BOL, David
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码TRP-PLIK2多肽的新型多核苷酸，其片段和同源物。本发明还提供分别编码TRP-PLIK2多肽，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型TRP-PLIK2，TRP-PLIK2b，TRP-PLIK2c和TRP-PLIK2d多肽应用于诊断，治疗和/或预防与这些相关的各种疾病和/或病症的诊断和治疗方法多肽。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明申请

WO2008127526A3 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS 审中-公开
公开(公告)号：WO2008127526A3
公开(公告)日：2008-12-31
申请号：PCT/US2008003258
申请日：2008-03-12
申请人： SQUIBB BRISTOL MYERS CO , WU SHUJIAN , AYERS MARK DAVID , HAN XIA , YOGANATHAN SUGANTHY , FARGNOLI JOSEPH
发明人： WU SHUJIAN , AYERS MARK DAVID , HAN XIA , YOGANATHAN SUGANTHY , FARGNOLI JOSEPH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the VEGFR-2 modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a VEGFR-2 modulator indicates that the mammal has responded therapeutically to the method of treating cancer.

5. 发明申请

WO2007117439A3 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO MICROTUBULE-STABILIZING AGENTS 审中-公开
标题翻译：生物标志物和确定微管稳定剂灵敏度的方法
公开(公告)号：WO2007117439A3
公开(公告)日：2007-12-06
申请号：PCT/US2007008269
申请日：2007-03-30
申请人： SQUIBB BRISTOL MYERS CO , LEE HYERIM , CLARK EDWIN A , WU SHUJIAN , XU LI-AN
发明人： LEE HYERIM , CLARK EDWIN A , WU SHUJIAN , XU LI-AN
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/57415 , G01N33/57484 , G01N33/57496 , G01N2800/52
摘要： Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.
摘要翻译：可用于鉴定对治疗反应或对治疗癌症的方法有反应的哺乳动物的生物标志物，其包括施用微管稳定剂。一方面，癌症是乳腺癌，并且微管稳定剂是埃坡霉素或其类似物或衍生物或伊沙匹隆。

6. 发明申请

WO2005001061A2 POLYNUCLEOTIDES ENCODING NOVEL ADIPONECTIN RECEPTOR VARIANTS 审中-公开
标题翻译：编码新型ADIPONECTIN受体变体的多核苷酸
公开(公告)号：WO2005001061A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/020399
申请日：2004-06-24
申请人： BRISTOL-MYERS SQUIBB COMPANY , CHEN, Jian , WU, Shujian , LEE, Ning
发明人： CHEN, Jian , WU, Shujian , LEE, Ning
IPC分类号： C12N
CPC分类号： C07K14/72
摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。预防与这些多肽相关的各种疾病和/或病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明申请

WO2003083076A2 POLYNUCLEOTIDES ENCODING NOVEL TWO SPLICE VARIANTS OF A HUMAN CELL SURFACE PROTEIN WITH IMMUNOLOGOBULIN FOLDS, BGS5G AND BGS5I 审中-公开
标题翻译：多核苷酸编码人免疫球蛋白，BGS5G和BGS5I的人类细胞表面蛋白质的新型两个差异变体
公开(公告)号：WO2003083076A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/009632
申请日：2003-03-28
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEE, Liana, M. , FEDER, John, N. , SIEMERS, Nathan, O. , WU, Shujian
发明人： LEE, Liana, M. , FEDER, John, N. , SIEMERS, Nathan, O. , WU, Shujian
IPC分类号： C12N
CPC分类号： C07K14/70503
摘要： The present invention provides novel polynucleotides encoding BGS-5G, and BGS-5I polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-5G, and BGS-5I polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-5G和BGS-5I多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-5G和BGS-5I多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

8. 发明申请

WO2003012063A3 POLYNUCLEOTIDE ENCODING A NOVEL TRP CHANNEL FAMILY MEMBER, LTRPC3, AND SPLICE VARIANTS THEREOF 审中-公开
公开(公告)号：WO2003012063A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024445
申请日：2002-08-01
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEE, Ning , CHEN, Jian , FEDER, John, N. , WU, Shujian , LEE, Liana , BLANAR, Michael, A. , BOL, David , LEVESQUE, Paul, C. , SUN, Lucy
发明人： LEE, Ning , CHEN, Jian , FEDER, John, N. , WU, Shujian , LEE, Liana , BLANAR, Michael, A. , BOL, David , LEVESQUE, Paul, C. , SUN, Lucy
IPC分类号： C12N15/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

9. 发明申请

WO2008115561A3 BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO MICROTUBULE-STABILIZING AGENTS 审中-公开
标题翻译：用于确定微生物稳定剂敏感性的生物标记物和方法
公开(公告)号：WO2008115561A3
公开(公告)日：2008-11-20
申请号：PCT/US2008003705
申请日：2008-03-21
申请人： SQUIBB BRISTOL MYERS CO , WU SHUJIAN , CHASALOW SCOTT D , LEE HYERIM
发明人： WU SHUJIAN , CHASALOW SCOTT D , LEE HYERIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/118 , C12Q2565/501
摘要： Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.
摘要翻译：可用于鉴定将对治疗癌症的治疗方法进行治疗或反应的哺乳动物有用的生物标志物，其包括施用微管稳定剂。一方面，癌症是乳腺癌，微管稳定剂是埃坡霉素或其类似物或衍生物，或伊沙匹隆。

10. 发明申请

WO2005026317A2 POLYNUCLEOTIDES ENCODING NOVEL VARIANTS OF THE TRP CHANNEL FAMILY MEMBER, LTRPC3 审中-公开
标题翻译：编码TRP频道家庭成员的新变体的多核苷酸
公开(公告)号：WO2005026317A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/014714
申请日：2004-05-11
申请人： BRISTOL-MYERS SQUIBB COMPANY , LEE, Ning , CHEN, Jian , FEDER, John, N. , WU, Shujian , BLANAR, Michael, A. , BOL, David, K. , LEVESQUE, Paul, C. , SUN, Lucy
发明人： LEE, Ning , CHEN, Jian , FEDER, John, N. , WU, Shujian , BLANAR, Michael, A. , BOL, David, K. , LEVESQUE, Paul, C. , SUN, Lucy
IPC分类号： C12N
CPC分类号： C07K14/705 , C07H21/04 , C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC31 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC31 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC31多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3g，LTRPC3h，LTRPC3i，LTRPC3j，LTRPC3k或LTRPC31多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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