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1. 发明申请

WO2007044522A1 P62 AS A RISK DETERMINANT FOR METABOLIC SYNDROME 审中-公开
标题翻译： P62作为代谢综合征的风险决定因素
公开(公告)号：WO2007044522A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/039151
申请日：2006-10-05
申请人： AUBURN UNIVERSITY , WOOTEN, Marie, W. , DIAZ-MECO, Maria, T. , MOSCAT, Jorge
发明人： WOOTEN, Marie, W. , DIAZ-MECO, Maria, T. , MOSCAT, Jorge
IPC分类号： G01N33/68 , A61K38/16
CPC分类号： A61K38/1709 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： The p62 protein has been analyzed and identified as the significant contributor to several metabolic pathways that lead to metabolic syndrome, Alzheimer's Disease, and other related diseases. The absence of the p62 protein has a profound effect on the accumulation of tau protein, amyloid beta protein and an increase in blood insulin levels. The accumulation of tau protein and amyloid beta protein in neurological tissues is a hallmark of neurological metabolic diseases such as Alzheimer's Disease and related dementias. Moreover, increase blood insulin levels is an indicator of insulin resistance in mammals. Accordingly, the present invention provides a method for screening a mammal for metabolic disease comprising the step of detecting the absence of the p62 protein. The present invention also contemplates a method of screening a mammal for a metabolic syndrome comprising the steps of detecting the level of p62 protein in a metabolic pathway and determining whether the level of p62 protein falls below a threshold level. A pharmaceutical composition is also contemplated for therapeutic supplementation of a metabolic pathway, the pharmaceutical composition comprising a p62 protein or an amide, ester or salt thereof and a pharmaceutically effective carrier. Such pharmaceutical composition will have an inhibitory action on the phosphorylation, ubiquitination, accumulation of tau protein, an inhibitory effect on the accumulation of APP/amyloid beta and may operate to lower blood insulin levels.
摘要翻译： p62蛋白已被分析并确定为导致代谢综合征，阿尔茨海默病和其他相关疾病的几种代谢途径的重要贡献者。 p62蛋白的缺失对tau蛋白，淀粉样蛋白β蛋白的积累和血液胰岛素水平的增加具有深远的影响。 tau蛋白和淀粉样β蛋白在神经组织中的积累是神经代谢疾病如阿尔茨海默病和相关痴呆的标志。此外，增加血液胰岛素水平是哺乳动物胰岛素抵抗的指标。因此，本发明提供了筛选哺乳动物代谢疾病的方法，包括检测p62蛋白不存在的步骤。本发明还考虑了筛选哺乳动物代谢综合征的方法，其包括以下步骤：检测代谢途径中p62蛋白的水平并确定p62蛋白的水平是否低于阈值水平。还考虑药物组合物用于治疗性补充代谢途径，所述药物组合物包含p62蛋白或其酰胺，酯或其盐和药学上有效的载体。这种药物组合物将对磷酸化，泛素化，tau蛋白的积累，对APP /淀粉样蛋白β的积累的抑制作用具有抑制作用并且可以降低血液胰岛素水平。

2. 发明申请

WO2005050170A2 METHODS AND COMPOSITIONS FOR INHIBITING INTRACELLULAR AGGREGATE FORMATION 审中-公开
标题翻译：抑制细胞内聚集体形成的方法和组合物
公开(公告)号：WO2005050170A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/038454
申请日：2004-11-16
申请人： AUBURN UNIVERSITY , WOOTEN, Marie, W.
发明人： WOOTEN, Marie, W.
IPC分类号： G01N
CPC分类号： G01N33/6896 , G01N2500/02 , G01N2800/2814
摘要： Methods and compositions for modulating the formation of intracellular aggregates are provided, in particular TRAF6 mediated intracellular aggregate formation. Additionally, methods and compositions for identifying modulators of intracellular aggregate formation are provided, for example methods for identifying compositions that inhibit or reduce the formation of intracellular aggregate formation.
摘要翻译：提供了用于调节细胞内聚集体形成的方法和组合物，特别是TRAF6介导的细胞内聚集体形成。另外，提供了用于鉴定细胞内聚集体形成调节剂的方法和组合物，例如用于鉴定抑制或减少细胞内聚集体形成形成的组合物的方法。

3. 发明申请

WO2005050170A3 METHODS AND COMPOSITIONS FOR INHIBITING INTRACELLULAR AGGREGATE FORMATION 审中-公开
标题翻译：抑制细胞内聚集形成的方法和组合物
公开(公告)号：WO2005050170A3
公开(公告)日：2009-04-16
申请号：PCT/US2004038454
申请日：2004-11-16
申请人： UNIV AUBURN , WOOTEN MARIE W
发明人： WOOTEN MARIE W
IPC分类号： A61K38/00 , A61K38/03 , A61K38/08 , A61K38/17 , G01N20060101 , G01N33/68
CPC分类号： G01N33/6896 , G01N2500/02 , G01N2800/2814
摘要： Methods and compositions for modulating the formation of intracellular aggregates are provided, in particular TRAF6 mediated intracellular aggregate formation. Additionally, methods and compositions for identifying modulators of intracellular aggregate formation are provided, for example methods for identifying compositions that inhibit or reduce the formation of intracellular aggregate formation.
摘要翻译：提供了用于调节细胞内聚集体形成的方法和组合物，特别是TRAF6介导的细胞内聚集体形成。另外，提供了用于鉴定细胞内聚集体形成调节剂的方法和组合物，例如用于鉴定抑制或减少细胞内聚集体形成形成的组合物的方法。

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